RUNX3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description runt-related transcription factor 3|This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 864)
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Genes

351 genes differentially expressed following the RUNX3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KLHL33 kelch-like family member 33 3.56995
NANOS2 nanos homolog 2 (Drosophila) 3.56995
TMEM176B transmembrane protein 176B 3.56995
PGAM4 phosphoglycerate mutase family member 4 3.56995
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 3.56995
PEAR1 platelet endothelial aggregation receptor 1 3.56995
CSTL1 cystatin-like 1 3.56995
PAX5 paired box 5 3.56995
FAM90A1 family with sequence similarity 90, member A1 3.56995
SIGLEC5 sialic acid binding Ig-like lectin 5 3.56995
ASB10 ankyrin repeat and SOCS box containing 10 3.56995
SLC46A2 solute carrier family 46, member 2 3.56995
GPR55 G protein-coupled receptor 55 3.56995
EQTN equatorin, sperm acrosome associated 3.56995
GGTLC2 gamma-glutamyltransferase light chain 2 3.56995
IZUMO1 izumo sperm-egg fusion 1 3.56995
FRMD7 FERM domain containing 7 3.56995
FFAR3 free fatty acid receptor 3 3.56995
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 3.56995
RNF151 ring finger protein 151 3.56995
FOLR1 folate receptor 1 (adult) 3.56995
RHOXF2B Rhox homeobox family, member 2B 3.56995
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 3.56995
MYO7B myosin VIIB 3.56995
TUBB8 tubulin, beta 8 class VIII 3.56995
UNC45B unc-45 homolog B (C. elegans) 3.56995
RFPL3 ret finger protein-like 3 3.56995
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.56995
STEAP4 STEAP family member 4 3.56995
SPAG8 sperm associated antigen 8 3.56995
ERAP2 endoplasmic reticulum aminopeptidase 2 3.56995
FGF3 fibroblast growth factor 3 3.56995
KRTAP13-4 keratin associated protein 13-4 3.56995
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 3.56995
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 3.56995
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 3.56995
ASCL2 achaete-scute family bHLH transcription factor 2 3.56995
TAS2R19 taste receptor, type 2, member 19 3.56995
ATOH1 atonal homolog 1 (Drosophila) 3.56995
CRYGN crystallin, gamma N 3.56995
PTGFR prostaglandin F receptor (FP) 3.56995
SFTPB surfactant protein B 3.56995
SFTPD surfactant protein D 3.56995
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 3.56995
C9ORF152 chromosome 9 open reading frame 152 3.56995
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.56995
TMEM89 transmembrane protein 89 3.56995
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 3.56995
MUC22 mucin 22 3.56995
HBD hemoglobin, delta 3.56995
NLRP4 NLR family, pyrin domain containing 4 3.56995
SPMAP1 sperm microtubule associated protein 1 3.56995
PLPP4 phospholipid phosphatase 4 3.56995
CCN5 cellular communication network factor 5 3.56995
CCN6 cellular communication network factor 6 3.56995
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.56995
LTB4R2 leukotriene B4 receptor 2 3.56995
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 3.56995
SLC1A7 solute carrier family 1 (glutamate transporter), member 7 3.56995
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 3.56995
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.56995
DOK2 docking protein 2, 56kDa 3.56995
SPATA46 spermatogenesis associated 46 3.56995
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 3.56995
ELOA2 elongin A2 3.56995
TEX53 testis expressed 53 3.56995
PRR20G proline rich 20G 3.56995
DPEP2NB DPEP2 neighbor 3.56995
CPNE8-AS1 CPNE8 antisense RNA 1 3.56995
MDFIC2 MyoD family inhibitor domain containing 2 3.56995
H3C13 H3 clustered histone 13 3.56995
RHEX regulator of hemoglobinization and erythroid cell expansion 3.56995
GLYATL1B glycine-N-acyltransferase like 1B 3.56995
SEPTIN12 septin 12 3.56995
H3-4 H3.4 histone, cluster member 3.56995
SPATA22 spermatogenesis associated 22 3.56995
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 3.56995
ZNF705D zinc finger protein 705D 3.56995
ZIC4 Zic family member 4 3.56995
GOLGA7B golgin A7 family, member B 3.56995
CXCL16 chemokine (C-X-C motif) ligand 16 3.56995
MSX2 msh homeobox 2 3.56995
LOC107986837 uncharacterized LOC107986837 3.56995
HPR haptoglobin-related protein 3.56995
AMBP alpha-1-microglobulin/bikunin precursor 3.56995
