Radotinib_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0851761
COL6A3 collagen, type VI, alpha 3 0.0547356
ERRFI1 ERBB receptor feedback inhibitor 1 0.0431349
VEGFA vascular endothelial growth factor A 0.0430395
COL5A1 collagen, type V, alpha 1 0.0312455
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0271794
EXT1 exostosin glycosyltransferase 1 0.0265874
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0234598
DOCK5 dedicator of cytokinesis 5 0.0220136
STC1 stanniocalcin 1 0.0214761
APP amyloid beta (A4) precursor protein 0.0206179
ASPH aspartate beta-hydroxylase 0.020602
MYH9 myosin, heavy chain 9, non-muscle 0.0205364
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197714
ANXA1 annexin A1 0.0186274
HMGA2 high mobility group AT-hook 2 0.0176421
ZSWIM6 zinc finger, SWIM-type containing 6 0.0169735
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0169358
FBXL13 F-box and leucine-rich repeat protein 13 0.0167232
CDH13 cadherin 13 0.016445
EFNA5 ephrin-A5 0.0160222
HSPA8 heat shock 70kDa protein 8 0.0158174
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0157683
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0157258
PLEC plectin 0.0154806
PDE10A phosphodiesterase 10A 0.0151481
GOLGB1 golgin B1 0.0145476
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0141824
GLIS3 GLIS family zinc finger 3 0.0140308
FAM107B family with sequence similarity 107, member B 0.0136992
FAT1 FAT atypical cadherin 1 0.0136118
ANTXR2 anthrax toxin receptor 2 0.0131912
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0130419
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0129705
EEF2 eukaryotic translation elongation factor 2 0.0125856
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0124357
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0120161
AGO2 argonaute RISC catalytic component 2 0.0119909
ARHGAP22 Rho GTPase activating protein 22 0.0114642
NAV2 neuron navigator 2 0.0114311
PDIA5 protein disulfide isomerase family A, member 5 0.0113986
WWTR1 WW domain containing transcription regulator 1 0.0113097
SMAD3 SMAD family member 3 0.0112916
FMNL2 formin-like 2 0.0108818
BTBD9 BTB (POZ) domain containing 9 0.0108414
EGFR epidermal growth factor receptor 0.010839
SAFB2 scaffold attachment factor B2 0.0105979
FNIP1 folliculin interacting protein 1 0.0105625
SHB Src homology 2 domain containing adaptor protein B 0.01056
RASA3 RAS p21 protein activator 3 0.010529
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0105179
MARCHF3 membrane associated ring-CH-type finger 3 0.0102977
JUN jun proto-oncogene 0.0102322
YEATS2 YEATS domain containing 2 0.0101169
RUNX1 runt-related transcription factor 1 0.00988417
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.00980134
NOTCH2 notch 2 0.00958296
SKI SKI proto-oncogene 0.00952792
LIF leukemia inhibitory factor 0.00952143
EIF4H eukaryotic translation initiation factor 4H 0.00945682
BACE2 beta-site APP-cleaving enzyme 2 0.00945502
SFPQ splicing factor proline/glutamine-rich 0.00928737
PMM2 phosphomannomutase 2 0.00925348
BRD2 bromodomain containing 2 0.00925243
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0092347
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.00914385
SETBP1 SET binding protein 1 0.00881847
FAM219A family with sequence similarity 219, member A 0.00880803
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.00877506
ANKRD36 ankyrin repeat domain 36 0.00875948
EGR1 early growth response 1 0.00873552
PTPRM protein tyrosine phosphatase, receptor type, M 0.00870329
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00865958
ANKH ANKH inorganic pyrophosphate transport regulator 0.00857802
MLF1 myeloid leukemia factor 1 0.0085299
TNS1 tensin 1 0.00845182
PACS1 phosphofurin acidic cluster sorting protein 1 0.00840736
CNOT12 CCR4-NOT transcription complex subunit 12 0.00840477
ZBTB38 zinc finger and BTB domain containing 38 0.0083788
GRB10 growth factor receptor-bound protein 10 0.00836639
DPYSL2 dihydropyrimidinase-like 2 0.00826065
MYO9B myosin IXB 0.00813479
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00812792
UBE3C ubiquitin protein ligase E3C 0.00810886
CHD1 chromodomain helicase DNA binding protein 1 0.0079953
FOS FBJ murine osteosarcoma viral oncogene homolog 0.00789365
LAMC2 laminin, gamma 2 0.00786545
HIPK2 homeodomain interacting protein kinase 2 0.00786437
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00786039
MACF1 microtubule-actin crosslinking factor 1 0.0077972
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.00762392
IARS1 isoleucyl-tRNA synthetase 1 0.00761642
RNMT RNA (guanine-7-) methyltransferase 0.00760234
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.00757733
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 0.00746438
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.00733652
ZMIZ1 zinc finger, MIZ-type containing 1 0.00706823
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.00705655
