| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.179862 |
| ENO1 | enolase 1, (alpha) | 0.0809743 |
| MT2A | metallothionein 2A | 0.0707727 |
| B2M | beta-2-microglobulin | 0.0696013 |
| PRELID2 | PRELI domain containing 2 | 0.0683512 |
| SET | SET nuclear proto-oncogene | 0.0673981 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0645905 |
| FTL | ferritin, light polypeptide | 0.056204 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0553235 |
| RPS12 | ribosomal protein S12 | 0.0546129 |
| RPS3 | ribosomal protein S3 | 0.0464522 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0406287 |
| RPS17 | ribosomal protein S17 | 0.0379093 |
| ANXA1 | annexin A1 | 0.0374941 |
| RPL12 | ribosomal protein L12 | 0.0371508 |
| RAD51B | RAD51 paralog B | 0.036372 |
| PCBP2 | poly(rC) binding protein 2 | 0.0363406 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0355885 |
| RPL37A | ribosomal protein L37a | 0.0321923 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0321472 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0315234 |
| MACROD2 | MACRO domain containing 2 | 0.0313034 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0305714 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0304808 |
| FLNA | filamin A, alpha | 0.030411 |
| PTMA | prothymosin, alpha | 0.0299257 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0292947 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0288809 |
| FHIT | fragile histidine triad | 0.0282902 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0282604 |
| TPM3 | tropomyosin 3 | 0.0278314 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0265699 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0253121 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0249652 |
| ZNF148 | zinc finger protein 148 | 0.0248535 |
| RPS8 | ribosomal protein S8 | 0.0246553 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0246268 |
| RPL9 | ribosomal protein L9 | 0.0245948 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0242084 |
| RPL18 | ribosomal protein L18 | 0.0240489 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0239851 |
| PKM | pyruvate kinase, muscle | 0.02316 |
| DSPP | dentin sialophosphoprotein | 0.0230937 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0228734 |
| RPL35A | ribosomal protein L35a | 0.0226718 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0225835 |
| WWOX | WW domain containing oxidoreductase | 0.0225621 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0224055 |
| RPL23 | ribosomal protein L23 | 0.0218285 |
| VCAN | versican | 0.021499 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0213314 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0211877 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0210315 |
| UTRN | utrophin | 0.0205994 |
| TPI1 | triosephosphate isomerase 1 | 0.0204028 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0199366 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0198956 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0196711 |
| RPL5 | ribosomal protein L5 | 0.0194027 |
| RPL26 | ribosomal protein L26 | 0.0193482 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0193111 |
| RPS19 | ribosomal protein S19 | 0.0189612 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0189467 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0186233 |
| FAM13A | family with sequence similarity 13, member A | 0.0183837 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0183585 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0183381 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0182262 |
| ZNF292 | zinc finger protein 292 | 0.0181852 |
| HDGF | hepatoma-derived growth factor | 0.0181463 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0179786 |
| LMNA | lamin A/C | 0.0179146 |
| RPL7A | ribosomal protein L7a | 0.0178707 |
| RPL35 | ribosomal protein L35 | 0.0178577 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0175912 |
| AXL | AXL receptor tyrosine kinase | 0.0175235 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0173693 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0170667 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0170447 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.016897 |
| SFPQ | splicing factor proline/glutamine-rich | 0.016812 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.0167901 |
| NFIB | nuclear factor I/B | 0.0167291 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.01655 |
| CDK19 | cyclin-dependent kinase 19 | 0.0165416 |
| IRS2 | insulin receptor substrate 2 | 0.0165227 |
| RNF213 | ring finger protein 213 | 0.0165145 |
| RPL31 | ribosomal protein L31 | 0.0165024 |
| ANGPTL4 | angiopoietin-like 4 | 0.0164273 |
| MYADM | myeloid-associated differentiation marker | 0.0164108 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.016388 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0163423 |
| RNF145 | ring finger protein 145 | 0.0162823 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0162339 |
| OCIAD2 | OCIA domain containing 2 | 0.0162121 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0162063 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.0161121 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0158995 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.015681 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.0155393 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.206507 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.115482 |
| ACTG1 | actin gamma 1 | -0.109423 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.100803 |
| CCND1 | cyclin D1 | -0.0560999 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0557096 |
| H1-0 | H1.0 linker histone | -0.0462707 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0450828 |
| AHNAK | AHNAK nucleoprotein | -0.0427333 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0404683 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0384169 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0382286 |
| TXNRD1 | thioredoxin reductase 1 | -0.0379669 |
| ITGB8 | integrin, beta 8 | -0.037944 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0362454 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0357154 |
| CANX | calnexin | -0.0329735 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0321451 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.031375 |
| PAX8 | paired box 8 | -0.0304786 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0290646 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0287991 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0285077 |
| ACTN4 | actinin, alpha 4 | -0.028425 |
| UBC | ubiquitin C | -0.0282179 |
| CD44 | CD44 molecule (Indian blood group) | -0.0281352 |
| ASPH | aspartate beta-hydroxylase | -0.0276647 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0268715 |
| RAB7A | RAB7A, member RAS oncogene family | -0.026701 |
| ATG7 | autophagy related 7 | -0.0264378 |
| HMGA2 | high mobility group AT-hook 2 | -0.0263357 |
| ARF1 | ADP-ribosylation factor 1 | -0.0257521 |
| LAMC2 | laminin, gamma 2 | -0.0255306 |
| CDCP1 | CUB domain containing protein 1 | -0.02546 |
| NF1 | neurofibromin 1 | -0.0250631 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0250347 |
| CD2AP | CD2-associated protein | -0.0250096 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0248979 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.024731 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0246892 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0245195 |
| EGR1 | early growth response 1 | -0.02446 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.024395 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0242961 |
| ZNF644 | zinc finger protein 644 | -0.0238875 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0238829 |
| TCF12 | transcription factor 12 | -0.0235497 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0232177 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0230878 |
| RPL34 | ribosomal protein L34 | -0.0229673 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0227381 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0225157 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0224991 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0222816 |
| RANBP17 | RAN binding protein 17 | -0.0221193 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0220158 |
| CLINT1 | clathrin interactor 1 | -0.0219088 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0216458 |
| ERBIN | erbb2 interacting protein | -0.0216457 |
| TUBB | tubulin, beta class I | -0.021409 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0212832 |
| FUS | FUS RNA binding protein | -0.0212577 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.021177 |
| GPATCH8 | G patch domain containing 8 | -0.0211321 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0209867 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0208108 |
| VCL | vinculin | -0.0202339 |
| SBF2 | SET binding factor 2 | -0.0201466 |
| RPL8 | ribosomal protein L8 | -0.0199619 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0198529 |
| ANKRD17 | ankyrin repeat domain 17 | -0.019835 |
| NDRG1 | N-myc downstream regulated 1 | -0.0196616 |
| EMP1 | epithelial membrane protein 1 | -0.0194486 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0193839 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0193338 |
| FBXO11 | F-box protein 11 | -0.0192878 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0192693 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0191791 |
| HDLBP | high density lipoprotein binding protein | -0.0188469 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0186249 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.018604 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0185202 |
| PHIP | pleckstrin homology domain interacting protein | -0.0185098 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0184686 |
| LAMA4 | laminin, alpha 4 | -0.0183836 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0183761 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0183469 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.018284 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0181455 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0180218 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.0180054 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0176058 |
| SVIL | supervillin | -0.0176034 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.0175206 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0175105 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0174475 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0174445 |
| FIGN | fidgetin | -0.0171432 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0171247 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.016849 |
