Ralimetinib dimesylate_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0800045
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0711257
MYH14 myosin, heavy chain 14, non-muscle 0.0576975
TRPS1 trichorhinophalangeal syndrome I 0.0557288
LMO7 LIM domain 7 0.0529872
PTPRK protein tyrosine phosphatase, receptor type, K 0.0524233
ATXN1 ataxin 1 0.0505832
FNDC3B fibronectin type III domain containing 3B 0.0485467
CCSER1 coiled-coil serine-rich protein 1 0.0481273
LAMA4 laminin, alpha 4 0.0480806
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0462054
PDE4D phosphodiesterase 4D, cAMP-specific 0.0454969
KRT20 keratin 20, type I 0.0432291
FRY furry homolog (Drosophila) 0.0422628
PDLIM5 PDZ and LIM domain 5 0.0407604
DST dystonin 0.0406962
GMDS GDP-mannose 4,6-dehydratase 0.0404333
KRT18 keratin 18, type I 0.0396154
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0387439
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0380891
SMAD3 SMAD family member 3 0.0367945
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.035841
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0343616
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0324687
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0322385
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0313538
TAS2R14 taste receptor, type 2, member 14 0.0307399
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0305043
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0302636
CTBP2 C-terminal binding protein 2 0.0289747
TMEM65 transmembrane protein 65 0.0288672
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.028683
PLK2 polo-like kinase 2 0.0283517
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0279105
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0277975
PTK2 protein tyrosine kinase 2 0.0269058
PRELID2 PRELI domain containing 2 0.0267685
KLF5 Kruppel-like factor 5 (intestinal) 0.0265053
NFIA nuclear factor I/A 0.0263662
DGKH diacylglycerol kinase, eta 0.0262717
PICALM phosphatidylinositol binding clathrin assembly protein 0.0259393
ERRFI1 ERBB receptor feedback inhibitor 1 0.0256693
MBNL1 muscleblind-like splicing regulator 1 0.0256487
KMT2C lysine (K)-specific methyltransferase 2C 0.0251491
ARHGAP26 Rho GTPase activating protein 26 0.0251148
HKDC1 hexokinase domain containing 1 0.0246638
FNIP1 folliculin interacting protein 1 0.024233
MBD5 methyl-CpG binding domain protein 5 0.0241226
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0233764
AKAP13 A kinase (PRKA) anchor protein 13 0.0232707
CHD7 chromodomain helicase DNA binding protein 7 0.023193
ZSWIM6 zinc finger, SWIM-type containing 6 0.0231288
KDM6A lysine (K)-specific demethylase 6A 0.0226971
DIAPH2 diaphanous-related formin 2 0.0226383
MYO6 myosin VI 0.0222992
LAMB3 laminin, beta 3 0.0220602
POF1B premature ovarian failure, 1B 0.0219612
ARHGAP32 Rho GTPase activating protein 32 0.0219513
PDZD8 PDZ domain containing 8 0.0218858
KRT8 keratin 8, type II 0.0218049
AFDN afadin, adherens junction formation factor 0.0217239
PRKN parkin RBR E3 ubiquitin protein ligase 0.0215691
ARGLU1 arginine and glutamate rich 1 0.021522
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0215102
ETV6 ets variant 6 0.0214387
CHD1 chromodomain helicase DNA binding protein 1 0.0207404
MYADM myeloid-associated differentiation marker 0.0205023
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0203925
NTN4 netrin 4 0.020316
ZBTB20 zinc finger and BTB domain containing 20 0.0197879
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0197327
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0196898
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0195424
BCAS1 breast carcinoma amplified sequence 1 0.0191841
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0189102
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.018766
SLC45A4 solute carrier family 45, member 4 0.0186806
PRR5L proline rich 5 like 0.0186698
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0180613
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0179864
ANKRD11 ankyrin repeat domain 11 0.0179157
BAIAP2L1 BAI1-associated protein 2-like 1 0.0178591
MYO5B myosin VB 0.017822
TM4SF4 transmembrane 4 L six family member 4 0.0178159
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0177699
SLTM SAFB-like, transcription modulator 0.0177523
EGFR epidermal growth factor receptor 0.0176284
EPS8L1 EPS8-like 1 0.0176273
MECOM MDS1 and EVI1 complex locus 0.0175865
TRAPPC9 trafficking protein particle complex 9 0.0172589
PEAK1 pseudopodium-enriched atypical kinase 1 0.0172012
ATXN7L1 ataxin 7-like 1 0.0171224
SGMS2 sphingomyelin synthase 2 0.0170706
TJP1 tight junction protein 1 0.0170461
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0170241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0169842
