RUNX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description runt-related transcription factor 1|Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 861)
Similar Terms
Downloads & Tools

Genes

360 genes differentially expressed following the RUNX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NMUR2 neuromedin U receptor 2 3.59319
GPR12 G protein-coupled receptor 12 3.59319
EFCAB9 EF-hand calcium binding domain 9 3.59319
CHIT1 chitinase 1 (chitotriosidase) 3.59319
GTSF1 gametocyte specific factor 1 3.59319
TRPV3 transient receptor potential cation channel, subfamily V, member 3 3.59319
NRROS negative regulator of reactive oxygen species 3.59319
TCEA3 transcription elongation factor A (SII), 3 3.59319
LIX1 Lix1 homolog (chicken) 3.59319
HAPLN2 hyaluronan and proteoglycan link protein 2 3.59319
DOK7 docking protein 7 3.59319
NPIPB7 nuclear pore complex interacting protein family, member B7 3.59319
SHC4 SHC (Src homology 2 domain containing) family, member 4 3.59319
MT1M metallothionein 1M 3.59319
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 3.59319
TBC1D3L TBC1 domain family, member 3L 3.59319
ERFE erythroferrone 3.59319
CTRC chymotrypsin C (caldecrin) 3.59319
GPR119 G protein-coupled receptor 119 3.59319
SAPCD1 suppressor APC domain containing 1 3.59319
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.59319
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 3.59319
GMNC geminin coiled-coil domain containing 3.59319
NXPH3 neurexophilin 3 3.56027
PCDHB4 protocadherin beta 4 3.56027
GLUD2 glutamate dehydrogenase 2 3.56027
LY86 lymphocyte antigen 86 3.56027
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 3.56027
CD160 CD160 molecule 3.56027
PTX3 pentraxin 3, long 3.56027
SLC26A4 solute carrier family 26 (anion exchanger), member 4 3.56027
MUC1 mucin 1, cell surface associated 3.56027
ADGRE1 adhesion G protein-coupled receptor E1 3.56027
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.56027
SPINK1 serine peptidase inhibitor, Kazal type 1 3.56027
CD19 CD19 molecule 3.56027
GJB3 gap junction protein, beta 3, 31kDa 3.56027
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.56027
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.56027
BOLA2 bolA family member 2 3.56027
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.56027
ATOH1 atonal homolog 1 (Drosophila) 3.56027
HBZ hemoglobin, zeta 3.56027
MISP mitotic spindle positioning 3.56027
SIM1 single-minded family bHLH transcription factor 1 3.56027
DLL4 delta-like 4 (Drosophila) 3.56027
LCN15 lipocalin 15 3.56027
HEATR9 HEAT repeat containing 9 3.56027
ARSF arylsulfatase F 3.56027
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 3.56027
CSMD3 CUB and Sushi multiple domains 3 3.56027
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.56027
PDE7B phosphodiesterase 7B 3.56027
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 3.56027
HRG histidine-rich glycoprotein 3.56027
GJA5 gap junction protein, alpha 5, 40kDa 3.56027
TUBA4B tubulin, alpha 4b 3.56027
PRDM7 PR domain containing 7 3.56027
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 3.56027
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 3.56027
GC group-specific component (vitamin D binding protein) 3.56027
PROX2 prospero homeobox 2 3.56027
TMPRSS6 transmembrane protease, serine 6 3.56027
PDF peptide deformylase (mitochondrial) 3.56027
HTRA4 HtrA serine peptidase 4 3.56027
ZG16 zymogen granule protein 16 3.56027
RAG2 recombination activating gene 2 3.56027
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 3.56027
TMEM275 transmembrane protein 275 3.56027
FAM237B family with sequence similarity 237 member B 3.56027
RNF227 ring finger protein 227 3.56027
GSTT4 glutathione S-transferase theta 4 3.56027
ANKRD42-DT ANKRD42 divergent transcript 3.56027
SOAT2 sterol O-acyltransferase 2 3.56027
COX8C cytochrome c oxidase subunit VIIIC 3.56027
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 3.56027
ZNF99 zinc finger protein 99 3.56027
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.56027
HHEX hematopoietically expressed homeobox 3.56027
OR2A1 olfactory receptor, family 2, subfamily A, member 1 3.56027
TCF23 transcription factor 23 3.56027
PRB2 proline-rich protein BstNI subfamily 2 3.56027
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 3.56027
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.56027
ANXA13 annexin A13 3.56027
TLR9 toll-like receptor 9 3.56027
RUNX3 runt-related transcription factor 3 3.56027
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 3.56027