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0070103
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.00689963

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.259926
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.218597
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191774
COL1A1 collagen, type I, alpha 1 -0.165163
TMSB10 thymosin beta 10 -0.112017
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.111876
COL1A2 collagen, type I, alpha 2 -0.108055
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0906312
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0833667
PTMA prothymosin, alpha -0.0741624
FTL ferritin, light polypeptide -0.0724869
MT2A metallothionein 2A -0.0715994
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0623331
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0618295
IER3 immediate early response 3 -0.0549377
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0532741
RPS6 ribosomal protein S6 -0.052606
B2M beta-2-microglobulin -0.0521783
TGFBI transforming growth factor, beta-induced, 68kDa -0.0502706
RPS8 ribosomal protein S8 -0.0477751
RPL35A ribosomal protein L35a -0.0434166
CADM1 cell adhesion molecule 1 -0.0424904
ENO1 enolase 1, (alpha) -0.0420314
UBC ubiquitin C -0.0403736
S100A9 S100 calcium binding protein A9 -0.0402527
TPM4 tropomyosin 4 -0.0400164
RPL8 ribosomal protein L8 -0.0398348
NDRG1 N-myc downstream regulated 1 -0.0388144
HLA-B major histocompatibility complex, class I, B -0.0355523
CALD1 caldesmon 1 -0.0354204
S100A6 S100 calcium binding protein A6 -0.033644
MAP1B microtubule-associated protein 1B -0.0335021
RPL23 ribosomal protein L23 -0.0331705
S100A10 S100 calcium binding protein A10 -0.0324127
ANXA2 annexin A2 -0.0317828
PFN1 profilin 1 -0.0311935
PDIA3 protein disulfide isomerase family A, member 3 -0.0302485
RPL19 ribosomal protein L19 -0.0299793
ALCAM activated leukocyte cell adhesion molecule -0.0298629
ACTG1 actin gamma 1 -0.0295884
IFI6 interferon, alpha-inducible protein 6 -0.0291986
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0291508
TMSB4X thymosin beta 4, X-linked -0.0290825
POSTN periostin, osteoblast specific factor -0.0289784
RPS19 ribosomal protein S19 -0.0287215
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0283548
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0281833
HLA-A major histocompatibility complex, class I, A -0.0279586
CYB5R3 cytochrome b5 reductase 3 -0.0278946
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0277793
DSTN destrin (actin depolymerizing factor) -0.0274984
VCAN versican -0.0268854
FN1 fibronectin 1 -0.0266947
COL6A1 collagen, type VI, alpha 1 -0.0265448
CALR calreticulin -0.0259563
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0259143
PGK1 phosphoglycerate kinase 1 -0.0257788
RPS11 ribosomal protein S11 -0.0256938
IGFBP7 insulin-like growth factor binding protein 7 -0.0251877
TPI1 triosephosphate isomerase 1 -0.0247921
EIF1 eukaryotic translation initiation factor 1 -0.0247142
DPYSL3 dihydropyrimidinase-like 3 -0.0244145
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0242994
TPM2 tropomyosin 2 (beta) -0.024209
HMGA1 high mobility group AT-hook 1 -0.0237871
SEPTIN7 septin 7 -0.0237757
LOX lysyl oxidase -0.0231848
RPL28 ribosomal protein L28 -0.0231206
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230053
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0228763
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0227343
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0227201
RPL12 ribosomal protein L12 -0.0227155
QKI QKI, KH domain containing, RNA binding -0.0226336
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0225759
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0223496
ZNF292 zinc finger protein 292 -0.0222828
RPLP0 ribosomal protein, large, P0 -0.0221586
GNAS GNAS complex locus -0.0220981
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0219568
RPL18 ribosomal protein L18 -0.0212929
RPL11 ribosomal protein L11 -0.0212502
TPT1 tumor protein, translationally-controlled 1 -0.0211184
CSDE1 cold shock domain containing E1, RNA-binding -0.0208918
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0208431
SOD2 superoxide dismutase 2, mitochondrial -0.0207698
DPYD dihydropyrimidine dehydrogenase -0.0207343
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0206871
RPS14 ribosomal protein S14 -0.0206478
ADM adrenomedullin -0.0203878
THY1 Thy-1 cell surface antigen -0.0202151
RPLP1 ribosomal protein, large, P1 -0.0200042
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0199272
USP3 ubiquitin specific peptidase 3 -0.0198575
RACK1 receptor for activated C kinase 1 -0.0198429
FAM162A family with sequence similarity 162, member A -0.0196077
RPS12 ribosomal protein S12 -0.0193711
WASF2 WAS protein family, member 2 -0.0192686
TRAM1 translocation associated membrane protein 1 -0.0191585
HILPDA hypoxia inducible lipid droplet-associated -0.0191116