RXRA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description retinoid X receptor, alpha|Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 6256)
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Genes

337 genes differentially expressed following the RXRA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.74023
CSPG4 chondroitin sulfate proteoglycan 4 2.74023
KLHDC8A kelch domain containing 8A 2.74023
NPFF neuropeptide FF-amide peptide precursor 2.74023
MEIKIN meiotic kinetochore factor 2.74023
LRG1 leucine-rich alpha-2-glycoprotein 1 2.74023
IMPG2 interphotoreceptor matrix proteoglycan 2 2.74023
F5 coagulation factor V (proaccelerin, labile factor) 2.74023
POTEJ POTE ankyrin domain family, member J 2.74023
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.74023
PLGLB1 plasminogen-like B1 2.74023
BBS5 Bardet-Biedl syndrome 5 2.74023
LRRC71 leucine rich repeat containing 71 2.74023
FAM221B family with sequence similarity 221, member B 2.74023
ANXA13 annexin A13 2.74023
SLC45A2 solute carrier family 45, member 2 2.74023
RFX6 regulatory factor X, 6 2.74023
BFSP2 beaded filament structural protein 2, phakinin 2.74023
CIMIP4 ciliary microtubule inner protein 4 2.74023
CFI complement factor I 2.74023
NANOS3 nanos homolog 3 (Drosophila) 2.74023
KIF1C-AS1 KIF1C antisense RNA 1 2.74023
MLANA melan-A 2.74023
NSG2 neuronal vesicle trafficking associated 2 2.74023
TNS2 tensin 2 2.74023
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 2.74023
ATP13A4 ATPase type 13A4 2.74023
MYLK2 myosin light chain kinase 2 2.74023
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.74023
NXPH3 neurexophilin 3 2.60832
TRPV6 transient receptor potential cation channel, subfamily V, member 6 2.60832
OLIG3 oligodendrocyte transcription factor 3 2.60832
FGF17 fibroblast growth factor 17 2.60832
STRA8 stimulated by retinoic acid 8 2.60832
DMRTC1B DMRT-like family C1B 2.60832
GPR55 G protein-coupled receptor 55 2.60832
HEATR9 HEAT repeat containing 9 2.60832
PCDHGB3 protocadherin gamma subfamily B, 3 2.60832
CASP4 caspase 4, apoptosis-related cysteine peptidase 2.60832
FNDC7 fibronectin type III domain containing 7 2.60832
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.60832
HAS1 hyaluronan synthase 1 2.60832
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.60832
PITX3 paired-like homeodomain 3 2.60832
RDH16 retinol dehydrogenase 16 (all-trans) 2.60832
EVPL envoplakin 2.60832
KCNU1 potassium channel, subfamily U, member 1 2.60832
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.60832
PRDM12 PR domain containing 12 2.60832
NPIPA8 nuclear pore complex interacting protein family, member A8 2.60832
GNG13 guanine nucleotide binding protein (G protein), gamma 13 2.60832
CRIP1 cysteine-rich protein 1 (intestinal) 2.60832
HOXB3 homeobox B3 2.60832
TTLL8 tubulin tyrosine ligase-like family member 8 2.60832
UBA7 ubiquitin-like modifier activating enzyme 7 2.60832
LGI1 leucine-rich, glioma inactivated 1 2.60832
MGARP mitochondria-localized glutamic acid-rich protein 2.60832
PCDH8 protocadherin 8 2.60832
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 2.60832
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 2.60832
EPCIP exosomal polycystin 1 interacting protein 2.60832
HBG2 hemoglobin, gamma G 2.60832
PNLIPRP1 pancreatic lipase-related protein 1 2.60832
FMO2 flavin containing monooxygenase 2 (non-functional) 2.60832
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.60832
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.60832
ZNF441 zinc finger protein 441 2.60832
LY6K lymphocyte antigen 6 complex, locus K 2.60832
GATA4 GATA binding protein 4 2.60832
C1ORF74 chromosome 1 open reading frame 74 2.60832
KY kyphoscoliosis peptidase 2.60832
FAM240C family with sequence similarity 240 member C 2.60832
FAM240A family with sequence similarity 240 member A 2.60832
CFAP97D2 CFAP97 domain containing 2 2.60832
EZHIP EZH inhibitory protein 2.60832
TERB1 telomere repeat binding bouquet formation protein 1 2.60832
CIROP ciliated left-right organizer metallopeptidase 2.60832
MARCHF2 membrane associated ring-CH-type finger 2 2.60832
