Radotinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.105967
GRAMD1B GRAM domain containing 1B 0.0965833
PDE4D phosphodiesterase 4D, cAMP-specific 0.0932191
IGFBP3 insulin-like growth factor binding protein 3 0.0930792
FTH1 ferritin, heavy polypeptide 1 0.0776829
MCL1 myeloid cell leukemia 1 0.075578
DOCK4 dedicator of cytokinesis 4 0.0658706
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.06326
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0605482
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0593037
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0531859
THSD4 thrombospondin, type I, domain containing 4 0.0521249
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0516837
CXCL8 chemokine (C-X-C motif) ligand 8 0.0487587
FNDC3B fibronectin type III domain containing 3B 0.0415308
SAMD4A sterile alpha motif domain containing 4A 0.0401502
PYGL phosphorylase, glycogen, liver 0.0373763
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0346331
TM4SF1 transmembrane 4 L six family member 1 0.0340372
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0336027
HSPA8 heat shock 70kDa protein 8 0.0325069
POTEF POTE ankyrin domain family, member F 0.0320778
LAMC2 laminin, gamma 2 0.032012
ARHGAP26 Rho GTPase activating protein 26 0.0310474
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0297978
EGFR epidermal growth factor receptor 0.0296121
SOD2 superoxide dismutase 2, mitochondrial 0.0293422
EGR1 early growth response 1 0.0288427
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0275697
ELL2 elongation factor, RNA polymerase II, 2 0.0271888
ERRFI1 ERBB receptor feedback inhibitor 1 0.0269698
BRD2 bromodomain containing 2 0.0268793
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0264692
FMNL2 formin-like 2 0.0260153
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0256185
ATXN1 ataxin 1 0.0254958
MACF1 microtubule-actin crosslinking factor 1 0.0254612
IL6 interleukin 6 0.0252434
NAV3 neuron navigator 3 0.0249963
SMOC1 SPARC related modular calcium binding 1 0.024935
COPA coatomer protein complex, subunit alpha 0.0246387
FLNB filamin B, beta 0.0245853
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0241416
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.023971
PTPRM protein tyrosine phosphatase, receptor type, M 0.0235853
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0235059
DOCK5 dedicator of cytokinesis 5 0.0233692
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0223567
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222841
USP34 ubiquitin specific peptidase 34 0.0222702
CMIP c-Maf inducing protein 0.0216935
NUMB numb homolog (Drosophila) 0.0216386
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0216057
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0211782
ANGPTL4 angiopoietin-like 4 0.0209452
FAM107B family with sequence similarity 107, member B 0.0207295
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0207052
RICTOR RPTOR independent companion of MTOR, complex 2 0.0206458
MT2A metallothionein 2A 0.0204261
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0203794
MAML3 mastermind-like 3 (Drosophila) 0.0200772
ZEB1 zinc finger E-box binding homeobox 1 0.0200206
PKM pyruvate kinase, muscle 0.0189866
BTBD9 BTB (POZ) domain containing 9 0.0189093
MSN moesin 0.0183053
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0183007
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.018161
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0181435
ZSWIM6 zinc finger, SWIM-type containing 6 0.0178376
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0174477
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0173719
SFPQ splicing factor proline/glutamine-rich 0.0173377
GLIS3 GLIS family zinc finger 3 0.0170414
NF1 neurofibromin 1 0.0167903
PTPRJ protein tyrosine phosphatase, receptor type, J 0.01675
SEC31A SEC31 homolog A (S. cerevisiae) 0.016519
LDHA lactate dehydrogenase A 0.016169
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0161412
GOLGB1 golgin B1 0.0160724
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0159809
ARF4 ADP-ribosylation factor 4 0.0158318
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0156055
SNX14 sorting nexin 14 0.0155945
WAC WW domain containing adaptor with coiled-coil 0.0155847
MORF4L2 mortality factor 4 like 2 0.0154884
INHBA inhibin, beta A 0.0153242
CDCP1 CUB domain containing protein 1 0.0153192
NDRG1 N-myc downstream regulated 1 0.0150992
EPAS1 endothelial PAS domain protein 1 0.0150262
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.014925
GOLGA4 golgin A4 0.0149161
HLA-B major histocompatibility complex, class I, B 0.0148113
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0147267
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0147241
RPL3 ribosomal protein L3 0.0145444
ATP11A ATPase, class VI, type 11A 0.0144949
