Ralimetinib dimesylate_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.177846
STC1 stanniocalcin 1 0.0812638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0794684
DGKD diacylglycerol kinase, delta 130kDa 0.0750137
VIM vimentin 0.0663316
FAM13A family with sequence similarity 13, member A 0.0631991
ANKRD11 ankyrin repeat domain 11 0.0618826
NDRG1 N-myc downstream regulated 1 0.0614977
ASPH aspartate beta-hydroxylase 0.0608362
CREB5 cAMP responsive element binding protein 5 0.0601946
OGA O-GlcNAcase 0.0564201
LDHA lactate dehydrogenase A 0.055933
CXCL8 chemokine (C-X-C motif) ligand 8 0.0538948
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0537933
DST dystonin 0.0533784
ATP13A3 ATPase type 13A3 0.0533409
AVL9 AVL9 homolog (S. cerevisiase) 0.052345
TNNC1 troponin C type 1 (slow) 0.0521082
SMAD3 SMAD family member 3 0.0513986
HELZ helicase with zinc finger 0.0510472
FTL ferritin, light polypeptide 0.0490246
AKAP9 A kinase (PRKA) anchor protein 9 0.04609
CANX calnexin 0.0446704
NAMPT nicotinamide phosphoribosyltransferase 0.0441886
RASA2 RAS p21 protein activator 2 0.0433321
COG5 component of oligomeric golgi complex 5 0.0427345
CD44 CD44 molecule (Indian blood group) 0.0427331
SBF2 SET binding factor 2 0.0390317
FNDC3B fibronectin type III domain containing 3B 0.0386514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0384118
DOCK5 dedicator of cytokinesis 5 0.0366255
GARS1 glycyl-tRNA synthetase 1 0.0364684
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0363669
RTN4 reticulon 4 0.0361941
GOLGB1 golgin B1 0.0351448
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0343643
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0342984
ZNF292 zinc finger protein 292 0.0342004
ZNF395 zinc finger protein 395 0.0340291
LRRC49 leucine rich repeat containing 49 0.034024
SEC23A Sec23 homolog A (S. cerevisiae) 0.033862
GOLGA4 golgin A4 0.0337981
PRRC2C proline-rich coiled-coil 2C 0.0337184
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.033128
MXI1 MAX interactor 1, dimerization protein 0.0328893
DLG1 discs, large homolog 1 (Drosophila) 0.0328234
ENO1 enolase 1, (alpha) 0.0325729
NFE2L1 nuclear factor, erythroid 2-like 1 0.0320724
EEF2 eukaryotic translation elongation factor 2 0.0318919
TXNIP thioredoxin interacting protein 0.031557
SMYD3 SET and MYND domain containing 3 0.0313319
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0312321
SAMD4A sterile alpha motif domain containing 4A 0.0310855
PHF21A PHD finger protein 21A 0.0307323
LPP LIM domain containing preferred translocation partner in lipoma 0.0306263
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0301835
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0301592
ELL2 elongation factor, RNA polymerase II, 2 0.0300642
MBNL1 muscleblind-like splicing regulator 1 0.0294076
SFXN1 sideroflexin 1 0.029388
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0293015
SETD5 SET domain containing 5 0.0292602
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0291381
ALCAM activated leukocyte cell adhesion molecule 0.0290871
RAI1 retinoic acid induced 1 0.0288596
ANXA2 annexin A2 0.0287316
TPM3 tropomyosin 3 0.0284663
KMT2E lysine (K)-specific methyltransferase 2E 0.0284358
CADM1 cell adhesion molecule 1 0.0282507
EGFR epidermal growth factor receptor 0.0281435
RLF rearranged L-myc fusion 0.0281109
MAST4 microtubule associated serine/threonine kinase family member 4 0.0280981
PRELID2 PRELI domain containing 2 0.0278791
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0278558
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0275315
PDIA3 protein disulfide isomerase family A, member 3 0.0272429
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0271806
ANK2 ankyrin 2, neuronal 0.0270988
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0269446
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0268362
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0268296
SPRED1 sprouty-related, EVH1 domain containing 1 0.0267064
ANKRD17 ankyrin repeat domain 17 0.026704
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.026666
AHNAK AHNAK nucleoprotein 0.0265602
GLIS3 GLIS family zinc finger 3 0.0264445
SEC24D SEC24 family member D 0.0263787
BBS9 Bardet-Biedl syndrome 9 0.0263741
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0263111
COPA coatomer protein complex, subunit alpha 0.0260166
SET SET nuclear proto-oncogene 0.0258568
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0256505
WDR26 WD repeat domain 26 0.0255385
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0255244
PRKCSH protein kinase C substrate 80K-H 0.0252677
NAP1L1 nucleosome assembly protein 1-like 1 0.0252176
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0250591
TTC3 tetratricopeptide repeat domain 3 0.0249961
MYH9 myosin, heavy chain 9, non-muscle 0.0247807
SKIC3 SKI3 subunit of superkiller complex 0.0247275

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.402322
FN1 fibronectin 1 -0.223554
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.199458