GIPC3 GIPC PDZ domain containing family, member 3 2.60832
MROH5 maestro heat-like repeat family member 5 2.60832
COX8C cytochrome c oxidase subunit VIIIC 2.60832
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.60832
LOC124906892 uncharacterized LOC124906892 2.60832
OR2A5 olfactory receptor, family 2, subfamily A, member 5 2.60832
SCARA5 scavenger receptor class A, member 5 2.60832
NRN1 neuritin 1 2.60832
FAM187B family with sequence similarity 187, member B 2.60832
CEMP1 cementum protein 1 2.60832
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 2.60832
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.60832
SLC35D3 solute carrier family 35, member D3 2.60832
PCDHB11 protocadherin beta 11 2.60832
FOXI2 forkhead box I2 2.60832
RNF113B ring finger protein 113B 2.60832
TLR7 toll-like receptor 7 2.60832
SIM2 single-minded family bHLH transcription factor 2 2.60832
GOLGA7B golgin A7 family, member B 2.60832
CXCL16 chemokine (C-X-C motif) ligand 16 2.60832
SCN10A sodium channel, voltage gated, type X alpha subunit 2.60832
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.60832
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 2.60832
LOXL4 lysyl oxidase-like 4 2.60832
OTC ornithine carbamoyltransferase 2.60832
PSKH2 protein serine kinase H2 2.60832
RANBP3L RAN binding protein 3-like 2.60832
EMP1 epithelial membrane protein 1 2.60832
RPS29 ribosomal protein S29 2.60832
BAHCC1 BAH domain and coiled-coil containing 1 2.60832
IL1A interleukin 1, alpha 2.60832
LOC102723971 beta-lactoglobulin-like 2.60832
TEX19 testis expressed 19 2.60832
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.60832
CPA3 carboxypeptidase A3 (mast cell) 2.60832
CD53 CD53 molecule 2.60832
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1 2.60832
AQP7 aquaporin 7 2.60832
SPATA31A1 SPATA31 subfamily A, member 1 2.60832
OR9A2 olfactory receptor, family 9, subfamily A, member 2 2.60832
CTAGE4 CTAGE family, member 4 2.60832
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.60832
SMIM23 small integral membrane protein 23 2.60832
CD27 CD27 molecule 2.60832
RARA retinoic acid receptor, alpha 2.60832
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 2.60832
LRRK2 leucine-rich repeat kinase 2 2.60832
TMEM31 transmembrane protein 31 2.60832
LHX2 LIM homeobox 2 2.60832
PLCD4 phospholipase C, delta 4 2.60832
LYPD5 LY6/PLAUR domain containing 5 2.60832
TRIM7 tripartite motif containing 7 2.60832
ORM1 orosomucoid 1 2.60832
GPR149 G protein-coupled receptor 149 2.60832
LRRN4 leucine rich repeat neuronal 4 2.60832
NLRP14 NLR family, pyrin domain containing 14 2.60832
NTN5 netrin 5 2.60832
SPHKAP SPHK1 interactor, AKAP domain containing 2.60832
KLK9 kallikrein-related peptidase 9 2.60832
KLK6 kallikrein-related peptidase 6 2.60832
SAMD7 sterile alpha motif domain containing 7 2.60832
TBX1 T-box 1 2.60832
HK3 hexokinase 3 (white cell) 2.60832
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.60832
TF transferrin 2.60832
TPPP3 tubulin polymerization-promoting protein family member 3 2.60832
SCNN1B sodium channel, non voltage gated 1 beta subunit 2.60832
ADAMDEC1 ADAM-like, decysin 1 2.60832
UBQLNL ubiquilin-like 2.60832
SUN3 Sad1 and UNC84 domain containing 3 2.60832
CPO carboxypeptidase O 2.60832
ANGPTL3 angiopoietin-like 3 2.60832
RHAG Rh-associated glycoprotein 2.60832
TTC36 tetratricopeptide repeat domain 36 2.60832
APOL1 apolipoprotein L, 1 2.60832
NLRP5 NLR family, pyrin domain containing 5 2.60832
PF4V1 platelet factor 4 variant 1 2.60832
OR56B1 olfactory receptor, family 56, subfamily B, member 1 2.60832
SHOX2 short stature homeobox 2 2.60832
PPY pancreatic polypeptide 2.60832
NOG noggin 2.60832
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.60832
TMEM156 transmembrane protein 156 2.60832
RAB7B RAB7B, member RAS oncogene family 2.60832
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 2.60832
RNF148 ring finger protein 148 2.60832
EHF ets homologous factor 2.60832
KPNA7 karyopherin alpha 7 (importin alpha 8) 2.60832
IFITM10 interferon induced transmembrane protein 10 2.60832
ADCY2 adenylate cyclase 2 (brain) 2.58174
SNX31 sorting nexin 31 2.56428
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae) 2.5224
