Radotinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.171138
EFNA5 ephrin-A5 0.0962622
DTNA dystrobrevin, alpha 0.0941886
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0909921
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0774183
GPC6 glypican 6 0.0733313
RUNX1 runt-related transcription factor 1 0.0728136
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0711179
FLNB filamin B, beta 0.0632783
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0598728
IGFBP3 insulin-like growth factor binding protein 3 0.0588925
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0582095
USP9X ubiquitin specific peptidase 9, X-linked 0.0581359
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0576381
NAMPT nicotinamide phosphoribosyltransferase 0.0574653
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0560799
PKM pyruvate kinase, muscle 0.0560595
CD109 CD109 molecule 0.0540809
RBM39 RNA binding motif protein 39 0.0535017
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0532239
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.05249
ENO1 enolase 1, (alpha) 0.0517029
FMN1 formin 1 0.0511639
AHNAK AHNAK nucleoprotein 0.0504867
LDHA lactate dehydrogenase A 0.0493914
RPS4X ribosomal protein S4, X-linked 0.0487322
SOD2 superoxide dismutase 2, mitochondrial 0.0485726
RPL37 ribosomal protein L37 0.0472991
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0461005
KIAA1217 KIAA1217 0.046097
FAM13A family with sequence similarity 13, member A 0.0458302
TXNRD1 thioredoxin reductase 1 0.0456076
ANKRD12 ankyrin repeat domain 12 0.0445146
ARHGAP5 Rho GTPase activating protein 5 0.0443734
MCL1 myeloid cell leukemia 1 0.0442242
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0402599
SLC38A1 solute carrier family 38, member 1 0.0384237
MED13L mediator complex subunit 13-like 0.0372671
LOC112694756 uncharaterized LOC112694756 0.0367459
EIF1 eukaryotic translation initiation factor 1 0.0363656
LPP LIM domain containing preferred translocation partner in lipoma 0.036087
POTEF POTE ankyrin domain family, member F 0.0343873
ANKRD11 ankyrin repeat domain 11 0.0341403
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337455
SMYD3 SET and MYND domain containing 3 0.0332175
EEF2 eukaryotic translation elongation factor 2 0.0322224
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0320554
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0316004
RPL31 ribosomal protein L31 0.030517
RPS24 ribosomal protein S24 0.0304911
ACTG1 actin gamma 1 0.029832
ASPH aspartate beta-hydroxylase 0.0293735
RNF213 ring finger protein 213 0.0292933
RTN4 reticulon 4 0.0278332
RPL37A ribosomal protein L37a 0.0277792
CD44 CD44 molecule (Indian blood group) 0.0275872
SEPTIN9 septin 9 0.0270708
NDRG1 N-myc downstream regulated 1 0.0269871
MYO1E myosin IE 0.0268338
SBF2 SET binding factor 2 0.0260426
COL5A1 collagen, type V, alpha 1 0.0260328
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0256805
SLC38A2 solute carrier family 38, member 2 0.0248403
EXT1 exostosin glycosyltransferase 1 0.0244865
NCOR1 nuclear receptor corepressor 1 0.0242493
RPL11 ribosomal protein L11 0.0230429
MACF1 microtubule-actin crosslinking factor 1 0.0227073
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0219463
SLTM SAFB-like, transcription modulator 0.0212835
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0210124
LCN2 lipocalin 2 0.0205849
DSPP dentin sialophosphoprotein 0.0197746
KDM2A lysine (K)-specific demethylase 2A 0.0188409
PTK2 protein tyrosine kinase 2 0.0187029
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0184031
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.016719
RAD51B RAD51 paralog B 0.0165388
DSCAM Down syndrome cell adhesion molecule 0.0151987
SPAG9 sperm associated antigen 9 0.0142187
RPS17 ribosomal protein S17 0.0139751
MYOF myoferlin 0.0137803
RPS3 ribosomal protein S3 0.0136305
PGK1 phosphoglycerate kinase 1 0.013598
PRELID2 PRELI domain containing 2 0.0134877
IGF2 insulin-like growth factor 2 0.0133701
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0133019
MAP4 microtubule-associated protein 4 0.0131206
VMP1 vacuole membrane protein 1 0.0130855
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0125765
LAMA4 laminin, alpha 4 0.0123781
ERRFI1 ERBB receptor feedback inhibitor 1 0.0109618
RBM25 RNA binding motif protein 25 0.0104497
SMAD3 SMAD family member 3 0.0103614
LAMB3 laminin, beta 3 0.0102261
RPL23 ribosomal protein L23 0.00988946
WAC WW domain containing adaptor with coiled-coil 0.00988702
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0094049
FTH1 ferritin, heavy polypeptide 1 0.00930203
ALCAM activated leukocyte cell adhesion molecule 0.00910816
ATP11A ATPase, class VI, type 11A 0.00906601

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.21643
AKAP12 A kinase (PRKA) anchor protein 12 -0.0888965
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0853635
STC1 stanniocalcin 1 -0.0734893
