| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ralimetinib dimesylate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0573931 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0563703 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0558342 |
| SMAD3 | SMAD family member 3 | 0.0502657 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0463611 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0427254 |
| IRS2 | insulin receptor substrate 2 | 0.0425243 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0421194 |
| DENND2B | DENN domain containing 2B | 0.0417893 |
| FLNA | filamin A, alpha | 0.0379987 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.036447 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0342392 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0342057 |
| NFIB | nuclear factor I/B | 0.0329635 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0327643 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0314426 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0312959 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0309378 |
| ANKRD33B | ankyrin repeat domain 33B | 0.030546 |
| WDR43 | WD repeat domain 43 | 0.0287018 |
| RPS12 | ribosomal protein S12 | 0.0286413 |
| ATP13A3 | ATPase type 13A3 | 0.028143 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0279137 |
| APP | amyloid beta (A4) precursor protein | 0.0278973 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.027393 |
| RPL37A | ribosomal protein L37a | 0.0271405 |
| RPS17 | ribosomal protein S17 | 0.0252976 |
| CHMP5 | charged multivesicular body protein 5 | 0.0248127 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0246037 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0238848 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0234208 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0233703 |
| CAVIN1 | caveolae associated protein 1 | 0.0226985 |
| RUNX1 | runt-related transcription factor 1 | 0.0224245 |
| LMNA | lamin A/C | 0.0223916 |
| RPL26 | ribosomal protein L26 | 0.0223288 |
| RPS3 | ribosomal protein S3 | 0.0217478 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0215195 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0213323 |
| CCDC146 | coiled-coil domain containing 146 | 0.0211955 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0211198 |
| RPS7 | ribosomal protein S7 | 0.0209183 |
| SAA2-SAA4 | SAA2-SAA4 readthrough | 0.0207049 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0205686 |
| ARRDC3 | arrestin domain containing 3 | 0.020329 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0201059 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0200645 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0199238 |
| HMGB2 | high mobility group box 2 | 0.0197837 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0197779 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0196465 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0194703 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0191084 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0188941 |
| RNF220 | ring finger protein 220 | 0.0187495 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0187043 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0186766 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0185878 |
| RPL12 | ribosomal protein L12 | 0.0183705 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0182605 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0181853 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0181247 |
| SET | SET nuclear proto-oncogene | 0.0180649 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0180465 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0180275 |
| SLFN5 | schlafen family member 5 | 0.0175712 |
| RIPK4 | receptor-interacting serine-threonine kinase 4 | 0.0175154 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0173988 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0173509 |
| NIBAN1 | niban apoptosis regulator 1 | 0.01723 |
| ETV6 | ets variant 6 | 0.0170117 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0169957 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0169749 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0166874 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0165156 |
| EFR3A | EFR3 homolog A (S. cerevisiae) | 0.0164891 |
| FNDC3B | fibronectin type III domain containing 3B | 0.016306 |
| VCAN | versican | 0.0162475 |
| CSNK1G1 | casein kinase 1, gamma 1 | 0.0161526 |
| LRRC49 | leucine rich repeat containing 49 | 0.0161454 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0158209 |
| ZNF608 | zinc finger protein 608 | 0.0156997 |
| ITSN2 | intersectin 2 | 0.0156609 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0156217 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0156134 |
| FNBP1L | formin binding protein 1-like | 0.0154891 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0153893 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0153049 |
| ABI1 | abl-interactor 1 | 0.0151345 |
| ATXN10 | ataxin 10 | 0.0149986 |
| PTK2 | protein tyrosine kinase 2 | 0.014835 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0148288 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0147132 |
| RPL13A | ribosomal protein L13a | 0.0146468 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0145978 |
| FAM13A | family with sequence similarity 13, member A | 0.0145932 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.0145315 |
