RWJ 50271 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9953357
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Genes

198 proteins with high or low expression in RWJ 50271 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ITGA1 integrin, alpha 1 1.78
CKM creatine kinase, muscle 0.89
PKLR pyruvate kinase, liver and RBC 0.86
VAV1 vav 1 guanine nucleotide exchange factor 0.75
NRP1 neuropilin 1 0.66
PRELID3B PRELI domain containing 3B 0.66
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.65
FANCE Fanconi anemia, complementation group E 0.64
MT2A metallothionein 2A 0.6
TCTN3 tectonic family member 3 0.57
ALPK3 alpha-kinase 3 0.57
RPGR retinitis pigmentosa GTPase regulator 0.54
CORO2B coronin, actin binding protein, 2B 0.52
TTLL4 tubulin tyrosine ligase-like family member 4 0.5
HIPK1 homeodomain interacting protein kinase 1 0.49
TASP1 taspase, threonine aspartase, 1 0.49
MT1E metallothionein 1E 0.47
FAM219B family with sequence similarity 219, member B 0.47
TP73 tumor protein p73 0.46
PLIN2 perilipin 2 0.46
TRAK2 trafficking protein, kinesin binding 2 0.45
SASH1 SAM and SH3 domain containing 1 0.44
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.44
MARCHF7 membrane associated ring-CH-type finger 7 0.44
KDM4D lysine (K)-specific demethylase 4D 0.43
LMX1B LIM homeobox transcription factor 1, beta 0.43
CYBA cytochrome b-245, alpha polypeptide 0.43
NT5E 5'-nucleotidase, ecto (CD73) 0.42
MT1X metallothionein 1X 0.42
ZNF436 zinc finger protein 436 0.42
FLCN folliculin 0.41
RASA4 RAS p21 protein activator 4 0.41
C12ORF73 chromosome 12 open reading frame 73 0.41
PROSER3 proline and serine rich 3 0.4
CYP4V2 cytochrome P450, family 4, subfamily V, polypeptide 2 0.39
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 0.38
H1-4 H1.4 linker histone, cluster member 0.37
CRCP CGRP receptor component 0.37
MT1F metallothionein 1F 0.37
MT1L metallothionein 1L (gene/pseudogene) 0.37
AEN apoptosis enhancing nuclease 0.36
CERK ceramide kinase 0.36
DGKD diacylglycerol kinase, delta 130kDa 0.35
ZNF669 zinc finger protein 669 0.35
AREG amphiregulin 0.34
CST6 cystatin E/M 0.34
KLK7 kallikrein-related peptidase 7 0.33
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.33
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 0.33
SELENOW selenoprotein W 0.32
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.32
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.32
CPA4 carboxypeptidase A4 0.32
ESYT2 extended synaptotagmin-like protein 2 0.31
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.3
SLC25A39 solute carrier family 25, member 39 0.3
ADAM19 ADAM metallopeptidase domain 19 0.3
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.3
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 0.3
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.29
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.29
WDR24 WD repeat domain 24 0.29
H3C1 H3 clustered histone 1 0.29
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.29
GPATCH2L G patch domain containing 2-like 0.29
CHCHD2P9 coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 0.29
GTF3C6 general transcription factor IIIC, polypeptide 6, alpha 35kDa 0.29
UPP1 uridine phosphorylase 1 0.29
RCOR1 REST corepressor 1 0.28
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.28
NDE1 nudE neurodevelopment protein 1 0.28
DCLRE1B DNA cross-link repair 1B 0.28
KDM4C lysine (K)-specific demethylase 4C 0.28
H1-0 H1.0 linker histone 0.27
TRMO tRNA methyltransferase O 0.27
H1-2 H1.2 linker histone, cluster member 0.27
SNRK SNF related kinase 0.27
ACP6 acid phosphatase 6, lysophosphatidic 0.27
IGF1R insulin-like growth factor 1 receptor 0.27
RPP25 ribonuclease P/MRP 25kDa subunit 0.27
MCPH1 microcephalin 1 0.27
FAM171B family with sequence similarity 171, member B 0.27
MFAP3L microfibrillar-associated protein 3-like 0.27
AHR aryl hydrocarbon receptor 0.27
PTBP2 polypyrimidine tract binding protein 2 0.27
RABAC1 Rab acceptor 1 (prenylated) 0.27
PLAUR plasminogen activator, urokinase receptor 0.27
ZBED5 zinc finger, BED-type containing 5 0.27
DDB2 damage-specific DNA binding protein 2, 48kDa 0.27
ODC1 ornithine decarboxylase 1 0.26
GAS8 growth arrest-specific 8 0.26
TSPAN5 tetraspanin 5 0.26
XBP1 X-box binding protein 1 0.26
NDEL1 nudE neurodevelopment protein 1-like 1 0.26
RPL11 ribosomal protein L11 0.26
LENG9 leukocyte receptor cluster (LRC) member 9 0.26
ARHGAP39 Rho GTPase activating protein 39 0.25
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 0.25