CHRD chordin 3.56995
TLE6 transducin-like enhancer of split 6 3.56995
ZFP28 ZFP28 zinc finger protein 3.56995
DMBX1 diencephalon/mesencephalon homeobox 1 3.56995
TLR7 toll-like receptor 7 3.56995
BHLHA9 basic helix-loop-helix family, member a9 3.56995
ASIC3 acid sensing (proton gated) ion channel 3 3.56995
OOSP1 oocyte secreted protein 1, pseudogene 3.56995
TSPO2 translocator protein 2 3.56995
CLDN22 claudin 22 3.56995
CDKN2A cyclin-dependent kinase inhibitor 2A 3.56995
CDSN corneodesmosin 3.56995
LSP1 lymphocyte-specific protein 1 3.56995
PRRT4 proline-rich transmembrane protein 4 3.56995
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.56995
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 3.56995
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.56995
CCL22 chemokine (C-C motif) ligand 22 3.56995
BPIFB3 BPI fold containing family B, member 3 3.56995
ERICH6B glutamate-rich 6B 3.56995
ADAM2 ADAM metallopeptidase domain 2 3.56995
CALHM1 calcium homeostasis modulator 1 3.56995
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 3.56995
IL36R interleukin 36 receptor 3.56995
PCDHGA3 protocadherin gamma subfamily A, 3 3.56995
VWA3A von Willebrand factor A domain containing 3A 3.56995
BCO1 beta-carotene oxygenase 1 3.56995
POU1F1 POU class 1 homeobox 1 3.56995
TAS2R50 taste receptor, type 2, member 50 3.56995
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.56995
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.56995
ERICH4 glutamate-rich 4 3.56995
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 3.56995
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 3.56995
CDC20B cell division cycle 20B 3.56995
CST7 cystatin F (leukocystatin) 3.56995
EFCAB3 EF-hand calcium binding domain 3 3.56995
S100A14 S100 calcium binding protein A14 3.56995
SPATA31E1 SPATA31 subfamily E, member 1 3.56995
CHI3L2 chitinase 3-like 2 3.56995
PLA1A phospholipase A1 member A 3.56995
KLK5 kallikrein-related peptidase 5 3.56995
CTSF cathepsin F 3.56995
UBXN10 UBX domain protein 10 3.56995
CTRB1 chymotrypsinogen B1 3.56995
ERVV-2 endogenous retrovirus group V, member 2 3.56995
POU4F1 POU class 4 homeobox 1 3.56995
TM4SF19 transmembrane 4 L six family member 19 3.56995
ETV3L ets variant 3-like 3.56995
AGXT alanine-glyoxylate aminotransferase 3.56995
WNT2 wingless-type MMTV integration site family member 2 3.56995
OTOP2 otopetrin 2 3.56995
CRHBP corticotropin releasing hormone binding protein 3.56995
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.56995
SPATA25 spermatogenesis associated 25 3.56995
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 3.56995
CTXN2 cortexin 2 3.56995
SPEF1 sperm flagellar 1 3.56995
DLX1 distal-less homeobox 1 3.56995
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 3.56995
ITGB7 integrin, beta 7 3.56995
RBM24 RNA binding motif protein 24 3.56995
ANKRD55 ankyrin repeat domain 55 3.56995
CXORF58 chromosome X open reading frame 58 3.56995
SLC25A52 solute carrier family 25, member 52 3.56995
TBC1D28 TBC1 domain family, member 28 3.56995
CD177 CD177 molecule 3.56995
IFITM10 interferon induced transmembrane protein 10 3.56995
CSF3R colony stimulating factor 3 receptor (granulocyte) 3.56995
TAS2R43 taste receptor, type 2, member 43 3.56995
LRRC31 leucine rich repeat containing 31 3.56995
FOXP3 forkhead box P3 3.56995
GRAP2 GRB2-related adaptor protein 2 3.56995
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.56995
ADGRF1 adhesion G protein-coupled receptor F1 3.56995
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 3.56995
LST1 leukocyte specific transcript 1 3.56995
HHIPL2 HHIP-like 2 3.56995
MAGEA12 melanoma antigen family A12 3.56995
TOPAZ1 testis and ovary specific PAZ domain containing 1 3.56995
NPAS4 neuronal PAS domain protein 4 3.56995
PHOSPHO1 phosphatase, orphan 1 3.56995
ZNF648 zinc finger protein 648 3.56995
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 3.56995
AHSG alpha-2-HS-glycoprotein 3.56995
GPRC5D G protein-coupled receptor, class C, group 5, member D 3.56995
ANGPTL3 angiopoietin-like 3 3.56995
ANGPTL7 angiopoietin-like 7 3.56995
OR1B1 olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 3.56995
TCF21 transcription factor 21 3.56995
MYLK4 myosin light chain kinase family, member 4 3.56746
CSAG3 CSAG family, member 3 3.4675
