RUNX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description runt-related transcription factor 2|This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 860)
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Genes

362 genes differentially expressed following the RUNX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C11ORF16 chromosome 11 open reading frame 16 2.3537
ZNF436 zinc finger protein 436 2.3537
TP73 tumor protein p73 2.3537
SPMIP9 sperm microtubule inner protein 9 2.3537
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 2.3537
ZBTB16 zinc finger and BTB domain containing 16 2.3537
SNAI2 snail family zinc finger 2 2.3537
SIX1 SIX homeobox 1 2.3537
DCST1 DC-STAMP domain containing 1 2.3537
SBSN suprabasin 2.3537
CYS1 cystin 1 2.3537
BPIFC BPI fold containing family C 2.3537
MMP20 matrix metallopeptidase 20 2.3537
TMPRSS15 transmembrane protease, serine 15 2.3537
BCO1 beta-carotene oxygenase 1 2.3537
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 2.3537
LRRC24 leucine rich repeat containing 24 2.3537
CIMAP1D CIMAP1 family member D 2.3537
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.3537
MAGEB17 melanoma antigen family B17 2.3537
RNF31 ring finger protein 31 2.3537
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.3537
FADS6 fatty acid desaturase 6 2.3537
TMC2 transmembrane channel-like 2 2.3537
PRODH2 proline dehydrogenase (oxidase) 2 2.29435
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase 2.29435
GPR151 G protein-coupled receptor 151 2.29435
TEX13B testis expressed 13B 2.29435
RNF212 ring finger protein 212 2.29435
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.29435
UGP2 UDP-glucose pyrophosphorylase 2 2.29435
FOLR1 folate receptor 1 (adult) 2.29435
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.29435
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.29435
ADGRE1 adhesion G protein-coupled receptor E1 2.29435
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 2.29435
AGTR1 angiotensin II receptor, type 1 2.29435
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.29435
UPK3B uroplakin 3B 2.29435
MAGEA2 melanoma antigen family A2 2.29435
OSGIN1 oxidative stress induced growth inhibitor 1 2.29435
ABHD16B abhydrolase domain containing 16B 2.29435
THRSP thyroid hormone responsive 2.29435
RRAD Ras-related associated with diabetes 2.29435
RGPD4 RANBP2-like and GRIP domain containing 4 2.29435
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 2.29435
CRX cone-rod homeobox 2.29435
TTPA tocopherol (alpha) transfer protein 2.29435
PCGF3 polycomb group ring finger 3 2.29435
TCP11 t-complex 11, testis-specific 2.29435
WNT8B wingless-type MMTV integration site family, member 8B 2.29435
WNT8A wingless-type MMTV integration site family, member 8A 2.29435
SLC5A12 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12 2.29435
LBP lipopolysaccharide binding protein 2.29435
PCDHGB3 protocadherin gamma subfamily B, 3 2.29435
IL5RA interleukin 5 receptor, alpha 2.29435
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.29435
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 2.29435
SLC25A41 solute carrier family 25, member 41 2.29435
TKTL1 transketolase-like 1 2.29435
DSG3 desmoglein 3 2.29435
APOA2 apolipoprotein A-II 2.29435
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.29435
OPRL1 opiate receptor-like 1 2.29435
MUC20 mucin 20, cell surface associated 2.29435
C1ORF232 chromosome 1 open reading frame 230 2.29435
PRDM7 PR domain containing 7 2.29435
C4ORF50 chromosome 4 open reading frame 50 2.29435
SYT15 synaptotagmin XV 2.29435
FAM107A family with sequence similarity 107, member A 2.29435
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 2.29435
WNT9B wingless-type MMTV integration site family, member 9B 2.29435
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.29435
ESRP2 epithelial splicing regulatory protein 2 2.29435
UTS2 urotensin 2 2.29435
FOXI2 forkhead box I2 2.29435
CLEC6A C-type lectin domain family 6, member A 2.29435
GC group-specific component (vitamin D binding protein) 2.29435
IFNGR1 interferon gamma receptor 1 2.29435
LOC122526780 uncharacterized LOC122526780 2.29435
LY6L lymphocyte antigen 6 family member L 2.29435
CFAP97D1 CFAP97 domain containing 1 2.29435
TBXT T-box transcription factor T 2.29435
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.29435
FYB1 FYN binding protein 1 2.29435
RACK1 receptor for activated C kinase 1 2.29435
CES4A carboxylesterase 4A 2.29435
