| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Radotinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.0996654 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0825769 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0811868 |
| NDRG1 | N-myc downstream regulated 1 | 0.0724324 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0692112 |
| VEGFA | vascular endothelial growth factor A | 0.068913 |
| PCBP2 | poly(rC) binding protein 2 | 0.0673967 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0671594 |
| NAV2 | neuron navigator 2 | 0.0664033 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0639316 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0617054 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0604842 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0584757 |
| PKM | pyruvate kinase, muscle | 0.0575905 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0516504 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.050202 |
| EFNA5 | ephrin-A5 | 0.0497548 |
| SMAD3 | SMAD family member 3 | 0.0484456 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0483373 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0463223 |
| EGFR | epidermal growth factor receptor | 0.0439135 |
| TGM2 | transglutaminase 2 | 0.0432824 |
| LOX | lysyl oxidase | 0.0430365 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0424963 |
| RUNX1 | runt-related transcription factor 1 | 0.0413075 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0410824 |
| LOXL2 | lysyl oxidase-like 2 | 0.0402965 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.039736 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0397012 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0390497 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.038227 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0372813 |
| EGR1 | early growth response 1 | 0.0370071 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0366774 |
| DTNA | dystrobrevin, alpha | 0.0353143 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0349979 |
| TGFB1 | transforming growth factor, beta 1 | 0.0347676 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0343345 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0341875 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0336047 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0333015 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0332974 |
| RPL3 | ribosomal protein L3 | 0.0329703 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.031262 |
| POTEF | POTE ankyrin domain family, member F | 0.0309351 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0307787 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0304399 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0299113 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0296646 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0294986 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0276888 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0269459 |
| NOTCH2 | notch 2 | 0.0269284 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0265173 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0264466 |
| BRD2 | bromodomain containing 2 | 0.0263326 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0260551 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0259418 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0257339 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0253056 |
| CA12 | carbonic anhydrase XII | 0.0251652 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.025165 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0251595 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0249613 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0249322 |
| AADAC | arylacetamide deacetylase | 0.0249105 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0247271 |
| ZNF638 | zinc finger protein 638 | 0.0245793 |
| ATXN1 | ataxin 1 | 0.0245302 |
| SEPTIN9 | septin 9 | 0.0240356 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.023676 |
| MYO10 | myosin X | 0.023221 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0228788 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0227983 |
| WLS | wntless Wnt ligand secretion mediator | 0.0226684 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0226116 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0224526 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0222091 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0221336 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0218987 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0218405 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0217465 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0216836 |
| FN1 | fibronectin 1 | 0.0216291 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0215139 |
| FAM107B | family with sequence similarity 107, member B | 0.021478 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0213854 |
| MMP2 | matrix metallopeptidase 2 | 0.0208457 |
| INTS6 | integrator complex subunit 6 | 0.0208233 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0208207 |
| PLIN2 | perilipin 2 | 0.0206785 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0206159 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0205975 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0203161 |
| CD44 | CD44 molecule (Indian blood group) | 0.0200484 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0199817 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0199776 |
| JUN | jun proto-oncogene | 0.0198975 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0198282 |
| SIK3 | SIK family kinase 3 | 0.0197246 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.250905 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.213207 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.183348 |
| TMSB10 | thymosin beta 10 | -0.144265 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.109313 |
| PTMA | prothymosin, alpha | -0.0835059 |
| RBM39 | RNA binding motif protein 39 | -0.0797232 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0783075 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0645434 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0628103 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0599554 |
| FTL | ferritin, light polypeptide | -0.0574309 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0570026 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.055058 |
| GOLGA4 | golgin A4 | -0.0549036 |
| IER3 | immediate early response 3 | -0.0541531 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0529487 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0528837 |
| CANX | calnexin | -0.0524538 |
| OGA | O-GlcNAcase | -0.0516814 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0510422 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0509871 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0492466 |
| OSMR | oncostatin M receptor | -0.0482701 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.047836 |
| PRELID2 | PRELI domain containing 2 | -0.0468199 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0467632 |
| USP34 | ubiquitin specific peptidase 34 | -0.046594 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0438149 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0411344 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0410194 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0399343 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0398408 |
| S100A6 | S100 calcium binding protein A6 | -0.0394109 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0393413 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0390905 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.038879 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0387354 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0384435 |
| RPS24 | ribosomal protein S24 | -0.0382505 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0381562 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0377547 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0372989 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0369222 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0367505 |
| GLCCI1 | glucocorticoid induced 1 | -0.036386 |
| SEPTIN2 | septin 2 | -0.0363843 |
| MECOM | MDS1 and EVI1 complex locus | -0.0363757 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0362089 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0361464 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0361128 |
| NRP1 | neuropilin 1 | -0.0360186 |
| RPS21 | ribosomal protein S21 | -0.0358346 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0355707 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0355164 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0355024 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0354872 |
| GPC6 | glypican 6 | -0.035363 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0351751 |
| CDCP1 | CUB domain containing protein 1 | -0.0351042 |
| H1-0 | H1.0 linker histone | -0.0346498 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0345788 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.03445 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0342918 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0340702 |
| ETV6 | ets variant 6 | -0.033968 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.0331876 |
| RPL32 | ribosomal protein L32 | -0.0331549 |
| HDLBP | high density lipoprotein binding protein | -0.0329047 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0326758 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0325808 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0325443 |
| PGK1 | phosphoglycerate kinase 1 | -0.0324098 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0322312 |
| NF1 | neurofibromin 1 | -0.0321168 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0320076 |
| CFDP1 | craniofacial development protein 1 | -0.0319493 |
| VIM | vimentin | -0.0317144 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.031305 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.031109 |
| SBF2 | SET binding factor 2 | -0.0310121 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0307832 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0303427 |
| TMEM263 | transmembrane protein 263 | -0.0302641 |
| PRRC2C | proline-rich coiled-coil 2C | -0.029842 |
| TXNRD1 | thioredoxin reductase 1 | -0.0297767 |
| KYNU | kynureninase | -0.0296975 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.029069 |
| NKTR | natural killer cell triggering receptor | -0.0289181 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0287303 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0285906 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0285425 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0280597 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.028042 |
| RPLP0 | ribosomal protein, large, P0 | -0.0279503 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0279208 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0278428 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0276682 |
| ANKRD17 | ankyrin repeat domain 17 | -0.027511 |
| RPS11 | ribosomal protein S11 | -0.0273101 |
