| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ralimetinib dimesylate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.0766662 |
| TXNRD1 | thioredoxin reductase 1 | 0.0732179 |
| RPL26 | ribosomal protein L26 | 0.0634545 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0589742 |
| RPS12 | ribosomal protein S12 | 0.0587542 |
| RPL12 | ribosomal protein L12 | 0.0526505 |
| RPS3 | ribosomal protein S3 | 0.0516615 |
| RAI1 | retinoic acid induced 1 | 0.0495145 |
| RPL18 | ribosomal protein L18 | 0.0474043 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0451909 |
| ANGPTL4 | angiopoietin-like 4 | 0.0418385 |
| RPL23 | ribosomal protein L23 | 0.0414409 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0405619 |
| RPL36 | ribosomal protein L36 | 0.039712 |
| RPL37A | ribosomal protein L37a | 0.0371297 |
| RPS19 | ribosomal protein S19 | 0.0368605 |
| ANXA1 | annexin A1 | 0.0358858 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0356225 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0349784 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0336004 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.032656 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0325367 |
| TMSB10 | thymosin beta 10 | 0.0315713 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0313734 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0304154 |
| RPL35 | ribosomal protein L35 | 0.0291077 |
| SON | SON DNA binding protein | 0.0287604 |
| EREG | epiregulin | 0.0287458 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0273212 |
| USP34 | ubiquitin specific peptidase 34 | 0.0264897 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.026164 |
| RPS17 | ribosomal protein S17 | 0.0255299 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0250899 |
| RPL9 | ribosomal protein L9 | 0.0245095 |
| HDAC9 | histone deacetylase 9 | 0.0235882 |
| RPL19 | ribosomal protein L19 | 0.0234161 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0230594 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0230204 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0228868 |
| RPL35A | ribosomal protein L35a | 0.022845 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0224236 |
| CDK19 | cyclin-dependent kinase 19 | 0.0219264 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0217053 |
| YEATS2 | YEATS domain containing 2 | 0.0215506 |
| YBX3 | Y box binding protein 3 | 0.0213799 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0212414 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0212303 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0206753 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0205703 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | 0.0205555 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0193744 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.019368 |
| KLF6 | Kruppel-like factor 6 | 0.0193612 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0193395 |
| EMP1 | epithelial membrane protein 1 | 0.0188753 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.018602 |
| RPS27 | ribosomal protein S27 | 0.0185239 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0181809 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0180933 |
| RPLP2 | ribosomal protein, large, P2 | 0.0178623 |
| RPL7 | ribosomal protein L7 | 0.0177096 |
| EHBP1 | EH domain binding protein 1 | 0.0173492 |
| JMJD1C | jumonji domain containing 1C | 0.0172622 |
| CREBRF | CREB3 regulatory factor | 0.0171045 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.017063 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0169754 |
| PRDX1 | peroxiredoxin 1 | 0.0167178 |
| RBM25 | RNA binding motif protein 25 | 0.0166481 |
| PYGB | phosphorylase, glycogen; brain | 0.0164191 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0163805 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0163747 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0161181 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0158725 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0158471 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0157901 |
| RTN4 | reticulon 4 | 0.0156282 |
| RPS8 | ribosomal protein S8 | 0.0156143 |
| PHF21A | PHD finger protein 21A | 0.0156121 |
| SERINC1 | serine incorporator 1 | 0.0156065 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0154714 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0154518 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0151678 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0150736 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0150601 |
| SMAP1 | small ArfGAP 1 | 0.0150222 |
| RPS4X | ribosomal protein S4, X-linked | 0.0149975 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0149285 |
| RASAL2 | RAS protein activator like 2 | 0.0149093 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.014694 |
| CDV3 | CDV3 homolog (mouse) | 0.0146084 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0145682 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0144876 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.0144278 |
| UPP1 | uridine phosphorylase 1 | 0.014391 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0142518 |
| ANO6 | anoctamin 6 | 0.0141995 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0141143 |
| RPL27 | ribosomal protein L27 | 0.0141067 |
| KLC1 | kinesin light chain 1 | 0.0139638 |