TMOD4 tropomodulin 4 (muscle) 2.29435
OTOS otospiralin 2.29435
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.29435
PAK1IP1 PAK1 interacting protein 1 2.29435
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.29435
VIT vitrin 2.29435
C5ORF52 chromosome 5 open reading frame 52 2.29435
RAB44 RAB44, member RAS oncogene family 2.29435
ZNF431 zinc finger protein 431 2.29435
FAM168A family with sequence similarity 168, member A 2.29435
E2F5 E2F transcription factor 5, p130-binding 2.29435
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.29435
CDC16 cell division cycle 16 2.29435
ZCWPW1 zinc finger, CW type with PWWP domain 1 2.29435
HBA2 hemoglobin, alpha 2 2.29435
VSX2 visual system homeobox 2 2.29435
FAM43B family with sequence similarity 43, member B 2.29435
DAO D-amino-acid oxidase 2.29435
ADAR adenosine deaminase, RNA-specific 2.29435
SLC45A2 solute carrier family 45, member 2 2.29435
ZNF575 zinc finger protein 575 2.29435
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.29435
ULBP1 UL16 binding protein 1 2.29435
CBLN3 cerebellin 3 precursor 2.29435
ANXA13 annexin A13 2.29435
CKM creatine kinase, muscle 2.29435
GOLGA6L4 golgin A6 family-like 4 2.29435
OR8D4 olfactory receptor, family 8, subfamily D, member 4 2.29435
TPBGL trophoblast glycoprotein-like 2.29435
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.29435
PRND prion protein 2 (dublet) 2.29435
SETMAR SET domain and mariner transposase fusion gene 2.29435
SMYD1 SET and MYND domain containing 1 2.29435
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.29435
CRHBP corticotropin releasing hormone binding protein 2.29435
ERMN ermin, ERM-like protein 2.29435
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 2.29435
NGB neuroglobin 2.29435
HEMGN hemogen 2.29435
MAPK11 mitogen-activated protein kinase 11 2.29435
ALOX15B arachidonate 15-lipoxygenase, type B 2.29435
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.29435
NR2E1 nuclear receptor subfamily 2, group E, member 1 2.29435
MKRN3 makorin ring finger protein 3 2.29435
LYPD5 LY6/PLAUR domain containing 5 2.29435
INSM1 insulinoma-associated 1 2.29435
EPX eosinophil peroxidase 2.29435
NUTM2A NUT family member 2A 2.29435
FAM25G family with sequence similarity 25, member G 2.29435
CABP5 calcium binding protein 5 2.29435
IL17REL interleukin 17 receptor E-like 2.29435
CRHR1 corticotropin releasing hormone receptor 1 2.29435
C2CD4A C2 calcium-dependent domain containing 4A 2.29435
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.29435
CLEC4D C-type lectin domain family 4, member D 2.29435
MAMLD1 mastermind-like domain containing 1 2.29435
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.29435
DRD2 dopamine receptor D2 2.29435
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 2.29435
SPINK9 serine peptidase inhibitor, Kazal type 9 2.29435
UTS2R urotensin 2 receptor 2.29435
CTXN3 cortexin 3 2.29435
CTNNBIP1 catenin, beta interacting protein 1 2.29435
AKR1B15 aldo-keto reductase family 1, member B15 2.29435
BRDT bromodomain, testis-specific 2.29435
AQP7 aquaporin 7 2.29435
CXCR6 chemokine (C-X-C motif) receptor 6 2.29435
CTAGE4 CTAGE family, member 4 2.29435
OR10R2 olfactory receptor, family 10, subfamily R, member 2 2.29435
MCTS1 malignant T cell amplified sequence 1 2.29435
FIBIN fin bud initiation factor homolog (zebrafish) 2.29435
CFAP126 cilia and flagella associated protein 126 2.29435
GALR2 galanin receptor 2 2.29435
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.29435
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) 2.29435
CSF1R colony stimulating factor 1 receptor 2.29435
FBRS fibrosin 2.29435
GRM6 glutamate receptor, metabotropic 6 2.29435
CHRDL2 chordin-like 2 2.29435
GOLGA8T golgin A8 family, member T 2.29435
C22ORF31 chromosome 22 open reading frame 31 2.29435
GALNTL5 polypeptide N-acetylgalactosaminyltransferase-like 5 2.29435
SLC10A5 solute carrier family 10, member 5 2.29435
PHACTR3 phosphatase and actin regulator 3 2.29435
AIRE autoimmune regulator 2.29435
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.29435
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.29435
TPPP tubulin polymerization promoting protein 2.29435
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.29435
SERTM1 serine-rich and transmembrane domain containing 1 2.29435
TMEM132C transmembrane protein 132C 2.29435
LRRC38 leucine rich repeat containing 38 2.29435
PAIP1 poly(A) binding protein interacting protein 1 2.29435
