| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Radotinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Radotinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.231643 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.128202 |
| CADM2 | cell adhesion molecule 2 | 0.11471 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0969059 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0871527 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0768174 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.076581 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0719536 |
| PEG10 | paternally expressed 10 | 0.069799 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0641707 |
| ITGAV | integrin, alpha V | 0.0614515 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0608101 |
| VIM | vimentin | 0.0578467 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0551332 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0534179 |
| PRELID2 | PRELI domain containing 2 | 0.0530615 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0513203 |
| POTEF | POTE ankyrin domain family, member F | 0.0499774 |
| DST | dystonin | 0.0460012 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0408289 |
| NTM | neurotrimin | 0.0407347 |
| COL5A2 | collagen, type V, alpha 2 | 0.0407108 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0400178 |
| RPS4X | ribosomal protein S4, X-linked | 0.0388447 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0383437 |
| LRRC4C | leucine rich repeat containing 4C | 0.0365196 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0361701 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0358965 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0345947 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.034577 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0344805 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0338309 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0331323 |
| ENO1 | enolase 1, (alpha) | 0.033103 |
| ANXA1 | annexin A1 | 0.0327333 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0317409 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0316105 |
| HDAC9 | histone deacetylase 9 | 0.0315734 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0300898 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.0295997 |
| KIF21A | kinesin family member 21A | 0.0293235 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0292425 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0291963 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0290457 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0287719 |
| SMYD3 | SET and MYND domain containing 3 | 0.0287495 |
| RPL11 | ribosomal protein L11 | 0.0286844 |
| TPR | translocated promoter region, nuclear basket protein | 0.0282641 |
| RPS3 | ribosomal protein S3 | 0.0280436 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0280362 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0277462 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0275098 |
| SET | SET nuclear proto-oncogene | 0.0269263 |
| PCM1 | pericentriolar material 1 | 0.026657 |
| RAD51B | RAD51 paralog B | 0.0265169 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0263118 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0258385 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0252047 |
| DENND1A | DENN/MADD domain containing 1A | 0.024974 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0248562 |
| GSE1 | Gse1 coiled-coil protein | 0.0246228 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0246125 |
| SESN2 | sestrin 2 | 0.0243378 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0241338 |
| SLK | STE20-like kinase | 0.023958 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0239483 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0238058 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0237007 |
| DOK6 | docking protein 6 | 0.0233687 |
| HYOU1 | hypoxia up-regulated 1 | 0.0231636 |
| SYT1 | synaptotagmin I | 0.0230852 |
| UTRN | utrophin | 0.0229115 |
| MYO9A | myosin IXA | 0.0227744 |
| RPS23 | ribosomal protein S23 | 0.0226189 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0225908 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0222613 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0221195 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0221017 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0220136 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.0218367 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0217826 |
| SKIL | SKI-like proto-oncogene | 0.0217412 |
| CBX3 | chromobox homolog 3 | 0.0216919 |
| PRR16 | proline rich 16 | 0.0216717 |
| ATXN10 | ataxin 10 | 0.0215743 |
| STAM2 | signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 | 0.0215149 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0214648 |
| SAMD4B | sterile alpha motif domain containing 4B | 0.021196 |
| RPL32 | ribosomal protein L32 | 0.0211051 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0210241 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0206362 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0205899 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.020568 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0205482 |
| PCDH7 | protocadherin 7 | 0.0205373 |
| WWOX | WW domain containing oxidoreductase | 0.0203925 |
| NRDC | nardilysin convertase | 0.0203732 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0203061 |
| WASF2 | WAS protein family, member 2 | 0.0202877 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0202395 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ANKRD33B | ankyrin repeat domain 33B | -0.109551 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0848096 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0779231 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0684329 |
| PTMA | prothymosin, alpha | -0.0638147 |
| PDGFC | platelet derived growth factor C | -0.0636383 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0630578 |
| TMSB10 | thymosin beta 10 | -0.0616777 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0574756 |
| RPS16 | ribosomal protein S16 | -0.0549058 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0513889 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0503521 |
| RPS27A | ribosomal protein S27a | -0.0503388 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0500433 |
| RPS8 | ribosomal protein S8 | -0.0486625 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0483165 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0480609 |
| FBXO11 | F-box protein 11 | -0.0466852 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0463037 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0460407 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0430239 |
| EMP1 | epithelial membrane protein 1 | -0.0425559 |
| RBM20 | RNA binding motif protein 20 | -0.0423509 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0423439 |
| ANXA2 | annexin A2 | -0.0412435 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0399202 |
| KIF4A | kinesin family member 4A | -0.039605 |
| CAVIN1 | caveolae associated protein 1 | -0.0392486 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0391431 |
| RPL35A | ribosomal protein L35a | -0.03898 |
| RBM39 | RNA binding motif protein 39 | -0.0388942 |
| ACTG1 | actin gamma 1 | -0.0386975 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0383879 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0380511 |
| B2M | beta-2-microglobulin | -0.0377225 |
| ENAH | enabled homolog (Drosophila) | -0.0374627 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0373877 |
| RLF | rearranged L-myc fusion | -0.0367566 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0366925 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0353442 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0350944 |
| UPP1 | uridine phosphorylase 1 | -0.0349304 |
| APP | amyloid beta (A4) precursor protein | -0.0345087 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0342994 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0338265 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0337051 |
| CENPE | centromere protein E, 312kDa | -0.0336574 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0333226 |
| VCL | vinculin | -0.0332827 |
| TXNRD1 | thioredoxin reductase 1 | -0.0329296 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0326504 |
| LATS2 | large tumor suppressor kinase 2 | -0.0326337 |
| HDAC2 | histone deacetylase 2 | -0.0324822 |
| FOXO3 | forkhead box O3 | -0.0322693 |
| MKI67 | marker of proliferation Ki-67 | -0.0318257 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0316473 |
| STAG2 | stromal antigen 2 | -0.0312334 |
| MB21D2 | Mab-21 domain containing 2 | -0.0310948 |
| CENPF | centromere protein F, 350/400kDa | -0.0305916 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0305268 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0305025 |
| ASTN2 | astrotactin 2 | -0.0301958 |
| MDFIC | MyoD family inhibitor domain containing | -0.0300303 |
| RPL31 | ribosomal protein L31 | -0.0298943 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0298324 |
| MAP4 | microtubule-associated protein 4 | -0.0297228 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0291329 |
| RPS24 | ribosomal protein S24 | -0.0290994 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0289815 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0287978 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0287289 |
| PLPP1 | phospholipid phosphatase 1 | -0.0285876 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0285382 |
| ZNF292 | zinc finger protein 292 | -0.0285203 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0285165 |
| AHNAK | AHNAK nucleoprotein | -0.0282582 |
| TRERF1 | transcriptional regulating factor 1 | -0.0279025 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0279024 |
| FOXP2 | forkhead box P2 | -0.0278314 |
| RHEB | Ras homolog enriched in brain | -0.0277331 |
| H3-3B | H3.3 histone B | -0.0276075 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0275379 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.027458 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0272446 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0269882 |
| BBX | bobby sox homolog (Drosophila) | -0.0268347 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0268277 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0268017 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0266336 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0264588 |
| ILRUN | inflammation and lipid regulator with UBA-like and NBR1-like domains | -0.0264156 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0263717 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0262745 |
| RFPL4B | ret finger protein-like 4B | -0.0259163 |
| RPS25 | ribosomal protein S25 | -0.0258654 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0258361 |
| ZNF207 | zinc finger protein 207 | -0.0257832 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0256357 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0256166 |
| RPL37 | ribosomal protein L37 | -0.0254779 |
