RTCB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description RNA 2',3'-cyclic phosphate and 5'-OH ligase| (NCBI Entrez Gene Database, 51493)
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Genes

356 genes differentially expressed following the RTCB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.94591
HGD homogentisate 1,2-dioxygenase 2.94591
HES7 hes family bHLH transcription factor 7 2.94591
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.94591
ARHGAP36 Rho GTPase activating protein 36 2.94591
FETUB fetuin B 2.94591
LRG1 leucine-rich alpha-2-glycoprotein 1 2.94591
FLI1 Fli-1 proto-oncogene, ETS transcription factor 2.94591
CA6 carbonic anhydrase VI 2.94591
PCDH8 protocadherin 8 2.94591
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.94591
TNNI1 troponin I type 1 (skeletal, slow) 2.94591
RAX retina and anterior neural fold homeobox 2.94591
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.94591
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 2.94591
CD7 CD7 molecule 2.94591
MYBPHL myosin binding protein H-like 2.94591
CDH5 cadherin 5, type 2 (vascular endothelium) 2.94591
USP26 ubiquitin specific peptidase 26 2.94591
ZNF492 zinc finger protein 492 2.94591
SCG2 secretogranin II 2.94591
MUC6 mucin 6, oligomeric mucus/gel-forming 2.94591
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.94591
CHL1 cell adhesion molecule L1-like 2.94591
SLC44A4 solute carrier family 44, member 4 2.94591
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.94591
SPAG8 sperm associated antigen 8 2.94591
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.94591
EPHB3 EPH receptor B3 2.94591
DNAH2 dynein, axonemal, heavy chain 2 2.94591
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.94591
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.94591
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 2.94591
TWIST1 twist family bHLH transcription factor 1 2.94591
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.94591
NMUR1 neuromedin U receptor 1 2.94591
KCNU1 potassium channel, subfamily U, member 1 2.94591
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.94591
CRYGN crystallin, gamma N 2.94591
PTK6 protein tyrosine kinase 6 2.94591
KRT78 keratin 78, type II 2.94591
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.94591
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.94591
GALR3 galanin receptor 3 2.94591
ASGR2 asialoglycoprotein receptor 2 2.94591
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 2.94591
DNAAF2 dynein, axonemal, assembly factor 2 2.94591
AMPD1 adenosine monophosphate deaminase 1 2.94591
GUCA1C guanylate cyclase activator 1C 2.94591
CATSPERH catsper channel auxiliary subunit eta 2.94591
OPRM1 opioid receptor, mu 1 2.94591
ACER1 alkaline ceramidase 1 2.94591
RHCG Rh family, C glycoprotein 2.94591
FMO2 flavin containing monooxygenase 2 (non-functional) 2.94591
PLCZ1 phospholipase C, zeta 1 2.94591
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.94591
MYZAP myocardial zonula adherens protein 2.94591
LMNTD1 lamin tail domain containing 1 2.94591
MYL10 myosin, light chain 10, regulatory 2.94591
ZNF441 zinc finger protein 441 2.94591
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1 2.94591
CARS1 cysteinyl-tRNA synthetase 1 2.94591
SPATA31G1 SPATA31 subfamily G member 1 2.94591
C1ORF232 chromosome 1 open reading frame 230 2.94591
LOC124903372 uncharacterized LOC124903372 2.94591
H4C14 H4 clustered histone 14 2.94591
SEPTIN12 septin 12 2.94591
MAJIN membrane anchored junction protein 2.94591
ERFE erythroferrone 2.94591
MARCHF10 membrane associated ring-CH-type finger 10 2.94591
CCN6 cellular communication network factor 6 2.94591
H3-5 H3.5 histone 2.94591
MAGIX MAGI family member, X-linked 2.94591
C15ORF62 chromosome 15 open reading frame 62 2.94591
AWAT1 acyl-CoA wax alcohol acyltransferase 1 2.94591
ZIC4 Zic family member 4 2.94591
ANXA10 annexin A10 2.94591
MAG myelin associated glycoprotein 2.94591
DAO D-amino-acid oxidase 2.94591
CLDN5 claudin 5 2.94591
CCDC17 coiled-coil domain containing 17 2.94591
TUBA3D tubulin, alpha 3d 2.94591
ACOT6 acyl-CoA thioesterase 6 2.94591
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.94591
RNF113B ring finger protein 113B 2.94591
ZNF257 zinc finger protein 257 2.94591
PARVG parvin, gamma 2.94591
DYNAP dynactin associated protein 2.94591
GDF7 growth differentiation factor 7 2.94591
