| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0867461 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0809406 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0619697 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.053547 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0400071 |
| MRTFA | myocardin related transcription factor A | 0.0376105 |
| TF | transferrin | 0.035728 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0356025 |
| CFB | complement factor B | 0.0321404 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0314978 |
| APOB | apolipoprotein B | 0.0296526 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.029549 |
| YTHDC1 | YTH domain containing 1 | 0.0281715 |
| USP6NL | USP6 N-terminal like | 0.0279546 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0278761 |
| PNN | pinin, desmosome associated protein | 0.0273346 |
| MED13L | mediator complex subunit 13-like | 0.0273326 |
| DTNA | dystrobrevin, alpha | 0.0269284 |
| TCP1 | t-complex 1 | 0.0267925 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0267868 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0257873 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0252884 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0248458 |
| SMOX | spermine oxidase | 0.0245984 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0243779 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.02391 |
| CDC14A | cell division cycle 14A | 0.0233111 |
| METTL16 | methyltransferase like 16 | 0.0230802 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0229102 |
| RPS12 | ribosomal protein S12 | 0.0228315 |
| ZNF789 | zinc finger protein 789 | 0.0217816 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.0217228 |
| ITGA6 | integrin, alpha 6 | 0.021684 |
| CCNY | cyclin Y | 0.0215465 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0211905 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0211181 |
| FOXO1 | forkhead box O1 | 0.0209461 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.0204129 |
| IL4R | interleukin 4 receptor | 0.0203181 |
| SH3GL1 | SH3-domain GRB2-like 1 | 0.0200934 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0200215 |
| WTAP | Wilms tumor 1 associated protein | 0.0197761 |
| PIKFYVE | phosphoinositide kinase, FYVE finger containing | 0.0196944 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0196101 |
| SPTLC1 | serine palmitoyltransferase, long chain base subunit 1 | 0.0195828 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0195131 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0192058 |
| RASA2 | RAS p21 protein activator 2 | 0.0191014 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0190885 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0189367 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.0184765 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0182828 |
| NBAS | neuroblastoma amplified sequence | 0.0180977 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0180084 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.0177958 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0176457 |
| GRAMD2B | GRAM domain containing 2B | 0.0176053 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0175349 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0174883 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0172851 |
| NOS1AP | nitric oxide synthase 1 (neuronal) adaptor protein | 0.0172792 |
| TKT | transketolase | 0.0172613 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0172461 |
| FHIT | fragile histidine triad | 0.0169625 |
| CCDC50 | coiled-coil domain containing 50 | 0.0169533 |
| TJP1 | tight junction protein 1 | 0.0169116 |
| SVIL | supervillin | 0.0168998 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0168674 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0166468 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | 0.0165882 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0165878 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0165005 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0163521 |
| UBN2 | ubinuclein 2 | 0.0163398 |
| PHF10 | PHD finger protein 10 | 0.0163382 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0161533 |
| DNM1L | dynamin 1-like | 0.0160523 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0160415 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0160151 |
| MCMBP | minichromosome maintenance complex binding protein | 0.0159763 |
| WASHC4 | WASH complex subunit 4 | 0.015938 |
| KIAA1217 | KIAA1217 | 0.015932 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0158332 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0155228 |
| RBM26 | RNA binding motif protein 26 | 0.0155213 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.015502 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0153363 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0152619 |
| CNKSR3 | CNKSR family member 3 | 0.0151335 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0148891 |
| SMAD2 | SMAD family member 2 | 0.0148285 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | 0.014682 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0145 |
| SET | SET nuclear proto-oncogene | 0.0144152 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.0143267 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0143025 |
| CWF19L2 | CWF19-like 2, cell cycle control (S. pombe) | 0.0141567 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0141197 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0140009 |
