Ralimetinib dimesylate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.132151
TRIO trio Rho guanine nucleotide exchange factor 0.0937013
NAV2 neuron navigator 2 0.0709222
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0665211
AUTS2 autism susceptibility candidate 2 0.0656551
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0609006
ATP13A3 ATPase type 13A3 0.0606238
FBN1 fibrillin 1 0.059925
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0503744
PRELID2 PRELI domain containing 2 0.0468575
FBXL7 F-box and leucine-rich repeat protein 7 0.0451829
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0441779
DST dystonin 0.0407993
STAT1 signal transducer and activator of transcription 1, 91kDa 0.040474
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0403142
DTNA dystrobrevin, alpha 0.0397774
GPC6 glypican 6 0.0367958
HDAC9 histone deacetylase 9 0.035547
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0347754
SOD2 superoxide dismutase 2, mitochondrial 0.0330878
FNDC3B fibronectin type III domain containing 3B 0.0317691
SBF2 SET binding factor 2 0.031627
ABI1 abl-interactor 1 0.0316191
MXI1 MAX interactor 1, dimerization protein 0.0312155
OGA O-GlcNAcase 0.030234
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0302119
GLS2 glutaminase 2 (liver, mitochondrial) 0.0301093
SOX9 SRY (sex determining region Y)-box 9 0.0300779
CYLD cylindromatosis (turban tumor syndrome) 0.0300649
SQSTM1 sequestosome 1 0.0300609
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0300545
NFE2L1 nuclear factor, erythroid 2-like 1 0.0297493
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0292566
DENND5A DENN/MADD domain containing 5A 0.0285542
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0276367
ZEB1 zinc finger E-box binding homeobox 1 0.0273417
PSD3 pleckstrin and Sec7 domain containing 3 0.0271478
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0267813
FMNL2 formin-like 2 0.0267006
YEATS2 YEATS domain containing 2 0.0266161
SDK1 sidekick cell adhesion molecule 1 0.0262734
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0259001
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0258014
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0249431
FNIP1 folliculin interacting protein 1 0.0246934
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0246639
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0242076
ARHGAP21 Rho GTPase activating protein 21 0.024148
PICALM phosphatidylinositol binding clathrin assembly protein 0.023503
DPYSL3 dihydropyrimidinase-like 3 0.0225475
FLNA filamin A, alpha 0.0224362
AFDN afadin, adherens junction formation factor 0.0220891
SSBP2 single-stranded DNA binding protein 2 0.0220665
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0216466
KDM3A lysine (K)-specific demethylase 3A 0.0215103
KIAA1217 KIAA1217 0.0214124
FBXL2 F-box and leucine-rich repeat protein 2 0.0213707
ANK2 ankyrin 2, neuronal 0.0212905
BHLHE40 basic helix-loop-helix family, member e40 0.0211147
CERT1 ceramide transporter 1 0.0210823
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0210273
RICTOR RPTOR independent companion of MTOR, complex 2 0.0208823
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0207371
ZBTB20 zinc finger and BTB domain containing 20 0.0206785
ANKRD10 ankyrin repeat domain 10 0.0203163
ATXN1 ataxin 1 0.020293
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.019998
ZNF292 zinc finger protein 292 0.0198825
ANKIB1 ankyrin repeat and IBR domain containing 1 0.01979
ZMIZ1 zinc finger, MIZ-type containing 1 0.0197766
WDFY1 WD repeat and FYVE domain containing 1 0.0192055
APP amyloid beta (A4) precursor protein 0.0191452
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0191429
MATR3 matrin 3 0.0190066
ZEB2 zinc finger E-box binding homeobox 2 0.0189997
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0189978
KIF13A kinesin family member 13A 0.018986
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0189167
AMPD3 adenosine monophosphate deaminase 3 0.0187661
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0186542
NAP1L1 nucleosome assembly protein 1-like 1 0.0186347
ANKRD36 ankyrin repeat domain 36 0.01861
NEK7 NIMA-related kinase 7 0.0185408
SUCO SUN domain containing ossification factor 0.0185127
MIMS1 mitochondrial inner membrane scaffold 1 0.0184635
RUNX1 runt-related transcription factor 1 0.0183984
MMP12 matrix metallopeptidase 12 0.018359
TDRD7 tudor domain containing 7 0.0183103
CDC73 cell division cycle 73 0.0182041
UBQLN1 ubiquilin 1 0.0182018
AVL9 AVL9 homolog (S. cerevisiase) 0.0181711
LRRC49 leucine rich repeat containing 49 0.0179874
HELZ helicase with zinc finger 0.0179167
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0177946
SON SON DNA binding protein 0.0176329
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.017585
