| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.347723 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0845636 |
| RPS4X | ribosomal protein S4, X-linked | 0.0731591 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0647233 |
| EGR1 | early growth response 1 | 0.0539972 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0520609 |
| RPS3 | ribosomal protein S3 | 0.0488983 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0482644 |
| OSMR | oncostatin M receptor | 0.0404537 |
| POTEF | POTE ankyrin domain family, member F | 0.0390976 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.038309 |
| EGFR | epidermal growth factor receptor | 0.0376261 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0373629 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0344425 |
| PDE10A | phosphodiesterase 10A | 0.0315174 |
| FMNL2 | formin-like 2 | 0.0312957 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0304682 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0293862 |
| RNF213 | ring finger protein 213 | 0.0290291 |
| SMAD3 | SMAD family member 3 | 0.028559 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0281094 |
| VMP1 | vacuole membrane protein 1 | 0.0276601 |
| ATP11A | ATPase, class VI, type 11A | 0.0274932 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0273059 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0272678 |
| ATP13A3 | ATPase type 13A3 | 0.0271621 |
| VCL | vinculin | 0.0242873 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0240453 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.023797 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0236825 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0233228 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0232244 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0231359 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0231226 |
| LOXL2 | lysyl oxidase-like 2 | 0.0224384 |
| HMGA2 | high mobility group AT-hook 2 | 0.0223794 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0222852 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.022121 |
| RPL3 | ribosomal protein L3 | 0.0218605 |
| NABP1 | nucleic acid binding protein 1 | 0.0218041 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0217773 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0215404 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0215119 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0206316 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0203546 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0201636 |
| RPS7 | ribosomal protein S7 | 0.0199636 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0199112 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.019313 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0192622 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0191508 |
| MCL1 | myeloid cell leukemia 1 | 0.0188873 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.018867 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0188503 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0187251 |
| PKM | pyruvate kinase, muscle | 0.0187249 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0186235 |
| TCIM | transcriptional and immune response regulator | 0.0180483 |
| ACTN1 | actinin, alpha 1 | 0.0180295 |
| HDAC4 | histone deacetylase 4 | 0.0179623 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0174294 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0173734 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0172979 |
| KLF6 | Kruppel-like factor 6 | 0.0170875 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0168136 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0167377 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0164299 |
| RBM19 | RNA binding motif protein 19 | 0.0163832 |
| CCNL1 | cyclin L1 | 0.0162878 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0161011 |
| GRAMD1B | GRAM domain containing 1B | 0.0160649 |
| WWOX | WW domain containing oxidoreductase | 0.0160495 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0160301 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0159519 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.015951 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0159125 |
| JUN | jun proto-oncogene | 0.015651 |
| ENO1 | enolase 1, (alpha) | 0.0156334 |
| AGRN | agrin | 0.0156181 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0155546 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0155323 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.015348 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0152921 |
| FTL | ferritin, light polypeptide | 0.0152129 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0151236 |
| CUL4A | cullin 4A | 0.0151215 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0150552 |
| MEF2D | myocyte enhancer factor 2D | 0.0148576 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.014719 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0145954 |
| INTS6 | integrator complex subunit 6 | 0.0145874 |
| LIF | leukemia inhibitory factor | 0.0145438 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0144259 |
| MT2A | metallothionein 2A | 0.0143545 |
| NRDC | nardilysin convertase | 0.0141949 |
| PHF14 | PHD finger protein 14 | 0.0140361 |
| HLA-C | major histocompatibility complex, class I, C | 0.0138339 |
| HCFC1 | host cell factor C1 | 0.0138309 |
| LIMA1 | LIM domain and actin binding 1 | 0.0137676 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0137278 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.252097 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.223513 |
| PTMA | prothymosin, alpha | -0.0802878 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0802816 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0783531 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0748556 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0726542 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0723366 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0685475 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0629007 |
| XPO1 | exportin 1 | -0.0570315 |
| MKI67 | marker of proliferation Ki-67 | -0.0566725 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0561011 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0546895 |
| PHIP | pleckstrin homology domain interacting protein | -0.0527813 |
| RPS21 | ribosomal protein S21 | -0.0511966 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0510647 |
| RPL38 | ribosomal protein L38 | -0.0467038 |
| UBC | ubiquitin C | -0.0460934 |
| RTN4 | reticulon 4 | -0.0442678 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0442161 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0440714 |
| BBX | bobby sox homolog (Drosophila) | -0.0439752 |
| CENPF | centromere protein F, 350/400kDa | -0.0437036 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0434943 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0423416 |
| CLTC | clathrin, heavy chain (Hc) | -0.0420675 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0411545 |
| GOLGA4 | golgin A4 | -0.0403009 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.039906 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0396038 |
| OGA | O-GlcNAcase | -0.0383127 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0376197 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0374531 |
| RPS8 | ribosomal protein S8 | -0.037245 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0369597 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.0369158 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0367891 |
| SRPK1 | SRSF protein kinase 1 | -0.0363822 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0362789 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0351498 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.03509 |
| RPS2 | ribosomal protein S2 | -0.0347696 |
| RPS15 | ribosomal protein S15 | -0.0346616 |
| TXNRD1 | thioredoxin reductase 1 | -0.0346283 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0346033 |
| VIM | vimentin | -0.0345646 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0339091 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.033863 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0335052 |
| RPS29 | ribosomal protein S29 | -0.0334412 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.033171 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0330545 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0329221 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.032878 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0328575 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0328044 |
| WDR45B | WD repeat domain 45B | -0.0327606 |
| RPLP0 | ribosomal protein, large, P0 | -0.0323569 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0310165 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0308944 |
| RPS6 | ribosomal protein S6 | -0.030303 |
| SPAG9 | sperm associated antigen 9 | -0.0303012 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0301878 |
| CTTN | cortactin | -0.0301211 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0299794 |
| TPX2 | TPX2, microtubule-associated | -0.0297574 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0296195 |
| SEPTIN7 | septin 7 | -0.0294855 |
| RPL19 | ribosomal protein L19 | -0.0292555 |
| SGO2 | shugoshin 2 | -0.0289924 |
| PCBP2 | poly(rC) binding protein 2 | -0.028968 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0289081 |
| ZFR | zinc finger RNA binding protein | -0.0287386 |
| RPL8 | ribosomal protein L8 | -0.028713 |
| TUBA1B | tubulin, alpha 1b | -0.0285888 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.028408 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0283385 |
| MTPN | myotrophin | -0.0282197 |
| RPS27A | ribosomal protein S27a | -0.0281525 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0281318 |
| CKAP5 | cytoskeleton associated protein 5 | -0.028075 |
| RPS10 | ribosomal protein S10 | -0.0279489 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0278462 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0278026 |
| CANX | calnexin | -0.0276722 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0276205 |
| TPI1 | triosephosphate isomerase 1 | -0.0275748 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0274787 |
| CCND2 | cyclin D2 | -0.0273135 |
| KIF5B | kinesin family member 5B | -0.0271586 |
| RAB10 | RAB10, member RAS oncogene family | -0.0271045 |
| RECQL | RecQ helicase-like | -0.0269447 |
| GOLT1B | golgi transport 1B | -0.026911 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.026712 |
| CEP192 | centrosomal protein 192kDa | -0.0266807 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0266759 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0264917 |
| SRP72 | signal recognition particle 72kDa | -0.0261478 |
| H3-3B | H3.3 histone B | -0.0260286 |
