Radotinib_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PALM2AKAP2 PALM2 and AKAP2 fusion 0.119339
LAMC2 laminin, gamma 2 0.0862738
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0779723
MTSS1 metastasis suppressor 1 0.0656015
MSN moesin 0.0587985
POTEF POTE ankyrin domain family, member F 0.0540557
ASPH aspartate beta-hydroxylase 0.0483298
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0463428
KIAA0040 KIAA0040 0.0417289
PODXL podocalyxin-like 0.0415359
HMGA2 high mobility group AT-hook 2 0.0409163
LUZP1 leucine zipper protein 1 0.0407306
EFNA5 ephrin-A5 0.0384383
CEMIP cell migration inducing protein, hyaluronan binding 0.0370205
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0364047
PDLIM5 PDZ and LIM domain 5 0.0356242
BCAR3 breast cancer anti-estrogen resistance 3 0.0355348
RNF217 ring finger protein 217 0.0352101
THSD4 thrombospondin, type I, domain containing 4 0.0342021
SLC35F3 solute carrier family 35, member F3 0.0341505
PDE4D phosphodiesterase 4D, cAMP-specific 0.0339815
RIN2 Ras and Rab interactor 2 0.033695
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0333016
SMAD3 SMAD family member 3 0.0327488
NTSR1 neurotensin receptor 1 (high affinity) 0.0325618
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0322061
SIK3 SIK family kinase 3 0.0318792
LMO7 LIM domain 7 0.0314808
RASAL2 RAS protein activator like 2 0.0311653
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0306376
AMOTL1 angiomotin like 1 0.0298869
EGR1 early growth response 1 0.0297707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0294854
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0292903
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0278074
PCDH1 protocadherin 1 0.0275763
LAMA5 laminin, alpha 5 0.0271437
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0269472
CDCP1 CUB domain containing protein 1 0.0266972
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0266618
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0261361
LOC112694756 uncharaterized LOC112694756 0.0260895
SMYD3 SET and MYND domain containing 3 0.025624
ANTXR2 anthrax toxin receptor 2 0.025342
DUSP4 dual specificity phosphatase 4 0.0252772
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0246881
MACF1 microtubule-actin crosslinking factor 1 0.02454
SDCCAG8 serologically defined colon cancer antigen 8 0.023599
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0231052
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0226707
ACTN1 actinin, alpha 1 0.0226541
FN1 fibronectin 1 0.0225731
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0224711
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0223262
HSPA8 heat shock 70kDa protein 8 0.0222721
KDM4C lysine (K)-specific demethylase 4C 0.0220436
IFI44L interferon-induced protein 44-like 0.0216979
AKAP13 A kinase (PRKA) anchor protein 13 0.0207576
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0203215
TGM2 transglutaminase 2 0.0201781
IVNS1ABP influenza virus NS1A binding protein 0.0201089
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0199712
DOCK4 dedicator of cytokinesis 4 0.0197739
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0196516
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0193473
ITGB4 integrin, beta 4 0.018981
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0189779
JAG1 jagged 1 0.0189438
LPAR1 lysophosphatidic acid receptor 1 0.0186732
CD59 CD59 molecule, complement regulatory protein 0.0182951
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0181205
FAM107B family with sequence similarity 107, member B 0.0181061
CSMD2 CUB and Sushi multiple domains 2 0.0177911
PLXNA2 plexin A2 0.0176855
MPRIP myosin phosphatase Rho interacting protein 0.0176134
DIAPH1 diaphanous-related formin 1 0.017605
SULF2 sulfatase 2 0.0172544
NRIP1 nuclear receptor interacting protein 1 0.0169024
TSPAN3 tetraspanin 3 0.0168148
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0167963
MCL1 myeloid cell leukemia 1 0.0167427
PEAK1 pseudopodium-enriched atypical kinase 1 0.0167345
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0164695
OSMR oncostatin M receptor 0.0164417
ZSWIM6 zinc finger, SWIM-type containing 6 0.0161482
SFPQ splicing factor proline/glutamine-rich 0.0159358
BMAL2 basic helix-loop-helix ARNT like 2 0.0158926
DUSP6 dual specificity phosphatase 6 0.0156323
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.01535
ABLIM3 actin binding LIM protein family, member 3 0.0152736
DPYSL2 dihydropyrimidinase-like 2 0.0152631
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0152412
GPR176 G protein-coupled receptor 176 0.0152357
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0150832
SGMS2 sphingomyelin synthase 2 0.015025
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0150247
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0149154
RAI14 retinoic acid induced 14 0.0148417
