| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Radotinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.220825 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.135566 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.131516 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.08996 |
| ANXA1 | annexin A1 | 0.0862753 |
| LDHA | lactate dehydrogenase A | 0.0783067 |
| TPI1 | triosephosphate isomerase 1 | 0.0716374 |
| ENO1 | enolase 1, (alpha) | 0.0657146 |
| RPS3 | ribosomal protein S3 | 0.0629192 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0539615 |
| TPM3 | tropomyosin 3 | 0.0536208 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0534541 |
| ASPH | aspartate beta-hydroxylase | 0.0525497 |
| EHBP1 | EH domain binding protein 1 | 0.0520489 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0473618 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0470563 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0466332 |
| RPS7 | ribosomal protein S7 | 0.0462955 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.045143 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0425224 |
| POTEF | POTE ankyrin domain family, member F | 0.041786 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0408413 |
| PRDX1 | peroxiredoxin 1 | 0.0397783 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0393285 |
| CCN2 | cellular communication network factor 2 | 0.0388816 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0386882 |
| RPL3 | ribosomal protein L3 | 0.0385049 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | 0.0376741 |
| RPS4X | ribosomal protein S4, X-linked | 0.0374243 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0367664 |
| SON | SON DNA binding protein | 0.0362403 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0360301 |
| RPS12 | ribosomal protein S12 | 0.0325036 |
| EGR1 | early growth response 1 | 0.0321484 |
| RPS2 | ribosomal protein S2 | 0.0315647 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0312138 |
| PLK2 | polo-like kinase 2 | 0.0300601 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0296674 |
| SET | SET nuclear proto-oncogene | 0.0296176 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0294809 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0294716 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.028735 |
| PCM1 | pericentriolar material 1 | 0.0282192 |
| ZNF407 | zinc finger protein 407 | 0.0275413 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0269284 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.02535 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0251218 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0244081 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0243933 |
| DTNA | dystrobrevin, alpha | 0.0241869 |
| MKI67 | marker of proliferation Ki-67 | 0.0236007 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0233657 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.023274 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0231098 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0219423 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0217952 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0216975 |
| EDN1 | endothelin 1 | 0.0216338 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0216008 |
| PEG10 | paternally expressed 10 | 0.0215811 |
| BRD2 | bromodomain containing 2 | 0.0213362 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0213201 |
| PCBP2 | poly(rC) binding protein 2 | 0.0211345 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0210835 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0210048 |
| HMGA2 | high mobility group AT-hook 2 | 0.0209732 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0208647 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.020863 |
| PGK1 | phosphoglycerate kinase 1 | 0.0208528 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0205741 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.02055 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0200881 |
| PKM | pyruvate kinase, muscle | 0.0199304 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.019872 |
| NRDC | nardilysin convertase | 0.019815 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0193522 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0192448 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0192205 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.0191595 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0190424 |
| EGFR | epidermal growth factor receptor | 0.018613 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0185944 |
| EZR | ezrin | 0.018556 |
| TUBA1C | tubulin, alpha 1c | 0.0184743 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0183955 |
| RPL9 | ribosomal protein L9 | 0.018362 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0183301 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0181415 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0180691 |
| WDR26 | WD repeat domain 26 | 0.0179871 |
| COPA | coatomer protein complex, subunit alpha | 0.0178661 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0178127 |
| TYMS | thymidylate synthetase | 0.017778 |