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 2.51506
GPR20 G protein-coupled receptor 20 2.48128
TBC1D9 TBC1 domain family, member 9 (with GRAM domain) 2.48128
CD300A CD300a molecule 2.48128
ATRIP ATR interacting protein 2.47254
PNP purine nucleoside phosphorylase 2.46878
FAM151A family with sequence similarity 151, member A 2.43533
CPLX2 complexin 2 2.39662
GGCX gamma-glutamyl carboxylase 2.39252
PNPLA3 patatin-like phospholipase domain containing 3 2.36344
LRRC49 leucine rich repeat containing 49 2.34977
ZNF316 zinc finger protein 316 2.3224
PRICKLE2 prickle homolog 2 (Drosophila) 2.27198
GPR108 G protein-coupled receptor 108 2.26558
TMPRSS11E transmembrane protease, serine 11E 2.26468
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 2.25849
TAC4 tachykinin 4 (hemokinin) 2.25584
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 2.24957
SHE Src homology 2 domain containing E 2.24957
SPAG17 sperm associated antigen 17 2.2301
KRT19 keratin 19, type I 2.22456
CA14 carbonic anhydrase XIV 2.2216
CIART circadian associated repressor of transcription 2.21784
LGALS14 lectin, galactoside-binding, soluble, 14 2.20753
COPS7A COP9 signalosome subunit 7A 2.20753
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 2.16276
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.14827
RHEBL1 Ras homolog enriched in brain like 1 2.11544
MRPS18A mitochondrial ribosomal protein S18A 2.10028
GXYLT1 glucoside xylosyltransferase 1 2.10028
RPP21 ribonuclease P/MRP 21kDa subunit 2.09453
CHSY3 chondroitin sulfate synthase 3 2.08969
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 2.08249
NEXMIF neurite extension and migration factor 2.08249
ZFAND5 zinc finger, AN1-type domain 5 2.06327
RBM18 RNA binding motif protein 18 2.05201
IGSF3 immunoglobulin superfamily, member 3 2.04811
ZBTB7C zinc finger and BTB domain containing 7C 2.04615
AMZ2 archaelysin family metallopeptidase 2 2.04615
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa 2.04615
NOL12 nucleolar protein 12 2.03296
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 2.03257
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 2.03257
TCP1 t-complex 1 2.03257
ERMP1 endoplasmic reticulum metallopeptidase 1 2.03257
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2 2.03257
TTC39C tetratricopeptide repeat domain 39C 2.03257
FGF4 fibroblast growth factor 4 2.02297
ASXL3 additional sex combs like transcriptional regulator 3 2.02297
PAWR PRKC, apoptosis, WT1, regulator 2.01788
DSC2 desmocollin 2 2.00895
RYBP RING1 and YY1 binding protein 2.00803
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa 2.00381
PRKACB protein kinase, cAMP-dependent, catalytic, beta 2.00381
BRAT1 BRCA1-associated ATM activator 1 2.00381

decreased expression

Symbol Name Standardized Value
CDKL4 cyclin-dependent kinase-like 4 -2.74023
HDGF hepatoma-derived growth factor -2.74023
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.74023
S1PR5 sphingosine-1-phosphate receptor 5 -2.74023
NHLH2 nescient helix loop helix 2 -2.74023
IFT70A intraflagellar transport 70A -2.74023
PLIN5 perilipin 5 -2.74023
TEX264 testis expressed 264 -2.63368
SPESP1 sperm equatorial segment protein 1 -2.60832
IQCC IQ motif containing C -2.60832
PON1 paraoxonase 1 -2.60832
TMEM100 transmembrane protein 100 -2.60832
TUBB3 tubulin, beta 3 class III -2.60832
CIMAP2 ciliary microtubule associated protein 2 -2.60832
MFAP5 microfibrillar associated protein 5 -2.60832
ADAMTSL2 ADAMTS-like 2 -2.60832
TTLL2 tubulin tyrosine ligase-like family member 2 -2.60832
GRID1 glutamate receptor, ionotropic, delta 1 -2.60832
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) -2.60832
FAM181B family with sequence similarity 181, member B -2.60832
PRSS27 protease, serine 27 -2.60832
SLC46A2 solute carrier family 46, member 2 -2.60832
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.60832
KLF12 Kruppel-like factor 12 -2.60832
TNS1-AS1 TNS1 antisense RNA 1 -2.60832
PLPPR1 phospholipid phosphatase related 1 -2.60832
TTLL13 tubulin tyrosine ligase like 13 -2.60832
RAG2 recombination activating gene 2 -2.60832
