RYK Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description receptor-like tyrosine kinase|The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012] (NCBI Entrez Gene Database, 6259)
External Link http://www.ncbi.nlm.nih.gov/gene/6259
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Genes

109 interacting proteins for RYK from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ADCY8 adenylate cyclase 8 (brain)
ADGRA2 adhesion G protein-coupled receptor A2
ADGRA3 adhesion G protein-coupled receptor A3
AGK acylglycerol kinase
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
APLP2 amyloid beta (A4) precursor-like protein 2
APOA2 apolipoprotein A-II
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
C6ORF48 chromosome 6 open reading frame 48
CANX calnexin
CAPNS1 calpain, small subunit 1
CD276 CD276 molecule
CDC37 cell division cycle 37
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDHR1 cadherin-related family member 1
CDK1 cyclin-dependent kinase 1
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLCA1 chloride channel accessory 1
CLINT1 clathrin interactor 1
CLTCL1 clathrin, heavy chain-like 1
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCHS1 dachsous cadherin-related 1
DSC2 desmocollin 2
DSC3 desmocollin 3
DSG2 desmoglein 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
ELAVL1 ELAV like RNA binding protein 1
EPHA4 EPH receptor A4
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EXO1 exonuclease 1
FAT3 FAT atypical cadherin 3
FAT4 FAT atypical cadherin 4
FREM2 FRAS1 related extracellular matrix protein 2
FZD8 frizzled class receptor 8
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GRN granulin
HAX1 HCLS1 associated protein X-1
HCLS1 hematopoietic cell-specific Lyn substrate 1
HSPA1B heat shock 70kDa protein 1B
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
ITM2B integral membrane protein 2B
ITM2C integral membrane protein 2C
KPNB1 karyopherin (importin) beta 1
LIMA1 LIM domain and actin binding 1
LIN7C lin-7 homolog C (C. elegans)
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MIB1 mindbomb E3 ubiquitin protein ligase 1
NCKAP1 NCK-associated protein 1
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1
NOMO3 NODAL modulator 3
NPEPPS aminopeptidase puromycin sensitive
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRP2 neuropilin 2
NUP93 nucleoporin 93kDa
OSGEP O-sialoglycoprotein endopeptidase
PARP1 poly (ADP-ribose) polymerase 1
PCDH20 protocadherin 20
PCDH7 protocadherin 7
PCDH9 protocadherin 9
PCDHGA11 protocadherin gamma subfamily A, 11
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PCNA proliferating cell nuclear antigen
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSAP prosaposin
PTK7 protein tyrosine kinase 7 (inactive)
PTPRF protein tyrosine phosphatase, receptor type, F
PTPRS protein tyrosine phosphatase, receptor type, S
RHOT2 ras homolog family member T2
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SQRDL sulfide quinone reductase-like (yeast)
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TJP1 tight junction protein 1
TJP3 tight junction protein 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM59 transmembrane protein 59
TMOD3 tropomodulin 3 (ubiquitous)
TP53 tumor protein p53
TPM3 tropomyosin 3
TRAP1 TNF receptor-associated protein 1
UBC ubiquitin C
VIM vimentin
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae)
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASF3 WAS protein family, member 3
WFS1 Wolfram syndrome 1 (wolframin)
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A
WSB1 WD repeat and SOCS box containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
XPO1 exportin 1