| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90). (Chemical Entities of Biological Interest Ontology, CHEBI_556075) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/6323491 |
| Similar Terms | |
| Downloads & Tools |
195 proteins with high or low expression in Radicicol relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BAHCC1 | BAH domain and coiled-coil containing 1 | 3.03 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | 2.94 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 2.73 |
| HSPA1A | heat shock 70kDa protein 1A | 2.68 |
| ZNF175 | zinc finger protein 175 | 2.58 |
| HSPB1 | heat shock 27kDa protein 1 | 2.5 |
| CLU | clusterin | 2.49 |
| HMOX1 | heme oxygenase 1 | 2.17 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 2.02 |
| CNTN1 | contactin 1 | 1.9 |
| FTL | ferritin, light polypeptide | 1.86 |
| BAG3 | BCL2-associated athanogene 3 | 1.83 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 1.79 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | 1.78 |
| DNAJA4 | DnaJ (Hsp40) homolog, subfamily A, member 4 | 1.75 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 1.73 |
| IGF1R | insulin-like growth factor 1 receptor | 1.64 |
| MAP2 | microtubule-associated protein 2 | 1.64 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | 1.63 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 1.59 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 1.57 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 1.53 |
| TRIM16 | tripartite motif containing 16 | 1.51 |
| SORBS1 | sorbin and SH3 domain containing 1 | 1.51 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.49 |
| HKDC1 | hexokinase domain containing 1 | 1.48 |
| VSIR | V-set immunoregulatory receptor | 1.42 |
| SQOR | sulfide quinone oxidoreductase | 1.37 |
| SRXN1 | sulfiredoxin 1 | 1.36 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 1.35 |
| MICB | MHC class I polypeptide-related sequence B | 1.34 |
| UPRT | uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) | 1.31 |
| HSPA8 | heat shock 70kDa protein 8 | 1.28 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 1.27 |
| TJP3 | tight junction protein 3 | 1.26 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 1.26 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 1.26 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 1.23 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 1.21 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 1.2 |
| F10 | coagulation factor X | 1.2 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | 1.18 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 1.18 |
| PRAF2 | PRA1 domain family, member 2 | 1.18 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 1.17 |
| CCND3 | cyclin D3 | 1.13 |
| TMLHE | trimethyllysine hydroxylase, epsilon | 1.12 |
| CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | 1.1 |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 1.09 |
| WSB1 | WD repeat and SOCS box containing 1 | 1.08 |
| TRIML2 | tripartite motif family-like 2 | 1.06 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1.05 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | 1.04 |
| HIBCH | 3-hydroxyisobutyryl-CoA hydrolase | 1.03 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | 1.03 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | 1.03 |
| DOCK11 | dedicator of cytokinesis 11 | 1.02 |
| ZNF227 | zinc finger protein 227 | 1.0 |
| PTPRS | protein tyrosine phosphatase, receptor type, S | 0.99 |
| SULT1A3 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 | 0.99 |
| SOD1 | superoxide dismutase 1, soluble | 0.99 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 0.99 |
| TRAF7 | TNF receptor-associated factor 7, E3 ubiquitin protein ligase | 0.97 |
| COBL | cordon-bleu WH2 repeat protein | 0.96 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.96 |
| CCDC84 | coiled-coil domain containing 84 | 0.95 |
| PRSS8 | protease, serine, 8 | 0.94 |
| EPDR1 | ependymin related 1 | 0.94 |
| CCDC102A | coiled-coil domain containing 102A | 0.94 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 | 0.93 |
| LYPLA1 | lysophospholipase I | 0.93 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.93 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | 0.93 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.92 |
| AASS | aminoadipate-semialdehyde synthase | 0.92 |
| HIKESHI | heat shock protein nuclear import factor hikeshi | 0.92 |
| IGFBP6 | insulin-like growth factor binding protein 6 | 0.92 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.91 |
| TSPYL2 | TSPY-like 2 | 0.91 |
| MRPL3 | mitochondrial ribosomal protein L3 | 0.9 |
| ANGPTL4 | angiopoietin-like 4 | 0.9 |
| PIR | pirin (iron-binding nuclear protein) | 0.9 |
| ABHD4 | abhydrolase domain containing 4 | 0.89 |
| HSPE1 | heat shock 10kDa protein 1 | 0.89 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | 0.89 |
| EFCAB7 | EF-hand calcium binding domain 7 | 0.89 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.88 |
| SCAND1 | SCAN domain containing 1 | 0.88 |
| GRN | granulin | 0.87 |
| PDE9A | phosphodiesterase 9A | 0.87 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 0.87 |
| PBXIP1 | pre-B-cell leukemia homeobox interacting protein 1 | 0.86 |
| TRIM15 | tripartite motif containing 15 | 0.86 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.86 |
