Ralimetinib dimesylate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PRELID2 PRELI domain containing 2 0.121501
RPS12 ribosomal protein S12 0.09257
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0915123
PDE4D phosphodiesterase 4D, cAMP-specific 0.0698015
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0582668
RNF145 ring finger protein 145 0.0542934
ATXN1 ataxin 1 0.0505778
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0486911
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0484322
RPS17 ribosomal protein S17 0.0473783
PKP2 plakophilin 2 0.043746
WWOX WW domain containing oxidoreductase 0.041338
PNISR PNN-interacting serine/arginine-rich protein 0.039854
RPL37A ribosomal protein L37a 0.0392789
SPRED1 sprouty-related, EVH1 domain containing 1 0.0377307
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0365387
RAD51B RAD51 paralog B 0.0358306
SMYD3 SET and MYND domain containing 3 0.0344438
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0336633
ZNF292 zinc finger protein 292 0.0322901
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0319197
RPS3 ribosomal protein S3 0.0315896
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0314835
CHD1 chromodomain helicase DNA binding protein 1 0.0312981
PARD3B par-3 family cell polarity regulator beta 0.0310526
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0307145
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.030214
EREG epiregulin 0.0299571
CCSER1 coiled-coil serine-rich protein 1 0.0294009
MED13L mediator complex subunit 13-like 0.0287658
OGA O-GlcNAcase 0.0283541
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0282333
FRMD5 FERM domain containing 5 0.0280199
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0275258
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0273699
ARHGAP29 Rho GTPase activating protein 29 0.0273524
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0271703
SAMD5 sterile alpha motif domain containing 5 0.0271647
DSCAM Down syndrome cell adhesion molecule 0.0271173
ANTXR2 anthrax toxin receptor 2 0.0270777
PSAT1 phosphoserine aminotransferase 1 0.0269721
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.026937
ETV6 ets variant 6 0.026625
NEBL nebulette 0.0265665
DST dystonin 0.025857
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0252042
EXT1 exostosin glycosyltransferase 1 0.0251369
RPL9 ribosomal protein L9 0.0248432
WWC1 WW and C2 domain containing 1 0.0246743
SH3RF2 SH3 domain containing ring finger 2 0.0244568
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.024412
DENND4C DENN/MADD domain containing 4C 0.0242689
CDK19 cyclin-dependent kinase 19 0.0240533
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0238935
METTL15 methyltransferase like 15 0.023669
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.02361
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0234843
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0232084
RPS7 ribosomal protein S7 0.0230907
FHL2 four and a half LIM domains 2 0.0230055
RPL7 ribosomal protein L7 0.0226667
EIF4B eukaryotic translation initiation factor 4B 0.0225538
MYO6 myosin VI 0.0222216
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0222128
FAM13A family with sequence similarity 13, member A 0.021777
MBD5 methyl-CpG binding domain protein 5 0.0215749
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0215062
MAST4 microtubule associated serine/threonine kinase family member 4 0.0214581
PTPRG protein tyrosine phosphatase, receptor type, G 0.0214252
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0213313
NFIB nuclear factor I/B 0.0213264
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212823
TBK1 TANK-binding kinase 1 0.021075
CCPG1 cell cycle progression 1 0.0210348
ANKRD12 ankyrin repeat domain 12 0.0209391
ABHD17C abhydrolase domain containing 17C 0.0209354
HYOU1 hypoxia up-regulated 1 0.0208978
YEATS2 YEATS domain containing 2 0.0208421
FBXL17 F-box and leucine-rich repeat protein 17 0.0207827
FOXP1 forkhead box P1 0.0206349
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0206271
MBNL1 muscleblind-like splicing regulator 1 0.0206166
FAT1 FAT atypical cadherin 1 0.0204949
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0204513
TBC1D5 TBC1 domain family, member 5 0.0203715
RPL21 ribosomal protein L21 0.0199042
RPS2 ribosomal protein S2 0.0198054
PCM1 pericentriolar material 1 0.0197851
SATB2 SATB homeobox 2 0.0195922
ARL15 ADP-ribosylation factor-like 15 0.0192757
EFNA5 ephrin-A5 0.019196
RBM33 RNA binding motif protein 33 0.0191934
ANO6 anoctamin 6 0.0189902
SPRED2 sprouty-related, EVH1 domain containing 2 0.0189785
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0189743
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0187852
DERA deoxyribose-phosphate aldolase (putative) 0.0187001
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0183988
