Ralimetinib dimesylate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.0517151
PCBP2 poly(rC) binding protein 2 0.048698
RPS3 ribosomal protein S3 0.044772
PRELID2 PRELI domain containing 2 0.0437333
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0425104
ANKRD11 ankyrin repeat domain 11 0.0411673
PNISR PNN-interacting serine/arginine-rich protein 0.0373747
RPS12 ribosomal protein S12 0.0371714
AKAP9 A kinase (PRKA) anchor protein 9 0.0367651
ZNF292 zinc finger protein 292 0.0354191
PRRC2C proline-rich coiled-coil 2C 0.0347582
TMF1 TATA element modulatory factor 1 0.0338625
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.033692
SRRM1 serine/arginine repetitive matrix 1 0.0330084
CDK19 cyclin-dependent kinase 19 0.0315791
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0309135
SRSF11 serine/arginine-rich splicing factor 11 0.0299909
ANKRD12 ankyrin repeat domain 12 0.0278795
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0263447
NEBL nebulette 0.0259875
OGA O-GlcNAcase 0.0253131
KTN1 kinectin 1 (kinesin receptor) 0.0252726
KMT2E lysine (K)-specific methyltransferase 2E 0.0251171
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247665
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0247552
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0246285
MATR3 matrin 3 0.0245689
HELZ helicase with zinc finger 0.0244437
BCLAF1 BCL2-associated transcription factor 1 0.0243088
YEATS2 YEATS domain containing 2 0.0242452
PTEN phosphatase and tensin homolog 0.0241855
KMT2C lysine (K)-specific methyltransferase 2C 0.0238131
HYOU1 hypoxia up-regulated 1 0.0236523
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0233503
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0232794
PCM1 pericentriolar material 1 0.0232387
SET SET nuclear proto-oncogene 0.0224681
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0224511
MT2A metallothionein 2A 0.0219748
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0218966
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0217411
METTL15 methyltransferase like 15 0.021707
USP33 ubiquitin specific peptidase 33 0.021414
USP47 ubiquitin specific peptidase 47 0.021144
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0211182
GARS1 glycyl-tRNA synthetase 1 0.0211051
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0203994
SETD5 SET domain containing 5 0.02003
PABPN1 poly(A) binding protein, nuclear 1 0.0198084
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0197347
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0195604
RPS17 ribosomal protein S17 0.0195506
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0194313
RPL37A ribosomal protein L37a 0.0194287
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0193259
NUCB2 nucleobindin 2 0.0191669
RPL36 ribosomal protein L36 0.0190258
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0189176
SFPQ splicing factor proline/glutamine-rich 0.0188004
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0187958
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.018683
ENO1 enolase 1, (alpha) 0.0186243
CCNL1 cyclin L1 0.0185329
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.018442
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0183661
COG6 component of oligomeric golgi complex 6 0.0182356
ESRP1 epithelial splicing regulatory protein 1 0.0182083
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0182041
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.0181136
PSAT1 phosphoserine aminotransferase 1 0.0178674
LCOR ligand dependent nuclear receptor corepressor 0.0178541
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0178198
B2M beta-2-microglobulin 0.0177871
DSCAM Down syndrome cell adhesion molecule 0.0177128
PNN pinin, desmosome associated protein 0.0174425
DSPP dentin sialophosphoprotein 0.0174395
ORC4 origin recognition complex, subunit 4 0.0173552
XPOT exportin, tRNA 0.0173386
CEP152 centrosomal protein 152kDa 0.0173202
FAM13A family with sequence similarity 13, member A 0.0173171
PGM3 phosphoglucomutase 3 0.0172746
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0170392
MBNL1 muscleblind-like splicing regulator 1 0.0169592
RPL13A ribosomal protein L13a 0.0169405
SMYD3 SET and MYND domain containing 3 0.0169272
CEP350 centrosomal protein 350kDa 0.0169016
UFL1 UFM1-specific ligase 1 0.0168994
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0168171
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0167826
EIF5 eukaryotic translation initiation factor 5 0.0164387
RPS6 ribosomal protein S6 0.0164134
YTHDC1 YTH domain containing 1 0.0163754
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0163737
SFXN1 sideroflexin 1 0.0162662
CHMP5 charged multivesicular body protein 5 0.0162348
TNRC6A trinucleotide repeat containing 6A 0.0161884
ZMYM2 zinc finger, MYM-type 2 0.0160963