EXOC3L4 exocyst complex component 3-like 4 3.56027
ABHD15 abhydrolase domain containing 15 3.56027
LRRC71 leucine rich repeat containing 71 3.56027
LGSN lengsin, lens protein with glutamine synthetase domain 3.56027
ZNF475 zinc finger protein 475 3.56027
FADS6 fatty acid desaturase 6 3.56027
DYTN dystrotelin 3.56027
CCDC154 coiled-coil domain containing 154 3.56027
MYF6 myogenic factor 6 (herculin) 3.56027
CD27 CD27 molecule 3.56027
UBQLNL ubiquilin-like 3.56027
AQP6 aquaporin 6, kidney specific 3.56027
RETNLB resistin like beta 3.56027
OR9A2 olfactory receptor, family 9, subfamily A, member 2 3.56027
SMIM22 small integral membrane protein 22 3.56027
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 3.56027
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 3.56027
PLGLB1 plasminogen-like B1 3.56027
DBX2 developing brain homeobox 2 3.56027
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.56027
TSPAN32 tetraspanin 32 3.56027
KLF5 Kruppel-like factor 5 (intestinal) 3.56027
HSPB9 heat shock protein, alpha-crystallin-related, B9 3.56027
ESAM endothelial cell adhesion molecule 3.56027
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 3.56027
C9ORF64 chromosome 9 open reading frame 64 3.56027
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.56027
PLA2G12B phospholipase A2, group XIIB 3.56027
VAV1 vav 1 guanine nucleotide exchange factor 3.56027
OTOP1 otopetrin 1 3.56027
BCL2L15 BCL2-like 15 3.56027
TMPPE transmembrane protein with metallophosphoesterase domain 3.56027
TSPAN19 tetraspanin 19 3.56027
C10ORF105 chromosome 10 open reading frame 105 3.56027
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.56027
TPPP3 tubulin polymerization-promoting protein family member 3 3.56027
PRR35 proline rich 35 3.56027
ZC3H11D zinc finger CCCH-type containing 11D 3.56027
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 3.56027
SPINK9 serine peptidase inhibitor, Kazal type 9 3.56027
PGK2 phosphoglycerate kinase 2 3.56027
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 3.56027
ISL1 ISL LIM homeobox 1 3.56027
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 3.56027
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 3.56027
MLIP muscular LMNA-interacting protein 3.56027
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 3.56027
ZBED6 zinc finger, BED-type containing 6 3.56027
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.56027
OR6B3 olfactory receptor, family 6, subfamily B, member 3 3.56027
RTN4RL1 reticulon 4 receptor-like 1 3.56027
CIB4 calcium and integrin binding family member 4 3.56027
IFITM10 interferon induced transmembrane protein 10 3.56027
ADAM29 ADAM metallopeptidase domain 29 3.56027
DBT dihydrolipoamide branched chain transacylase E2 3.56027
RNF148 ring finger protein 148 3.56027
TAS2R46 taste receptor, type 2, member 46 3.56027
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.56027
LOXL4 lysyl oxidase-like 4 3.56027
MMP12 matrix metallopeptidase 12 3.56027
SLITRK1 SLIT and NTRK-like family, member 1 3.56027
MEIG1 meiosis/spermiogenesis associated 1 3.56027
TMEM88 transmembrane protein 88 3.56027
GALP galanin-like peptide 3.56027
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.56027
ASCL1 achaete-scute family bHLH transcription factor 1 3.56027
GAB3 GRB2-associated binding protein 3 3.53543
CCDC63 coiled-coil domain containing 63 3.53543
ZNF285 zinc finger protein 285 3.53543
ODAD1 outer dynein arm docking complex subunit 1 3.53543
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 3.53543
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 3.53543
SEC23B Sec23 homolog B (S. cerevisiae) 2.87549
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 2.83368
GUCD1 guanylyl cyclase domain containing 1 2.65729
C2ORF15 chromosome 2 open reading frame 15 2.65516
CNOT9 CCR4-NOT transcription complex subunit 9 2.65161
GPATCH2 G patch domain containing 2 2.62537
RNASEH1 ribonuclease H1 2.61649
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa 2.5972
TMEM134 transmembrane protein 134 2.5683
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 2.56789
CCDC194 coiled-coil domain containing 194 2.55671
SPATA32 spermatogenesis associated 32 2.55671
DEGS2 delta(4)-desaturase, sphingolipid 2 2.55671
SPOCD1 SPOC domain containing 1 2.55671
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.55671
TMEM81 transmembrane protein 81 2.55671
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.54492
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.54492
DNM2 dynamin 2 2.54111