| ME1 | malic enzyme 1, NADP(+)-dependent, cytosolic | 0.86 |
| NIBAN1 | niban apoptosis regulator 1 | 0.86 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DUOX1 | dual oxidase 1 | -1.95 |
| RRM2 | ribonucleotide reductase M2 | -1.77 |
| PCLAF | PCNA clamp associated factor | -1.74 |
| FOXM1 | forkhead box M1 | -1.64 |
| CCNB2 | cyclin B2 | -1.64 |
| WDR76 | WD repeat domain 76 | -1.6 |
| EXO1 | exonuclease 1 | -1.59 |
| ESCO2 | establishment of sister chromatid cohesion N-acetyltransferase 2 | -1.57 |
| CDC20 | cell division cycle 20 | -1.53 |
| TK1 | thymidine kinase 1, soluble | -1.52 |
| CCNB1 | cyclin B1 | -1.52 |
| STK35 | serine/threonine kinase 35 | -1.52 |
| CLSPN | claspin | -1.52 |
| CCNA2 | cyclin A2 | -1.51 |
| FOSL1 | FOS-like antigen 1 | -1.51 |
| KIFC1 | kinesin family member C1 | -1.44 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | -1.43 |
| TPX2 | TPX2, microtubule-associated | -1.41 |
| DEPDC1B | DEP domain containing 1B | -1.39 |
| RAD54B | RAD54 homolog B (S. cerevisiae) | -1.39 |
| PTTG1 | pituitary tumor-transforming 1 | -1.39 |
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | -1.37 |
| KIF22 | kinesin family member 22 | -1.37 |
| MCM10 | minichromosome maintenance complex component 10 | -1.36 |
| GMNN | geminin, DNA replication inhibitor | -1.36 |
| CHEK1 | checkpoint kinase 1 | -1.35 |
| EGR1 | early growth response 1 | -1.35 |
| KIF18B | kinesin family member 18B | -1.35 |
| KIF20B | kinesin family member 20B | -1.33 |
| CDK1 | cyclin-dependent kinase 1 | -1.31 |
| KIF18A | kinesin family member 18A | -1.29 |
| RECQL4 | RecQ protein-like 4 | -1.29 |
| FAM111B | family with sequence similarity 111, member B | -1.28 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -1.28 |
| GTSE1 | G-2 and S-phase expressed 1 | -1.25 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -1.23 |
| CEP55 | centrosomal protein 55kDa | -1.22 |
| KIF2C | kinesin family member 2C | -1.2 |
| TIFA | TRAF-interacting protein with forkhead-associated domain | -1.2 |
| FAAP100 | FA core complex associated protein 100 | -1.19 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -1.18 |
| FBXO5 | F-box protein 5 | -1.18 |
| ATAD2 | ATPase family, AAA domain containing 2 | -1.17 |
| DCLRE1C | DNA cross-link repair 1C | -1.17 |
| FANCA | Fanconi anemia, complementation group A | -1.15 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -1.14 |
| CCDC82 | coiled-coil domain containing 82 | -1.12 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -1.09 |
| SGO2 | shugoshin 2 | -1.09 |
| E2F7 | E2F transcription factor 7 | -1.08 |
| CDCA5 | cell division cycle associated 5 | -1.08 |
| HASPIN | histone H3 associated protein kinase | -1.07 |
| CENPJ | centromere protein J | -1.07 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -1.07 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -1.07 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -1.06 |
| FANCG | Fanconi anemia, complementation group G | -1.06 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -1.06 |
| RAF1 | Raf-1 proto-oncogene, serine/threonine kinase | -1.06 |
| BLM | Bloom syndrome, RecQ helicase-like | -1.05 |
| NET1 | neuroepithelial cell transforming 1 | -1.05 |
| ONECUT3 | one cut homeobox 3 | -1.05 |
| CDC25B | cell division cycle 25B | -1.05 |
| COL13A1 | collagen, type XIII, alpha 1 | -1.04 |
| CKAP2L | cytoskeleton associated protein 2-like | -1.04 |
| XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | -1.04 |
| PLK1 | polo-like kinase 1 | -1.04 |
| CENPF | centromere protein F, 350/400kDa | -1.03 |
| MIS18BP1 | MIS18 binding protein 1 | -1.03 |
| CDK11A | cyclin-dependent kinase 11A | -1.03 |
| MASTL | microtubule associated serine/threonine kinase-like | -1.03 |
| HPS5 | Hermansky-Pudlak syndrome 5 | -1.02 |
| CENPQ | centromere protein Q | -1.0 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.99 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.99 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -0.99 |
| DCLRE1A | DNA cross-link repair 1A | -0.99 |
| INCENP | inner centromere protein antigens 135/155kDa | -0.98 |
| CENPE | centromere protein E, 312kDa | -0.98 |
| CDC7 | cell division cycle 7 | -0.97 |
| KBTBD4 | kelch repeat and BTB (POZ) domain containing 4 | -0.97 |
| KNL1 | kinetochore scaffold 1 | -0.97 |
| CHUK | conserved helix-loop-helix ubiquitous kinase | -0.96 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | -0.96 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | -0.95 |
| RAD51 | RAD51 recombinase | -0.95 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.95 |
| BARD1 | BRCA1 associated RING domain 1 | -0.95 |
| ANLN | anillin, actin binding protein | -0.94 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.94 |
| ENTPD5 | ectonucleoside triphosphate diphosphohydrolase 5 | -0.94 |
| PASK | PAS domain containing serine/threonine kinase | -0.94 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | -0.94 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.94 |
| NR1D1 | nuclear receptor subfamily 1, group D, member 1 | -0.94 |
| CBWD1 | COBW domain containing 1 | -0.93 |
| FTSJ1 | FtsJ RNA methyltransferase homolog 1 (E. coli) | -0.93 |
| ITFG2 | integrin alpha FG-GAP repeat containing 2 | -0.93 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | -0.93 |
