Radotinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RIGI RNA sensor RIG-I 0.10225
RSAD2 radical S-adenosyl methionine domain containing 2 0.0652088
KYNU kynureninase 0.0618231
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0575515
TRIO trio Rho guanine nucleotide exchange factor 0.0449309
EXT1 exostosin glycosyltransferase 1 0.0439011
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0421293
PTMA prothymosin, alpha 0.0418648
SLC38A2 solute carrier family 38, member 2 0.041402
NALF1 NALCN channel auxiliary factor 1 0.0410048
AKAP12 A kinase (PRKA) anchor protein 12 0.0406829
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0403669
MYH9 myosin, heavy chain 9, non-muscle 0.0388578
RHOBTB3 Rho-related BTB domain containing 3 0.0387736
MED13L mediator complex subunit 13-like 0.0381997
ANXA1 annexin A1 0.0377374
PTK2 protein tyrosine kinase 2 0.0377147
OASL 2'-5'-oligoadenylate synthetase-like 0.0376513
EGFR epidermal growth factor receptor 0.0373211
EIF4A2 eukaryotic translation initiation factor 4A2 0.0372337
VCL vinculin 0.0362329
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0359951
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.035855
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0357473
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0353869
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0352894
ADGRB3 adhesion G protein-coupled receptor B3 0.0350832
RNF149 ring finger protein 149 0.03468
ATP11A ATPase, class VI, type 11A 0.0345896
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0344338
RPS3 ribosomal protein S3 0.0341574
GPHN gephyrin 0.0338866
FUS FUS RNA binding protein 0.0337868
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0335811
MYO10 myosin X 0.03352
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0334915
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0334753
PDE10A phosphodiesterase 10A 0.0334087
CSDE1 cold shock domain containing E1, RNA-binding 0.0333382
SEPTIN9 septin 9 0.0331388
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0329214
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0326765
FGF12 fibroblast growth factor 12 0.0326694
AEBP2 AE binding protein 2 0.032366
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0322327
CLTC clathrin, heavy chain (Hc) 0.0321554
ANO6 anoctamin 6 0.0315636
PRRC2C proline-rich coiled-coil 2C 0.031316
ZNFX1 zinc finger, NFX1-type containing 1 0.0308435
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0307426
PRKG1 protein kinase, cGMP-dependent, type I 0.0305984
WARS1 tryptophanyl-tRNA synthetase 1 0.0303471
PDE4B phosphodiesterase 4B, cAMP-specific 0.0302987
AHI1 Abelson helper integration site 1 0.030241
RPL26 ribosomal protein L26 0.0299386
FAT1 FAT atypical cadherin 1 0.0298834
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0298335
EHBP1 EH domain binding protein 1 0.0297017
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0295211
SPIDR scaffolding protein involved in DNA repair 0.0293021
RICTOR RPTOR independent companion of MTOR, complex 2 0.0290222
ADAR adenosine deaminase, RNA-specific 0.0289909
TXNRD1 thioredoxin reductase 1 0.0287035
RRBP1 ribosome binding protein 1 0.0286944
APP amyloid beta (A4) precursor protein 0.0286122
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0284359
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.028388
EFNA5 ephrin-A5 0.0282624
FRMD5 FERM domain containing 5 0.028021
ANKHD1 ankyrin repeat and KH domain containing 1 0.0278578
PLAUR plasminogen activator, urokinase receptor 0.027718
ARHGAP26 Rho GTPase activating protein 26 0.0276425
TSC22D1 TSC22 domain family, member 1 0.0276316
SMYD3 SET and MYND domain containing 3 0.0276054
DTNA dystrobrevin, alpha 0.0271929
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.027133
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0270293
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0268047
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0264003
ATP13A3 ATPase type 13A3 0.0263012
ASPH aspartate beta-hydroxylase 0.0262335
CAVIN1 caveolae associated protein 1 0.026138
TUT4 terminal uridylyl transferase 4 0.025964
RPS12 ribosomal protein S12 0.0259023
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0258792
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0258083
KMT2E lysine (K)-specific methyltransferase 2E 0.0257447
MCTP1 multiple C2 domains, transmembrane 1 0.0256571
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0254722
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0253349
MATR3 matrin 3 0.0252462
ANKRD28 ankyrin repeat domain 28 0.0252046
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0251765
NAV1 neuron navigator 1 0.0250353
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.025028
ZBTB20 zinc finger and BTB domain containing 20 0.0249208
SRRM2 serine/arginine repetitive matrix 2 0.0247831
COL6A3 collagen, type VI, alpha 3 0.0247428
ISG15 ISG15 ubiquitin-like modifier 0.0245482
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0245242

decreased expression

Symbol Name Standardized Value
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.136586