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0678697
BBX bobby sox homolog (Drosophila) -0.0655394
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.061782
ELOVL5 ELOVL fatty acid elongase 5 -0.0598425
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0590506
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0555331
VIM vimentin -0.054603
KMT2C lysine (K)-specific methyltransferase 2C -0.0544689
CDH13 cadherin 13 -0.0539453
ERBIN erbb2 interacting protein -0.0519275
FNDC3A fibronectin type III domain containing 3A -0.0516159
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0513948
PDLIM5 PDZ and LIM domain 5 -0.0507238
TCF12 transcription factor 12 -0.0488716
AOPEP aminopeptidase O (putative) -0.0476968
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0476548
ZNF292 zinc finger protein 292 -0.046333
FNDC3B fibronectin type III domain containing 3B -0.0446998
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0442193
HMGA2 high mobility group AT-hook 2 -0.043966
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.043916
PARD3 par-3 family cell polarity regulator -0.0434676
RPLP2 ribosomal protein, large, P2 -0.0431249
RORA RAR-related orphan receptor A -0.0416113
CCNY cyclin Y -0.0406025
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0405362
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0389066
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0387838
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0381373
THSD4 thrombospondin, type I, domain containing 4 -0.0376009
PRRC2C proline-rich coiled-coil 2C -0.0370475
RPL35A ribosomal protein L35a -0.036886
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0363533
OXR1 oxidation resistance 1 -0.0362585
SETD5 SET domain containing 5 -0.0350763
INHBA inhibin, beta A -0.0347328
LRP1B low density lipoprotein receptor-related protein 1B -0.0346066
PRKD3 protein kinase D3 -0.0336589
COL6A3 collagen, type VI, alpha 3 -0.0329522
RPS6 ribosomal protein S6 -0.0328065
LIMS1 LIM and senescent cell antigen-like domains 1 -0.032336
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.032119
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.031757
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0315533
MARCHF7 membrane associated ring-CH-type finger 7 -0.0313943
RIGI RNA sensor RIG-I -0.0312299
OGA O-GlcNAcase -0.0311975
TMSB10 thymosin beta 10 -0.0307623
FTL ferritin, light polypeptide -0.0303273
APP amyloid beta (A4) precursor protein -0.0301908
RPS8 ribosomal protein S8 -0.0299888
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0296914
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0291304
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.029022
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0288801
SRPK2 SRSF protein kinase 2 -0.028635
GRB10 growth factor receptor-bound protein 10 -0.0285436
JARID2 jumonji, AT rich interactive domain 2 -0.0280223
PRKG1 protein kinase, cGMP-dependent, type I -0.0264689
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0263854
PSD3 pleckstrin and Sec7 domain containing 3 -0.0253851
RPS12 ribosomal protein S12 -0.0253726
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0249796
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0249181
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0247193
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0244735
TPM4 tropomyosin 4 -0.0243237
GMDS GDP-mannose 4,6-dehydratase -0.0238685
COL6A1 collagen, type VI, alpha 1 -0.0236914
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0235975
ELL2 elongation factor, RNA polymerase II, 2 -0.0235892
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0235715
RPL12 ribosomal protein L12 -0.0235366
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0233769
PICALM phosphatidylinositol binding clathrin assembly protein -0.0224037
EMP1 epithelial membrane protein 1 -0.0217821
DST dystonin -0.0209482
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0207216
RPS14 ribosomal protein S14 -0.0199017
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0194924
RPL15 ribosomal protein L15 -0.0193595
TRPS1 trichorhinophalangeal syndrome I -0.0187694
NIPBL Nipped-B homolog (Drosophila) -0.0185668
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0185516
MBNL1 muscleblind-like splicing regulator 1 -0.0185318
KMT2E lysine (K)-specific methyltransferase 2E -0.0181764
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0180885
MAML3 mastermind-like 3 (Drosophila) -0.0177655
TPT1 tumor protein, translationally-controlled 1 -0.0174637
JMJD1C jumonji domain containing 1C -0.0165647
RPLP1 ribosomal protein, large, P1 -0.0156306
NBEAL1 neurobeachin-like 1 -0.0149581
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0139767
PDE10A phosphodiesterase 10A -0.0136892
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0136248
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0133657