| CSMD1 | CUB and Sushi multiple domains 1 | 0.0177397 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0176979 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0176627 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0173903 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0171677 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0171158 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.017017 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.257201 |
| TMSB10 | thymosin beta 10 | -0.123836 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.117999 |
| NLGN1 | neuroligin 1 | -0.110577 |
| MMP12 | matrix metallopeptidase 12 | -0.0926817 |
| RPS6 | ribosomal protein S6 | -0.0844845 |
| RPL35A | ribosomal protein L35a | -0.0832023 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0790573 |
| RPLP1 | ribosomal protein, large, P1 | -0.0778268 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0776786 |
| RPL38 | ribosomal protein L38 | -0.0666702 |
| AREG | amphiregulin | -0.06637 |
| RPL23 | ribosomal protein L23 | -0.064567 |
| RPL8 | ribosomal protein L8 | -0.0626065 |
| TENM3 | teneurin transmembrane protein 3 | -0.0621902 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0619858 |
| AHNAK | AHNAK nucleoprotein | -0.0612117 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0607947 |
| RPL34 | ribosomal protein L34 | -0.0598911 |
| RPS8 | ribosomal protein S8 | -0.0576346 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0574375 |
| RPS21 | ribosomal protein S21 | -0.0573185 |
| RPLP2 | ribosomal protein, large, P2 | -0.0544762 |
| VIM | vimentin | -0.0514601 |
| GNAS | GNAS complex locus | -0.0495962 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0493678 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0484847 |
| RPS16 | ribosomal protein S16 | -0.0479916 |
| RPS19 | ribosomal protein S19 | -0.0479528 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.046386 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0445935 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0437225 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0430909 |
| CANX | calnexin | -0.0420592 |
| RPS27A | ribosomal protein S27a | -0.0418314 |
| RPS23 | ribosomal protein S23 | -0.041355 |
| HMGB1 | high mobility group box 1 | -0.0404186 |
| RPS27 | ribosomal protein S27 | -0.0399576 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0393932 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.038573 |
| PTMA | prothymosin, alpha | -0.0375378 |
| H1-0 | H1.0 linker histone | -0.0368864 |
| S100A6 | S100 calcium binding protein A6 | -0.0367874 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.03676 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0364968 |
| CALR | calreticulin | -0.0360966 |
| RPS15 | ribosomal protein S15 | -0.0359301 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0352486 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0348958 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0347734 |
| RPL36A | ribosomal protein L36a | -0.0347138 |
| EIF4B | eukaryotic translation initiation factor 4B | -0.0347072 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0344126 |
| RTN3 | reticulon 3 | -0.0333742 |
| BCHE | butyrylcholinesterase | -0.0323432 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0321922 |
| RPLP0 | ribosomal protein, large, P0 | -0.0319694 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0318982 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0318962 |
| S100A10 | S100 calcium binding protein A10 | -0.0317772 |
| RPS29 | ribosomal protein S29 | -0.0317093 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0316334 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0315434 |
| RPS20 | ribosomal protein S20 | -0.0315208 |
| RPS24 | ribosomal protein S24 | -0.0313097 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0312868 |
| RPL19 | ribosomal protein L19 | -0.0309503 |
| ZNF207 | zinc finger protein 207 | -0.0301309 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0301157 |
| EDARADD | EDAR-associated death domain | -0.0290943 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0289097 |
| WWOX | WW domain containing oxidoreductase | -0.0286299 |
| CPOX | coproporphyrinogen oxidase | -0.0281621 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0280158 |
| RPL28 | ribosomal protein L28 | -0.0277169 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0275972 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0275827 |
| RPS5 | ribosomal protein S5 | -0.0269483 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0268878 |
| RPL12 | ribosomal protein L12 | -0.0263937 |
| VMP1 | vacuole membrane protein 1 | -0.026347 |
| RBM39 | RNA binding motif protein 39 | -0.0262879 |
| OGA | O-GlcNAcase | -0.0262095 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0259607 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | -0.0257911 |
| RPL32 | ribosomal protein L32 | -0.0257827 |
| CUX1 | cut-like homeobox 1 | -0.0257759 |
| CMIP | c-Maf inducing protein | -0.0251454 |
| VCL | vinculin | -0.0249809 |
| RAB10 | RAB10, member RAS oncogene family | -0.0247724 |
| SETD5 | SET domain containing 5 | -0.0244251 |
| FUS | FUS RNA binding protein | -0.0242958 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0242698 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0240656 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0240582 |
| XPO1 | exportin 1 | -0.0239488 |
| S100A9 | S100 calcium binding protein A9 | -0.0236501 |
| CLDN1 | claudin 1 | -0.0234271 |
| PRR11 | proline rich 11 | -0.0233948 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0232943 |
