| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.242882 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.240994 |
| ASPH | aspartate beta-hydroxylase | 0.162756 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.151846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.128492 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.121922 |
| LAMB3 | laminin, beta 3 | 0.115188 |
| NDRG1 | N-myc downstream regulated 1 | 0.114246 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.112571 |
| LAMC2 | laminin, gamma 2 | 0.110075 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.106492 |
| LDHA | lactate dehydrogenase A | 0.100097 |
| FTL | ferritin, light polypeptide | 0.0996422 |
| LMO7 | LIM domain 7 | 0.0946128 |
| POTEF | POTE ankyrin domain family, member F | 0.0918435 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0840638 |
| ARRDC3 | arrestin domain containing 3 | 0.0805596 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0773136 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0716932 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0677757 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0667653 |
| FN1 | fibronectin 1 | 0.0664412 |
| ENO1 | enolase 1, (alpha) | 0.0601153 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0598281 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0597269 |
| HMGA1 | high mobility group AT-hook 1 | 0.0593504 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0580692 |
| DTNA | dystrobrevin, alpha | 0.0579266 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0576095 |
| ACTG1 | actin gamma 1 | 0.0530122 |
| EGR1 | early growth response 1 | 0.0511818 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0507663 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0476908 |
| EZR | ezrin | 0.0476291 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0475217 |
| CDCP1 | CUB domain containing protein 1 | 0.0469265 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0458755 |
| HMGB2 | high mobility group box 2 | 0.0456124 |
| TMF1 | TATA element modulatory factor 1 | 0.0455974 |
| ANXA1 | annexin A1 | 0.0450005 |
| PGK1 | phosphoglycerate kinase 1 | 0.0448832 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0442326 |
| RPS3 | ribosomal protein S3 | 0.0439281 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0430753 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0424332 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0412869 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0411966 |
| BRD2 | bromodomain containing 2 | 0.0411888 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0408206 |
| RACK1 | receptor for activated C kinase 1 | 0.0391123 |
| DUSP6 | dual specificity phosphatase 6 | 0.0387927 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.038396 |
| MYO5B | myosin VB | 0.0382776 |
| CLDN4 | claudin 4 | 0.0381099 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0368596 |
| MXD1 | MAX dimerization protein 1 | 0.0368076 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0366438 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0366375 |
| VGLL3 | vestigial-like family member 3 | 0.0366106 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0364285 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0357436 |
| EFNA5 | ephrin-A5 | 0.0353459 |
| ANXA2 | annexin A2 | 0.0351346 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0343494 |
| VEGFA | vascular endothelial growth factor A | 0.0339686 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0337689 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.033272 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0328408 |
| TPM3 | tropomyosin 3 | 0.0322921 |
| SPAG9 | sperm associated antigen 9 | 0.0320797 |
| PKM | pyruvate kinase, muscle | 0.0312818 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0310735 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.030997 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.0304562 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0302435 |
| TP53BP2 | tumor protein p53 binding protein 2 | 0.0300761 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.029451 |
| RPL3 | ribosomal protein L3 | 0.0292475 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0289175 |
| G0S2 | G0/G1 switch 2 | 0.0287677 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0286278 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0285113 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0281447 |
| CSTB | cystatin B (stefin B) | 0.0277813 |
| RPL4 | ribosomal protein L4 | 0.0277326 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0276944 |
| TOP1 | topoisomerase (DNA) I | 0.0275574 |
| TPM4 | tropomyosin 4 | 0.0274109 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0272477 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0272121 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0272009 |
| RCOR1 | REST corepressor 1 | 0.0267992 |
| CD44 | CD44 molecule (Indian blood group) | 0.0264942 |
| ANXA5 | annexin A5 | 0.0262997 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0262181 |
| TXNIP | thioredoxin interacting protein | 0.0262017 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0260051 |
| MSN | moesin | 0.0259721 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0259517 |
| RTN4 | reticulon 4 | 0.0258057 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.118614 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0993734 |
| TMSB10 | thymosin beta 10 | -0.0658734 |
| RNF213 | ring finger protein 213 | -0.0633611 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0624843 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0575631 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0542088 |
| AHNAK | AHNAK nucleoprotein | -0.0481857 |
| RPL35A | ribosomal protein L35a | -0.0477447 |
| FBXO32 | F-box protein 32 | -0.0461747 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0453561 |
| RAD51B | RAD51 paralog B | -0.0424204 |
| FHIT | fragile histidine triad | -0.039707 |
| MYOF | myoferlin | -0.038474 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0382412 |
| NAV2 | neuron navigator 2 | -0.0363311 |
| PALLD | palladin, cytoskeletal associated protein | -0.0355636 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0351041 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0343755 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0341864 |
| RIGI | RNA sensor RIG-I | -0.0338245 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.033533 |
| RPS21 | ribosomal protein S21 | -0.0335201 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0329877 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0327139 |
| HLA-B | major histocompatibility complex, class I, B | -0.0325945 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0311683 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0308055 |
| ETV6 | ets variant 6 | -0.0307551 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0299792 |
| VCL | vinculin | -0.0295329 |
| RUNX1 | runt-related transcription factor 1 | -0.0291823 |
| MX2 | MX dynamin-like GTPase 2 | -0.0279086 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0275628 |
| RPL34 | ribosomal protein L34 | -0.0274194 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0269796 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0266136 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0264319 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0262632 |
| AOPEP | aminopeptidase O (putative) | -0.0261845 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0256348 |
| RBM47 | RNA binding motif protein 47 | -0.025379 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0253763 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.0248409 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0248083 |
| RPS29 | ribosomal protein S29 | -0.0247837 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0247809 |
| SRPK2 | SRSF protein kinase 2 | -0.0247303 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0244416 |
| RRBP1 | ribosome binding protein 1 | -0.0243926 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0243493 |
| XPO1 | exportin 1 | -0.0242203 |
| EXOC4 | exocyst complex component 4 | -0.0240927 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0240462 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0238487 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0237473 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0236949 |
| GNAS | GNAS complex locus | -0.0234362 |
| SMYD3 | SET and MYND domain containing 3 | -0.0233885 |
| NEMF | nuclear export mediator factor | -0.0233495 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0232504 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0229392 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0227381 |
| RPLP2 | ribosomal protein, large, P2 | -0.0224842 |
| TUFT1 | tuftelin 1 | -0.0223699 |
| STEAP4 | STEAP family member 4 | -0.0223638 |
| FBXO34 | F-box protein 34 | -0.0222819 |
| SEPTIN11 | septin 11 | -0.0222619 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0221333 |
| RPS8 | ribosomal protein S8 | -0.0218471 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0213771 |
| RPL38 | ribosomal protein L38 | -0.021318 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0212726 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.02068 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0204537 |
| RPS23 | ribosomal protein S23 | -0.020421 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0203935 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.020352 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0203104 |
| LMNA | lamin A/C | -0.0202113 |
| RPS25 | ribosomal protein S25 | -0.01978 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0197125 |
| STC2 | stanniocalcin 2 | -0.0195661 |
| MAP4 | microtubule-associated protein 4 | -0.0194119 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0194087 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0193717 |
| RAB10 | RAB10, member RAS oncogene family | -0.0192609 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0190507 |
| HERC5 | HECT and RLD domain containing E3 ubiquitin protein ligase 5 | -0.0189388 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0188154 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0187078 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0186397 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0185633 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0185252 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0184609 |
| COL1A1 | collagen, type I, alpha 1 | -0.0183848 |
| CTSD | cathepsin D | -0.0182899 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0180358 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0180049 |
| SP100 | SP100 nuclear antigen | -0.0178231 |
