Radotinib_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Radotinib perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Radotinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.17473
IGFBP3 insulin-like growth factor binding protein 3 0.119972
EEF2 eukaryotic translation elongation factor 2 0.102661
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0811943
VEGFA vascular endothelial growth factor A 0.080864
LDHA lactate dehydrogenase A 0.0664021
RPS4X ribosomal protein S4, X-linked 0.0590418
LOC112694756 uncharaterized LOC112694756 0.0516123
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0469858
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0467544
NDRG1 N-myc downstream regulated 1 0.0444775
VIM vimentin 0.0431188
PLIN2 perilipin 2 0.0358866
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0343201
PKM pyruvate kinase, muscle 0.032624
ANXA1 annexin A1 0.0307474
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0301668
TSC22D2 TSC22 domain family, member 2 0.0283765
C3 complement component 3 0.0281048
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0280141
ENO1 enolase 1, (alpha) 0.0271067
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0268255
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0259071
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0257366
COL5A1 collagen, type V, alpha 1 0.0245625
DDIT4 DNA-damage-inducible transcript 4 0.0244972
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0243541
CANX calnexin 0.0243012
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0235578
JUN jun proto-oncogene 0.0235266
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0232388
MATR3 matrin 3 0.0225723
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0219745
PGK1 phosphoglycerate kinase 1 0.0216844
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0216753
MXI1 MAX interactor 1, dimerization protein 0.0211666
YBX1 Y box binding protein 1 0.0204903
CEP250 centrosomal protein 250kDa 0.0204375
RPL3 ribosomal protein L3 0.02009
APLP2 amyloid beta (A4) precursor-like protein 2 0.0197563
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0193783
EFNA5 ephrin-A5 0.0193734
HLA-C major histocompatibility complex, class I, C 0.0193444
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0189518
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0188475
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187912
UBE2O ubiquitin-conjugating enzyme E2O 0.0186008
BTG1 B-cell translocation gene 1, anti-proliferative 0.0185981
GADD45B growth arrest and DNA-damage-inducible, beta 0.018373
APP amyloid beta (A4) precursor protein 0.0183688
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0183021
LMAN1 lectin, mannose-binding, 1 0.0180015
LOX lysyl oxidase 0.0177974
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0177289
CDH13 cadherin 13 0.0177221
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0176348
ZNF292 zinc finger protein 292 0.0175575
RAD23B RAD23 homolog B (S. cerevisiae) 0.0174538
PPP1R18 protein phosphatase 1, regulatory subunit 18 0.0173555
BHLHE40 basic helix-loop-helix family, member e40 0.0170238
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0170019
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0165144
PABPC1 poly(A) binding protein, cytoplasmic 1 0.016441
BACE2 beta-site APP-cleaving enzyme 2 0.0163745
STC2 stanniocalcin 2 0.0159928
EIF4H eukaryotic translation initiation factor 4H 0.0159811
HELZ helicase with zinc finger 0.0159667
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0159526
ZFP36L1 ZFP36 ring finger protein-like 1 0.0159067
HILPDA hypoxia inducible lipid droplet-associated 0.0158379
USP37 ubiquitin specific peptidase 37 0.0158209
MMP2 matrix metallopeptidase 2 0.0156954
DEPP1 DEPP autophagy regulator 1 0.0155511
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0154577
UGCG UDP-glucose ceramide glucosyltransferase 0.0153834
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0152217
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0151368
FAM13A family with sequence similarity 13, member A 0.0149708
HOOK2 hook microtubule-tethering protein 2 0.0148848
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0147111
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0146096
UBA6 ubiquitin-like modifier activating enzyme 6 0.0143414
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0142565
KDM3A lysine (K)-specific demethylase 3A 0.0142013
FAM162A family with sequence similarity 162, member A 0.0138603
HLA-E major histocompatibility complex, class I, E 0.0138372
CD46 CD46 molecule, complement regulatory protein 0.0137201
EEF1G eukaryotic translation elongation factor 1 gamma 0.0137027
C1D C1D nuclear receptor corepressor 0.0136966
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0136864
ATXN2L ataxin 2-like 0.0134861
LOC102724023 ES1 protein homolog, mitochondrial 0.0134802
MMP12 matrix metallopeptidase 12 0.0134427
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0133098
RPS3 ribosomal protein S3 0.0132759
GDF15 growth differentiation factor 15 0.0132635
NGLY1 N-glycanase 1 0.0131296
