| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.100091 |
| VIM | vimentin | 0.094643 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0891585 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0714296 |
| NDRG1 | N-myc downstream regulated 1 | 0.0637676 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0594264 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0554295 |
| ENO1 | enolase 1, (alpha) | 0.0538951 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0523578 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0508684 |
| PTK2 | protein tyrosine kinase 2 | 0.0485544 |
| RPS12 | ribosomal protein S12 | 0.0457489 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0446354 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.043472 |
| CADM1 | cell adhesion molecule 1 | 0.0412372 |
| ASPH | aspartate beta-hydroxylase | 0.0411793 |
| PRELID2 | PRELI domain containing 2 | 0.0409867 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0397524 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0390418 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0389862 |
| FMNL2 | formin-like 2 | 0.0388669 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0382576 |
| LDHA | lactate dehydrogenase A | 0.0382459 |
| NAV2 | neuron navigator 2 | 0.0378887 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0376635 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0368465 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0362037 |
| PDE10A | phosphodiesterase 10A | 0.0359754 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0359463 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0351525 |
| ATP13A3 | ATPase type 13A3 | 0.0342536 |
| B2M | beta-2-microglobulin | 0.0342508 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0330971 |
| HYOU1 | hypoxia up-regulated 1 | 0.0330279 |
| VEGFA | vascular endothelial growth factor A | 0.0326309 |
| RPS3 | ribosomal protein S3 | 0.0326053 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0320879 |
| MYO10 | myosin X | 0.0319327 |
| KIF1B | kinesin family member 1B | 0.0299811 |
| EGFR | epidermal growth factor receptor | 0.0299083 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0296057 |
| GOLGA4 | golgin A4 | 0.0293652 |
| RPL37A | ribosomal protein L37a | 0.0292379 |
| DOCK7 | dedicator of cytokinesis 7 | 0.0288516 |
| VCAN | versican | 0.0278036 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0273958 |
| FLNA | filamin A, alpha | 0.0267289 |
| RUNX1 | runt-related transcription factor 1 | 0.0267094 |
| MTDH | metadherin | 0.0261143 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0259298 |
| CALR | calreticulin | 0.0259132 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0256517 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0253256 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.025206 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0249154 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.024853 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.024655 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0245525 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0242497 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0240148 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0239971 |
| OGA | O-GlcNAcase | 0.0239819 |
| SLC22A23 | solute carrier family 22, member 23 | 0.023774 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0236852 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0233997 |
| YEATS2 | YEATS domain containing 2 | 0.0231889 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0229377 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0229359 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0228657 |
| BNC2 | basonuclin 2 | 0.0224344 |
| TNS1 | tensin 1 | 0.0222669 |
| ZNF292 | zinc finger protein 292 | 0.02215 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0220748 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0220551 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0220265 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0220262 |
| STC2 | stanniocalcin 2 | 0.0220033 |
| ZNF148 | zinc finger protein 148 | 0.0219746 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | 0.0219675 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.021967 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0219457 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0218821 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0218349 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0217414 |
| RPL36 | ribosomal protein L36 | 0.0211863 |
| HIP1 | huntingtin interacting protein 1 | 0.021104 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0209259 |
| MTSS1 | metastasis suppressor 1 | 0.0206321 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0205359 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0205265 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0204576 |
| PCBP2 | poly(rC) binding protein 2 | 0.0201586 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0201277 |
| NAV1 | neuron navigator 1 | 0.0201079 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0200646 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0200211 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0200076 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0199773 |
