| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0745927 |
| EGR1 | early growth response 1 | 0.0711106 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0669632 |
| STC1 | stanniocalcin 1 | 0.0656413 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0614673 |
| PKM | pyruvate kinase, muscle | 0.0565787 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0497827 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0457481 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0440444 |
| POTEF | POTE ankyrin domain family, member F | 0.0408745 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0384248 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0375408 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0354606 |
| RPS4X | ribosomal protein S4, X-linked | 0.0317585 |
| MCL1 | myeloid cell leukemia 1 | 0.0309456 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0303265 |
| EFNA5 | ephrin-A5 | 0.0294918 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0275104 |
| RPS3 | ribosomal protein S3 | 0.024499 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0238386 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.023552 |
| AREG | amphiregulin | 0.0225306 |
| FRY | furry homolog (Drosophila) | 0.0223833 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0223673 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0216838 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0215781 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0212355 |
| HSPA8 | heat shock 70kDa protein 8 | 0.019603 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0188438 |
| RPL3 | ribosomal protein L3 | 0.0184995 |
| TMEM45B | transmembrane protein 45B | 0.0179216 |
| MSN | moesin | 0.0177869 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0176515 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.017423 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0172893 |
| SQOR | sulfide quinone oxidoreductase | 0.0169512 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0168577 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0166292 |
| ENO1 | enolase 1, (alpha) | 0.0163953 |
| RNF213 | ring finger protein 213 | 0.0163506 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0161192 |
| VEGFA | vascular endothelial growth factor A | 0.0151619 |
| HMGA1 | high mobility group AT-hook 1 | 0.0150366 |
| EP400 | E1A binding protein p400 | 0.0146741 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.0144406 |
| C1D | C1D nuclear receptor corepressor | 0.0143324 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0143003 |
| IFI44L | interferon-induced protein 44-like | 0.0142974 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0141305 |
| PER2 | period circadian clock 2 | 0.0140824 |
| SF3A1 | splicing factor 3a, subunit 1, 120kDa | 0.0138265 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0138048 |
| CD47 | CD47 molecule | 0.0137162 |
| DIAPH1 | diaphanous-related formin 1 | 0.0136739 |
| MT2A | metallothionein 2A | 0.0134175 |
| CST3 | cystatin C | 0.0132324 |
| HLA-A | major histocompatibility complex, class I, A | 0.013221 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0131395 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0126575 |
| ATP11A | ATPase, class VI, type 11A | 0.0126115 |
| FBRS | fibrosin | 0.0124888 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0122435 |
| ADAM28 | ADAM metallopeptidase domain 28 | 0.0122408 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0122229 |
| SMAD3 | SMAD family member 3 | 0.0122212 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0122004 |
| ITGB4 | integrin, beta 4 | 0.0120503 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0120461 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.011968 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0119629 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0119333 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.0118913 |
| TPCN1 | two pore segment channel 1 | 0.0118512 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.0117763 |
| VIM | vimentin | 0.0117311 |
| DHFR | dihydrofolate reductase | 0.0117166 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0116725 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0115387 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0114206 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0113874 |
| TXNIP | thioredoxin interacting protein | 0.0113479 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0111884 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | 0.0111642 |
| SLK | STE20-like kinase | 0.0111624 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0111545 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0111294 |
| GSAP | gamma-secretase activating protein | 0.011018 |
| SCFD2 | sec1 family domain containing 2 | 0.0109851 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0108883 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0107662 |
| CAV2 | caveolin 2 | 0.0106529 |
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.0106484 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0106438 |
| FAM13A | family with sequence similarity 13, member A | 0.0106342 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0105573 |
| CES1 | carboxylesterase 1 | 0.0104409 |
| TPM3 | tropomyosin 3 | 0.0103996 |
| RNF149 | ring finger protein 149 | 0.0102828 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0102646 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0102395 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.226714 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.198398 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.125942 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.124641 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.111032 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.106919 |
| ASPH | aspartate beta-hydroxylase | -0.104901 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0993917 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0986235 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0933683 |
| MYOF | myoferlin | -0.0849402 |
| SPAG9 | sperm associated antigen 9 | -0.0839106 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0742394 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0686494 |
| AHNAK | AHNAK nucleoprotein | -0.068183 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.066757 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0661849 |
| MKI67 | marker of proliferation Ki-67 | -0.0656772 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0654777 |
| VCL | vinculin | -0.0650656 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0625132 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0624799 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0611557 |
| OSMR | oncostatin M receptor | -0.0581069 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0579486 |
| NABP1 | nucleic acid binding protein 1 | -0.0573185 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0571649 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0561501 |
| H1-0 | H1.0 linker histone | -0.0552951 |
| RBM39 | RNA binding motif protein 39 | -0.0540504 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0540234 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0527576 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0503147 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0499393 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0496429 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0491358 |
| UBC | ubiquitin C | -0.0482657 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0482141 |
| TOP1 | topoisomerase (DNA) I | -0.0477354 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0477011 |
| ANXA2 | annexin A2 | -0.046963 |
| USP34 | ubiquitin specific peptidase 34 | -0.0467131 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0465004 |
| JMJD1C | jumonji domain containing 1C | -0.0461027 |
| CANX | calnexin | -0.0452506 |
| TES | testin LIM domain protein | -0.0425993 |
| PGK1 | phosphoglycerate kinase 1 | -0.0425691 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0425685 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0416431 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0414988 |
| MAP7 | microtubule-associated protein 7 | -0.0410796 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0402619 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0402619 |
| FBXO11 | F-box protein 11 | -0.0395457 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0393714 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0389083 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0387584 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0382689 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0374955 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0366493 |
| GPHN | gephyrin | -0.0360549 |
| CUX1 | cut-like homeobox 1 | -0.0360217 |
| NF1 | neurofibromin 1 | -0.0358994 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0356226 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0351447 |
| BBX | bobby sox homolog (Drosophila) | -0.0348315 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0331031 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0329409 |
| ACTG1 | actin gamma 1 | -0.0327671 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.03231 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0320235 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0317421 |
| USP53 | ubiquitin specific peptidase 53 | -0.0317092 |
| PUM2 | pumilio RNA-binding family member 2 | -0.031551 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0314363 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0310528 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0308458 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0307249 |
| RPS25 | ribosomal protein S25 | -0.0307103 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0302324 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0302211 |
| GPC6 | glypican 6 | -0.0300446 |
| NBEAL1 | neurobeachin-like 1 | -0.0298933 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0297846 |
| MYO1E | myosin IE | -0.0297319 |
| HDLBP | high density lipoprotein binding protein | -0.0294439 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0293229 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0292168 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0291707 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0291655 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0291488 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0291207 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0287615 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0285952 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0285694 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0285331 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.028428 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0283037 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0282748 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0280676 |
