| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/135564749 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in RVX-208 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 2.06 |
| MT2A | metallothionein 2A | 1.65 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 1.32 |
| MAP2 | microtubule-associated protein 2 | 1.21 |
| MIGA2 | mitoguardin 2 | 1.06 |
| MT1X | metallothionein 1X | 1.03 |
| BAIAP3 | BAI1-associated protein 3 | 1.03 |
| MT1E | metallothionein 1E | 0.91 |
| MT1F | metallothionein 1F | 0.79 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.78 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.73 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.7 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.65 |
| MT1L | metallothionein 1L (gene/pseudogene) | 0.63 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.62 |
| H1-0 | H1.0 linker histone | 0.6 |
| SLFN5 | schlafen family member 5 | 0.6 |
| IRX4 | iroquois homeobox 4 | 0.58 |
| EPPK1 | epiplakin 1 | 0.58 |
| DOP1A | DOP1 leucine zipper like protein A | 0.58 |
| FLNB | filamin B, beta | 0.55 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.54 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.53 |
| TST | thiosulfate sulfurtransferase (rhodanese) | 0.52 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | 0.51 |
| GCH1 | GTP cyclohydrolase 1 | 0.51 |
| PTK2B | protein tyrosine kinase 2 beta | 0.5 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.5 |
| ZER1 | zyg-11 related, cell cycle regulator | 0.5 |
| KLHL24 | kelch-like family member 24 | 0.5 |
| KCTD21 | potassium channel tetramerization domain containing 21 | 0.5 |
| CCNDBP1 | cyclin D-type binding-protein 1 | 0.5 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.49 |
| TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.48 |
| MYBPC1 | myosin binding protein C, slow type | 0.47 |
| TSPAN33 | tetraspanin 33 | 0.47 |
| CAPN5 | calpain 5 | 0.47 |
| H1FX | H1 histone family, member X | 0.47 |
| ABLIM2 | actin binding LIM protein family, member 2 | 0.46 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.46 |
| EFNB2 | ephrin-B2 | 0.45 |
| LAMB2 | laminin, beta 2 (laminin S) | 0.45 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.45 |
| ITGB4 | integrin, beta 4 | 0.44 |
| CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | 0.44 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.44 |
| STXBP1 | syntaxin binding protein 1 | 0.44 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 0.43 |
| EVI5L | ecotropic viral integration site 5-like | 0.43 |
| FAM234A | family with sequence similarity 234 member A | 0.43 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.42 |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 0.42 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.42 |
| TTC7A | tetratricopeptide repeat domain 7A | 0.42 |
| TRPT1 | tRNA phosphotransferase 1 | 0.42 |
| GLRX2 | glutaredoxin 2 | 0.41 |
| RABIF | RAB interacting factor | 0.41 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.41 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | 0.41 |
| PRAF2 | PRA1 domain family, member 2 | 0.4 |
| LRP11 | low density lipoprotein receptor-related protein 11 | 0.4 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.4 |
| DGKQ | diacylglycerol kinase, theta 110kDa | 0.4 |
| DNAL4 | dynein, axonemal, light chain 4 | 0.39 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.39 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.39 |
| KLHL9 | kelch-like family member 9 | 0.39 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.38 |
| PEX13 | peroxisomal biogenesis factor 13 | 0.38 |
| HSBP1 | heat shock factor binding protein 1 | 0.38 |
| SLC25A30 | solute carrier family 25, member 30 | 0.38 |
| CASTOR2 | cytosolic arginine sensor for mTORC1 subunit 2 | 0.38 |
| RETREG3 | reticulophagy regulator family member 3 | 0.37 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.37 |
| DOP1B | DOP1 leucine zipper like protein B | 0.37 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.37 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.37 |
| BBS2 | Bardet-Biedl syndrome 2 | 0.37 |
| AHNAK | AHNAK nucleoprotein | 0.37 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.37 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.36 |
| ALAD | aminolevulinate dehydratase | 0.36 |
| ARSD | arylsulfatase D | 0.36 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.36 |
| NAGK | N-acetylglucosamine kinase | 0.36 |
| TAOK3 | TAO kinase 3 | 0.36 |
| RTL8C | retrotransposon Gag like 8C | 0.36 |
| OSBPL2 | oxysterol binding protein-like 2 | 0.36 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.36 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | 0.35 |
| ZNF654 | zinc finger protein 654 | 0.35 |
| ADIRF | adipogenesis regulatory factor | 0.35 |
| SMTN | smoothelin | 0.35 |
| HPS4 | Hermansky-Pudlak syndrome 4 | 0.35 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.35 |
| EPM2AIP1 | EPM2A (laforin) interacting protein 1 | 0.35 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.35 |
| LRCH4 | leucine-rich repeats and calponin homology (CH) domain containing 4 | 0.35 |
| DLGAP4 | discs, large (Drosophila) homolog-associated protein 4 | 0.35 |
| CIRBP | cold inducible RNA binding protein | 0.34 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -1.28 |
