| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0783273 |
| KRT8 | keratin 8, type II | 0.0494969 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0467232 |
| PKM | pyruvate kinase, muscle | 0.0454808 |
| RNF145 | ring finger protein 145 | 0.0448932 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0434691 |
| TNS4 | tensin 4 | 0.0409914 |
| VEGFA | vascular endothelial growth factor A | 0.0409307 |
| FAT1 | FAT atypical cadherin 1 | 0.0407373 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0394945 |
| POTEF | POTE ankyrin domain family, member F | 0.0392705 |
| LDHA | lactate dehydrogenase A | 0.0392333 |
| RPL3 | ribosomal protein L3 | 0.0386144 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0382429 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0372693 |
| NDRG1 | N-myc downstream regulated 1 | 0.0369847 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0357818 |
| TXNIP | thioredoxin interacting protein | 0.0343427 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0333935 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0331733 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0326 |
| ASPH | aspartate beta-hydroxylase | 0.0293753 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.029332 |
| ENO1 | enolase 1, (alpha) | 0.0291472 |
| HMGA1 | high mobility group AT-hook 1 | 0.028561 |
| LMO7 | LIM domain 7 | 0.028269 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0282612 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0279178 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0271719 |
| RPS4X | ribosomal protein S4, X-linked | 0.0265115 |
| RNF43 | ring finger protein 43 | 0.0264096 |
| RPS3 | ribosomal protein S3 | 0.0250666 |
| CCNL1 | cyclin L1 | 0.0249654 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0246599 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.024541 |
| EREG | epiregulin | 0.0243399 |
| GOLGA4 | golgin A4 | 0.0241334 |
| VMP1 | vacuole membrane protein 1 | 0.0240609 |
| NUP58 | nucleoporin 58 | 0.0240607 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0236117 |
| TPM3 | tropomyosin 3 | 0.0230663 |
| MED13L | mediator complex subunit 13-like | 0.0226752 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 0.0225955 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0221788 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0211276 |
| ZFP36 | ZFP36 ring finger protein | 0.0206036 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0202535 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0197296 |
| BRD2 | bromodomain containing 2 | 0.0194009 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0192767 |
| FAM13A | family with sequence similarity 13, member A | 0.0191371 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | 0.018845 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0186893 |
| ETNK1 | ethanolamine kinase 1 | 0.0185517 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0185387 |
| PCBP2 | poly(rC) binding protein 2 | 0.0182944 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0182514 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0181062 |
| COPA | coatomer protein complex, subunit alpha | 0.0180616 |
| AREG | amphiregulin | 0.0178625 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0172336 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.016877 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0165524 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0163718 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0163429 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0161429 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0161367 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0160506 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0159227 |
| RPS7 | ribosomal protein S7 | 0.0159109 |
| KIAA0040 | KIAA0040 | 0.0156961 |
| DUSP4 | dual specificity phosphatase 4 | 0.015601 |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.0155897 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0155869 |
| PNN | pinin, desmosome associated protein | 0.0155095 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0152744 |
| RPL29 | ribosomal protein L29 | 0.0149448 |
| SETD5 | SET domain containing 5 | 0.0149165 |
| USP6NL | USP6 N-terminal like | 0.0147536 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.014735 |
| TPI1 | triosephosphate isomerase 1 | 0.0146463 |
| RPS12 | ribosomal protein S12 | 0.0145818 |
| PLS1 | plastin 1 | 0.0145754 |
| JAG1 | jagged 1 | 0.0143009 |
| CCNC | cyclin C | 0.0141931 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.01412 |
| TXNRD1 | thioredoxin reductase 1 | 0.0139012 |
| TFG | TRK-fused gene | 0.0138527 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.0137955 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.0137769 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0137596 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0137544 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0137509 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0137272 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0136068 |
| TBK1 | TANK-binding kinase 1 | 0.013601 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0135579 |
| CCDC6 | coiled-coil domain containing 6 | 0.013527 |
