| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.195819 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.141162 |
| RPL23 | ribosomal protein L23 | 0.0710041 |
| VMP1 | vacuole membrane protein 1 | 0.0584499 |
| DTNA | dystrobrevin, alpha | 0.0578545 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | 0.0521035 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0518934 |
| ASPH | aspartate beta-hydroxylase | 0.0511924 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0487864 |
| RPS3 | ribosomal protein S3 | 0.0485221 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0472142 |
| YPEL2 | yippee-like 2 (Drosophila) | 0.0435887 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0425482 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0414904 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0391497 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0378486 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0370557 |
| RPL19 | ribosomal protein L19 | 0.0365536 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0331374 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.032277 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0322555 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0320257 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0313662 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0306524 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0304739 |
| FOXP1 | forkhead box P1 | 0.0296135 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | 0.0290773 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0288879 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.028306 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0275789 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0273738 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0271991 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0268296 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0267314 |
| PRKD1 | protein kinase D1 | 0.0264565 |
| RPS12 | ribosomal protein S12 | 0.0263661 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0262346 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0260057 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0253874 |
| TENM2 | teneurin transmembrane protein 2 | 0.0252324 |
| ATXN1 | ataxin 1 | 0.0251343 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0250873 |
| AUTS2 | autism susceptibility candidate 2 | 0.0248896 |
| RAI1 | retinoic acid induced 1 | 0.024596 |
| MACROD2 | MACRO domain containing 2 | 0.0245511 |
| ITGB6 | integrin, beta 6 | 0.0244348 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0243177 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0239656 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0238567 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0237988 |
| TTC6 | tetratricopeptide repeat domain 6 | 0.02262 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0220447 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0218332 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0209359 |
| BPTF | bromodomain PHD finger transcription factor | 0.0207822 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0207333 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0204324 |
| RPS17 | ribosomal protein S17 | 0.0199986 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0197119 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0196663 |
| RPL12 | ribosomal protein L12 | 0.0194632 |
| SMIM14 | small integral membrane protein 14 | 0.0192482 |
| NFIA | nuclear factor I/A | 0.0191828 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0190359 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | 0.0188945 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0187951 |
| TMC5 | transmembrane channel-like 5 | 0.018755 |
| TC2N | tandem C2 domains, nuclear | 0.0186482 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0184057 |
| INSR | insulin receptor | 0.0183876 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0183589 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0175752 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0175616 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.017529 |
| CD47 | CD47 molecule | 0.0175101 |
| DENND2B | DENN domain containing 2B | 0.0174768 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0172091 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0167438 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0166527 |
| CEP250 | centrosomal protein 250kDa | 0.0164077 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0163016 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.016284 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0162556 |
| SIDT1 | SID1 transmembrane family, member 1 | 0.0161919 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0161607 |
| TMSB10 | thymosin beta 10 | 0.0160228 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0159672 |
| STAU2 | staufen double-stranded RNA binding protein 2 | 0.0157172 |
| SYTL2 | synaptotagmin-like 2 | 0.0156347 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0156135 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.015582 |
| TNNC1 | troponin C type 1 (slow) | 0.0155191 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.014984 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0147823 |
| FOXA1 | forkhead box A1 | 0.0147341 |
| NRCAM | neuronal cell adhesion molecule | 0.0145921 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0144622 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0144123 |
| NEBL | nebulette | 0.0143801 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0143644 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204746 |
| ACTG1 | actin gamma 1 | -0.133568 |
| NDRG1 | N-myc downstream regulated 1 | -0.112585 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.109123 |
| CLTC | clathrin, heavy chain (Hc) | -0.0857217 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0721492 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0670355 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0590867 |
| UBC | ubiquitin C | -0.0560373 |
| POTEF | POTE ankyrin domain family, member F | -0.0545018 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0537416 |
| CDK12 | cyclin-dependent kinase 12 | -0.0512834 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0479544 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0477125 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0473775 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0457435 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0451865 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0402103 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0400593 |
| PTMA | prothymosin, alpha | -0.03991 |
| TPD52 | tumor protein D52 | -0.0386859 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0385499 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0375757 |
| CCND1 | cyclin D1 | -0.0370952 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0362632 |
| VEGFA | vascular endothelial growth factor A | -0.0356607 |
| GOLGA4 | golgin A4 | -0.0352252 |
| TMEM123 | transmembrane protein 123 | -0.0346513 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0343583 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.033416 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0333823 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0331536 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0329462 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0329385 |
| TMSB4X | thymosin beta 4, X-linked | -0.0326773 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0326727 |
| PRR11 | proline rich 11 | -0.032621 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0323194 |
| RPS2 | ribosomal protein S2 | -0.0323133 |
| WASF2 | WAS protein family, member 2 | -0.0322227 |
| KRT19 | keratin 19, type I | -0.032152 |
| TMEM165 | transmembrane protein 165 | -0.0320541 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0317122 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0316226 |
| PFDN4 | prefoldin subunit 4 | -0.0312805 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0312585 |
| DSTN | destrin (actin depolymerizing factor) | -0.030883 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0301256 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0297639 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0292127 |
| VCL | vinculin | -0.0288709 |
| RRBP1 | ribosome binding protein 1 | -0.0287331 |
| TPM4 | tropomyosin 4 | -0.0285308 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0284544 |
| SBF2 | SET binding factor 2 | -0.0278648 |
| CANX | calnexin | -0.0274763 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0272896 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | -0.0269787 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0268549 |
| RPL8 | ribosomal protein L8 | -0.0267361 |
| WAC | WW domain containing adaptor with coiled-coil | -0.026654 |
| ADAR | adenosine deaminase, RNA-specific | -0.0263613 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0263611 |
| KRT7 | keratin 7, type II | -0.0263064 |
| TMEM263 | transmembrane protein 263 | -0.0261635 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0260122 |
| S100A9 | S100 calcium binding protein A9 | -0.0259349 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0257435 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0257293 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.025723 |
| COPA | coatomer protein complex, subunit alpha | -0.025547 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0255328 |
| NAA50 | N(alpha)-acetyltransferase 50, NatE catalytic subunit | -0.0255073 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0252242 |
| H1-0 | H1.0 linker histone | -0.0250631 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0249833 |
| INSIG1 | insulin induced gene 1 | -0.0249385 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0248761 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.02487 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0244565 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0244139 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0238787 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0236272 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.023507 |
| DSPP | dentin sialophosphoprotein | -0.0234904 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0233818 |
| ACTN4 | actinin, alpha 4 | -0.0233062 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0232691 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0230985 |
| TOB1 | transducer of ERBB2, 1 | -0.0230018 |
| INHBA | inhibin, beta A | -0.0229962 |
| VCP | valosin containing protein | -0.0229951 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0228144 |
| CTTN | cortactin | -0.0227366 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0226158 |
| F11R | F11 receptor | -0.022605 |
| FBXO11 | F-box protein 11 | -0.0223916 |
| DSG2 | desmoglein 2 | -0.0219096 |
| KRT86 | keratin 86, type II | -0.0218534 |
| CALU | calumenin | -0.0217999 |
