Radotinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.171156
AKAP12 A kinase (PRKA) anchor protein 12 0.0984793
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0967235
FN1 fibronectin 1 0.0926321
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0908407
SVIL supervillin 0.0898336
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0884212
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0816515
C3 complement component 3 0.0785355
ELL2 elongation factor, RNA polymerase II, 2 0.0724073
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0636744
TNS1 tensin 1 0.0615613
TF transferrin 0.057352
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0572262
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0542955
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.051449
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0487284
VMP1 vacuole membrane protein 1 0.0469443
FAT1 FAT atypical cadherin 1 0.0431405
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0418032
PEG3 paternally expressed 3 0.0413414
LOC112694756 uncharaterized LOC112694756 0.039687
VEGFA vascular endothelial growth factor A 0.0378962
RPL3 ribosomal protein L3 0.0373619
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.035708
JMJD1C jumonji domain containing 1C 0.0331434
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0322265
CCL20 chemokine (C-C motif) ligand 20 0.0319731
ITGB5 integrin, beta 5 0.0309776
DOCK5 dedicator of cytokinesis 5 0.0308714
GRB10 growth factor receptor-bound protein 10 0.0304574
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0295538
RAI14 retinoic acid induced 14 0.0293117
MCL1 myeloid cell leukemia 1 0.0285151
DDIT4 DNA-damage-inducible transcript 4 0.028272
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0280532
EEF2 eukaryotic translation elongation factor 2 0.0279055
SESTD1 SEC14 and spectrin domains 1 0.027905
ARHGAP21 Rho GTPase activating protein 21 0.0270049
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0266996
MAML2 mastermind-like 2 (Drosophila) 0.0265917
TCIM transcriptional and immune response regulator 0.02643
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0260967
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.0259747
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0259672
AFDN afadin, adherens junction formation factor 0.0256076
WWTR1 WW domain containing transcription regulator 1 0.0254657
FTH1 ferritin, heavy polypeptide 1 0.0254067
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.024662
CRY1 cryptochrome circadian clock 1 0.0245304
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0243967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0243853
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0243546
IGFBP1 insulin-like growth factor binding protein 1 0.0242146
NKD1 naked cuticle homolog 1 (Drosophila) 0.0237046
DNAH17 dynein, axonemal, heavy chain 17 0.0234633
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0228968
GK glycerol kinase 0.0222631
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0222135
GMDS GDP-mannose 4,6-dehydratase 0.0221517
DSPP dentin sialophosphoprotein 0.0221026
ABTB3 ankyrin repeat and BTB domain containing 3 0.0220864
LMCD1 LIM and cysteine-rich domains 1 0.0217402
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0216328
KALRN kalirin, RhoGEF kinase 0.0214149
WWC2 WW and C2 domain containing 2 0.0205764
FAM13A family with sequence similarity 13, member A 0.0204591
SMAD3 SMAD family member 3 0.0199134
OSBPL10 oxysterol binding protein-like 10 0.0196118
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0193203
ITGA1 integrin, alpha 1 0.0190204
RUNX1 runt-related transcription factor 1 0.0187588
BHLHE40 basic helix-loop-helix family, member e40 0.0186714
PKP4 plakophilin 4 0.0184706
TXNRD1 thioredoxin reductase 1 0.0183207
FNDC3B fibronectin type III domain containing 3B 0.0182193
NUP58 nucleoporin 58 0.0180118
DLC1 DLC1 Rho GTPase activating protein 0.0176696
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0174185
A2M alpha-2-macroglobulin 0.0173371
MALT1 MALT1 paracaspase 0.0173302
SNX9 sorting nexin 9 0.0173048
ARRDC3 arrestin domain containing 3 0.0172702
NGLY1 N-glycanase 1 0.0172443
ATP10A ATPase, class V, type 10A 0.0171791
MYO6 myosin VI 0.017168
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0170669
ATF3 activating transcription factor 3 0.017066
GCLC glutamate-cysteine ligase, catalytic subunit 0.017008
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0168907
ANKH ANKH inorganic pyrophosphate transport regulator 0.0164735
FERMT1 fermitin family member 1 0.0164405
KRT23 keratin 23, type I 0.016256
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0161721
MATR3 matrin 3 0.0161259
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0161204
EPAS1 endothelial PAS domain protein 1 0.0161163