MAP2K4 mitogen-activated protein kinase kinase 4 2.531
MAST1 microtubule associated serine/threonine kinase 1 2.52646
CTU1 cytosolic thiouridylase subunit 1 2.50773
ACMSD aminocarboxymuconate semialdehyde decarboxylase 2.50034
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2.50001
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.46744
POTEF POTE ankyrin domain family, member F 2.43385
PTRH2 peptidyl-tRNA hydrolase 2 2.42774
SALL2 spalt-like transcription factor 2 2.4124
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.38396
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.38396
CD68 CD68 molecule 2.3655
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.35414
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 2.33987
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 2.33847
CHKB choline kinase beta 2.32546
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.30169
SCARB2 scavenger receptor class B, member 2 2.28869
CMKLR2 chemerin chemokine-like receptor 2 2.28264
RPN2 ribophorin II 2.27995
EXO1 exonuclease 1 2.2743
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.2743
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2.26559
TCAF1 TRPM8 channel-associated factor 1 2.21062
ATF3 activating transcription factor 3 2.2028
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 2.20014
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) 2.20014
PEX5L peroxisomal biogenesis factor 5-like 2.1982
TMEM184C transmembrane protein 184C 2.18222
EEF1AKMT1 EEF1A lysine methyltransferase 1 2.1697
DTYMK deoxythymidylate kinase (thymidylate kinase) 2.15896
TMEM64 transmembrane protein 64 2.14147
NOMO3 NODAL modulator 3 2.13768
DEAF1 DEAF1 transcription factor 2.12372
GPHA2 glycoprotein hormone alpha 2 2.11657
REPIN1 replication initiator 1 2.09695
LRP1 low density lipoprotein receptor-related protein 1 2.09695
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 2.09497
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2.08077
RHOXF1 Rhox homeobox family, member 1 2.08077
TIMP2 TIMP metallopeptidase inhibitor 2 2.07468
ZBTB17 zinc finger and BTB domain containing 17 2.07456
DPY19L3 dpy-19-like 3 (C. elegans) 2.06823
CEP295 centrosomal protein 295kDa 2.04731
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 2.03271
SF3A2 splicing factor 3a, subunit 2, 66kDa 2.03224
MARK3 MAP/microtubule affinity-regulating kinase 3 2.02264
MTIF2 mitochondrial translational initiation factor 2 2.02264
COPA coatomer protein complex, subunit alpha 2.01478
ZNF440 zinc finger protein 440 2.00395
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.00395

decreased expression

Symbol Name Standardized Value
ZNF112 zinc finger protein 112 -3.59319
PTGDS prostaglandin D2 synthase 21kDa (brain) -3.57065
PLSCR2 phospholipid scramblase 2 -3.57065
AURKC aurora kinase C -3.57065
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 -3.57065
XIRP2 xin actin binding repeat containing 2 -3.57065
ZNF823 zinc finger protein 823 -3.56027
IL2RB interleukin 2 receptor, beta -3.53543
ASCL3 achaete-scute family bHLH transcription factor 3 -3.53543
CPO carboxypeptidase O -3.53543
TMC8 transmembrane channel-like 8 -3.53543
HEPHL1 hephaestin-like 1 -3.53543
SPATA22 spermatogenesis associated 22 -3.53543
TMEM132D transmembrane protein 132D -3.53543
OVCH1 ovochymase 1 -3.53543
TMEM236 transmembrane protein 236 -3.53543
LECT2 leukocyte cell-derived chemotaxin 2 -3.53543
THPO thrombopoietin -3.53543
PANO1 proapoptotic nucleolar protein 1 -3.53543
SLC35D3 solute carrier family 35, member D3 -3.53543
GGN gametogenetin -3.53543
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B -3.53543
ZNF436 zinc finger protein 436 -3.53543
EPN3 epsin 3 -3.53543
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -3.53543
PSORS1C2 psoriasis susceptibility 1 candidate 2 -3.53543
ATP5PF ATP synthase peripheral stalk subunit F6 -3.53543
FPR3 formyl peptide receptor 3 -3.53543
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 -3.53543
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -3.53543
RIBC1 RIB43A domain with coiled-coils 1 -3.53543
PTGR3 prostaglandin reductase 3 -3.53543
FLACC1 flagellum associated containing coiled-coil domains 1 -3.53543
EFCAB12 EF-hand calcium binding domain 12 -3.53543
RP1L1 retinitis pigmentosa 1-like 1 -3.53543
VSTM2A V-set and transmembrane domain containing 2A -3.53543
SGPP2 sphingosine-1-phosphate phosphatase 2 -3.53543
TEX29 testis expressed 29 -3.53543
TSSK4 testis-specific serine kinase 4 -3.53543
EPHA10 EPH receptor A10 -3.53543
