| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Radotinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.131417 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.12157 |
| POTEF | POTE ankyrin domain family, member F | 0.0966791 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0944311 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0802765 |
| ANGPTL4 | angiopoietin-like 4 | 0.0651511 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0629827 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0610903 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0596743 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0548648 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.054535 |
| CAPRIN2 | caprin family member 2 | 0.0542023 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0536741 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0534917 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0521161 |
| PDE10A | phosphodiesterase 10A | 0.0493829 |
| MT2A | metallothionein 2A | 0.0492575 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0484498 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0470537 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0441477 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0435258 |
| PYGL | phosphorylase, glycogen, liver | 0.042143 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.03801 |
| JUN | jun proto-oncogene | 0.037664 |
| TXNIP | thioredoxin interacting protein | 0.0365072 |
| HLA-B | major histocompatibility complex, class I, B | 0.0364255 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0360874 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0351186 |
| NPAS2 | neuronal PAS domain protein 2 | 0.033134 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0329689 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0320511 |
| VMP1 | vacuole membrane protein 1 | 0.0319661 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0319459 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0318482 |
| TP63 | tumor protein p63 | 0.0310086 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0308819 |
| NAV2 | neuron navigator 2 | 0.0302717 |
| PKM | pyruvate kinase, muscle | 0.029788 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.029274 |
| VEGFA | vascular endothelial growth factor A | 0.0285218 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0281724 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0280532 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0279554 |
| NHSL1 | NHS-like 1 | 0.027707 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0275119 |
| RPS6 | ribosomal protein S6 | 0.0272066 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0270309 |
| SLK | STE20-like kinase | 0.0268585 |
| FOSL1 | FOS-like antigen 1 | 0.0268477 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0265568 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0261923 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0261212 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0257859 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0256626 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0256058 |
| EZR | ezrin | 0.0254703 |
| EGR1 | early growth response 1 | 0.0249321 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0249155 |
| JMJD1C | jumonji domain containing 1C | 0.0248336 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0246351 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246154 |
| MEF2A | myocyte enhancer factor 2A | 0.0245868 |
| PCDH1 | protocadherin 1 | 0.0244134 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0242416 |
| NDRG1 | N-myc downstream regulated 1 | 0.0240582 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0239607 |
| FMNL2 | formin-like 2 | 0.0239248 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0233176 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0233037 |
| ENO1 | enolase 1, (alpha) | 0.0229654 |
| B2M | beta-2-microglobulin | 0.0228003 |
| DNER | delta/notch-like EGF repeat containing | 0.0220756 |
| CCNL1 | cyclin L1 | 0.0219638 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.021914 |
| RUNX1 | runt-related transcription factor 1 | 0.0219098 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0215309 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0215216 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0214907 |
| TGM2 | transglutaminase 2 | 0.0214873 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0214053 |
| PRKCE | protein kinase C, epsilon | 0.0209038 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0207728 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0207202 |
| UPP1 | uridine phosphorylase 1 | 0.0206419 |
| EMP1 | epithelial membrane protein 1 | 0.0205503 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0201785 |
| RPLP2 | ribosomal protein, large, P2 | 0.02012 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0201088 |
| HLA-A | major histocompatibility complex, class I, A | 0.0200444 |
| RPS3 | ribosomal protein S3 | 0.0199556 |
| SPAG9 | sperm associated antigen 9 | 0.0197767 |
| SIK3 | SIK family kinase 3 | 0.0196664 |
| RAB7A | RAB7A, member RAS oncogene family | 0.019397 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.019315 |
| OFD1 | oral-facial-digital syndrome 1 | 0.0190181 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0190155 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0188806 |
| PODXL | podocalyxin-like | 0.0187646 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0185354 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0183616 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.103375 |
| AHNAK | AHNAK nucleoprotein | -0.0740669 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0634878 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0610711 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0546523 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0532856 |
| TMSB4X | thymosin beta 4, X-linked | -0.0448895 |
| CD44 | CD44 molecule (Indian blood group) | -0.0423378 |
| TOP1 | topoisomerase (DNA) I | -0.0421524 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0420917 |
| TMSB10 | thymosin beta 10 | -0.0419093 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0404524 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0376587 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0369558 |
| CENPF | centromere protein F, 350/400kDa | -0.0355037 |
| VCL | vinculin | -0.034977 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0344422 |
| PTMA | prothymosin, alpha | -0.0329812 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0319954 |
| ACTG1 | actin gamma 1 | -0.0318253 |
| SMAD3 | SMAD family member 3 | -0.031696 |
| ANXA2 | annexin A2 | -0.0312471 |
| RASAL2 | RAS protein activator like 2 | -0.0297039 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0296532 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.029371 |
| CANX | calnexin | -0.0293155 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0285995 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0284158 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0264548 |
| DOCK11 | dedicator of cytokinesis 11 | -0.025869 |
| SMYD3 | SET and MYND domain containing 3 | -0.0256625 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0254898 |
| EHBP1 | EH domain binding protein 1 | -0.0253768 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0253051 |
| ANKRD50 | ankyrin repeat domain 50 | -0.0246904 |
| OGA | O-GlcNAcase | -0.0245961 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0243937 |
| STK17A | serine/threonine kinase 17a | -0.0237482 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0234915 |
| VIM | vimentin | -0.0229779 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0228152 |
| ECT2 | epithelial cell transforming 2 | -0.0226391 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0226311 |
| EPHA4 | EPH receptor A4 | -0.0224949 |
| HDLBP | high density lipoprotein binding protein | -0.0215487 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0214569 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.021353 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0213025 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0211799 |
| PRELID2 | PRELI domain containing 2 | -0.0211746 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0207612 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0206398 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0201451 |
| MB21D2 | Mab-21 domain containing 2 | -0.0197002 |
| ZNF217 | zinc finger protein 217 | -0.0195391 |
| RACK1 | receptor for activated C kinase 1 | -0.0195209 |
| SLC38A2 | solute carrier family 38, member 2 | -0.019501 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0190891 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0190802 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0188134 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0187852 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0185543 |
| MKI67 | marker of proliferation Ki-67 | -0.018549 |
| PLK2 | polo-like kinase 2 | -0.0184094 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0182286 |
| DIAPH3 | diaphanous-related formin 3 | -0.0182219 |
| FNIP1 | folliculin interacting protein 1 | -0.0181517 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0181006 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0179022 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0174237 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0173979 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0173237 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0171596 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0171314 |
| PRMT2 | protein arginine methyltransferase 2 | -0.0169879 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0169796 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0168979 |
| GOLGA4 | golgin A4 | -0.016816 |
| HPCAL1 | hippocalcin-like 1 | -0.0167458 |
| EFNA5 | ephrin-A5 | -0.0167362 |
| RAD51B | RAD51 paralog B | -0.0167119 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0166029 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0165693 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.0165317 |
| RPS24 | ribosomal protein S24 | -0.0165079 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0164977 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0164325 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0162766 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0162526 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0161124 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.015883 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0157315 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0150779 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | -0.0150422 |
| ANLN | anillin, actin binding protein | -0.0149324 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0149139 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0148502 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0147977 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0146681 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0146621 |