| TPM4 | tropomyosin 4 | 0.0198544 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0197408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.339523 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.337096 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.330788 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.308599 |
| COL1A1 | collagen, type I, alpha 1 | -0.15902 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0939771 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0879164 |
| IER3 | immediate early response 3 | -0.0857397 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0813434 |
| CD44 | CD44 molecule (Indian blood group) | -0.0589026 |
| UBC | ubiquitin C | -0.0510549 |
| ACTG1 | actin gamma 1 | -0.0471672 |
| LOX | lysyl oxidase | -0.0452307 |
| H1-0 | H1.0 linker histone | -0.0449051 |
| INHBA | inhibin, beta A | -0.0441687 |
| MAP1B | microtubule-associated protein 1B | -0.0439007 |
| MT1X | metallothionein 1X | -0.0415248 |
| EGR1 | early growth response 1 | -0.0408934 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0394455 |
| PALLD | palladin, cytoskeletal associated protein | -0.039302 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0354532 |
| VCL | vinculin | -0.0339317 |
| OSMR | oncostatin M receptor | -0.0321485 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0315314 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.03114 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0296426 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.028846 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0286868 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0273278 |
| LOC112694756 | uncharaterized LOC112694756 | -0.027266 |
| CALU | calumenin | -0.0270527 |
| STC1 | stanniocalcin 1 | -0.0263716 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0263423 |
| CANX | calnexin | -0.0255509 |
| POSTN | periostin, osteoblast specific factor | -0.0248149 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0246119 |
| TMEM263 | transmembrane protein 263 | -0.0236315 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0236304 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0234728 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0232787 |
| CLIC4 | chloride intracellular channel 4 | -0.022868 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0227544 |
| RHEB | Ras homolog enriched in brain | -0.0222838 |
| POTEF | POTE ankyrin domain family, member F | -0.0217638 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.021457 |
| RPL8 | ribosomal protein L8 | -0.0211497 |
| TUBB | tubulin, beta class I | -0.0209464 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0207089 |
| AHNAK | AHNAK nucleoprotein | -0.0202433 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0200917 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0199872 |
| IL6 | interleukin 6 | -0.0199682 |
| FSTL1 | follistatin-like 1 | -0.0194796 |
| ANLN | anillin, actin binding protein | -0.0191122 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.019091 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.019014 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0187023 |
| TAPBP | TAP binding protein (tapasin) | -0.0184953 |
| HDLBP | high density lipoprotein binding protein | -0.0184353 |
| PTMA | prothymosin, alpha | -0.0183747 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0181547 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0181206 |
| THY1 | Thy-1 cell surface antigen | -0.0180243 |
| S100A9 | S100 calcium binding protein A9 | -0.0177097 |
| RHOA | ras homolog family member A | -0.0174619 |
| WASF2 | WAS protein family, member 2 | -0.0171847 |
| NABP1 | nucleic acid binding protein 1 | -0.0169115 |
| S100A10 | S100 calcium binding protein A10 | -0.0161585 |
| RPL34 | ribosomal protein L34 | -0.0161134 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0158053 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0157361 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0151631 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0150859 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0149017 |
| ACTN4 | actinin, alpha 4 | -0.0147924 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0146559 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0144539 |
| CALM3 | calmodulin 3 (phosphorylase kinase, delta) | -0.014395 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0143113 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0141267 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0140118 |
| RAD21 | RAD21 homolog (S. pombe) | -0.014002 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0139106 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0138877 |
| CALD1 | caldesmon 1 | -0.0137943 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0136395 |
| HMGB1 | high mobility group box 1 | -0.0136383 |
| RSU1 | Ras suppressor protein 1 | -0.0136059 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0132975 |
| HBP1 | HMG-box transcription factor 1 | -0.0131261 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0131199 |
| GLIS3 | GLIS family zinc finger 3 | -0.0130632 |
| CXCL3 | chemokine (C-X-C motif) ligand 3 | -0.0130438 |
| ARF1 | ADP-ribosylation factor 1 | -0.0129833 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0129598 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0125686 |
| XPO7 | exportin 7 | -0.0124476 |
| DEK | DEK proto-oncogene | -0.0124374 |
| FBN1 | fibrillin 1 | -0.0123616 |
| HAS2 | hyaluronan synthase 2 | -0.0122191 |
