Ralimetinib dimesylate_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.148297
FAM13A family with sequence similarity 13, member A 0.080934
PTMA prothymosin, alpha 0.0800278
EGFR epidermal growth factor receptor 0.0785811
MT2A metallothionein 2A 0.0769919
RPS3 ribosomal protein S3 0.0678201
ENO1 enolase 1, (alpha) 0.0664713
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0644694
GCLC glutamate-cysteine ligase, catalytic subunit 0.0553909
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0550061
RPL37A ribosomal protein L37a 0.0546208
ZMYND8 zinc finger, MYND-type containing 8 0.0484598
RPL35A ribosomal protein L35a 0.0467181
TPT1 tumor protein, translationally-controlled 1 0.0451878
RPLP1 ribosomal protein, large, P1 0.0446783
CAV1 caveolin 1, caveolae protein, 22kDa 0.0427112
RPS12 ribosomal protein S12 0.0424817
RPS24 ribosomal protein S24 0.0420061
LRP1B low density lipoprotein receptor-related protein 1B 0.0401364
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.039333
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0391696
RPS25 ribosomal protein S25 0.03894
RPS17 ribosomal protein S17 0.0384425
RPS8 ribosomal protein S8 0.0371645
LDHA lactate dehydrogenase A 0.0356247
TTC3 tetratricopeptide repeat domain 3 0.0330411
FTL ferritin, light polypeptide 0.033011
CST3 cystatin C 0.0324838
TMEM165 transmembrane protein 165 0.0321337
IRS2 insulin receptor substrate 2 0.0320407
EFNA5 ephrin-A5 0.0318042
RNF145 ring finger protein 145 0.0315111
RNF213 ring finger protein 213 0.0314864
RPL31 ribosomal protein L31 0.0311143
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0307024
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0305907
SEPTIN2 septin 2 0.0304568
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0302181
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0295302
RPL23 ribosomal protein L23 0.0289307
SEC61G Sec61 gamma subunit 0.028046
S100P S100 calcium binding protein P 0.0275475
B2M beta-2-microglobulin 0.0265263
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0264378
RPL19 ribosomal protein L19 0.0260087
ANXA2 annexin A2 0.0258168
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.025652
RPS19 ribosomal protein S19 0.0255409
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0251033
RPL11 ribosomal protein L11 0.0250184
CIB1 calcium and integrin binding 1 (calmyrin) 0.0247305
RPS27A ribosomal protein S27a 0.0238814
ANGPTL4 angiopoietin-like 4 0.0238025
S100A6 S100 calcium binding protein A6 0.0236576
TENT5A terminal nucleotidyltransferase 5A 0.0234318
UBE2O ubiquitin-conjugating enzyme E2O 0.0232913
BIRC3 baculoviral IAP repeat containing 3 0.0231068
RPL37 ribosomal protein L37 0.0228738
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0227865
RPL36 ribosomal protein L36 0.0226813
S100A10 S100 calcium binding protein A10 0.0225195
TRIM56 tripartite motif containing 56 0.0221389
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0221282
RPLP2 ribosomal protein, large, P2 0.0217595
LIMCH1 LIM and calponin homology domains 1 0.0216351
RPL12 ribosomal protein L12 0.0215003
SPTSSA serine palmitoyltransferase, small subunit A 0.0214135
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0212247
TXNRD1 thioredoxin reductase 1 0.0210778
IFI6 interferon, alpha-inducible protein 6 0.0207473
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0207368
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.020216
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0202041
TKT transketolase 0.0200661
GSTP1 glutathione S-transferase pi 1 0.0200091
RPS14 ribosomal protein S14 0.0196988
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0196363
ALCAM activated leukocyte cell adhesion molecule 0.0195843
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0194085
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0192411
RPL5 ribosomal protein L5 0.0191064
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0190256
RACK1 receptor for activated C kinase 1 0.0189827
MXI1 MAX interactor 1, dimerization protein 0.0188835
SMIM14 small integral membrane protein 14 0.0187552
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0186827
WSB1 WD repeat and SOCS box containing 1 0.0185541
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0185518
BMP7 bone morphogenetic protein 7 0.0184624
HYOU1 hypoxia up-regulated 1 0.0184416
SRSF11 serine/arginine-rich splicing factor 11 0.0182666
KIAA0319 KIAA0319 0.0182389
KRT18 keratin 18, type I 0.01816
RPL30 ribosomal protein L30 0.0180957
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0180746
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0179712
S100A11 S100 calcium binding protein A11 0.0178913
SLMAP sarcolemma associated protein 0.0178465
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0177134
DAAM1 dishevelled associated activator of morphogenesis 1 0.017657