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0148172
ERRFI1 ERBB receptor feedback inhibitor 1 0.0145847

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160687
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.151527
PTMA prothymosin, alpha -0.135942
CLU clusterin -0.132844
AHNAK AHNAK nucleoprotein -0.124024
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115455
KRT17 keratin 17, type I -0.102412
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.10066
TMSB10 thymosin beta 10 -0.0853631
RPS6 ribosomal protein S6 -0.0847466
GOLGA4 golgin A4 -0.0812116
TRIO trio Rho guanine nucleotide exchange factor -0.0779693
CANX calnexin -0.0778265
MYOF myoferlin -0.0775047
S100A10 S100 calcium binding protein A10 -0.073268
SULF1 sulfatase 1 -0.0724906
GNAS GNAS complex locus -0.0676594
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0652743
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0650597
RPS21 ribosomal protein S21 -0.0617245
NAMPT nicotinamide phosphoribosyltransferase -0.060137
RPLP2 ribosomal protein, large, P2 -0.0600526
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.058904
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0582297
CAV1 caveolin 1, caveolae protein, 22kDa -0.0579738
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0564062
RBM39 RNA binding motif protein 39 -0.0546657
PGK1 phosphoglycerate kinase 1 -0.0520858
KTN1 kinectin 1 (kinesin receptor) -0.0518737
RPL11 ribosomal protein L11 -0.051164
FNDC3A fibronectin type III domain containing 3A -0.0510189
MT2A metallothionein 2A -0.0508063
PALLD palladin, cytoskeletal associated protein -0.0494934
ITGA6 integrin, alpha 6 -0.0490917
DLG1 discs, large homolog 1 (Drosophila) -0.0486854
LMNA lamin A/C -0.0486192
RPLP1 ribosomal protein, large, P1 -0.0483038
KRT6A keratin 6A, type II -0.0479512
CALR calreticulin -0.047492
OGA O-GlcNAcase -0.0472334
RPS8 ribosomal protein S8 -0.047087
H1-0 H1.0 linker histone -0.0469415
GARS1 glycyl-tRNA synthetase 1 -0.0468003
PDIA3 protein disulfide isomerase family A, member 3 -0.0462377
TMSB4X thymosin beta 4, X-linked -0.0461698
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0444193
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0439747
WASF2 WAS protein family, member 2 -0.0432874
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0429274
MORF4L2 mortality factor 4 like 2 -0.0428268
B2M beta-2-microglobulin -0.0426688
RPS19 ribosomal protein S19 -0.0422811
ANLN anillin, actin binding protein -0.0420378
ENO1 enolase 1, (alpha) -0.0418484
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0417638
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0414103
SQLE squalene epoxidase -0.0412912
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0410888
ITCH itchy E3 ubiquitin protein ligase -0.040809
SPAG9 sperm associated antigen 9 -0.0406595
DSTN destrin (actin depolymerizing factor) -0.0403229
RPL12 ribosomal protein L12 -0.0399606
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0394891
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0393748
HDLBP high density lipoprotein binding protein -0.0392077
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0391557
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0390055
RPL8 ribosomal protein L8 -0.0387982
MT1X metallothionein 1X -0.0387946
IGF2 insulin-like growth factor 2 -0.0386946
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.038569
NCOA3 nuclear receptor coactivator 3 -0.037897
KRT14 keratin 14, type I -0.0373936
RPS13 ribosomal protein S13 -0.0369071
S100A6 S100 calcium binding protein A6 -0.0366602
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0358763
S100A9 S100 calcium binding protein A9 -0.0354798
TKT transketolase -0.0353788
NPEPPS aminopeptidase puromycin sensitive -0.0351623
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0351038
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0350918
COPB1 coatomer protein complex, subunit beta 1 -0.0345936
VDAC1 voltage-dependent anion channel 1 -0.0344905
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0339596
TTC3 tetratricopeptide repeat domain 3 -0.0337401
GRB10 growth factor receptor-bound protein 10 -0.0335648
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0335504
SEC31A SEC31 homolog A (S. cerevisiae) -0.0335195
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0332716
GLYAT glycine-N-acyltransferase -0.0331202
FSCN1 fascin actin-bundling protein 1 -0.0331148
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0330733
RPL23 ribosomal protein L23 -0.0327827
PLAT plasminogen activator, tissue -0.0324847
UBE2H ubiquitin-conjugating enzyme E2H -0.0324409
IGFBP6 insulin-like growth factor binding protein 6 -0.0321084
ABI3BP ABI family, member 3 (NESH) binding protein -0.0321046
HM13 histocompatibility (minor) 13 -0.0319264
VCL vinculin -0.031633
RPS14 ribosomal protein S14 -0.0313529