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.132921
BACE2 beta-site APP-cleaving enzyme 2 -0.122423
ATOSA atos homolog A -0.119342
KRT17 keratin 17, type I -0.111808
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.110755
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0919375
CEMIP cell migration inducing protein, hyaluronan binding -0.0814553
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0800898
SAMD4A sterile alpha motif domain containing 4A -0.0760951
FN1 fibronectin 1 -0.0755065
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0742987
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0741709
NDRG1 N-myc downstream regulated 1 -0.0721398
ANXA2 annexin A2 -0.0674545
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0657036
ACTG1 actin gamma 1 -0.0646074
FTH1 ferritin, heavy polypeptide 1 -0.0645815
S100A9 S100 calcium binding protein A9 -0.0628739
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0603166
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0581593
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0566363
IGF2 insulin-like growth factor 2 -0.0564077
STC1 stanniocalcin 1 -0.0561063
MRPS6 mitochondrial ribosomal protein S6 -0.0558287
EZR ezrin -0.0540454
CDK13 cyclin-dependent kinase 13 -0.0537493
TM4SF1 transmembrane 4 L six family member 1 -0.0535836
ESYT2 extended synaptotagmin-like protein 2 -0.0530349
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0522701
MUC16 mucin 16, cell surface associated -0.0512538
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0500309
LAMC2 laminin, gamma 2 -0.0497991
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.049036
ANTXR2 anthrax toxin receptor 2 -0.0481774
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0473022
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0463497
MXD1 MAX dimerization protein 1 -0.046276
TMSB10 thymosin beta 10 -0.0460906
FNIP1 folliculin interacting protein 1 -0.0442312
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0436002
MCL1 myeloid cell leukemia 1 -0.0433599
CMIP c-Maf inducing protein -0.0429919
CDH13 cadherin 13 -0.0427981
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0425611
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0423371
RB1CC1 RB1-inducible coiled-coil 1 -0.0420871
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0416247
AKAP13 A kinase (PRKA) anchor protein 13 -0.0415484
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0408368
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0405387
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0404471
SVIL supervillin -0.040118
USP34 ubiquitin specific peptidase 34 -0.0401122
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0383234
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0383233
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0381492
USP53 ubiquitin specific peptidase 53 -0.0375269
PARD6B par-6 family cell polarity regulator beta -0.0374939
TMEM165 transmembrane protein 165 -0.0374357
KDM7A lysine (K)-specific demethylase 7A -0.0372886
KLHL24 kelch-like family member 24 -0.0371482
UBC ubiquitin C -0.0369572
EIF1 eukaryotic translation initiation factor 1 -0.0359453
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0355267
S100A11 S100 calcium binding protein A11 -0.0355006
MYO1E myosin IE -0.0354925
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0354516
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.0351655
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0349404
UBE2H ubiquitin-conjugating enzyme E2H -0.0348984
PSD3 pleckstrin and Sec7 domain containing 3 -0.0343792
KDM2A lysine (K)-specific demethylase 2A -0.0341961
PTPRM protein tyrosine phosphatase, receptor type, M -0.0341038
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0336855
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0331434
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0329634
BTG1 B-cell translocation gene 1, anti-proliferative -0.0329461
ZNF217 zinc finger protein 217 -0.0329258
PRDM1 PR domain containing 1, with ZNF domain -0.0328374
DENND2C DENN/MADD domain containing 2C -0.0328206
NT5C2 5'-nucleotidase, cytosolic II -0.0327327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0326497
SLMAP sarcolemma associated protein -0.0325908
MARCHF3 membrane associated ring-CH-type finger 3 -0.0325728
IGFBP3 insulin-like growth factor binding protein 3 -0.0325038
SOS2 son of sevenless homolog 2 (Drosophila) -0.0324629
IGSF1 immunoglobulin superfamily, member 1 -0.0317462
PATJ PATJ crumbs cell polarity complex component -0.0311506
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0311402
FNDC3B fibronectin type III domain containing 3B -0.0310353
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0309434
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0309262
FLNB filamin B, beta -0.0308558
RAB1A RAB1A, member RAS oncogene family -0.0303716
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.030307
JUP junction plakoglobin -0.0301767
KRT19 keratin 19, type I -0.0300161
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0299553
DYNLRB1 dynein, light chain, roadblock-type 1 -0.029856