| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0532552 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0417525 |
| TRERF1 | transcriptional regulating factor 1 | 0.0416309 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0416045 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0407058 |
| HKDC1 | hexokinase domain containing 1 | 0.032444 |
| ATXN1 | ataxin 1 | 0.0281078 |
| MCU | mitochondrial calcium uniporter | 0.0250997 |
| SEPTIN9 | septin 9 | 0.0240179 |
| USP54 | ubiquitin specific peptidase 54 | 0.0230317 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0222198 |
| RAD51B | RAD51 paralog B | 0.0210504 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0205591 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.020013 |
| SMAD3 | SMAD family member 3 | 0.0194419 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0193165 |
| PRELID2 | PRELI domain containing 2 | 0.019313 |
| NCKAP5 | NCK-associated protein 5 | 0.0191123 |
| SERINC5 | serine incorporator 5 | 0.018761 |
| RGS6 | regulator of G-protein signaling 6 | 0.0185545 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.0183528 |
| INTS6 | integrator complex subunit 6 | 0.0176935 |
| RASEF | RAS and EF-hand domain containing | 0.0174628 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0173298 |
| SNX29 | sorting nexin 29 | 0.0172675 |
| POF1B | premature ovarian failure, 1B | 0.0169183 |
| SMYD3 | SET and MYND domain containing 3 | 0.0166983 |
| CDHR2 | cadherin-related family member 2 | 0.0163013 |
| DPP4 | dipeptidyl-peptidase 4 | 0.0162492 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0160985 |
| PERP | PERP, TP53 apoptosis effector | 0.0158877 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0153631 |
| LIPH | lipase, member H | 0.0153172 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.0149551 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0149202 |
| WWOX | WW domain containing oxidoreductase | 0.0148824 |
| MAP2K6 | mitogen-activated protein kinase kinase 6 | 0.0148755 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0147211 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0146463 |
| KRT8 | keratin 8, type II | 0.0145789 |
| TMEM241 | transmembrane protein 241 | 0.0144443 |
| JMJD1C | jumonji domain containing 1C | 0.0144153 |
| TMEM65 | transmembrane protein 65 | 0.0140774 |
| GLRX3 | glutaredoxin 3 | 0.0137055 |
| ATM | ATM serine/threonine kinase | 0.0136354 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0135531 |
| GOLM1 | golgi membrane protein 1 | 0.0135472 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0134483 |
| PTPN22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.0133858 |
| ASIC4 | acid sensing (proton gated) ion channel family member 4 | 0.0132066 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0131618 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0130644 |
| IRS2 | insulin receptor substrate 2 | 0.0130097 |
| SET | SET nuclear proto-oncogene | 0.0128773 |
| STX3 | syntaxin 3 | 0.0128345 |
| SLC22A23 | solute carrier family 22, member 23 | 0.012689 |
| SLK | STE20-like kinase | 0.0126879 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0122444 |
| KIAA1217 | KIAA1217 | 0.0122162 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 0.0119874 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0119782 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0119125 |
| RAB30 | RAB30, member RAS oncogene family | 0.0116999 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0116967 |
| PCBP2 | poly(rC) binding protein 2 | 0.0115063 |
| STYXL2 | serine/threonine/tyrosine interacting like 2 | 0.0113793 |
| TOGARAM1 | TOG array regulator of axonemal microtubules 1 | 0.011239 |
| CPT1A | carnitine palmitoyltransferase 1A (liver) | 0.0112125 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0111659 |
| DNAH5 | dynein, axonemal, heavy chain 5 | 0.0111139 |
| TMEM63A | transmembrane protein 63A | 0.0109868 |
| CCDC122 | coiled-coil domain containing 122 | 0.0108655 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0108549 |
| WDR70 | WD repeat domain 70 | 0.0107829 |
| C3ORF52 | chromosome 3 open reading frame 52 | 0.0107504 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0106475 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0105283 |
| MACROD2 | MACRO domain containing 2 | 0.0104908 |
| CDC73 | cell division cycle 73 | 0.0104465 |
| MGLL | monoglyceride lipase | 0.0104398 |
| MCM3 | minichromosome maintenance complex component 3 | 0.0103757 |
| ALG11 | ALG11, alpha-1,2-mannosyltransferase | 0.0102389 |
| GRIPAP1 | GRIP1 associated protein 1 | 0.0100541 |
| NT5DC3 | 5'-nucleotidase domain containing 3 | 0.0100243 |
| CHFR | checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase | 0.00985112 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.00979895 |
| PHF3 | PHD finger protein 3 | 0.00977217 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.009743 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.00972943 |
| NHLRC3 | NHL repeat containing 3 | 0.00970861 |
| GTF2E2 | general transcription factor IIE, polypeptide 2, beta 34kDa | 0.00969515 |
| FNIP1 | folliculin interacting protein 1 | 0.00968406 |
| EPHB2 | EPH receptor B2 | 0.00966423 |
| CORIN | corin, serine peptidase | 0.00960016 |
| MFAP1 | microfibrillar-associated protein 1 | 0.00957097 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00946088 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.00945106 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.00941105 |
| SYNJ2 | synaptojanin 2 | 0.00933786 |