NDRG1 N-myc downstream regulated 1 0.0160827
IL1RAP interleukin 1 receptor accessory protein 0.0160473
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0159467

decreased expression

Symbol Name Standardized Value
APOA2 apolipoprotein A-II -0.154728
TPT1 tumor protein, translationally-controlled 1 -0.124705
TMSB10 thymosin beta 10 -0.1113
LRMDA leucine rich melanocyte differentiation associated -0.106678
GPC6 glypican 6 -0.106462
MT2A metallothionein 2A -0.099421
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0862044
VCL vinculin -0.0816267
RPS24 ribosomal protein S24 -0.0682055
ZBTB20 zinc finger and BTB domain containing 20 -0.0641406
PLIN2 perilipin 2 -0.0613427
PTCHD4 patched domain containing 4 -0.0592858
RPL11 ribosomal protein L11 -0.0584947
HMGA1 high mobility group AT-hook 1 -0.0574483
RPS8 ribosomal protein S8 -0.0572817
RPS21 ribosomal protein S21 -0.0567547
PDLIM5 PDZ and LIM domain 5 -0.0541133
RPL35A ribosomal protein L35a -0.0532665
RPL37A ribosomal protein L37a -0.0496409
RNF213 ring finger protein 213 -0.049199
ATXN1 ataxin 1 -0.0482705
FTL ferritin, light polypeptide -0.0481307
RPL34 ribosomal protein L34 -0.0471588
RPLP1 ribosomal protein, large, P1 -0.0470499
GPC3 glypican 3 -0.0461455
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0459389
RPLP2 ribosomal protein, large, P2 -0.0435073
RPLP0 ribosomal protein, large, P0 -0.0430837
SOX5 SRY (sex determining region Y)-box 5 -0.0425617
INTS6 integrator complex subunit 6 -0.0416594
DST dystonin -0.0411571
LPP LIM domain containing preferred translocation partner in lipoma -0.0407705
ACTG1 actin gamma 1 -0.0403829
RPS27A ribosomal protein S27a -0.0401159
TM4SF1 transmembrane 4 L six family member 1 -0.0393974
ISG15 ISG15 ubiquitin-like modifier -0.037333
DTNA dystrobrevin, alpha -0.0372
PTPRK protein tyrosine phosphatase, receptor type, K -0.0370428
RPL23 ribosomal protein L23 -0.0362513
RPS19 ribosomal protein S19 -0.0358738
EXT1 exostosin glycosyltransferase 1 -0.0358118
RPL9 ribosomal protein L9 -0.0353454
GNAS GNAS complex locus -0.0353219
STAU1 staufen double-stranded RNA binding protein 1 -0.0348828
APOE apolipoprotein E -0.0347441
ITGAV integrin, alpha V -0.0345877
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0345067
KIF21A kinesin family member 21A -0.0343713
S100A9 S100 calcium binding protein A9 -0.0325224
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0323467
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0322174
AMBP alpha-1-microglobulin/bikunin precursor -0.0321298
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.031784
SAMD4A sterile alpha motif domain containing 4A -0.0310794
RPS6 ribosomal protein S6 -0.0310575
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.030945
PTMA prothymosin, alpha -0.0301246
RPS23 ribosomal protein S23 -0.0301169
PHF3 PHD finger protein 3 -0.0291472
RPL28 ribosomal protein L28 -0.029121
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0286858
RPS13 ribosomal protein S13 -0.0278039
PTPRF protein tyrosine phosphatase, receptor type, F -0.0277792
IFI6 interferon, alpha-inducible protein 6 -0.027778
PERP PERP, TP53 apoptosis effector -0.0275653
AHSG alpha-2-HS-glycoprotein -0.0274829
RPL31 ribosomal protein L31 -0.0273642
IFITM1 interferon induced transmembrane protein 1 -0.0270048
UGP2 UDP-glucose pyrophosphorylase 2 -0.0269473
RPS14 ribosomal protein S14 -0.0268154
IGF2 insulin-like growth factor 2 -0.0266841
RPL12 ribosomal protein L12 -0.0263522
RPS12 ribosomal protein S12 -0.0262829
B2M beta-2-microglobulin -0.026225
TPM4 tropomyosin 4 -0.0259827
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0256772
MYO1E myosin IE -0.0253728
ZMYND8 zinc finger, MYND-type containing 8 -0.0245817
RPL38 ribosomal protein L38 -0.0243896
RPS29 ribosomal protein S29 -0.024024
RPL32 ribosomal protein L32 -0.0239694
MIDN midnolin -0.0238293
SOX4 SRY (sex determining region Y)-box 4 -0.0237529
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0235277
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0235261
H3-3B H3.3 histone B -0.0225812
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0225116
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0225098
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0223786
KPNB1 karyopherin (importin) beta 1 -0.0222886
PEBP1 phosphatidylethanolamine binding protein 1 -0.0222231
RPL5 ribosomal protein L5 -0.0222005
RPS10 ribosomal protein S10 -0.0221665
IFIH1 interferon induced with helicase C domain 1 -0.0217777
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0217188
NPAS2 neuronal PAS domain protein 2 -0.0216295
RIGI RNA sensor RIG-I -0.0214368
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0214153
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0213011
CKAP4 cytoskeleton-associated protein 4 -0.02127