ZFC3H1 zinc finger, C3H1-type containing 0.0160852
WASHC4 WASH complex subunit 4 0.0159995
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0158066

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.4353
AHNAK AHNAK nucleoprotein -0.192909
FAT1 FAT atypical cadherin 1 -0.179002
NDRG1 N-myc downstream regulated 1 -0.149408
LOC112694756 uncharaterized LOC112694756 -0.109168
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.10555
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0808798
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0527756
ARF4 ADP-ribosylation factor 4 -0.0526876
ACTG1 actin gamma 1 -0.0507892
PKM pyruvate kinase, muscle -0.0486644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0480679
UBC ubiquitin C -0.0470288
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0451013
EZR ezrin -0.0440332
SERINC5 serine incorporator 5 -0.0436825
CANX calnexin -0.0421507
TXNRD1 thioredoxin reductase 1 -0.0406999
EGR1 early growth response 1 -0.0400488
S100A10 S100 calcium binding protein A10 -0.0399925
RAB7A RAB7A, member RAS oncogene family -0.0387844
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0386195
LMAN1 lectin, mannose-binding, 1 -0.0383274
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0379428
POTEF POTE ankyrin domain family, member F -0.0372273
ARF1 ADP-ribosylation factor 1 -0.0368611
TPT1 tumor protein, translationally-controlled 1 -0.0367212
KRT19 keratin 19, type I -0.0366591
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0355288
ANXA2 annexin A2 -0.0342954
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0342668
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0333108
FHIT fragile histidine triad -0.0314133
TBC1D22A TBC1 domain family, member 22A -0.0311617
MCL1 myeloid cell leukemia 1 -0.0307308
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0306904
SQSTM1 sequestosome 1 -0.0288678
EGFR epidermal growth factor receptor -0.0287922
KRT18 keratin 18, type I -0.0286311
FUS FUS RNA binding protein -0.0285665
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0282523
SLC38A2 solute carrier family 38, member 2 -0.0280612
YBX1 Y box binding protein 1 -0.0275711
CCND1 cyclin D1 -0.0273435
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0270664
HMGA1 high mobility group AT-hook 1 -0.0269342
VCL vinculin -0.0264791
H1-0 H1.0 linker histone -0.0263629
UGDH UDP-glucose 6-dehydrogenase -0.0256702
PATJ PATJ crumbs cell polarity complex component -0.0254938
HDLBP high density lipoprotein binding protein -0.025458
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0248984
CD2AP CD2-associated protein -0.0247579
SBF2 SET binding factor 2 -0.0246397
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0239084
MED13L mediator complex subunit 13-like -0.023743
AGO2 argonaute RISC catalytic component 2 -0.022863
TUBB tubulin, beta class I -0.0228037
INTS6 integrator complex subunit 6 -0.0226338
SDC4 syndecan 4 -0.0226244
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0225225
RPL8 ribosomal protein L8 -0.0224033
PGK1 phosphoglycerate kinase 1 -0.0221915
AFF4 AF4/FMR2 family, member 4 -0.0219174
RPL4 ribosomal protein L4 -0.0217396
FRMD5 FERM domain containing 5 -0.0214905
RRBP1 ribosome binding protein 1 -0.0212313
DSG2 desmoglein 2 -0.021041
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0209484
KRT8 keratin 8, type II -0.020664
TCF12 transcription factor 12 -0.0206087
RPS15 ribosomal protein S15 -0.0204523
FDPS farnesyl diphosphate synthase -0.0202922
FNDC3B fibronectin type III domain containing 3B -0.0201161
SEC31A SEC31 homolog A (S. cerevisiae) -0.0200864
RPL34 ribosomal protein L34 -0.0194486
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0193383
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0192706
UFM1 ubiquitin-fold modifier 1 -0.0191303
SLC38A1 solute carrier family 38, member 1 -0.0190293
KDM7A lysine (K)-specific demethylase 7A -0.01898
NSD2 nuclear receptor binding SET domain protein 2 -0.0189707
TENM3 teneurin transmembrane protein 3 -0.0188495
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0188432
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0188159
INSIG1 insulin induced gene 1 -0.0188078
LARP4B La ribonucleoprotein domain family, member 4B -0.0187375
APP amyloid beta (A4) precursor protein -0.0186609
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0185831
LDHA lactate dehydrogenase A -0.0184271
PTPRK protein tyrosine phosphatase, receptor type, K -0.0183201
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0181952
ACTN4 actinin, alpha 4 -0.0180153
HBP1 HMG-box transcription factor 1 -0.017852
ZC3H11A zinc finger CCCH-type containing 11A -0.0178222
TPM4 tropomyosin 4 -0.0177371
TMSB10 thymosin beta 10 -0.0177336
KLF5 Kruppel-like factor 5 (intestinal) -0.0175807
CDCP1 CUB domain containing protein 1 -0.0175244
MYO1E myosin IE -0.0175095