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.124995
GRB10 growth factor receptor-bound protein 10 -0.123268
NALF1 NALCN channel auxiliary factor 1 -0.118604
COL6A3 collagen, type VI, alpha 3 -0.0896733
HLA-B major histocompatibility complex, class I, B -0.0751293
NLGN1 neuroligin 1 -0.0740053
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0709483
TMSB10 thymosin beta 10 -0.0669257
IGFBP5 insulin-like growth factor binding protein 5 -0.0601432
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0599926
PDE4D phosphodiesterase 4D, cAMP-specific -0.059814
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0584214
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0544062
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0523544
KYNU kynureninase -0.0522433
IGF2 insulin-like growth factor 2 -0.0518686
PRSS23 protease, serine, 23 -0.0509397
NAV1 neuron navigator 1 -0.0484302
RIGI RNA sensor RIG-I -0.0458093
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 -0.0452015
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0377205
IFIH1 interferon induced with helicase C domain 1 -0.0374882
ACTG1 actin gamma 1 -0.0365205
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.036464
CLMP CXADR-like membrane protein -0.0359942
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0358289
WARS1 tryptophanyl-tRNA synthetase 1 -0.0357391
POTEF POTE ankyrin domain family, member F -0.0354039
EXT1 exostosin glycosyltransferase 1 -0.0344539
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0319875
RAB7A RAB7A, member RAS oncogene family -0.0314703
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0312524
SDK1 sidekick cell adhesion molecule 1 -0.0309341
WSB1 WD repeat and SOCS box containing 1 -0.0307365
AHR aryl hydrocarbon receptor -0.0306094
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0302468
AUTS2 autism susceptibility candidate 2 -0.0301219
B2M beta-2-microglobulin -0.0298163
COL5A1 collagen, type V, alpha 1 -0.029649
OASL 2'-5'-oligoadenylate synthetase-like -0.0296345
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0289581
TENT5A terminal nucleotidyltransferase 5A -0.02848
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.028125
PTPRG protein tyrosine phosphatase, receptor type, G -0.0277705
OXR1 oxidation resistance 1 -0.0273997
ZNF804A zinc finger protein 804A -0.0273222
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0270626
TGFBI transforming growth factor, beta-induced, 68kDa -0.0270115
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0264697
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253062
ENO2 enolase 2 (gamma, neuronal) -0.0252447
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0249333
PSD3 pleckstrin and Sec7 domain containing 3 -0.0246036
COL8A1 collagen, type VIII, alpha 1 -0.0244495
ISG15 ISG15 ubiquitin-like modifier -0.0243778
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0243642
PTK2 protein tyrosine kinase 2 -0.0239462
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0227788
HLA-A major histocompatibility complex, class I, A -0.0223325
SYT1 synaptotagmin I -0.0222812
TPT1 tumor protein, translationally-controlled 1 -0.022245
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0221845
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0221132
EGR1 early growth response 1 -0.0218433
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0214854
INTS6 integrator complex subunit 6 -0.0212307
PTPRK protein tyrosine phosphatase, receptor type, K -0.0210536
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0210048
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0209101
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0207622
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0204411
MAML3 mastermind-like 3 (Drosophila) -0.0204217
DMD dystrophin -0.020378
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0202367
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0201409
XYLT1 xylosyltransferase I -0.0199649
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0198972
TENM3 teneurin transmembrane protein 3 -0.0195602
PDE10A phosphodiesterase 10A -0.0193925
AOPEP aminopeptidase O (putative) -0.0191659
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0191499
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.019011
PXDN peroxidasin -0.0190041
SAMD9 sterile alpha motif domain containing 9 -0.0188383
PTPRD protein tyrosine phosphatase, receptor type, D -0.0184962
IFI44 interferon-induced protein 44 -0.0182615
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0181991
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0181498
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.01814
NRXN3 neurexin 3 -0.0178788
CCL5 chemokine (C-C motif) ligand 5 -0.0177849
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0177754
RPS11 ribosomal protein S11 -0.0172914
SOX5 SRY (sex determining region Y)-box 5 -0.0172646
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0172533
GLCCI1 glucocorticoid induced 1 -0.0170756
PRR16 proline rich 16 -0.0169609