| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ralimetinib dimesylate_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.0641869 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0549053 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0517861 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.051158 |
| RTN4 | reticulon 4 | 0.0456651 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.044796 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0397758 |
| SPAG9 | sperm associated antigen 9 | 0.0342937 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0335606 |
| SETD5 | SET domain containing 5 | 0.0327398 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0322702 |
| LDHA | lactate dehydrogenase A | 0.031518 |
| VCL | vinculin | 0.0275464 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0273898 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0268423 |
| TPX2 | TPX2, microtubule-associated | 0.0259514 |
| CAPRIN2 | caprin family member 2 | 0.0256585 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0248498 |
| CD109 | CD109 molecule | 0.0243861 |
| NUP58 | nucleoporin 58 | 0.0241998 |
| PRELID2 | PRELI domain containing 2 | 0.0236196 |
| KLF6 | Kruppel-like factor 6 | 0.0228547 |
| CD44 | CD44 molecule (Indian blood group) | 0.022582 |
| TXNIP | thioredoxin interacting protein | 0.0220141 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0219992 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0213493 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0211239 |
| NECTIN2 | nectin cell adhesion molecule 2 | 0.0209896 |
| ZNF292 | zinc finger protein 292 | 0.0207708 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0207037 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0203086 |
| USP3 | ubiquitin specific peptidase 3 | 0.0202538 |
| ZNF148 | zinc finger protein 148 | 0.0202482 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.02021 |
| DNMBP | dynamin binding protein | 0.0197886 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0197581 |
| ECT2 | epithelial cell transforming 2 | 0.0194261 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0193982 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0193435 |
| CLEC1B | C-type lectin domain family 1, member B | 0.0191936 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.0191365 |
| PKM | pyruvate kinase, muscle | 0.0189746 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.018947 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0189245 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0188865 |
| METTL15 | methyltransferase like 15 | 0.0180779 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0179259 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0177938 |
| MATR3 | matrin 3 | 0.0176264 |
| SBF2 | SET binding factor 2 | 0.0174612 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0170528 |
| OGA | O-GlcNAcase | 0.0169326 |
| NPTN | neuroplastin | 0.0169016 |
| KIF18A | kinesin family member 18A | 0.0165229 |
| LPIN2 | lipin 2 | 0.0163685 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0161529 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0161116 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0160424 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0158111 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0157522 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0155696 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0155166 |
| DOT1L | DOT1-like histone H3K79 methyltransferase | 0.0154977 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.015453 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.01539 |
| WDR26 | WD repeat domain 26 | 0.0153017 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0149938 |
| CCNL1 | cyclin L1 | 0.0148474 |
| TMEM39A | transmembrane protein 39A | 0.0148194 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0147149 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0146896 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0144355 |
| ANLN | anillin, actin binding protein | 0.0144178 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0143725 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.014324 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0142179 |
| ETNK1 | ethanolamine kinase 1 | 0.0141777 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0141276 |
| CLTC | clathrin, heavy chain (Hc) | 0.0140112 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0139747 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0139326 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0138631 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0138342 |
| CKAP2 | cytoskeleton associated protein 2 | 0.0138212 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.0137918 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0137875 |
| WDR45B | WD repeat domain 45B | 0.013787 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0137186 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0136249 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0135476 |
| TFG | TRK-fused gene | 0.0134319 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0133002 |
| SGO2 | shugoshin 2 | 0.0131915 |
| KIF11 | kinesin family member 11 | 0.0131444 |
| ABI1 | abl-interactor 1 | 0.0130923 |
| CDK19 | cyclin-dependent kinase 19 | 0.0128437 |
| RASA2 | RAS p21 protein activator 2 | 0.0127713 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0127199 |