IL33 interleukin 33 2.29435
C1ORF105 chromosome 1 open reading frame 105 2.29435
SNTN sentan, cilia apical structure protein 2.29435
CD8A CD8a molecule 2.29435
GSC2 goosecoid homeobox 2 2.29435
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.29435
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 2.29435
GPBAR1 G protein-coupled bile acid receptor 1 2.29435
GLT6D1 glycosyltransferase 6 domain containing 1 2.29435
CHRM1 cholinergic receptor, muscarinic 1 2.29435
GAS2L2 growth arrest-specific 2 like 2 2.29435
LYZL4 lysozyme-like 4 2.29435
TM4SF1 transmembrane 4 L six family member 1 2.29435
SFTA2 surfactant associated 2 2.29435
CLCNKB chloride channel, voltage-sensitive Kb 2.29435
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.29435
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.29435
TGM3 transglutaminase 3 2.29435
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 2.27495
ABHD1 abhydrolase domain containing 1 2.26429
LRRC20 leucine rich repeat containing 20 2.26024
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 2.2554
TOLLIP toll interacting protein 2.22188
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.21271
ZNF782 zinc finger protein 782 2.20776
FGF2 fibroblast growth factor 2 (basic) 2.2027
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 2.20229
GLI1 GLI family zinc finger 1 2.19283
FAM20C family with sequence similarity 20, member C 2.19283
WDR82 WD repeat domain 82 2.1804
ERMP1 endoplasmic reticulum metallopeptidase 1 2.1794
ANXA7 annexin A7 2.17709
EMC6 ER membrane protein complex subunit 6 2.17675
KLHL12 kelch-like family member 12 2.17415
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.16762
IPO4 importin 4 2.13791
TTC17 tetratricopeptide repeat domain 17 2.12462
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 2.12151
KIF26B kinesin family member 26B 2.11888
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 2.11613
CPNE3 copine III 2.11114
GLI4 GLI family zinc finger 4 2.11114
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta 2.07636
MMP24OS MMP24 opposite strand 2.06161
P3H1 prolyl 3-hydroxylase 1 2.05952
MTRFR mitochondrial translation release factor in rescue 2.04924
IL7 interleukin 7 2.04924
SCN1A sodium channel, voltage gated, type I alpha subunit 2.0431
RNF135 ring finger protein 135 2.04138
FERMT1 fermitin family member 1 2.02892
L3MBTL4 l(3)mbt-like 4 (Drosophila) 2.02182
LRP4 low density lipoprotein receptor-related protein 4 2.02164
RAN RAN, member RAS oncogene family 2.01702
C2ORF69 chromosome 2 open reading frame 69 2.0089
DYSF dysferlin 2.00533
FREM1 FRAS1 related extracellular matrix 1 2.0053
TKT transketolase 2.00333
ELK1 ELK1, member of ETS oncogene family 2.00319
RELL1 RELT-like 1 2.00319

decreased expression

Symbol Name Standardized Value
RBP1 retinol binding protein 1, cellular -2.3537
CHGB chromogranin B -2.3537
ASB18 ankyrin repeat and SOCS box containing 18 -2.3537
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -2.3537
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.3537
TBC1D24 TBC1 domain family, member 24 -2.3537
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.31299
FANK1 fibronectin type III and ankyrin repeat domains 1 -2.31299
MYL5 myosin, light chain 5, regulatory -2.31299
GTF2IRD2 GTF2I repeat domain containing 2 -2.31299
COL24A1 collagen, type XXIV, alpha 1 -2.31299
PODN podocan -2.29435
VENTX VENT homeobox -2.29435
SPMIP11 sperm microtubule inner protein 11 -2.29435
BTBD18 BTB (POZ) domain containing 18 -2.29435
ATXN7L3B ataxin 7-like 3B -2.29435
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 -2.29435
SYTL4 synaptotagmin-like 4 -2.29435
AKT3 v-akt murine thymoma viral oncogene homolog 3 -2.29435
LEKR1 leucine, glutamate and lysine rich 1 -2.29435
LPAR5 lysophosphatidic acid receptor 5 -2.29435
CMKLR1 chemerin chemokine-like receptor 1 -2.29435
RAB31 RAB31, member RAS oncogene family -2.29435
PRRT4 proline-rich transmembrane protein 4 -2.29435
CEP295NL CEP295 N-terminal like -2.29435
ANKEF1 ankyrin repeat and EF-hand domain containing 1 -2.29435
MBLAC1 metallo-beta-lactamase domain containing 1 -2.29435
C19ORF67 chromosome 19 open reading frame 67 -2.29435
RPL3L ribosomal protein L3-like -2.29435
CACNB1 calcium channel, voltage-dependent, beta 1 subunit -2.29435
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 -2.29435
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 -2.29435
TMPRSS11E transmembrane protease, serine 11E -2.29435