| RPL21 | ribosomal protein L21 | 0.0135209 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0134424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.225603 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.166793 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.15031 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.129315 |
| PTMA | prothymosin, alpha | -0.115413 |
| AHNAK | AHNAK nucleoprotein | -0.0986994 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0980181 |
| RPS6 | ribosomal protein S6 | -0.0927052 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0919704 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0819073 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0817031 |
| ACTG1 | actin gamma 1 | -0.0764543 |
| RPL34 | ribosomal protein L34 | -0.0678418 |
| RPLP1 | ribosomal protein, large, P1 | -0.0637539 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0620167 |
| RPL35A | ribosomal protein L35a | -0.0619085 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0618704 |
| TMSB10 | thymosin beta 10 | -0.0605613 |
| MYO1E | myosin IE | -0.0571857 |
| PIGR | polymeric immunoglobulin receptor | -0.0564307 |
| FHIT | fragile histidine triad | -0.0540343 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0538218 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0526687 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0523274 |
| ANXA2 | annexin A2 | -0.0510207 |
| S100A6 | S100 calcium binding protein A6 | -0.0508072 |
| RPS8 | ribosomal protein S8 | -0.0502118 |
| AGR2 | anterior gradient 2 | -0.0496434 |
| EPCAM | epithelial cell adhesion molecule | -0.0492808 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0490571 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0489229 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0465154 |
| RPS24 | ribosomal protein S24 | -0.0453039 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0450292 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0449649 |
| FLNB | filamin B, beta | -0.0448978 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0446131 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0437734 |
| IER3 | immediate early response 3 | -0.0423344 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0418881 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0410872 |
| TPM4 | tropomyosin 4 | -0.0409655 |
| VCL | vinculin | -0.0406244 |
| NFIA | nuclear factor I/A | -0.0401713 |
| DIAPH2 | diaphanous-related formin 2 | -0.0399147 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0393541 |
| RPS27A | ribosomal protein S27a | -0.0390447 |
| RAD51B | RAD51 paralog B | -0.0386454 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0383478 |
| RPL7A | ribosomal protein L7a | -0.0381017 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0375783 |
| ONECUT3 | one cut homeobox 3 | -0.0373818 |
| FRMD5 | FERM domain containing 5 | -0.0373724 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0370817 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0369961 |
| RPS29 | ribosomal protein S29 | -0.0366745 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.036462 |
| CANX | calnexin | -0.0361521 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0354908 |
| EHBP1 | EH domain binding protein 1 | -0.0354655 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0353545 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0349507 |
| RRBP1 | ribosome binding protein 1 | -0.0345721 |
| GPHN | gephyrin | -0.0342217 |
| RIN2 | Ras and Rab interactor 2 | -0.0341523 |
| RPL38 | ribosomal protein L38 | -0.0330814 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0328738 |
| TFF1 | trefoil factor 1 | -0.0327164 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0326576 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0325438 |
| CCND1 | cyclin D1 | -0.0319069 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.0315815 |
| RNF217 | ring finger protein 217 | -0.0311722 |
| ABR | active BCR-related | -0.0311321 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.0309589 |
| CUX1 | cut-like homeobox 1 | -0.0308395 |
| SH3D19 | SH3 domain containing 19 | -0.0307087 |
| PALLD | palladin, cytoskeletal associated protein | -0.0306246 |
| MTAP | methylthioadenosine phosphorylase | -0.0304265 |
| SLCO3A1 | solute carrier organic anion transporter family, member 3A1 | -0.0303658 |
| SMYD3 | SET and MYND domain containing 3 | -0.0302961 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0302509 |
| HMGB1 | high mobility group box 1 | -0.0300389 |
| ITGA6 | integrin, alpha 6 | -0.0298691 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0298081 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0297292 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0297125 |
| POF1B | premature ovarian failure, 1B | -0.029643 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0295531 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0295459 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.029437 |
| EZR | ezrin | -0.0292199 |
| RPL8 | ribosomal protein L8 | -0.0291315 |
| RPS21 | ribosomal protein S21 | -0.0289102 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0288477 |
| MECOM | MDS1 and EVI1 complex locus | -0.0285445 |
| RPLP2 | ribosomal protein, large, P2 | -0.0284468 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0283264 |
| RPL13A | ribosomal protein L13a | -0.028299 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0282744 |