| EEF1B2 | eukaryotic translation elongation factor 1 beta 2 | 0.013991 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.509167 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.236555 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.214681 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.202504 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.124225 |
| FN1 | fibronectin 1 | -0.117524 |
| APOA2 | apolipoprotein A-II | -0.107299 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0848175 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0829287 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0796635 |
| NDRG1 | N-myc downstream regulated 1 | -0.0748624 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0690592 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0682844 |
| FTL | ferritin, light polypeptide | -0.0644248 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0639891 |
| PEG3 | paternally expressed 3 | -0.0628331 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.061525 |
| C3 | complement component 3 | -0.0594517 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0531766 |
| TMEM123 | transmembrane protein 123 | -0.0489601 |
| RPS6 | ribosomal protein S6 | -0.0483957 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0478259 |
| ENO1 | enolase 1, (alpha) | -0.0472761 |
| H1-0 | H1.0 linker histone | -0.0460699 |
| RPL34 | ribosomal protein L34 | -0.0456048 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0453821 |
| MT2A | metallothionein 2A | -0.0451121 |
| PLIN2 | perilipin 2 | -0.0449636 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0444885 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.044024 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0439733 |
| HMGA1 | high mobility group AT-hook 1 | -0.0433079 |
| EHBP1 | EH domain binding protein 1 | -0.0423669 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0414413 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0406289 |
| GPC3 | glypican 3 | -0.0405348 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0384432 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0382012 |
| CP | ceruloplasmin (ferroxidase) | -0.0381575 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0378218 |
| AHSG | alpha-2-HS-glycoprotein | -0.0378143 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.03735 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0372931 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0368053 |
| GNAS | GNAS complex locus | -0.0356631 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.035568 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0340158 |
| RPLP1 | ribosomal protein, large, P1 | -0.0334954 |
| RPS21 | ribosomal protein S21 | -0.0332947 |
| CANX | calnexin | -0.0329986 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0327174 |
| PARD3 | par-3 family cell polarity regulator | -0.0326334 |
| RPS24 | ribosomal protein S24 | -0.0324975 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0320399 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0314917 |
| LYZ | lysozyme | -0.03138 |
| DSPP | dentin sialophosphoprotein | -0.0310395 |
| RPS23 | ribosomal protein S23 | -0.0310238 |
| RBM39 | RNA binding motif protein 39 | -0.0308681 |
| RPLP0 | ribosomal protein, large, P0 | -0.0307556 |
| EGR1 | early growth response 1 | -0.0303508 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0300893 |
| NPAS2 | neuronal PAS domain protein 2 | -0.029535 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0293904 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0287707 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0286536 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0286259 |
| PKM | pyruvate kinase, muscle | -0.0270308 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.026934 |
| RPS11 | ribosomal protein S11 | -0.026783 |
| RPS5 | ribosomal protein S5 | -0.0266116 |
| RPL32 | ribosomal protein L32 | -0.0262607 |
| ASPH | aspartate beta-hydroxylase | -0.0260569 |
| GDF15 | growth differentiation factor 15 | -0.0258101 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0255415 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0255081 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0253256 |
| ATP10A | ATPase, class V, type 10A | -0.0249394 |
| GOLGA4 | golgin A4 | -0.024885 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0244917 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | -0.0241908 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0241818 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0240929 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0237911 |
| IER3 | immediate early response 3 | -0.0236982 |
| WDR45B | WD repeat domain 45B | -0.0236494 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.023588 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0234735 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0234168 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0229831 |
| A2M | alpha-2-macroglobulin | -0.0228406 |
| RACK1 | receptor for activated C kinase 1 | -0.0225344 |
| RPS19 | ribosomal protein S19 | -0.022211 |
| CTSB | cathepsin B | -0.022133 |
| RPL27A | ribosomal protein L27a | -0.022112 |
| ANGPTL8 | angiopoietin like 8 | -0.0220173 |
| ATXN1 | ataxin 1 | -0.0218621 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0217614 |
| HELZ | helicase with zinc finger | -0.021723 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.021611 |
