Radotinib_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.121644
PODXL podocalyxin-like 0.101782
IGFBP3 insulin-like growth factor binding protein 3 0.0999479
AKAP12 A kinase (PRKA) anchor protein 12 0.0806747
MT2A metallothionein 2A 0.0660866
PKM pyruvate kinase, muscle 0.0647004
LDHA lactate dehydrogenase A 0.0628369
COL5A1 collagen, type V, alpha 1 0.0603514
LOC112694756 uncharaterized LOC112694756 0.0534454
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052561
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0508104
CDH13 cadherin 13 0.0473538
NDRG1 N-myc downstream regulated 1 0.0464258
BHLHE40 basic helix-loop-helix family, member e40 0.0460133
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0440521
ENO1 enolase 1, (alpha) 0.0435916
POTEF POTE ankyrin domain family, member F 0.0433357
CSTB cystatin B (stefin B) 0.0427805
CALR calreticulin 0.042082
ERRFI1 ERBB receptor feedback inhibitor 1 0.041131
EFNA5 ephrin-A5 0.040619
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0384875
EEF2 eukaryotic translation elongation factor 2 0.0364909
NAP1L1 nucleosome assembly protein 1-like 1 0.036454
TMSB10 thymosin beta 10 0.0353681
P4HB prolyl 4-hydroxylase, beta polypeptide 0.03467
ASPH aspartate beta-hydroxylase 0.0345813
TRIO trio Rho guanine nucleotide exchange factor 0.03447
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0337826
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0335807
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0330203
EGFR epidermal growth factor receptor 0.0329138
MSN moesin 0.0328063
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0326202
TPM3 tropomyosin 3 0.032518
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0317893
VEGFA vascular endothelial growth factor A 0.0304558
RPS3 ribosomal protein S3 0.029837
KLF6 Kruppel-like factor 6 0.0297452
GADD45B growth arrest and DNA-damage-inducible, beta 0.0290193
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0290157
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0285926
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0280437
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0279908
MYH9 myosin, heavy chain 9, non-muscle 0.0273546
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0271177
HMGB2 high mobility group box 2 0.026641
CANX calnexin 0.0263373
SEC61G Sec61 gamma subunit 0.0262329
FOSL1 FOS-like antigen 1 0.0262037
RPS4X ribosomal protein S4, X-linked 0.0260008
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0256535
EIF4H eukaryotic translation initiation factor 4H 0.0255584
IARS1 isoleucyl-tRNA synthetase 1 0.0249305
B2M beta-2-microglobulin 0.0247363
RPL37A ribosomal protein L37a 0.0246972
DSPP dentin sialophosphoprotein 0.0241961
BRD2 bromodomain containing 2 0.0237895
GOLGB1 golgin B1 0.0236111
ZMIZ1 zinc finger, MIZ-type containing 1 0.0235089
AKAP9 A kinase (PRKA) anchor protein 9 0.0232751
RPL26 ribosomal protein L26 0.0232532
AHNAK2 AHNAK nucleoprotein 2 0.0231437
FAM107B family with sequence similarity 107, member B 0.0227619
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0224323
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0222914
TPR translocated promoter region, nuclear basket protein 0.0221521
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0216657
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0214226
EZR ezrin 0.0208972
MPRIP myosin phosphatase Rho interacting protein 0.0208788
CENPF centromere protein F, 350/400kDa 0.0208673
LAMC2 laminin, gamma 2 0.0208355
ANKRD11 ankyrin repeat domain 11 0.0206967
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0205162
WDR43 WD repeat domain 43 0.0204598
DENND1A DENN/MADD domain containing 1A 0.0202234
GADD45A growth arrest and DNA-damage-inducible, alpha 0.020159
NFE2L1 nuclear factor, erythroid 2-like 1 0.0198831
UBXN4 UBX domain protein 4 0.0194277
CSPG4 chondroitin sulfate proteoglycan 4 0.0193463
RAB7A RAB7A, member RAS oncogene family 0.0193189
FTL ferritin, light polypeptide 0.0191627
CTBP2 C-terminal binding protein 2 0.0189961
LAMB1 laminin, beta 1 0.0188519
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0187558
RPS12 ribosomal protein S12 0.0187406
IWS1 IWS1 homolog (S. cerevisiae) 0.0187054
CEP350 centrosomal protein 350kDa 0.0186157
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0186011
JMJD1C jumonji domain containing 1C 0.0184835
SRRM2 serine/arginine repetitive matrix 2 0.0184762
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 0.018436
TBCA tubulin folding cofactor A 0.0180649
BACE2 beta-site APP-cleaving enzyme 2 0.0179818
JUN jun proto-oncogene 0.0177039
SH3GL1 SH3-domain GRB2-like 1 0.0177039
EGR1 early growth response 1 0.0176117
KLF10 Kruppel-like factor 10 0.0175407
TMF1 TATA element modulatory factor 1 0.0173617

decreased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.260902
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.175208
FBN1 fibrillin 1 -0.140184