| SAA2 | serum amyloid A2 | 0.0145129 |
| HPCAL1 | hippocalcin-like 1 | 0.0144955 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0144951 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.406024 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.251833 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.236791 |
| ASPH | aspartate beta-hydroxylase | -0.131895 |
| POTEF | POTE ankyrin domain family, member F | -0.128503 |
| FTL | ferritin, light polypeptide | -0.117368 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.1057 |
| UBC | ubiquitin C | -0.102564 |
| FRMD4A | FERM domain containing 4A | -0.09802 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0950817 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.094972 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0911937 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0882171 |
| MAP1B | microtubule-associated protein 1B | -0.0822711 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0816585 |
| VIM | vimentin | -0.0770534 |
| GPC6 | glypican 6 | -0.0741512 |
| CD44 | CD44 molecule (Indian blood group) | -0.0735152 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0675315 |
| NDRG1 | N-myc downstream regulated 1 | -0.0671782 |
| PFN1 | profilin 1 | -0.0670035 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0643304 |
| RPS6 | ribosomal protein S6 | -0.0590462 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0587619 |
| RTN4 | reticulon 4 | -0.0576515 |
| RAI14 | retinoic acid induced 14 | -0.0569581 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.056639 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0548769 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0542299 |
| CANX | calnexin | -0.0507363 |
| S100A10 | S100 calcium binding protein A10 | -0.0493997 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0490195 |
| GLIS3 | GLIS family zinc finger 3 | -0.048379 |
| ACTG1 | actin gamma 1 | -0.0472844 |
| CTSD | cathepsin D | -0.0466838 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0434678 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0428282 |
| ADM | adrenomedullin | -0.0428086 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0426359 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0425499 |
| TUBA1B | tubulin, alpha 1b | -0.0419094 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0414387 |
| GDF15 | growth differentiation factor 15 | -0.0413904 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0406854 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0405945 |
| TPM4 | tropomyosin 4 | -0.0399936 |
| RPL8 | ribosomal protein L8 | -0.039491 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0394189 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0384868 |
| HLA-B | major histocompatibility complex, class I, B | -0.0383569 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0376702 |
| PKM | pyruvate kinase, muscle | -0.0369276 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0366219 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.03589 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | -0.0357521 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0354569 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.035194 |
| CALR | calreticulin | -0.0347195 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0345281 |
| PLIN2 | perilipin 2 | -0.0342829 |
| RND3 | Rho family GTPase 3 | -0.0342039 |
| G0S2 | G0/G1 switch 2 | -0.0336127 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0333565 |
| CXXC1 | CXXC finger protein 1 | -0.0332863 |
| ELOVL5 | ELOVL fatty acid elongase 5 | -0.0332812 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.033225 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0330217 |
| INSIG1 | insulin induced gene 1 | -0.0326724 |
| FN1 | fibronectin 1 | -0.0324323 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0318398 |
| VCL | vinculin | -0.031273 |
| ARF1 | ADP-ribosylation factor 1 | -0.0307978 |
| ADAR | adenosine deaminase, RNA-specific | -0.0306751 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.030056 |
| PRKCA | protein kinase C, alpha | -0.0299166 |
| FAT1 | FAT atypical cadherin 1 | -0.0296475 |
| ACLY | ATP citrate lyase | -0.0292795 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0292124 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0289113 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0287123 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0285353 |
| SETX | senataxin | -0.0284391 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0283954 |
| CDCP1 | CUB domain containing protein 1 | -0.0281312 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.027644 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0275455 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0275001 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.0273438 |
| RPS11 | ribosomal protein S11 | -0.027292 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.0272843 |
| RPS23 | ribosomal protein S23 | -0.027131 |
| ITM2B | integral membrane protein 2B | -0.0270964 |
| SQSTM1 | sequestosome 1 | -0.0269072 |
| TMEM263 | transmembrane protein 263 | -0.0265549 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0265153 |
| OPTN | optineurin | -0.0264356 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0263318 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0259827 |
| TAPBP | TAP binding protein (tapasin) | -0.0259112 |
| RPL35A | ribosomal protein L35a | -0.0258952 |