| SYTL3 | synaptotagmin-like 3 | -1.08 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -1.03 |
| GLI2 | GLI family zinc finger 2 | -1.02 |
| NAV3 | neuron navigator 3 | -0.94 |
| KLK6 | kallikrein-related peptidase 6 | -0.92 |
| PLD6 | phospholipase D family, member 6 | -0.85 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | -0.84 |
| TRIB1 | tribbles pseudokinase 1 | -0.83 |
| TYRO3 | TYRO3 protein tyrosine kinase | -0.76 |
| TRAF5 | TNF receptor-associated factor 5 | -0.76 |
| NAV2 | neuron navigator 2 | -0.73 |
| TCEA3 | transcription elongation factor A (SII), 3 | -0.71 |
| SLC38A2 | solute carrier family 38, member 2 | -0.7 |
| PLIN2 | perilipin 2 | -0.68 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.68 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.67 |
| S100A2 | S100 calcium binding protein A2 | -0.64 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.64 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.62 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.62 |
| ELF1 | E74-like factor 1 (ets domain transcription factor) | -0.61 |
| ARMC4 | armadillo repeat containing 4 | -0.61 |
| TRIM16 | tripartite motif containing 16 | -0.6 |
| APOBEC3B | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B | -0.59 |
| KITLG | KIT ligand | -0.58 |
| S100A5 | S100 calcium binding protein A5 | -0.58 |
| FGF2 | fibroblast growth factor 2 (basic) | -0.58 |
| JADE2 | jade family PHD finger 2 | -0.58 |
| L3MBTL3 | l(3)mbt-like 3 (Drosophila) | -0.57 |
| ARHGAP28 | Rho GTPase activating protein 28 | -0.57 |
| MTFP1 | mitochondrial fission process 1 | -0.56 |
| RNF141 | ring finger protein 141 | -0.56 |
| FZD3 | frizzled class receptor 3 | -0.56 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.56 |
| EREG | epiregulin | -0.55 |
| ZNF618 | zinc finger protein 618 | -0.55 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | -0.55 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.53 |
| APOBEC3D | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | -0.53 |
| SUMF1 | sulfatase modifying factor 1 | -0.53 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.53 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.52 |
| E2F8 | E2F transcription factor 8 | -0.52 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.51 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.51 |
| FAIM | Fas apoptotic inhibitory molecule | -0.51 |
| IRS1 | insulin receptor substrate 1 | -0.51 |
| ARL14EPL | ADP-ribosylation factor-like 14 effector protein-like | -0.51 |
| RAP1GAP | RAP1 GTPase activating protein | -0.51 |
| ELFN1 | extracellular leucine-rich repeat and fibronectin type III domain containing 1 | -0.5 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | -0.49 |
| TNS3 | tensin 3 | -0.47 |
| DUSP9 | dual specificity phosphatase 9 | -0.47 |
| ICAM5 | intercellular adhesion molecule 5, telencephalin | -0.47 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.47 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | -0.46 |
| NEK3 | NIMA-related kinase 3 | -0.46 |
| IVNS1ABP | influenza virus NS1A binding protein | -0.46 |
| BMP4 | bone morphogenetic protein 4 | -0.46 |
| SLC38A5 | solute carrier family 38, member 5 | -0.46 |
| ATE1 | arginyltransferase 1 | -0.45 |
| CALHM2 | calcium homeostasis modulator 2 | -0.45 |
| IFRD2 | interferon-related developmental regulator 2 | -0.45 |
| AEN | apoptosis enhancing nuclease | -0.45 |
| LRRC45 | leucine rich repeat containing 45 | -0.44 |
| ELFN2 | extracellular leucine-rich repeat and fibronectin type III domain containing 2 | -0.44 |
| RCOR2 | REST corepressor 2 | -0.44 |
| TRIML2 | tripartite motif family-like 2 | -0.44 |
| RAB3IL1 | RAB3A interacting protein (rabin3)-like 1 | -0.44 |
| CASP4 | caspase 4, apoptosis-related cysteine peptidase | -0.44 |
| HIPK1 | homeodomain interacting protein kinase 1 | -0.44 |
| RBM47 | RNA binding motif protein 47 | -0.43 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.43 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.43 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.43 |
| VSNL1 | visinin-like 1 | -0.43 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.43 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.42 |
| ZNF444 | zinc finger protein 444 | -0.42 |
| IFRD1 | interferon-related developmental regulator 1 | -0.42 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.42 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | -0.42 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.42 |
| PTBP2 | polypyrimidine tract binding protein 2 | -0.42 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.41 |
| COX11 | COX11 cytochrome c oxidase copper chaperone | -0.41 |
| MSL3P1 | male-specific lethal 3 homolog (Drosophila) pseudogene 1 | -0.41 |
| PRKX | protein kinase, X-linked | -0.41 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.41 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.41 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.41 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.4 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | -0.4 |
| CAV2 | caveolin 2 | -0.4 |
| DONSON | downstream neighbor of SON | -0.4 |
| MLKL | mixed lineage kinase domain-like | -0.4 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | -0.4 |
| GTF3C6 | general transcription factor IIIC, polypeptide 6, alpha 35kDa | -0.4 |