SFPQ splicing factor proline/glutamine-rich 0.0169582
CCDC91 coiled-coil domain containing 91 0.0168562
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0167576
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 0.0166847

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.300674
FTL ferritin, light polypeptide -0.250034
RPS6 ribosomal protein S6 -0.159775
RPLP1 ribosomal protein, large, P1 -0.155149
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.119235
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.116169
RPS19 ribosomal protein S19 -0.11162
ACTG1 actin gamma 1 -0.108599
NDRG1 N-myc downstream regulated 1 -0.106183
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0984003
RPL23 ribosomal protein L23 -0.0981944
POTEF POTE ankyrin domain family, member F -0.0969947
RPL35A ribosomal protein L35a -0.0901102
RPL34 ribosomal protein L34 -0.0863537
RPS13 ribosomal protein S13 -0.0859417
EIF1 eukaryotic translation initiation factor 1 -0.0852037
RPS11 ribosomal protein S11 -0.0819327
TPT1 tumor protein, translationally-controlled 1 -0.0803627
TMSB10 thymosin beta 10 -0.078798
RPS23 ribosomal protein S23 -0.0754883
RPS8 ribosomal protein S8 -0.0742725
RPS5 ribosomal protein S5 -0.0733058
RPLP2 ribosomal protein, large, P2 -0.0721843
LYZ lysozyme -0.0664895
RPL8 ribosomal protein L8 -0.0642315
RPL11 ribosomal protein L11 -0.063088
PTMA prothymosin, alpha -0.0622313
RPLP0 ribosomal protein, large, P0 -0.0613781
RPS21 ribosomal protein S21 -0.0613346
RPL28 ribosomal protein L28 -0.0606897
RPS16 ribosomal protein S16 -0.0586796
LOC112694756 uncharaterized LOC112694756 -0.0568229
S100A10 S100 calcium binding protein A10 -0.0550238
TXNRD1 thioredoxin reductase 1 -0.0547562
ITPKC inositol-trisphosphate 3-kinase C -0.0538346
EGR1 early growth response 1 -0.0533353
RPL31 ribosomal protein L31 -0.0526541
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0512731
EEF2 eukaryotic translation elongation factor 2 -0.0496962
RPL19 ribosomal protein L19 -0.0486036
RPS24 ribosomal protein S24 -0.0474458
UBC ubiquitin C -0.0465351
RPL12 ribosomal protein L12 -0.0458806
FTH1 ferritin, heavy polypeptide 1 -0.0447793
RPL9 ribosomal protein L9 -0.044175
RPL13A ribosomal protein L13a -0.0430408
RPS14 ribosomal protein S14 -0.0430244
HMGB1 high mobility group box 1 -0.0428575
YBX1 Y box binding protein 1 -0.0420211
GOLGA4 golgin A4 -0.0415946
S100A6 S100 calcium binding protein A6 -0.041496
ATP5F1E ATP synthase F1 subunit epsilon -0.0413414
RPS29 ribosomal protein S29 -0.0412709
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0405489
B2M beta-2-microglobulin -0.0392527
NAMPT nicotinamide phosphoribosyltransferase -0.0390322
RPL27A ribosomal protein L27a -0.0387845
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0383295
RPS15 ribosomal protein S15 -0.0376243
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0371113
RPL32 ribosomal protein L32 -0.0370687
ASTN2 astrotactin 2 -0.0361134
MKI67 marker of proliferation Ki-67 -0.0359732
RPL5 ribosomal protein L5 -0.0356291
GCLC glutamate-cysteine ligase, catalytic subunit -0.0356182
SEPTIN7 septin 7 -0.0353977
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0341925
GNAS GNAS complex locus -0.0337464
CENPF centromere protein F, 350/400kDa -0.0333261
RPL35 ribosomal protein L35 -0.0330807
MYL12B myosin, light chain 12B, regulatory -0.0329717
RPL36 ribosomal protein L36 -0.0325077
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0321873
RAD21 RAD21 homolog (S. pombe) -0.031875
VIM vimentin -0.0317326
RPS25 ribosomal protein S25 -0.0315704
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0315083
RPS27A ribosomal protein S27a -0.0314796
RPL38 ribosomal protein L38 -0.0311774
CANX calnexin -0.0311756
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0311497
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0308522
HMGA1 high mobility group AT-hook 1 -0.03068
DEK DEK proto-oncogene -0.0302971
RPL37 ribosomal protein L37 -0.0299137
PLAUR plasminogen activator, urokinase receptor -0.029867
UBE2B ubiquitin-conjugating enzyme E2B -0.0298154
RAB1A RAB1A, member RAS oncogene family -0.0297435
GARS1 glycyl-tRNA synthetase 1 -0.029615
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0295615
FOSL1 FOS-like antigen 1 -0.0294329
RPL36A ribosomal protein L36a -0.0292853
RPL7 ribosomal protein L7 -0.0290891
PGK1 phosphoglycerate kinase 1 -0.0290483
POMP proteasome maturation protein -0.0289813
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0286513
H1-0 H1.0 linker histone -0.0284198
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0282183
MT2A metallothionein 2A -0.028092
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0279443