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.94591
C9 complement component 9 2.94591
UTS2 urotensin 2 2.94591
PGLYRP1 peptidoglycan recognition protein 1 2.94591
S100G S100 calcium binding protein G 2.94591
FOXI2 forkhead box I2 2.94591
RASAL3 RAS protein activator like 3 2.94591
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.94591
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.94591
FOXP2 forkhead box P2 2.94591
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.94591
GOLGA6C golgin A6 family, member C 2.94591
WFDC8 WAP four-disulfide core domain 8 2.94591
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.94591
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.94591
C16ORF78 chromosome 16 open reading frame 78 2.94591
CLEC4D C-type lectin domain family 4, member D 2.94591
ODF1 outer dense fiber of sperm tails 1 2.94591
DRD5 dopamine receptor D5 2.94591
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.94591
S100A14 S100 calcium binding protein A14 2.94591
PCDHGB1 protocadherin gamma subfamily B, 1 2.94591
PCDHGB2 protocadherin gamma subfamily B, 2 2.94591
CCDC152 coiled-coil domain containing 152 2.94591
GAB3 GRB2-associated binding protein 3 2.94591
DYDC1 DPY30 domain containing 1 2.94591
LCT lactase 2.94591
CDC20B cell division cycle 20B 2.94591
CSTA cystatin A (stefin A) 2.94591
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.94591
PCDHGA7 protocadherin gamma subfamily A, 7 2.94591
NUPR1 nuclear protein, transcriptional regulator, 1 2.94591
WNT7B wingless-type MMTV integration site family, member 7B 2.94591
SLA Src-like-adaptor 2.94591
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.94591
CCNA1 cyclin A1 2.94591
C22ORF31 chromosome 22 open reading frame 31 2.94591
TEX29 testis expressed 29 2.94591
TEX26 testis expressed 26 2.94591
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.94591
ZNF831 zinc finger protein 831 2.94591
OR52N4 olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene) 2.94591
LYPD5 LY6/PLAUR domain containing 5 2.94591
PLCD4 phospholipase C, delta 4 2.94591
TMEM132E transmembrane protein 132E 2.94591
PCDHA13 protocadherin alpha 13 2.94591
ART1 ADP-ribosyltransferase 1 2.94591
CD200R1 CD200 receptor 1 2.94591
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.94591
DMRT1 doublesex and mab-3 related transcription factor 1 2.94591
CA5A carbonic anhydrase VA, mitochondrial 2.94591
DAW1 dynein assembly factor with WDR repeat domains 1 2.94591
NID2 nidogen 2 (osteonidogen) 2.94591
EIF4E1B eukaryotic translation initiation factor 4E family member 1B 2.94591
IER5L immediate early response 5-like 2.94591
LPO lactoperoxidase 2.94591
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.94591
STOML3 stomatin (EPB72)-like 3 2.94591
TNMD tenomodulin 2.94591
TMPRSS12 transmembrane (C-terminal) protease, serine 12 2.94591
PTGDR prostaglandin D2 receptor (DP) 2.94591
TBC1D26 TBC1 domain family, member 26 2.94591
SHOX short stature homeobox 2.94591
GPR17 G protein-coupled receptor 17 2.94591
ALLC allantoicase 2.94591
VWC2L von Willebrand factor C domain containing protein 2-like 2.94591
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.94591
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.94591
TMEM86A transmembrane protein 86A 2.94591
COL22A1 collagen, type XXII, alpha 1 2.94591
C17ORF100 chromosome 17 open reading frame 100 2.94591
EFCC1 EF-hand and coiled-coil domain containing 1 2.94591
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28 2.94591
GPBAR1 G protein-coupled bile acid receptor 1 2.94591
TAS2R46 taste receptor, type 2, member 46 2.94591
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 2.93462
RBM20 RNA binding motif protein 20 2.90048
PMM1 phosphomannomutase 1 2.90048
NPY5R neuropeptide Y receptor Y5 2.90048
VARS2 valyl-tRNA synthetase 2, mitochondrial 2.78616
SKIL SKI-like proto-oncogene 2.751
SARS1 seryl-tRNA synthetase 1 2.73758
GPX1 glutathione peroxidase 1 2.68875
LRRC36 leucine rich repeat containing 36 2.63542
GPR68 G protein-coupled receptor 68 2.63542
FAM43B family with sequence similarity 43, member B 2.63542
FUZ fuzzy planar cell polarity protein 2.63542
RGS8 regulator of G-protein signaling 8 2.63542
TENM2 teneurin transmembrane protein 2 2.58995
STK24 serine/threonine kinase 24 2.50134
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.48314
DUSP12 dual specificity phosphatase 12 2.44547
KLHDC8B kelch domain containing 8B 2.43568