| CEP170 | centrosomal protein 170kDa | 0.0139611 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.619575 |
| POTEF | POTE ankyrin domain family, member F | -0.157729 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0823181 |
| VIM | vimentin | -0.0821991 |
| ACTG1 | actin gamma 1 | -0.0760967 |
| CD44 | CD44 molecule (Indian blood group) | -0.0735497 |
| PTMA | prothymosin, alpha | -0.0658139 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0640495 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0614105 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0579235 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0540392 |
| CADM2 | cell adhesion molecule 2 | -0.0539747 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0532532 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0488892 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0476527 |
| UBC | ubiquitin C | -0.0475339 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0456609 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0453372 |
| HMGA1 | high mobility group AT-hook 1 | -0.0448507 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0438725 |
| LOC112694756 | uncharaterized LOC112694756 | -0.043844 |
| TP63 | tumor protein p63 | -0.0435406 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0433119 |
| TMSB4X | thymosin beta 4, X-linked | -0.0424036 |
| CANX | calnexin | -0.0412309 |
| SPAG9 | sperm associated antigen 9 | -0.0400585 |
| AHNAK | AHNAK nucleoprotein | -0.038138 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0376666 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0369931 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0367752 |
| RNF213 | ring finger protein 213 | -0.0366714 |
| FBXO11 | F-box protein 11 | -0.0362415 |
| GLG1 | golgi glycoprotein 1 | -0.0361813 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0359496 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0353855 |
| VCL | vinculin | -0.034702 |
| DEK | DEK proto-oncogene | -0.03447 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0343366 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0339807 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0330213 |
| ECE1 | endothelin converting enzyme 1 | -0.0324074 |
| PGK1 | phosphoglycerate kinase 1 | -0.0319367 |
| YBX1 | Y box binding protein 1 | -0.0319044 |
| RAD51B | RAD51 paralog B | -0.0316924 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.031635 |
| JUN | jun proto-oncogene | -0.0314936 |
| PODXL | podocalyxin-like | -0.0311402 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0309454 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0307628 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0306071 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0301943 |
| PTK2 | protein tyrosine kinase 2 | -0.0299532 |
| LDHA | lactate dehydrogenase A | -0.0295769 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0293231 |
| RIGI | RNA sensor RIG-I | -0.0280238 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.027914 |
| PKM | pyruvate kinase, muscle | -0.0278691 |
| NDRG1 | N-myc downstream regulated 1 | -0.0272219 |
| TAPBP | TAP binding protein (tapasin) | -0.026968 |
| CENPF | centromere protein F, 350/400kDa | -0.026856 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0268512 |
| TXNIP | thioredoxin interacting protein | -0.0267644 |
| CALR | calreticulin | -0.0262131 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0260321 |
| H1-0 | H1.0 linker histone | -0.0253533 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0252208 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0247114 |
| WDR45B | WD repeat domain 45B | -0.0247078 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0245911 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0244205 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0239873 |
| TUBB | tubulin, beta class I | -0.0238953 |
| SP100 | SP100 nuclear antigen | -0.0236204 |
| RPL8 | ribosomal protein L8 | -0.0236156 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0234832 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0234066 |
| WASF2 | WAS protein family, member 2 | -0.0231717 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0231084 |
| EGR1 | early growth response 1 | -0.0229305 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0229258 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0228506 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0226544 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0225675 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0223799 |
| OPTN | optineurin | -0.0221168 |
| TMEM123 | transmembrane protein 123 | -0.0219606 |
| HLA-B | major histocompatibility complex, class I, B | -0.0219219 |
| TRIM56 | tripartite motif containing 56 | -0.0216777 |
| ACTN1 | actinin, alpha 1 | -0.0214959 |
| S100A9 | S100 calcium binding protein A9 | -0.0213655 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0212703 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0209061 |
| RUNX1 | runt-related transcription factor 1 | -0.0208644 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0208517 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0206199 |
| TNS3 | tensin 3 | -0.0205551 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0204993 |
| PARD3 | par-3 family cell polarity regulator | -0.0203179 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0203135 |
| APP | amyloid beta (A4) precursor protein | -0.0201439 |