LDLRAD2 low density lipoprotein receptor class A domain containing 2 3.4675
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta 3.41739
SNRPG small nuclear ribonucleoprotein polypeptide G 3.38913
IGFBP4 insulin-like growth factor binding protein 4 3.06392
NIPSNAP3B nipsnap homolog 3B (C. elegans) 3.03343
ABHD17C abhydrolase domain containing 17C 3.00552
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) 2.99326
NFXL1 nuclear transcription factor, X-box binding-like 1 2.95791
FOXP2 forkhead box P2 2.94177
GBX1 gastrulation brain homeobox 1 2.93
STXBP6 syntaxin binding protein 6 (amisyn) 2.81123
SERBP1 SERPINE1 mRNA binding protein 1 2.73603
CLEC2D C-type lectin domain family 2, member D 2.73242
TP53INP1 tumor protein p53 inducible nuclear protein 1 2.63848
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 2.62839
FBXO45 F-box protein 45 2.49575
CEP131 centrosomal protein 131kDa 2.48173
LPAR4 lysophosphatidic acid receptor 4 2.47257
TMBIM6 transmembrane BAX inhibitor motif containing 6 2.47257
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 2.43775
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.41605
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 2.41605
OLAH oleoyl-ACP hydrolase 2.41605
NF1 neurofibromin 1 2.41283
CUL9 cullin 9 2.40038
ZBTB4 zinc finger and BTB domain containing 4 2.39953
GPR176 G protein-coupled receptor 176 2.39953
GOLGA6C golgin A6 family, member C 2.3989
FRMPD2 FERM and PDZ domain containing 2 2.3989
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 2.3989
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 2.3989
SNPH syntaphilin 2.3989
ADGRG1 adhesion G protein-coupled receptor G1 2.3989
VIL1 villin 1 2.32484
ACY3 aminoacylase 3 2.31283
CNTF ciliary neurotrophic factor 2.31283
ZRANB3 zinc finger, RAN-binding domain containing 3 2.29934
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.29934
GLIS1 GLIS family zinc finger 1 2.29869
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 2.29676
PODXL podocalyxin-like 2.28239
EDC4 enhancer of mRNA decapping 4 2.28239
RAD18 RAD18 E3 ubiquitin protein ligase 2.26531
NOA1 nitric oxide associated 1 2.2647
COX7B cytochrome c oxidase subunit VIIb 2.26403
CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) 2.26067
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 2.18046
BMAL2 basic helix-loop-helix ARNT like 2 2.1791
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 2.1678
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 2.16183
PIGM phosphatidylinositol glycan anchor biosynthesis, class M 2.15092
ZNF316 zinc finger protein 316 2.14174
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 2.13633
GABRP gamma-aminobutyric acid (GABA) A receptor, pi 2.12722
ZC3H12C zinc finger CCCH-type containing 12C 2.12722
USP9X ubiquitin specific peptidase 9, X-linked 2.11817
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.09614
CDV3 CDV3 homolog (mouse) 2.08589
NANOGP8 Nanog homeobox pseudogene 8 2.08589
NRBP1 nuclear receptor binding protein 1 2.05954
CAND2 cullin-associated and neddylation-dissociated 2 (putative) 2.05954
SRSF4 serine/arginine-rich splicing factor 4 2.05954
CREB3L4 cAMP responsive element binding protein 3-like 4 2.02085

decreased expression

Symbol Name Standardized Value
MAP3K4-AS1 MAP3K4 antisense RNA 1 -3.56995
MTTP microsomal triglyceride transfer protein -3.56995
SFXN3 sideroflexin 3 -3.56995
GPR22 G protein-coupled receptor 22 -3.56995
PCDH8 protocadherin 8 -3.56995
LCN12 lipocalin 12 -3.56995
ZBTB42 zinc finger and BTB domain containing 42 -3.56995
TMC3 transmembrane channel-like 3 -3.56995
GYS2 glycogen synthase 2 (liver) -3.56995
WFDC13 WAP four-disulfide core domain 13 -3.56995
CLNK cytokine-dependent hematopoietic cell linker -3.56995
FRMPD1 FERM and PDZ domain containing 1 -3.56995
SLC51B solute carrier family 51, beta subunit -3.56995
RNF222 ring finger protein 222 -3.56995
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -3.56995
TNNI1 troponin I type 1 (skeletal, slow) -3.56995
GFRA3 GDNF family receptor alpha 3 -3.56995
UBE2L5 ubiquitin conjugating enzyme E2 L5 -3.56995
CCNP cyclin P -3.56995
PTH1R parathyroid hormone 1 receptor -3.56995
WDR64 WD repeat domain 64 -3.56995
PNPLA1 patatin-like phospholipase domain containing 1 -3.56995
TIMD4 T-cell immunoglobulin and mucin domain containing 4 -3.56995