LIPT2-AS1 LIPT2 antisense RNA 1 2.43461
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 2.43461
ECEL1 endothelin converting enzyme-like 1 2.43461
SMIM22 small integral membrane protein 22 2.43461
LIPI lipase, member I 2.42894
UBR1 ubiquitin protein ligase E3 component n-recognin 1 2.38508
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 2.36944
XPO4 exportin 4 2.36944
SERHL2 serine hydrolase-like 2 2.32066
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.30924
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 2.30764
PSAT1 phosphoserine aminotransferase 1 2.30653
ZNF615 zinc finger protein 615 2.30579
MRPL45 mitochondrial ribosomal protein L45 2.30153
LPIN1 lipin 1 2.29961
RNF185 ring finger protein 185 2.29628
ARHGAP23 Rho GTPase activating protein 23 2.27939
PRRG3 proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) 2.25837
SRFBP1 serum response factor binding protein 1 2.246
ELL elongation factor RNA polymerase II 2.24577
ATP5PD ATP synthase peripheral stalk subunit d 2.23976
GATAD2A GATA zinc finger domain containing 2A 2.23007
LIFR leukemia inhibitory factor receptor alpha 2.2241
ZBED4 zinc finger, BED-type containing 4 2.22156
DCTN2 dynactin 2 (p50) 2.22003
ZNF536 zinc finger protein 536 2.20847
TRIR telomerase RNA component interacting RNase 2.19888
PPM1N protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative) 2.18811
ACSS3 acyl-CoA synthetase short-chain family member 3 2.18805
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 2.18805
MTA3 metastasis associated 1 family, member 3 2.18131
RRAGC Ras-related GTP binding C 2.16963
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.16317
SNURF SNRPN upstream reading frame 2.16168
FBXO27 F-box protein 27 2.15918
MAP2 microtubule-associated protein 2 2.15918
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 2.15306
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.14162
SMG9 SMG9 nonsense mediated mRNA decay factor 2.14162
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 2.13107
BOD1 biorientation of chromosomes in cell division 1 2.11984
TM9SF2 transmembrane 9 superfamily member 2 2.11984
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 2.10215
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 2.09707
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.09402
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.09089
TUT4 terminal uridylyl transferase 4 2.08262
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.07341
ITSN1 intersectin 1 (SH3 domain protein) 2.04251
FBXO45 F-box protein 45 2.04251
CXXC5 CXXC finger protein 5 2.03327
KIAA1958 KIAA1958 2.02404
FBXL17 F-box and leucine-rich repeat protein 17 2.02404
EPS15 epidermal growth factor receptor pathway substrate 15 2.01635
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 2.01342
SBF2 SET binding factor 2 2.01114
FAS Fas cell surface death receptor 2.00665
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.00665

decreased expression

Symbol Name Standardized Value
DPY19L1 dpy-19-like 1 (C. elegans) -2.94591
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -2.94591
SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 -2.94591
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.94591
AKAP6 A kinase (PRKA) anchor protein 6 -2.94591
HTATSF1 HIV-1 Tat specific factor 1 -2.94591
MBLAC2 metallo-beta-lactamase domain containing 2 -2.94591
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.94591
SCML1 sex comb on midleg-like 1 (Drosophila) -2.94591
PTAFR platelet-activating factor receptor -2.94591
CAPN11 calpain 11 -2.94591
ADAM12 ADAM metallopeptidase domain 12 -2.94591
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.94432
GEMIN7 gem (nuclear organelle) associated protein 7 -2.90048
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 -2.90048
KCNK15 potassium channel, two pore domain subfamily K, member 15 -2.90048
CLPSL1 colipase-like 1 -2.90048
SCARA5 scavenger receptor class A, member 5 -2.90048
DNAH6 dynein, axonemal, heavy chain 6 -2.90048
NLRP7 NLR family, pyrin domain containing 7 -2.90048
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -2.90048
SYCE3 synaptonemal complex central element protein 3 -2.90048
TMEM171 transmembrane protein 171 -2.90048
TGFB3 transforming growth factor, beta 3 -2.90048
KIAA1755 KIAA1755 -2.90048
CNTN2 contactin 2 (axonal) -2.90048
TMEM176A transmembrane protein 176A -2.90048
GRM2 glutamate receptor, metabotropic 2 -2.90048