| CD70 | CD70 molecule | 0.00932387 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.153307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127672 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.127005 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.111711 |
| B2M | beta-2-microglobulin | -0.0972966 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0957973 |
| NDRG1 | N-myc downstream regulated 1 | -0.0926834 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0924276 |
| PTMA | prothymosin, alpha | -0.0905954 |
| TXNIP | thioredoxin interacting protein | -0.0815 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0801173 |
| RNF213 | ring finger protein 213 | -0.0763896 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0740172 |
| HLA-B | major histocompatibility complex, class I, B | -0.0734655 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0672081 |
| XAF1 | XIAP associated factor 1 | -0.0631429 |
| AREG | amphiregulin | -0.0618333 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0613383 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0610539 |
| IFNGR1 | interferon gamma receptor 1 | -0.0583827 |
| UBC | ubiquitin C | -0.0578929 |
| RBM39 | RNA binding motif protein 39 | -0.0575755 |
| H1-0 | H1.0 linker histone | -0.0569156 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0552585 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0526734 |
| RPS6 | ribosomal protein S6 | -0.0513129 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0491796 |
| LYZ | lysozyme | -0.0486224 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0485103 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0478272 |
| PKM | pyruvate kinase, muscle | -0.0472554 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0471025 |
| RRBP1 | ribosome binding protein 1 | -0.0462165 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0458747 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0447338 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0445562 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.042635 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0415943 |
| GOLGB1 | golgin B1 | -0.0415363 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0412322 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.040604 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.039393 |
| MX1 | MX dynamin-like GTPase 1 | -0.0391121 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0387242 |
| PLSCR1 | phospholipid scramblase 1 | -0.0386855 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0386653 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0382331 |
| EGR1 | early growth response 1 | -0.0381299 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0372868 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0372073 |
| SP100 | SP100 nuclear antigen | -0.0361235 |
| HLA-C | major histocompatibility complex, class I, C | -0.0361067 |
| SQSTM1 | sequestosome 1 | -0.0357334 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0355329 |
| NF1 | neurofibromin 1 | -0.035446 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0353929 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0353118 |
| SSH2 | slingshot protein phosphatase 2 | -0.0347715 |
| ACTG1 | actin gamma 1 | -0.0343044 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0342654 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0339256 |
| TMSB10 | thymosin beta 10 | -0.0338855 |
| MX2 | MX dynamin-like GTPase 2 | -0.0337717 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0336964 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0333781 |
| ZNF292 | zinc finger protein 292 | -0.0332827 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0332552 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -0.0331001 |
| CCNL1 | cyclin L1 | -0.0330142 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0329372 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0328614 |
| EPCAM | epithelial cell adhesion molecule | -0.0324804 |
| RPL34 | ribosomal protein L34 | -0.0324329 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0322269 |
| RNF43 | ring finger protein 43 | -0.0320647 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0320361 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0312138 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0311972 |
| ADAR | adenosine deaminase, RNA-specific | -0.0310301 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0309856 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0307992 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0307178 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0306086 |
| HM13 | histocompatibility (minor) 13 | -0.0304861 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0303401 |
| RIGI | RNA sensor RIG-I | -0.0301595 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.030105 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0300333 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0299129 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0298389 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0294601 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0294066 |
| GNAS | GNAS complex locus | -0.0293347 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0291814 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0290881 |
| CANX | calnexin | -0.0290804 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0289023 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0288997 |
| FBXO11 | F-box protein 11 | -0.02839 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0283292 |
