| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0471496 |
| RAD51B | RAD51 paralog B | 0.0306463 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.027767 |
| POTEF | POTE ankyrin domain family, member F | 0.0234802 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0233769 |
| MSN | moesin | 0.0233696 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0224022 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0213392 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0203554 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.019789 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0195048 |
| MCL1 | myeloid cell leukemia 1 | 0.0193027 |
| LAMA5 | laminin, alpha 5 | 0.0166971 |
| PKM | pyruvate kinase, muscle | 0.016372 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0157351 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0155494 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0154633 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0144979 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0136587 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0127785 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0125463 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0124536 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.011811 |
| AUTS2 | autism susceptibility candidate 2 | 0.0117838 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0116224 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0112584 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0111836 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0111689 |
| DST | dystonin | 0.0100849 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.00999929 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.00983921 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.00965095 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.00961745 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00943952 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0092627 |
| RPS4X | ribosomal protein S4, X-linked | 0.00901319 |
| NRXN3 | neurexin 3 | 0.00879203 |
| LSAMP | limbic system-associated membrane protein | 0.00835231 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.00834172 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.00831316 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.00817554 |
| ZNF638 | zinc finger protein 638 | 0.00800962 |
| VEGFA | vascular endothelial growth factor A | 0.00788004 |
| WWOX | WW domain containing oxidoreductase | 0.00740024 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.00735235 |
| SH2D2A | SH2 domain containing 2A | 0.00735019 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | 0.00733807 |
| TUBA1B | tubulin, alpha 1b | 0.0072724 |
| OBSCN | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.00719379 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.00717765 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | 0.00708633 |
| CD109 | CD109 molecule | 0.00706512 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.00700751 |
| HSPA8 | heat shock 70kDa protein 8 | 0.00697811 |
| MEF2A | myocyte enhancer factor 2A | 0.00690001 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.00685532 |
| EGFR | epidermal growth factor receptor | 0.00675865 |
| C1D | C1D nuclear receptor corepressor | 0.00674217 |
| DNER | delta/notch-like EGF repeat containing | 0.00673101 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.00669758 |
| AADAC | arylacetamide deacetylase | 0.00661076 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.00649189 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.00648726 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.00648662 |
| RANBP17 | RAN binding protein 17 | 0.0064737 |
| SLC9A2 | solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 | 0.00642423 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.00630132 |
| BMP6 | bone morphogenetic protein 6 | 0.00622579 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00618412 |
| FNIP1 | folliculin interacting protein 1 | 0.00617476 |
| MYADM | myeloid-associated differentiation marker | 0.00617424 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.00615457 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.00614424 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.00611066 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.00607826 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.0059628 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.00594031 |
| RPL21 | ribosomal protein L21 | 0.005873 |
| KDM6B | lysine (K)-specific demethylase 6B | 0.00586713 |
| PCBP2 | poly(rC) binding protein 2 | 0.0058606 |
| RNF213 | ring finger protein 213 | 0.00582017 |
| FRY | furry homolog (Drosophila) | 0.00579145 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.00577554 |
| INTS6 | integrator complex subunit 6 | 0.00577269 |
| HDAC9 | histone deacetylase 9 | 0.00572795 |
| PTEN | phosphatase and tensin homolog | 0.0056463 |
| ATXN1 | ataxin 1 | 0.00563462 |
| IGF2 | insulin-like growth factor 2 | 0.00560956 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.00560697 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.00559183 |
| RPL9 | ribosomal protein L9 | 0.00559045 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.00554527 |
| MAPK1IP1L | mitogen-activated protein kinase 1 interacting protein 1-like | 0.00552851 |
| NRDC | nardilysin convertase | 0.00550927 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.00541073 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.00539302 |
| CLMN | calmin (calponin-like, transmembrane) | 0.00538592 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.00532659 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.00531552 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.00524838 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.191407 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.156807 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.12616 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.104395 |
| FN1 | fibronectin 1 | -0.101708 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0858647 |
| PTMA | prothymosin, alpha | -0.0754085 |
| CANX | calnexin | -0.0639319 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0635388 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0614025 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0608814 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0572395 |
| TMSB10 | thymosin beta 10 | -0.0553339 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0509704 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0489704 |
| RPLP1 | ribosomal protein, large, P1 | -0.047292 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0461969 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0452522 |
| SPAG9 | sperm associated antigen 9 | -0.0450921 |
| FTL | ferritin, light polypeptide | -0.0407448 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0384725 |
| EFNA5 | ephrin-A5 | -0.0374848 |
| TXNRD1 | thioredoxin reductase 1 | -0.0373245 |
| OGA | O-GlcNAcase | -0.0366441 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0360819 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0360747 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0358346 |
| PGK1 | phosphoglycerate kinase 1 | -0.0347271 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0337043 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0325404 |
| RPL23 | ribosomal protein L23 | -0.0324966 |
| RPL12 | ribosomal protein L12 | -0.0322025 |
| RPS24 | ribosomal protein S24 | -0.0319067 |
| RGS2 | regulator of G-protein signaling 2 | -0.0310406 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0309494 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0309468 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0305016 |
| MYOF | myoferlin | -0.0301543 |
| RBM39 | RNA binding motif protein 39 | -0.0300731 |
| RPL19 | ribosomal protein L19 | -0.029033 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0283737 |
| NEK7 | NIMA-related kinase 7 | -0.0282141 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0280617 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0278467 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0276211 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0274576 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0266426 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0265986 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0264809 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.026008 |
| GOLGA4 | golgin A4 | -0.0252167 |
| RTN4 | reticulon 4 | -0.0251332 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0250157 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0245459 |
| AHNAK | AHNAK nucleoprotein | -0.024235 |
| GNAS | GNAS complex locus | -0.0238678 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0238165 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0237067 |
| RPL26 | ribosomal protein L26 | -0.0236931 |
| TBXT | T-box transcription factor T | -0.0235447 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0233261 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0232818 |
| PHF20 | PHD finger protein 20 | -0.0231338 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0224717 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0223481 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0222659 |
| GDA | guanine deaminase | -0.0222554 |
| RPL35 | ribosomal protein L35 | -0.0220426 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0219925 |
| RAB1A | RAB1A, member RAS oncogene family | -0.021956 |
| SRGN | serglycin | -0.0218493 |
| RPS27A | ribosomal protein S27a | -0.0217453 |
| LAMA1 | laminin, alpha 1 | -0.0217307 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0215769 |
| WDR45B | WD repeat domain 45B | -0.0214479 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0213512 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0211854 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0207997 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0207466 |
| USP3 | ubiquitin specific peptidase 3 | -0.0205699 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0205647 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0204861 |
| RPL31 | ribosomal protein L31 | -0.0204379 |
| RPS19 | ribosomal protein S19 | -0.0204 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0203994 |
| RPLP0 | ribosomal protein, large, P0 | -0.0203537 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0203388 |
| RPL13A | ribosomal protein L13a | -0.0198809 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0198622 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0198381 |
| S100A10 | S100 calcium binding protein A10 | -0.0197067 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0195382 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0195165 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0195157 |
| PDE10A | phosphodiesterase 10A | -0.0194245 |
| RPS27 | ribosomal protein S27 | -0.0193318 |
| SRPK2 | SRSF protein kinase 2 | -0.0192044 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0187722 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.018764 |
| KYNU | kynureninase | -0.0187218 |