MFAP4 microfibrillar-associated protein 4 -2.90048
POTEJ POTE ankyrin domain family, member J -2.90048
ERVV-2 endogenous retrovirus group V, member 2 -2.90048
CRX cone-rod homeobox -2.90048
C9ORF43 chromosome 9 open reading frame 43 -2.90048
KLK8 kallikrein-related peptidase 8 -2.90048
LRRC19 leucine rich repeat containing 19 -2.90048
PCDHAC1 protocadherin alpha subfamily C, 1 -2.90048
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.90048
HJV hemojuvelin BMP co-receptor -2.90048
ATP5MGL ATP synthase membrane subunit g like -2.90048
CFAP299 cilia and flagella associated protein 299 -2.90048
GHRHR growth hormone releasing hormone receptor -2.90048
HSPB2 heat shock 27kDa protein 2 -2.90048
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.90048
KLB klotho beta -2.90048
TAS2R31 taste receptor, type 2, member 31 -2.90048
BAIAP3 BAI1-associated protein 3 -2.90048
CCDC92 coiled-coil domain containing 92 -2.90048
PIH1D2 PIH1 domain containing 2 -2.90048
PDE1B phosphodiesterase 1B, calmodulin-dependent -2.90048
GAMT guanidinoacetate N-methyltransferase -2.89779
POM121C POM121 transmembrane nucleoporin C -2.88006
PLXND1 plexin D1 -2.81851
SELENBP1 selenium binding protein 1 -2.79331
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -2.78525
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) -2.77077
RBIS ribosomal biogenesis factor -2.73758
MOSPD2 motile sperm domain containing 2 -2.73758
MEI4 meiosis-specific 4 homolog (S. cerevisiae) -2.73758
RECQL RecQ helicase-like -2.64333
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -2.63542
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -2.57632
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O -2.50778
CALM1 calmodulin 1 (phosphorylase kinase, delta) -2.47907
FPGT fucose-1-phosphate guanylyltransferase -2.46902
ASB2 ankyrin repeat and SOCS box containing 2 -2.46902
ELMO3 engulfment and cell motility 3 -2.46902
ERVK3-1 endogenous retrovirus group K3, member 1 -2.46327
RASA2 RAS p21 protein activator 2 -2.449
PTPN2 protein tyrosine phosphatase, non-receptor type 2 -2.44547
PHLDB3 pleckstrin homology-like domain, family B, member 3 -2.42507
AMT aminomethyltransferase -2.41503
KRABD4 KRAB domain containing 4 -2.39323
ZNF568 zinc finger protein 568 -2.35398
FAM156A family with sequence similarity 156, member A -2.32776
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.32116
LDB2 LIM domain binding 2 -2.28993
LRP2BP LRP2 binding protein -2.28312
RAD23B RAD23 homolog B (S. cerevisiae) -2.28312
TSLIG3B tRNA splicing ligase complex subunit 3B -2.28312
FBXO31 F-box protein 31 -2.25264
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.25264
WWC1 WW and C2 domain containing 1 -2.23857
CEP192 centrosomal protein 192kDa -2.23473
LIN7B lin-7 homolog B (C. elegans) -2.22156
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -2.21403
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.19319
ITGA6 integrin, alpha 6 -2.18811
TP53 tumor protein p53 -2.18805
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -2.18435
WNT9A wingless-type MMTV integration site family, member 9A -2.17657
GIPR gastric inhibitory polypeptide receptor -2.17209
BNIPL BCL2/adenovirus E1B 19kD interacting protein like -2.17209
GHRL ghrelin/obestatin prepropeptide -2.17209
ARLN allregulin -2.17209
CD1D CD1d molecule -2.17209
CFLAR CASP8 and FADD-like apoptosis regulator -2.1587
FMNL2 formin-like 2 -2.14143
PDGFRB platelet-derived growth factor receptor, beta polypeptide -2.12507
RGS14 regulator of G-protein signaling 14 -2.12507
SPATA6L spermatogenesis associated 6-like -2.09707
MICB MHC class I polypeptide-related sequence B -2.09707
RCOR1 REST corepressor 1 -2.09707
CDC27 cell division cycle 27 -2.08328
GLIPR1L1 GLI pathogenesis-related 1 like 1 -2.08299
ERLIN1 ER lipid raft associated 1 -2.06596
GABPB2 GA binding protein transcription factor, beta subunit 2 -2.06024
NT5C2 5'-nucleotidase, cytosolic II -2.04813
SALL3 spalt-like transcription factor 3 -2.04813
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.03415
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.0292
CORO1B coronin, actin binding protein, 1B -2.0292
USP1 ubiquitin specific peptidase 1 -2.02404
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.02404
PNMA3 paraneoplastic Ma antigen 3 -2.02283
USP48 ubiquitin specific peptidase 48 -2.01342
VPS13B vacuolar protein sorting 13 homolog B (yeast) -2.01114