YIPF7 Yip1 domain family, member 7 -2.60832
FMO3 flavin containing monooxygenase 3 -2.60832
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.60832
COL13A1 collagen, type XIII, alpha 1 -2.60832
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.60832
C6ORF118 chromosome 6 open reading frame 118 -2.60832
CXCL14 chemokine (C-X-C motif) ligand 14 -2.60832
ULBP3 UL16 binding protein 3 -2.60832
IDO2 indoleamine 2,3-dioxygenase 2 -2.60832
ZFP28 ZFP28 zinc finger protein -2.60832
GMNC geminin coiled-coil domain containing -2.60832
ZNF317 zinc finger protein 317 -2.60832
MROH7 maestro heat-like repeat family member 7 -2.60832
CAGE1 cancer antigen 1 -2.60832
SCN1B sodium channel, voltage gated, type I beta subunit -2.60832
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 -2.60832
AMIGO1 adhesion molecule with Ig-like domain 1 -2.60832
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.60832
PTGDS prostaglandin D2 synthase 21kDa (brain) -2.60832
NTSR1 neurotensin receptor 1 (high affinity) -2.60832
PIK3IP1 phosphoinositide-3-kinase interacting protein 1 -2.60832
SHISA8 shisa family member 8 -2.60832
CST1 cystatin SN -2.60832
PNMT phenylethanolamine N-methyltransferase -2.60832
SLA Src-like-adaptor -2.60832
ZNF624 zinc finger protein 624 -2.60832
RPRD1A regulation of nuclear pre-mRNA domain containing 1A -2.60832
GATAD2A GATA zinc finger domain containing 2A -2.60832
GLIPR1 GLI pathogenesis-related 1 -2.60832
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.60832
BMP2 bone morphogenetic protein 2 -2.58425
LDHAL6A lactate dehydrogenase A-like 6A -2.58425
PALS1 protein associated with LIN7 1, MAGUK p55 family member -2.55448
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -2.53543
H2BC17 H2B clustered histone 17 -2.5224
EXOC7 exocyst complex component 7 -2.45315
NOS1 nitric oxide synthase 1 (neuronal) -2.44793
ARL11 ADP-ribosylation factor-like 11 -2.41711
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.40721
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) -2.40549
GRIK4 glutamate receptor, ionotropic, kainate 4 -2.36546
LHFPL3 lipoma HMGIC fusion partner-like 3 -2.35605
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -2.3452
SLC7A14 solute carrier family 7, member 14 -2.34352
GLRA2 glycine receptor, alpha 2 -2.30763
DPYSL4 dihydropyrimidinase-like 4 -2.29298
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -2.28398
ANKRD54 ankyrin repeat domain 54 -2.27388
ZNF385D zinc finger protein 385D -2.27198
CWC15 CWC15 spliceosome-associated protein -2.24948
SLC37A1 solute carrier family 37 (glucose-6-phosphate transporter), member 1 -2.23009
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -2.22456
OSTF1 osteoclast stimulating factor 1 -2.20248
SPATA6L spermatogenesis associated 6-like -2.14827
TEX14 testis expressed 14 -2.12834
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -2.11814
LRRC3 leucine rich repeat containing 3 -2.10028
FBRS fibrosin -2.10028
BBC3 BCL2 binding component 3 -2.10028
MAST3 microtubule associated serine/threonine kinase 3 -2.09976
TMEM50B transmembrane protein 50B -2.09903
BBIP1 BBSome interacting protein 1 -2.08445
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.08307
PKD2L2 polycystic kidney disease 2-like 2 -2.08249
RIN3 Ras and Rab interactor 3 -2.07617
HMGB2 high mobility group box 2 -2.07406
MICALL1 MICAL-like 1 -2.07378
IFNGR1 interferon gamma receptor 1 -2.05201
SERINC2 serine incorporator 2 -2.0513
INCENP inner centromere protein antigens 135/155kDa -2.04825
AK4 adenylate kinase 4 -2.04615
CDK18 cyclin-dependent kinase 18 -2.04615
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 -2.03445
CATSPERG catsper channel auxiliary subunit gamma -2.03296
HEXD hexosaminidase D -2.03257
CCZ1 CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) -2.03101
CCNYL1 cyclin Y-like 1 -2.02348
ZNF789 zinc finger protein 789 -2.02028
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.01922
DMGDH dimethylglycine dehydrogenase -2.0159
ZC3H6 zinc finger CCCH-type containing 6 -2.0092
DCHS1 dachsous cadherin-related 1 -2.0092
SFPQ splicing factor proline/glutamine-rich -2.00764
SPATA12 spermatogenesis associated 12 -2.00176