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0131007
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0130229
TTC3 tetratricopeptide repeat domain 3 0.0129405

decreased expression

Symbol Name Standardized Value
FRMD4A FERM domain containing 4A -0.202973
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.159677
VCL vinculin -0.155974
NAMPT nicotinamide phosphoribosyltransferase -0.126937
SOD2 superoxide dismutase 2, mitochondrial -0.118709
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.106676
FNDC3B fibronectin type III domain containing 3B -0.0827859
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0824397
BICC1 BicC family RNA binding protein 1 -0.0800518
DST dystonin -0.0785533
KYNU kynureninase -0.0763151
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0715601
EXT1 exostosin glycosyltransferase 1 -0.0653875
CD44 CD44 molecule (Indian blood group) -0.0642872
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0633841
TRIO trio Rho guanine nucleotide exchange factor -0.0616352
TMSB10 thymosin beta 10 -0.0603078
ELL2 elongation factor, RNA polymerase II, 2 -0.0571937
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0565713
MT2A metallothionein 2A -0.0562604
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0552315
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0541544
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.053965
IER3 immediate early response 3 -0.0525966
NABP1 nucleic acid binding protein 1 -0.052268
SPAG9 sperm associated antigen 9 -0.0520313
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0514397
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0499537
HLA-B major histocompatibility complex, class I, B -0.0498181
PDE10A phosphodiesterase 10A -0.0492769
PTMA prothymosin, alpha -0.0474041
TPT1 tumor protein, translationally-controlled 1 -0.0467053
RPS24 ribosomal protein S24 -0.0459723
RIGI RNA sensor RIG-I -0.0454959
LAMP2 lysosomal-associated membrane protein 2 -0.0452561
NAV1 neuron navigator 1 -0.0444642
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0440734
GLIS3 GLIS family zinc finger 3 -0.0430318
CLTC clathrin, heavy chain (Hc) -0.041267
RPS2 ribosomal protein S2 -0.0411361
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0401934
RTN4 reticulon 4 -0.0396853
IGFBP7 insulin-like growth factor binding protein 7 -0.0393457
PSD3 pleckstrin and Sec7 domain containing 3 -0.0377208
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0376159
ZFAND3 zinc finger, AN1-type domain 3 -0.0372363
FRMD5 FERM domain containing 5 -0.0369421
DUSP5 dual specificity phosphatase 5 -0.0369391
UBC ubiquitin C -0.0368833
PALLD palladin, cytoskeletal associated protein -0.0366107
SBF2 SET binding factor 2 -0.0364498
MYOF myoferlin -0.036226
JMJD1C jumonji domain containing 1C -0.0358751
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0358158
OSMR oncostatin M receptor -0.0350685
CLIC4 chloride intracellular channel 4 -0.0350636
THBS1 thrombospondin 1 -0.0346996
TOP2A topoisomerase (DNA) II alpha 170kDa -0.03414
VMP1 vacuole membrane protein 1 -0.0340228
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.033964
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0334529
MKI67 marker of proliferation Ki-67 -0.0333685
SLC38A2 solute carrier family 38, member 2 -0.0329282
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0327829
ANKRD12 ankyrin repeat domain 12 -0.0327509
COL1A1 collagen, type I, alpha 1 -0.0325182
NAV2 neuron navigator 2 -0.0324434
BCAR3 breast cancer anti-estrogen resistance 3 -0.032053
TRIP12 thyroid hormone receptor interactor 12 -0.0317646
BIRC2 baculoviral IAP repeat containing 2 -0.031421
FBXO11 F-box protein 11 -0.0311654
SYAP1 synapse associated protein 1 -0.0308405
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0303565
RPS8 ribosomal protein S8 -0.0303267
PTPRK protein tyrosine phosphatase, receptor type, K -0.0302537
FMN1 formin 1 -0.030052
SMYD3 SET and MYND domain containing 3 -0.0293604
CENPF centromere protein F, 350/400kDa -0.0291547
PLPP6 phospholipid phosphatase 6 -0.0289781
CDCP1 CUB domain containing protein 1 -0.0287001
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0285744
RPL19 ribosomal protein L19 -0.028571
NF1 neurofibromin 1 -0.0284901
RBM39 RNA binding motif protein 39 -0.0284642
ZNFX1 zinc finger, NFX1-type containing 1 -0.0284084
TGFBI transforming growth factor, beta-induced, 68kDa -0.0283661
RPL32 ribosomal protein L32 -0.0283384
CD59 CD59 molecule, complement regulatory protein -0.0280278
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0279534
MAPK8 mitogen-activated protein kinase 8 -0.0278415
MAML2 mastermind-like 2 (Drosophila) -0.0277118
PLSCR1 phospholipid scramblase 1 -0.0277085
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0276679
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0274713
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0274012
FNIP1 folliculin interacting protein 1 -0.0270494
RPS6 ribosomal protein S6 -0.0269059
RPLP2 ribosomal protein, large, P2 -0.0268174
HMGA2 high mobility group AT-hook 2 -0.0266563
TNIP1 TNFAIP3 interacting protein 1 -0.0263316