| HELZ | helicase with zinc finger | 0.0127189 |
| TENM2 | teneurin transmembrane protein 2 | 0.0126833 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A1 | collagen, type V, alpha 1 | -0.209518 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.204446 |
| VIM | vimentin | -0.195785 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.183408 |
| CDH13 | cadherin 13 | -0.162527 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.158814 |
| NDRG1 | N-myc downstream regulated 1 | -0.141252 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.124952 |
| FN1 | fibronectin 1 | -0.114296 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.113838 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.113754 |
| NAV1 | neuron navigator 1 | -0.10788 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.106141 |
| ASPH | aspartate beta-hydroxylase | -0.104728 |
| MYO10 | myosin X | -0.103103 |
| IGF2 | insulin-like growth factor 2 | -0.100761 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0939591 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0880115 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0863154 |
| LAMB3 | laminin, beta 3 | -0.0859514 |
| RAI14 | retinoic acid induced 14 | -0.0831122 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0817563 |
| HMGA2 | high mobility group AT-hook 2 | -0.0814799 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0712284 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0709627 |
| ACTG1 | actin gamma 1 | -0.0695575 |
| RPS6 | ribosomal protein S6 | -0.0689254 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0682468 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0664305 |
| ADM | adrenomedullin | -0.0626473 |
| MMP12 | matrix metallopeptidase 12 | -0.0617316 |
| CLMP | CXADR-like membrane protein | -0.0588923 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0587045 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0585992 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0583993 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.058283 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0565382 |
| AHNAK | AHNAK nucleoprotein | -0.0549775 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0532051 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0531193 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0506604 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0495696 |
| FRMD4A | FERM domain containing 4A | -0.0494721 |
| GOLGB1 | golgin B1 | -0.0488467 |
| FMN1 | formin 1 | -0.0472313 |
| TNS1 | tensin 1 | -0.0465511 |
| DIAPH2 | diaphanous-related formin 2 | -0.0461544 |
| RPLP1 | ribosomal protein, large, P1 | -0.0458243 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0456944 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0454409 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0453732 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0444087 |
| COL7A1 | collagen, type VII, alpha 1 | -0.043133 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0424516 |
| COL1A1 | collagen, type I, alpha 1 | -0.0421907 |
| DTNA | dystrobrevin, alpha | -0.0418421 |
| MT1E | metallothionein 1E | -0.0415231 |
| ATXN1 | ataxin 1 | -0.0408357 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0404452 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0404259 |
| RPL35A | ribosomal protein L35a | -0.0400771 |
| CANX | calnexin | -0.0396014 |
| TGFB1 | transforming growth factor, beta 1 | -0.0394372 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0391459 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0385965 |
| HLA-B | major histocompatibility complex, class I, B | -0.0383207 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0378221 |
| CCND1 | cyclin D1 | -0.0375131 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0363835 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0363226 |
| CAVIN1 | caveolae associated protein 1 | -0.0353157 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0352005 |
| RPL34 | ribosomal protein L34 | -0.0349645 |
| SQSTM1 | sequestosome 1 | -0.0348663 |
| IL11 | interleukin 11 | -0.0348544 |
| RUNX1 | runt-related transcription factor 1 | -0.0348359 |
| RASA3 | RAS p21 protein activator 3 | -0.0345509 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0343242 |
| RRBP1 | ribosome binding protein 1 | -0.0340112 |
| PTK2 | protein tyrosine kinase 2 | -0.0338829 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.033749 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0335572 |
| C2CD2 | C2 calcium-dependent domain containing 2 | -0.0333689 |
| EGFR | epidermal growth factor receptor | -0.0333128 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0331942 |
| HM13 | histocompatibility (minor) 13 | -0.0331636 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0330807 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0330783 |
| ZNF638 | zinc finger protein 638 | -0.0329879 |
| TPM1 | tropomyosin 1 (alpha) | -0.0329807 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.03254 |
| VEGFA | vascular endothelial growth factor A | -0.0325232 |
| ANXA2 | annexin A2 | -0.0322571 |
| INHBA | inhibin, beta A | -0.0321373 |
| NAV2 | neuron navigator 2 | -0.0318004 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0316101 |
| PCBP3 | poly(rC) binding protein 3 | -0.0315649 |
| IER3 | immediate early response 3 | -0.0314532 |
| PDE10A | phosphodiesterase 10A | -0.0312441 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0310065 |
