| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS12 | ribosomal protein S12 | 0.0601289 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0564231 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0547915 |
| RPL37A | ribosomal protein L37a | 0.036149 |
| RPS3 | ribosomal protein S3 | 0.0357025 |
| WWOX | WW domain containing oxidoreductase | 0.0354078 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0349859 |
| PCDH9 | protocadherin 9 | 0.0319831 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0312717 |
| TMEM41B | transmembrane protein 41B | 0.030582 |
| PDGFC | platelet derived growth factor C | 0.0297451 |
| RPL23 | ribosomal protein L23 | 0.0277324 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0274461 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0261342 |
| TMSB10 | thymosin beta 10 | 0.0260915 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0257406 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0242391 |
| GASK1B | golgi associated kinase 1B | 0.0238994 |
| PRELID2 | PRELI domain containing 2 | 0.0235991 |
| TNPO1 | transportin 1 | 0.0229786 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0225363 |
| BCHE | butyrylcholinesterase | 0.0219772 |
| SMYD3 | SET and MYND domain containing 3 | 0.0216787 |
| RPL37 | ribosomal protein L37 | 0.0212596 |
| RPS17 | ribosomal protein S17 | 0.0210462 |
| RPS7 | ribosomal protein S7 | 0.0209826 |
| RPL26 | ribosomal protein L26 | 0.0203999 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0199937 |
| RPL9 | ribosomal protein L9 | 0.0194547 |
| RPS8 | ribosomal protein S8 | 0.0191809 |
| RPL36 | ribosomal protein L36 | 0.019046 |
| NFIA | nuclear factor I/A | 0.0188843 |
| OGA | O-GlcNAcase | 0.0187735 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0187645 |
| HMGB2 | high mobility group box 2 | 0.0183338 |
| RPS19 | ribosomal protein S19 | 0.0180798 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0179488 |
| MTAP | methylthioadenosine phosphorylase | 0.0179357 |
| KLF6 | Kruppel-like factor 6 | 0.0178361 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.0177316 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0176871 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0174953 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.01734 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0171852 |
| EPHA6 | EPH receptor A6 | 0.0170999 |
| NRXN3 | neurexin 3 | 0.0170449 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.0165361 |
| E2F7 | E2F transcription factor 7 | 0.0160547 |
| PNN | pinin, desmosome associated protein | 0.0160263 |
| ATP11A | ATPase, class VI, type 11A | 0.0159715 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.015763 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0157276 |
| FANCL | Fanconi anemia, complementation group L | 0.0156601 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0155221 |
| MATR3 | matrin 3 | 0.0155119 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0154358 |
| RPL12 | ribosomal protein L12 | 0.015359 |
| CISD1 | CDGSH iron sulfur domain 1 | 0.0152967 |
| NEGR1 | neuronal growth regulator 1 | 0.0149187 |
| YAP1 | Yes-associated protein 1 | 0.014858 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0147677 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0147485 |
| SET | SET nuclear proto-oncogene | 0.0144966 |
| MEF2C | myocyte enhancer factor 2C | 0.0143023 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0141612 |
| THOC1 | THO complex 1 | 0.0140635 |
| PTMA | prothymosin, alpha | 0.0140458 |
| YBX3 | Y box binding protein 3 | 0.0137801 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0135583 |
| RPL7 | ribosomal protein L7 | 0.0135245 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | 0.0134313 |
| CIP2A | cellular inhibitor of PP2A | 0.0133737 |
| RPL18 | ribosomal protein L18 | 0.0132478 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0128436 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0126052 |
| EDARADD | EDAR-associated death domain | 0.0125645 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0125403 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0124065 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0123133 |
| ZNF326 | zinc finger protein 326 | 0.0122421 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0121802 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0121737 |
| PTMS | parathymosin | 0.0121391 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0121315 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0121191 |
| EIF3I | eukaryotic translation initiation factor 3, subunit I | 0.0120463 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0120167 |
| SERINC1 | serine incorporator 1 | 0.0120043 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.011943 |
| NCKAP1 | NCK-associated protein 1 | 0.0118072 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0117936 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0117768 |
| NUP54 | nucleoporin 54kDa | 0.0117213 |
| MKI67 | marker of proliferation Ki-67 | 0.011658 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0116036 |
| RPLP2 | ribosomal protein, large, P2 | 0.0115824 |
| NEMF | nuclear export mediator factor | 0.0115579 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0115011 |
| METTL15 | methyltransferase like 15 | 0.0114647 |
| CEP152 | centrosomal protein 152kDa | 0.0112717 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.34959 |