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0183207
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0182176

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209624
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.156791
FLNB filamin B, beta -0.140088
LMO7 LIM domain 7 -0.12959
ACTG1 actin gamma 1 -0.11722
MSI2 musashi RNA-binding protein 2 -0.112668
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.112252
CALB1 calbindin 1, 28kDa -0.108552
THSD4 thrombospondin, type I, domain containing 4 -0.108183
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0935453
EZR ezrin -0.0921554
GMDS GDP-mannose 4,6-dehydratase -0.08002
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0707872
UBE2H ubiquitin-conjugating enzyme E2H -0.0655786
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0651494
TPT1 tumor protein, translationally-controlled 1 -0.0630172
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0612785
F3 coagulation factor III (thromboplastin, tissue factor) -0.0610855
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0610494
OXSR1 oxidative stress responsive 1 -0.0597431
PTPRR protein tyrosine phosphatase, receptor type, R -0.0592588
PKM pyruvate kinase, muscle -0.0563852
P3H2 prolyl 3-hydroxylase 2 -0.0560119
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0551208
ANXA2 annexin A2 -0.0540737
ACTN4 actinin, alpha 4 -0.0529958
MPRIP myosin phosphatase Rho interacting protein -0.0527522
ITGA6 integrin, alpha 6 -0.0525284
MYOF myoferlin -0.0508412
RPLP1 ribosomal protein, large, P1 -0.0489329
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0476273
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0475131
UBC ubiquitin C -0.0473724
PTPRB protein tyrosine phosphatase, receptor type, B -0.0462192
LOC112694756 uncharaterized LOC112694756 -0.0452729
AKAP13 A kinase (PRKA) anchor protein 13 -0.0448164
FBXO11 F-box protein 11 -0.042923
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0427728
PALLD palladin, cytoskeletal associated protein -0.0426957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0418803
POTEF POTE ankyrin domain family, member F -0.0411409
CYSTM1 cysteine-rich transmembrane module containing 1 -0.041089
SEC31A SEC31 homolog A (S. cerevisiae) -0.0406465
GDF15 growth differentiation factor 15 -0.0405789
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.038801
TMSB10 thymosin beta 10 -0.0386778
DSPP dentin sialophosphoprotein -0.0386558
RPL35A ribosomal protein L35a -0.038592
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0382931
HDLBP high density lipoprotein binding protein -0.0382431
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.038013
TJP1 tight junction protein 1 -0.0373522
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0369926
AOPEP aminopeptidase O (putative) -0.0368902
RPS23 ribosomal protein S23 -0.0364517
CANX calnexin -0.0362498
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0361422
KLF3 Kruppel-like factor 3 (basic) -0.0358118
MYO1E myosin IE -0.0357749
COBL cordon-bleu WH2 repeat protein -0.035729
ETNK1 ethanolamine kinase 1 -0.0356334
SLC38A2 solute carrier family 38, member 2 -0.0355556
RAB7A RAB7A, member RAS oncogene family -0.0355145
LAMA4 laminin, alpha 4 -0.0354756
RRBP1 ribosome binding protein 1 -0.035456
NT5C2 5'-nucleotidase, cytosolic II -0.0353406
MX1 MX dynamin-like GTPase 1 -0.0351919
AHNAK AHNAK nucleoprotein -0.034724
RPL8 ribosomal protein L8 -0.0346204
RPS13 ribosomal protein S13 -0.0345245
PGK1 phosphoglycerate kinase 1 -0.0338875
ANKRD17 ankyrin repeat domain 17 -0.0337828
ATP5F1B ATP synthase F1 subunit beta -0.0334497
CCNI cyclin I -0.0334402
RPLP0 ribosomal protein, large, P0 -0.0333694
SP100 SP100 nuclear antigen -0.0332763
KRT19 keratin 19, type I -0.0331765
MYH14 myosin, heavy chain 14, non-muscle -0.0327167
TC2N tandem C2 domains, nuclear -0.0326552
CLDN4 claudin 4 -0.0324817
MAML2 mastermind-like 2 (Drosophila) -0.0322804
PSD3 pleckstrin and Sec7 domain containing 3 -0.0319949
CATSPERB catsper channel auxiliary subunit beta -0.0308913
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0307356
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0306759
HMGA1 high mobility group AT-hook 1 -0.0305692
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0304129
SPON1 spondin 1, extracellular matrix protein -0.0303993
S100A10 S100 calcium binding protein A10 -0.0301959
SH3D19 SH3 domain containing 19 -0.0301898
RPS6 ribosomal protein S6 -0.030163
INO80 INO80 complex subunit -0.0300712
RPL34 ribosomal protein L34 -0.030022
S100A6 S100 calcium binding protein A6 -0.0298449
PDLIM5 PDZ and LIM domain 5 -0.0298049
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0296748
RPS11 ribosomal protein S11 -0.0296452
TPM1 tropomyosin 1 (alpha) -0.0293881
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0291748
EIF1 eukaryotic translation initiation factor 1 -0.0289617