TMED6 transmembrane emp24 protein transport domain containing 6 -3.53543
FAM3D family with sequence similarity 3, member D -3.53543
MINAR2 membrane integral NOTCH2 associated receptor 2 -3.53543
HAS1 hyaluronan synthase 1 -3.53543
INSYN1 inhibitory synaptic factor 1 -3.53543
OSTN osteocrin -3.53543
COL17A1 collagen, type XVII, alpha 1 -3.53543
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -3.53543
KLK14 kallikrein-related peptidase 14 -3.53543
LOX lysyl oxidase -3.53543
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa -2.93746
NEDD1 neural precursor cell expressed, developmentally down-regulated 1 -2.89888
KANSL2 KAT8 regulatory NSL complex subunit 2 -2.84687
SOWAHC sosondowah ankyrin repeat domain family member C -2.83823
KPTN kaptin (actin binding protein) -2.8313
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1 -2.82178
SH2B1 SH2B adaptor protein 1 -2.77415
BCL7A B-cell CLL/lymphoma 7A -2.65516
ZNF33B zinc finger protein 33B -2.59965
MED13L mediator complex subunit 13-like -2.56294
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) -2.55671
INSIG2 insulin induced gene 2 -2.54492
PLAAT5 phospholipase A and acyltransferase 5 -2.54022
GHITM growth hormone inducible transmembrane protein -2.5239
CAVIN4 caveolae associated protein 4 -2.52015
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -2.52015
ZNF404 zinc finger protein 404 -2.52015
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor -2.51059
ATOSA atos homolog A -2.51059
ENPEP glutamyl aminopeptidase (aminopeptidase A) -2.50188
DYNLT2B dynein light chain Tctex-type 2B -2.50188
SHPK sedoheptulokinase -2.48146
SHANK3 SH3 and multiple ankyrin repeat domains 3 -2.48146
OAZ1 ornithine decarboxylase antizyme 1 -2.46744
ARHGAP26 Rho GTPase activating protein 26 -2.43662
CA13 carbonic anhydrase XIII -2.4194
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.41751
MYLK4 myosin light chain kinase family, member 4 -2.41751
STAC2 SH3 and cysteine rich domain 2 -2.37948
ICAM1 intercellular adhesion molecule 1 -2.37948
ZNF516 zinc finger protein 516 -2.37722
MED29 mediator complex subunit 29 -2.37199
IQUB IQ motif and ubiquitin domain containing -2.36642
ARC activity-regulated cytoskeleton-associated protein -2.36642
LRRC3 leucine rich repeat containing 3 -2.33987
FAM178B family with sequence similarity 178, member B -2.33987
KCNK12 potassium channel, two pore domain subfamily K, member 12 -2.29344
STK32B serine/threonine kinase 32B -2.28524
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.28108
CEP250 centrosomal protein 250kDa -2.27899
CHD9NB CHD9 neighbor -2.2743
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) -2.2743
WTIP Wilms tumor 1 interacting protein -2.2743
FBXO42 F-box protein 42 -2.26559
SETD9 SET domain containing 9 -2.25205
ZNF641 zinc finger protein 641 -2.24558
USP4 ubiquitin specific peptidase 4 (proto-oncogene) -2.24375
NASP nuclear autoantigenic sperm protein (histone-binding) -2.24238
MEF2B myocyte enhancer factor 2B -2.22105
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1 -2.21682
DNAH6 dynein, axonemal, heavy chain 6 -2.20573
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.20573
SLC5A10 solute carrier family 5 (sodium/sugar cotransporter), member 10 -2.20573
HIPK4 homeodomain interacting protein kinase 4 -2.20573
GARIN5A golgi associated RAB2 interactor 5A -2.20014
RAB19 RAB19, member RAS oncogene family -2.19887
BSPRY B-box and SPRY domain containing -2.18222
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 -2.17407
PSKH1 protein serine kinase H1 -2.16549
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -2.09695
IRF3 interferon regulatory factor 3 -2.09695
MTRFR mitochondrial translation release factor in rescue -2.09687
RPS10 ribosomal protein S10 -2.0903
C2ORF92 chromosome 2 open reading frame 92 -2.08479
XG Xg blood group -2.08479
ZNF76 zinc finger protein 76 -2.08021
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -2.07605
MTLN mitoregulin -2.07256
TMEM69 transmembrane protein 69 -2.05249
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.05249
ZNF689 zinc finger protein 689 -2.04976
CEMIP2 cell migration inducing hyaluronidase 2 -2.04793
UST uronyl-2-sulfotransferase -2.04748
FAM3A family with sequence similarity 3, member A -2.03444
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.02786
PRMT6 protein arginine methyltransferase 6 -2.02605
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) -2.02264
MAMDC2 MAM domain containing 2 -2.02264
USP22 ubiquitin specific peptidase 22 -2.02244
FHOD1 formin homology 2 domain containing 1 -2.01149