MED13 mediator complex subunit 13 0.0144843
SH3KBP1 SH3-domain kinase binding protein 1 0.0144533
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.014327
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0143059

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.111843
TMSB10 thymosin beta 10 -0.0935319
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0598423
FTL ferritin, light polypeptide -0.0548136
TXNRD1 thioredoxin reductase 1 -0.0492357
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0452795
PTMA prothymosin, alpha -0.0430765
RPL19 ribosomal protein L19 -0.0396144
VIM vimentin -0.0389786
PM20D1 peptidase M20 domain containing 1 -0.0379182
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0367652
RPL23 ribosomal protein L23 -0.0366126
WDR43 WD repeat domain 43 -0.0345786
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0342499
FGB fibrinogen beta chain -0.0331919
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0328765
RPS21 ribosomal protein S21 -0.0315991
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0311244
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0285103
SLC38A2 solute carrier family 38, member 2 -0.0260843
USP3 ubiquitin specific peptidase 3 -0.0250466
RTN4 reticulon 4 -0.0238166
TFPI2 tissue factor pathway inhibitor 2 -0.0232955
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0232341
NEGR1 neuronal growth regulator 1 -0.0227895
RAD21 RAD21 homolog (S. pombe) -0.0226928
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0221907
NTN4 netrin 4 -0.0217575
RPS19 ribosomal protein S19 -0.0213333
RPLP1 ribosomal protein, large, P1 -0.0209638
CAVIN1 caveolae associated protein 1 -0.0208784
S100A6 S100 calcium binding protein A6 -0.0206672
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0206567
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0204331
TMEM123 transmembrane protein 123 -0.0204212
MBNL1 muscleblind-like splicing regulator 1 -0.0203412
ANXA2 annexin A2 -0.0202877
PAWR PRKC, apoptosis, WT1, regulator -0.0202276
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0201025
SRGN serglycin -0.0199357
RPL8 ribosomal protein L8 -0.0197395
CHN1 chimerin 1 -0.0195241
CYRIB CYFIP related Rac1 interactor B -0.019223
ATP5F1B ATP synthase F1 subunit beta -0.0191361
MYL12B myosin, light chain 12B, regulatory -0.0187415
RHEB Ras homolog enriched in brain -0.0187173
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0182797
ECT2 epithelial cell transforming 2 -0.0181712
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -0.0181512
RPS27A ribosomal protein S27a -0.0178645
LMNA lamin A/C -0.0178011
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0178003
BICC1 BicC family RNA binding protein 1 -0.0177739
RPL36 ribosomal protein L36 -0.0176889
YBX3 Y box binding protein 3 -0.0176793
TUBB tubulin, beta class I -0.0174559
IST1 increased sodium tolerance 1 homolog (yeast) -0.0174219
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0172207
HDAC9 histone deacetylase 9 -0.0171559
RPLP0 ribosomal protein, large, P0 -0.0171405
ACACA acetyl-CoA carboxylase alpha -0.0171047
GARS1 glycyl-tRNA synthetase 1 -0.0169004
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0168116
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0166702
RPS24 ribosomal protein S24 -0.0166347
PFN1 profilin 1 -0.0164868
RPL5 ribosomal protein L5 -0.0162373
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0161869
RPL32 ribosomal protein L32 -0.0161743
RPL35A ribosomal protein L35a -0.0160531
HMGA1 high mobility group AT-hook 1 -0.0160153
RPS29 ribosomal protein S29 -0.0157289
RPL11 ribosomal protein L11 -0.0155405
ADGRG6 adhesion G protein-coupled receptor G6 -0.0154991
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -0.0154563
RPL37A ribosomal protein L37a -0.0154383
RPS25 ribosomal protein S25 -0.0153293
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.015174
ANLN anillin, actin binding protein -0.0151619
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0150397
RPL34 ribosomal protein L34 -0.0149963
RSL1D1 ribosomal L1 domain containing 1 -0.0149742
NOP58 NOP58 ribonucleoprotein -0.0148342
TPD52 tumor protein D52 -0.0147785
FGG fibrinogen gamma chain -0.0146166
ANKRD28 ankyrin repeat domain 28 -0.0145705
RPL31 ribosomal protein L31 -0.0145116
RPS23 ribosomal protein S23 -0.0143919
ERBIN erbb2 interacting protein -0.0143871
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0143012
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0142306
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0142024
THBS1 thrombospondin 1 -0.0140929
JAK1 Janus kinase 1 -0.0140903
ENAH enabled homolog (Drosophila) -0.0140736
TFG TRK-fused gene -0.0140531
RHOA ras homolog family member A -0.0139875
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0139312
RPS5 ribosomal protein S5 -0.0138875
VCL vinculin -0.013722