low expression

Symbol Name Standardized Value
UNC93B1 unc-93 homolog B1 (C. elegans) -1.9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -1.5
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -1.37
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -1.09
LGALSL lectin, galactoside-binding-like -0.8
ADGRF1 adhesion G protein-coupled receptor F1 -0.78
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.72
FGFBP1 fibroblast growth factor binding protein 1 -0.68
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.65
FGB fibrinogen beta chain -0.63
OSGIN1 oxidative stress induced growth inhibitor 1 -0.63
C5 complement component 5 -0.62
CEMIP cell migration inducing protein, hyaluronan binding -0.6
ADCY9 adenylate cyclase 9 -0.59
ABHD3 abhydrolase domain containing 3 -0.59
VSIR V-set immunoregulatory receptor -0.58
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.57
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.55
GLI2 GLI family zinc finger 2 -0.55
KSR2 kinase suppressor of ras 2 -0.53
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.51
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -0.5
RPGRIP1L RPGRIP1-like -0.49
FBXW2 F-box and WD repeat domain containing 2 -0.49
AVEN apoptosis, caspase activation inhibitor -0.49
NCAM1 neural cell adhesion molecule 1 -0.49
SQLE squalene epoxidase -0.48
TET2 tet methylcytosine dioxygenase 2 -0.48
ITGA7 integrin, alpha 7 -0.48
TECPR2 tectonin beta-propeller repeat containing 2 -0.48
MPV17 MpV17 mitochondrial inner membrane protein -0.47
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.46
FBXO33 F-box protein 33 -0.46
SEC14L1 SEC14-like 1 (S. cerevisiae) -0.45
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -0.45
CALD1 caldesmon 1 -0.44
PIWIL2 piwi-like RNA-mediated gene silencing 2 -0.44
ELL3 elongation factor RNA polymerase II-like 3 -0.43
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.43
LPIN1 lipin 1 -0.43
ALMS1 Alstrom syndrome protein 1 -0.42
PER2 period circadian clock 2 -0.42
CCDC73 coiled-coil domain containing 73 -0.42
LZTS1 leucine zipper, putative tumor suppressor 1 -0.42
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.41
PHF1 PHD finger protein 1 -0.4
SLC26A11 solute carrier family 26 (anion exchanger), member 11 -0.4
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -0.39
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.38
RNF220 ring finger protein 220 -0.38
DESI2 desumoylating isopeptidase 2 -0.38
SREBF2 sterol regulatory element binding transcription factor 2 -0.37
MSMO1 methylsterol monooxygenase 1 -0.36
FAM241B family with sequence similarity 241 member B -0.36
CDC26 cell division cycle 26 -0.36
HGH1 HGH1 homolog (S. cerevisiae) -0.36
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -0.36
RAB40C RAB40C, member RAS oncogene family -0.36
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.35
IDI1 isopentenyl-diphosphate delta isomerase 1 -0.34
GRAMD2B GRAM domain containing 2B -0.34
CDK6 cyclin-dependent kinase 6 -0.34
BTBD11 BTB (POZ) domain containing 11 -0.33
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.33
CORO2A coronin, actin binding protein, 2A -0.33
UBE2G2 ubiquitin-conjugating enzyme E2G 2 -0.33
ZBTB12 zinc finger and BTB domain containing 12 -0.33
CTDNEP1 CTD nuclear envelope phosphatase 1 -0.33
SC5D sterol-C5-desaturase -0.33
DAPK2 death-associated protein kinase 2 -0.33
SUCO SUN domain containing ossification factor -0.33
LRP6 low density lipoprotein receptor-related protein 6 -0.33
NDFIP2 Nedd4 family interacting protein 2 -0.32
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.32
TCP11L1 t-complex 11, testis-specific-like 1 -0.32
ZNF808 zinc finger protein 808 -0.32
MRC2 mannose receptor, C type 2 -0.32
ZNF503 zinc finger protein 503 -0.32
FCHO1 FCH domain only 1 -0.32
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.32
MCEE methylmalonyl CoA epimerase -0.32
GCSH glycine cleavage system protein H (aminomethyl carrier) -0.32
TMEM64 transmembrane protein 64 -0.32
FAM177A1 family with sequence similarity 177, member A1 -0.32
ANGPTL4 angiopoietin-like 4 -0.31
UNKL unkempt family zinc finger-like -0.31
LIMCH1 LIM and calponin homology domains 1 -0.31
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.31
PACS2 phosphofurin acidic cluster sorting protein 2 -0.31
OSMR oncostatin M receptor -0.31
SCAPER S-phase cyclin A-associated protein in the ER -0.31
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa -0.31
RHBDF1 rhomboid 5 homolog 1 (Drosophila) -0.3
NME6 NME/NM23 nucleoside diphosphate kinase 6 -0.3
FN1 fibronectin 1 -0.3
FBXO3 F-box protein 3 -0.3
LRRK1 leucine-rich repeat kinase 1 -0.3
TYRO3 TYRO3 protein tyrosine kinase -0.3
MCL1 myeloid cell leukemia 1 -0.29
ARL4A ADP-ribosylation factor-like 4A -0.29