COL1A2 collagen, type I, alpha 2 -0.114238
COL8A1 collagen, type VIII, alpha 1 -0.109505
MX2 MX dynamin-like GTPase 2 -0.0906759
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0857562
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0850084
ZBTB20 zinc finger and BTB domain containing 20 -0.0799972
AHNAK AHNAK nucleoprotein -0.0794349
COL3A1 collagen, type III, alpha 1 -0.0735915
S100A10 S100 calcium binding protein A10 -0.0715647
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0703369
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0625104
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0619614
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0574524
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0560297
NAV1 neuron navigator 1 -0.0552002
AUTS2 autism susceptibility candidate 2 -0.0546545
MYOF myoferlin -0.0540605
SUCNR1 succinate receptor 1 -0.0539617
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0531643
CUX1 cut-like homeobox 1 -0.0520617
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0520582
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.051255
SAMD9 sterile alpha motif domain containing 9 -0.0510621
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0508939
COL5A2 collagen, type V, alpha 2 -0.0507335
DST dystonin -0.0503516
FRMD5 FERM domain containing 5 -0.0488713
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0478727
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0476595
GPC6 glypican 6 -0.0473506
RIGI RNA sensor RIG-I -0.0468732
DPYSL3 dihydropyrimidinase-like 3 -0.0461935
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0441323
VIM vimentin -0.0424648
IFIH1 interferon induced with helicase C domain 1 -0.0420346
WARS1 tryptophanyl-tRNA synthetase 1 -0.0403821
MEIS2 Meis homeobox 2 -0.0384977
RNF213 ring finger protein 213 -0.0377061
CD99 CD99 molecule -0.037553
HLA-B major histocompatibility complex, class I, B -0.0371873
SAMD9L sterile alpha motif domain containing 9-like -0.0371428
ZNFX1 zinc finger, NFX1-type containing 1 -0.0368098
SBF2 SET binding factor 2 -0.0367311
PDE4D phosphodiesterase 4D, cAMP-specific -0.0365383
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0365034
IQGAP1 IQ motif containing GTPase activating protein 1 -0.034967
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0347377
TPM1 tropomyosin 1 (alpha) -0.0347071
SOD2 superoxide dismutase 2, mitochondrial -0.0345565
NF1 neurofibromin 1 -0.0342129
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0341077
MT1X metallothionein 1X -0.0333855
FNDC3A fibronectin type III domain containing 3A -0.0325845
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.032338
PSD3 pleckstrin and Sec7 domain containing 3 -0.0317674
IFI16 interferon, gamma-inducible protein 16 -0.0316117
VCL vinculin -0.030797
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0306813
TENT5A terminal nucleotidyltransferase 5A -0.0305362
TNS3 tensin 3 -0.0299946
OGA O-GlcNAcase -0.0298109
ZNF148 zinc finger protein 148 -0.0297779
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0288563
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0285929
ADAR adenosine deaminase, RNA-specific -0.0285218
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0283211
KIFAP3 kinesin-associated protein 3 -0.0278371
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0275373
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0272168
LPP LIM domain containing preferred translocation partner in lipoma -0.0271053
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0269027
FNDC3B fibronectin type III domain containing 3B -0.0266819
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0266344
PARD3 par-3 family cell polarity regulator -0.0266264
NT5C2 5'-nucleotidase, cytosolic II -0.0266161
ZMYND8 zinc finger, MYND-type containing 8 -0.0265134
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.026499
LOX lysyl oxidase -0.0264439
JAZF1 JAZF zinc finger 1 -0.0264329
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0261974
LOXL2 lysyl oxidase-like 2 -0.0261665
TOX thymocyte selection-associated high mobility group box -0.0260245
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0258082
TENM3 teneurin transmembrane protein 3 -0.0257967
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.025717
SETD5 SET domain containing 5 -0.0256415
RHOBTB3 Rho-related BTB domain containing 3 -0.0255667
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0253747
DENND5A DENN/MADD domain containing 5A -0.0253098
PRELID2 PRELI domain containing 2 -0.0252812
USP34 ubiquitin specific peptidase 34 -0.0251839
ABI3BP ABI family, member 3 (NESH) binding protein -0.0251527
TUBB tubulin, beta class I -0.0251351
SDK1 sidekick cell adhesion molecule 1 -0.0249508
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0248874
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0248059
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0246314