ATOH7 atonal homolog 7 (Drosophila) -2.29435
LIPI lipase, member I -2.29435
KISS1R KISS1 receptor -2.29435
C6ORF120 chromosome 6 open reading frame 120 -2.29435
CUL5 cullin 5 -2.29435
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -2.29435
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.29435
RCSD1 RCSD domain containing 1 -2.29435
CMTM4 CKLF-like MARVEL transmembrane domain containing 4 -2.29435
H4C14 H4 clustered histone 14 -2.29435
SSC5D scavenger receptor cysteine rich family, 5 domains -2.29435
CC2D1B coiled-coil and C2 domain containing 1B -2.29435
PCDHA13 protocadherin alpha 13 -2.29435
NT5DC4 5'-nucleotidase domain containing 4 -2.29435
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -2.29435
GRAMD1C GRAM domain containing 1C -2.29435
ADGRD1 adhesion G protein-coupled receptor D1 -2.29435
CEP43 centrosomal protein 43 -2.29435
PAQR9 progestin and adipoQ receptor family member IX -2.29435
BBOF1 basal body orientation factor 1 -2.29435
ADAP1 ArfGAP with dual PH domains 1 -2.29435
ADGRL4 adhesion G protein-coupled receptor L4 -2.29435
RASA4 RAS p21 protein activator 4 -2.29435
ACSS3 acyl-CoA synthetase short-chain family member 3 -2.29435
ART1 ADP-ribosyltransferase 1 -2.29435
FBXO15 F-box protein 15 -2.29435
MROH7 maestro heat-like repeat family member 7 -2.29435
CDC20B cell division cycle 20B -2.29435
PLCZ1 phospholipase C, zeta 1 -2.29435
RAD51AP2 RAD51 associated protein 2 -2.29435
EFCAB8 EF-hand calcium binding domain 8 -2.29435
VN1R1 vomeronasal 1 receptor 1 -2.29435
APOH apolipoprotein H (beta-2-glycoprotein I) -2.29435
DCLK2 doublecortin-like kinase 2 -2.29435
ISY1 ISY1 splicing factor homolog (S. cerevisiae) -2.29435
CD53 CD53 molecule -2.29435
PFKM phosphofructokinase, muscle -2.29435
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -2.29435
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -2.29435
PDE12 phosphodiesterase 12 -2.27989
CYB5A cytochrome b5 type A (microsomal) -2.272
SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 -2.26024
RNF145 ring finger protein 145 -2.2137
C19ORF38 chromosome 19 open reading frame 38 -2.21079
FYB2 FYN binding protein 2 -2.21079
TRIL TLR4 interactor with leucine-rich repeats -2.16357
CD248 CD248 molecule, endosialin -2.16357
NET1 neuroepithelial cell transforming 1 -2.16357
DCAF12L1 DDB1 and CUL4 associated factor 12-like 1 -2.16357
HRC histidine rich calcium binding protein -2.16357
CNGA4 cyclic nucleotide gated channel alpha 4 -2.16357
WDR35 WD repeat domain 35 -2.16098
PER1 period circadian clock 1 -2.16098
HSPA8 heat shock 70kDa protein 8 -2.15557
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -2.15318
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.14492
TOP1 topoisomerase (DNA) I -2.13974
FSTL1 follistatin-like 1 -2.13177
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -2.1199
OFD1 oral-facial-digital syndrome 1 -2.11888
MSI1 musashi RNA-binding protein 1 -2.09593
TRAPPC6B trafficking protein particle complex 6B -2.09589
PI4K2A phosphatidylinositol 4-kinase type 2 alpha -2.09478
CROT carnitine O-octanoyltransferase -2.09022
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -2.07648
ADGRA3 adhesion G protein-coupled receptor A3 -2.07636
KNL1 kinetochore scaffold 1 -2.07048
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) -2.06846
EIF3H eukaryotic translation initiation factor 3, subunit H -2.06161
BMP6 bone morphogenetic protein 6 -2.04924
CORO2B coronin, actin binding protein, 2B -2.04924
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -2.04546
ARLN allregulin -2.0431
PGS1 phosphatidylglycerophosphate synthase 1 -2.03586
MRPL16 mitochondrial ribosomal protein L16 -2.02369
MCF2 MCF.2 cell line derived transforming sequence -2.02289
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 -2.02164
ARID5B AT rich interactive domain 5B (MRF1-like) -2.01447
SOX13 SRY (sex determining region Y)-box 13 -2.01215
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -2.00989
FHDC1 FH2 domain containing 1 -2.0089
EML1 echinoderm microtubule associated protein like 1 -2.0053
CREBBP CREB binding protein -2.0053
DUSP28 dual specificity phosphatase 28 -2.00319
KLHL10 kelch-like family member 10 -2.00319
CHP2 calcineurin-like EF-hand protein 2 -2.00319
MMD2 monocyte to macrophage differentiation-associated 2 -2.00319
FAM240C family with sequence similarity 240 member C -2.00319
BTN1A1 butyrophilin, subfamily 1, member A1 -2.00319
IFIH1 interferon induced with helicase C domain 1 -2.00319