| AREG | amphiregulin | -0.150918 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.123184 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.122793 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0924595 |
| MMP12 | matrix metallopeptidase 12 | -0.0816907 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0813605 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0760424 |
| ACTG1 | actin gamma 1 | -0.0746517 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0724727 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0663286 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.061415 |
| CCN2 | cellular communication network factor 2 | -0.0607945 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0583303 |
| USP34 | ubiquitin specific peptidase 34 | -0.0578523 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0541963 |
| FBXO11 | F-box protein 11 | -0.0526991 |
| RASAL2 | RAS protein activator like 2 | -0.0519543 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0505374 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0481855 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0478901 |
| CLDN1 | claudin 1 | -0.0474573 |
| POTEF | POTE ankyrin domain family, member F | -0.0459234 |
| ANXA1 | annexin A1 | -0.0455521 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0454832 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0441467 |
| ERBIN | erbb2 interacting protein | -0.0425759 |
| EGR1 | early growth response 1 | -0.0421412 |
| HMGA1 | high mobility group AT-hook 1 | -0.0419524 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0413472 |
| UBC | ubiquitin C | -0.0400707 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0394489 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0388562 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0386661 |
| RHOA | ras homolog family member A | -0.0385804 |
| TGM2 | transglutaminase 2 | -0.0385787 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0373836 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0373243 |
| TAOK1 | TAO kinase 1 | -0.0373117 |
| RAB10 | RAB10, member RAS oncogene family | -0.0353615 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0352509 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0352391 |
| SYT1 | synaptotagmin I | -0.0346155 |
| AHNAK | AHNAK nucleoprotein | -0.0345852 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0342036 |
| PCBP2 | poly(rC) binding protein 2 | -0.0336587 |
| NLGN1 | neuroligin 1 | -0.0336098 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0335399 |
| GSK3B | glycogen synthase kinase 3 beta | -0.033083 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0329016 |
| ADIPOR2 | adiponectin receptor 2 | -0.0322302 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.032037 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.031939 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0318418 |
| PFN1 | profilin 1 | -0.0315871 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0315707 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0315292 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0308878 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0306065 |
| RPL8 | ribosomal protein L8 | -0.0302972 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0301798 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0298092 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0297935 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0297302 |
| EHBP1 | EH domain binding protein 1 | -0.0295238 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.029241 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0290132 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0289887 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0286654 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0285917 |
| PLK2 | polo-like kinase 2 | -0.0280664 |
| LMO7 | LIM domain 7 | -0.027583 |
| NF1 | neurofibromin 1 | -0.0275525 |
| TXNRD1 | thioredoxin reductase 1 | -0.0274527 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0273246 |
| PTK2 | protein tyrosine kinase 2 | -0.0271965 |
| SRPK2 | SRSF protein kinase 2 | -0.0269299 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0268845 |
| ACLY | ATP citrate lyase | -0.0265914 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0262023 |
| SPAG9 | sperm associated antigen 9 | -0.0262003 |
| H1-0 | H1.0 linker histone | -0.0261901 |
| MAP4 | microtubule-associated protein 4 | -0.0261723 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.026047 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0259158 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0259015 |
| RBMX | RNA binding motif protein, X-linked | -0.0257751 |
| BPTF | bromodomain PHD finger transcription factor | -0.025708 |
| ATF6 | activating transcription factor 6 | -0.0256372 |
| EGFR | epidermal growth factor receptor | -0.025444 |
| RNF213 | ring finger protein 213 | -0.0254037 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0252997 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0251896 |
| SETX | senataxin | -0.0247354 |
| HSPA4 | heat shock 70kDa protein 4 | -0.0246955 |
| PGK1 | phosphoglycerate kinase 1 | -0.0245183 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0244505 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.024393 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0243534 |
| FAM168A | family with sequence similarity 168, member A | -0.0242783 |