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0174636
NCKAP1 NCK-associated protein 1 0.0174079
XRN1 5'-3' exoribonuclease 1 0.0172749
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.017087

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.425376
IGFBP3 insulin-like growth factor binding protein 3 -0.235642
VIM vimentin -0.235003
TMSB10 thymosin beta 10 -0.181684
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.181442
MT2A metallothionein 2A -0.164965
S100A10 S100 calcium binding protein A10 -0.131919
PLAT plasminogen activator, tissue -0.0980931
HLA-B major histocompatibility complex, class I, B -0.094414
AKAP12 A kinase (PRKA) anchor protein 12 -0.0829229
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0687533
NDRG1 N-myc downstream regulated 1 -0.0662927
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0659507
NAV1 neuron navigator 1 -0.0627598
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0594787
LOC112694756 uncharaterized LOC112694756 -0.0572124
B2M beta-2-microglobulin -0.0561182
S100A6 S100 calcium binding protein A6 -0.0559089
MT1X metallothionein 1X -0.0552875
MAP1B microtubule-associated protein 1B -0.0532808
CD44 CD44 molecule (Indian blood group) -0.0529342
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0511244
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0510762
IFITM1 interferon induced transmembrane protein 1 -0.0482466
TPM4 tropomyosin 4 -0.0474371
CSTB cystatin B (stefin B) -0.0470139
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0468816
CD99 CD99 molecule -0.0465968
SLC38A1 solute carrier family 38, member 1 -0.046383
ANXA2 annexin A2 -0.0463534
UBC ubiquitin C -0.0462467
ACTG1 actin gamma 1 -0.0456905
HLA-C major histocompatibility complex, class I, C -0.0449579
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0427849
IFITM3 interferon induced transmembrane protein 3 -0.0424739
PODXL podocalyxin-like -0.041385
EIF1 eukaryotic translation initiation factor 1 -0.0411622
PRSS23 protease, serine, 23 -0.0407888
LMNA lamin A/C -0.0398732
TAGLN2 transgelin 2 -0.0397942
FN1 fibronectin 1 -0.0391935
RPL28 ribosomal protein L28 -0.0387757
FTL ferritin, light polypeptide -0.0375063
WWTR1 WW domain containing transcription regulator 1 -0.0371527
S100A11 S100 calcium binding protein A11 -0.0369328
CDH13 cadherin 13 -0.0367516
GLIS3 GLIS family zinc finger 3 -0.0359167
FSTL1 follistatin-like 1 -0.0357797
POTEF POTE ankyrin domain family, member F -0.03545
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0352332
RTN4 reticulon 4 -0.0350753
AHNAK AHNAK nucleoprotein -0.0348992
LOX lysyl oxidase -0.0345525
TM4SF1 transmembrane 4 L six family member 1 -0.034344
CANX calnexin -0.0343216
RPLP1 ribosomal protein, large, P1 -0.034009
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0337652
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0334662
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0333977
STC1 stanniocalcin 1 -0.0322266
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0322113
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0321428
BSG basigin (Ok blood group) -0.0317526
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0317171
RPS6 ribosomal protein S6 -0.0311038
RPL35A ribosomal protein L35a -0.0304383
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0303136
EXT1 exostosin glycosyltransferase 1 -0.0301612
RPS11 ribosomal protein S11 -0.029429
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0290648
CTSB cathepsin B -0.0286967
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0286758
GNAS GNAS complex locus -0.0286432
HSPB1 heat shock 27kDa protein 1 -0.0285293
EFNA5 ephrin-A5 -0.0280695
HLA-A major histocompatibility complex, class I, A -0.0278428
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0278359
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0278178
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0277339
PKM pyruvate kinase, muscle -0.0275293
COL5A1 collagen, type V, alpha 1 -0.027265
RPLP2 ribosomal protein, large, P2 -0.0270708
RPL32 ribosomal protein L32 -0.0270384
H3-3B H3.3 histone B -0.0269962
RPS15 ribosomal protein S15 -0.0268737
RRBP1 ribosome binding protein 1 -0.0268515
ACTN4 actinin, alpha 4 -0.026764
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.026758
FBXO11 F-box protein 11 -0.0266697
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0265038
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.026278
PFN1 profilin 1 -0.026114
RPS23 ribosomal protein S23 -0.0260983
CD81 CD81 molecule -0.0260559
TUBB4B tubulin, beta 4B class IVb -0.0260144
PTMA prothymosin, alpha -0.0259064
DGKG diacylglycerol kinase, gamma 90kDa -0.0257203
SUCNR1 succinate receptor 1 -0.0257009
ARF1 ADP-ribosylation factor 1 -0.0255732
S100A9 S100 calcium binding protein A9 -0.0254116