RBM47 RNA binding motif protein 47 -3.56995
LECT2 leukocyte cell-derived chemotaxin 2 -3.56995
STRIT1 small transmembrane regulator of ion transport 1 -3.56995
C1ORF162 chromosome 1 open reading frame 162 -3.56995
CAPN13 calpain 13 -3.56995
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 -3.56995
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled -3.56995
SCN3B sodium channel, voltage gated, type III beta subunit -3.56995
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 -3.56995
AMN amnion associated transmembrane protein -3.56995
RBM20 RNA binding motif protein 20 -3.56995
PCDH17 protocadherin 17 -3.56995
LMOD2 leiomodin 2 (cardiac) -3.56995
CRHR1 corticotropin releasing hormone receptor 1 -3.56995
TFAP2E transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) -3.56995
AQP3 aquaporin 3 (Gill blood group) -3.56995
S100Z S100 calcium binding protein Z -3.56995
NPIPB15 nuclear pore complex interacting protein family, member B15 -3.56995
AKNAD1 AKNA domain containing 1 -3.56995
TRABD2A TraB domain containing 2A -3.56995
MSMP microseminoprotein, prostate associated -3.56995
LRRC43 leucine rich repeat containing 43 -3.56995
EFCAB9 EF-hand calcium binding domain 9 -3.56995
POU6F2 POU class 6 homeobox 2 -3.39034
GRAMD1C GRAM domain containing 1C -3.36196
WASHC2A WASH complex subunit 2A -3.36103
RNF7 ring finger protein 7 -3.29601
PIWIL2 piwi-like RNA-mediated gene silencing 2 -3.28175
NRSN2 neurensin 2 -3.2348
SOCS4 suppressor of cytokine signaling 4 -3.14992
PNO1 partner of NOB1 homolog (S. cerevisiae) -3.13715
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) -2.97645
CC2D1B coiled-coil and C2 domain containing 1B -2.88005
NECAB2 N-terminal EF-hand calcium binding protein 2 -2.84658
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -2.81023
CHUK conserved helix-loop-helix ubiquitous kinase -2.77925
MYH14 myosin, heavy chain 14, non-muscle -2.77436
FOXH1 forkhead box H1 -2.67332
PIH1D1 PIH1 domain containing 1 -2.64546
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 -2.64013
MRPL41 mitochondrial ribosomal protein L41 -2.62318
MCOLN1 mucolipin 1 -2.60167
PRCD progressive rod-cone degeneration -2.58715
PCDHGA8 protocadherin gamma subfamily A, 8 -2.58715
KRTCAP3 keratinocyte associated protein 3 -2.50499
KCTD21 potassium channel tetramerization domain containing 21 -2.47257
SYNGR1 synaptogyrin 1 -2.39953
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -2.38684
LGI4 leucine-rich repeat LGI family, member 4 -2.37224
FIBCD1 fibrinogen C domain containing 1 -2.36925
HCRTR1 hypocretin (orexin) receptor 1 -2.34459
LOC124902694 uncharacterized LOC124902694 -2.29698
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -2.29698
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like -2.29698
SF3B5 splicing factor 3b, subunit 5, 10kDa -2.27613
NFS1 NFS1 cysteine desulfurase -2.27102
ERBB4 erb-b2 receptor tyrosine kinase 4 -2.26666
AMT aminomethyltransferase -2.26067
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.25434
CCDC7 coiled-coil domain containing 7 -2.24694
SEC14L5 SEC14-like 5 (S. cerevisiae) -2.24013
SNX22 sorting nexin 22 -2.24013
AGA-DT AGA divergent transcript -2.24013
NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 -2.23964
LCK LCK proto-oncogene, Src family tyrosine kinase -2.23813
SH2D5 SH2 domain containing 5 -2.23711
METTL1 methyltransferase like 1 -2.21954
ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 -2.19618
CAMK1D calcium/calmodulin-dependent protein kinase ID -2.18235
GFUS GDP-L-fucose synthase -2.18046
CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 -2.18046
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -2.17788
CBX5 chromobox homolog 5 -2.17788
DTWD2 DTW domain containing 2 -2.16954
ZNF23 zinc finger protein 23 -2.16105
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -2.14174
AK2 adenylate kinase 2 -2.13371
LDHAL6A lactate dehydrogenase A-like 6A -2.12722
NUP88 nucleoporin 88kDa -2.11226
APLF aprataxin and PNKP like factor -2.1023
NUBP2 nucleotide binding protein 2 -2.10046
HS1BP3 HCLS1 binding protein 3 -2.10029
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.08589
PPP1R8 protein phosphatase 1, regulatory subunit 8 -2.05456
RNF4 ring finger protein 4 -2.02648
MXD1 MAX dimerization protein 1 -2.00843
MYO15B myosin XVB -2.0014
RPL13 ribosomal protein L13 -2.0014