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.255548
THSD4 thrombospondin, type I, domain containing 4 -0.13497
LAMC2 laminin, gamma 2 -0.129219
NDRG1 N-myc downstream regulated 1 -0.118185
ELL2 elongation factor, RNA polymerase II, 2 -0.103272
SLTM SAFB-like, transcription modulator -0.0995472
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0871418
PDLIM5 PDZ and LIM domain 5 -0.0816079
SPAG9 sperm associated antigen 9 -0.0812721
GSK3B glycogen synthase kinase 3 beta -0.0772769
LMO7 LIM domain 7 -0.0761156
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0729264
PTPRM protein tyrosine phosphatase, receptor type, M -0.0717057
CES1 carboxylesterase 1 -0.0678068
MCL1 myeloid cell leukemia 1 -0.0627107
NABP1 nucleic acid binding protein 1 -0.0604536
UBC ubiquitin C -0.056774
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0557176
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0549019
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0541814
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0539712
DSCAM Down syndrome cell adhesion molecule -0.0530218
CDCP1 CUB domain containing protein 1 -0.0488813
NAMPT nicotinamide phosphoribosyltransferase -0.0487188
SOD2 superoxide dismutase 2, mitochondrial -0.0468639
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0468037
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.046049
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0444732
INTS6 integrator complex subunit 6 -0.0443268
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0438
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0434481
MYO1E myosin IE -0.042932
JMJD1C jumonji domain containing 1C -0.0427778
CEMIP cell migration inducing protein, hyaluronan binding -0.0419692
VCL vinculin -0.0418444
SAMD4A sterile alpha motif domain containing 4A -0.0415312
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0412191
IGFBP3 insulin-like growth factor binding protein 3 -0.0411103
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0408788
TRIP12 thyroid hormone receptor interactor 12 -0.0404842
OSMR oncostatin M receptor -0.0399951
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0398907
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0387288
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0384699
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0384006
USP53 ubiquitin specific peptidase 53 -0.0381809
ASPH aspartate beta-hydroxylase -0.0380328
USP34 ubiquitin specific peptidase 34 -0.0379509
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0375206
GRAMD1B GRAM domain containing 1B -0.0373055
BCAR3 breast cancer anti-estrogen resistance 3 -0.0373053
STC1 stanniocalcin 1 -0.0364974
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0363252
CANX calnexin -0.0362499
LOC112694756 uncharaterized LOC112694756 -0.0356878
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0354874
GRB10 growth factor receptor-bound protein 10 -0.0353386
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0351089
MACF1 microtubule-actin crosslinking factor 1 -0.0348933
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0348349
SETX senataxin -0.0348143
ZC3H11A zinc finger CCCH-type containing 11A -0.0347825
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0345506
GLS2 glutaminase 2 (liver, mitochondrial) -0.0341485
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0339681
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0337134
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.032998
FBXO11 F-box protein 11 -0.0326527
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0323501
OXSR1 oxidative stress responsive 1 -0.0321578
TSC22D2 TSC22 domain family, member 2 -0.0317551
BMAL2 basic helix-loop-helix ARNT like 2 -0.0316969
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0313223
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0309299
RCOR1 REST corepressor 1 -0.0307064
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0304618
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0304573
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0301087
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0298096
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0296756
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0296387
H1-0 H1.0 linker histone -0.0294669
PAPOLA poly(A) polymerase alpha -0.0291232
SCEL sciellin -0.0287737
MSN moesin -0.0286411
RASA2 RAS p21 protein activator 2 -0.0285742
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0285535
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0285289
PATJ PATJ crumbs cell polarity complex component -0.0280405
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0279768
AKAP13 A kinase (PRKA) anchor protein 13 -0.0279545
MAML3 mastermind-like 3 (Drosophila) -0.027916
ZFAND6 zinc finger, AN1-type domain 6 -0.0275043
MED13L mediator complex subunit 13-like -0.0274509
CCNL1 cyclin L1 -0.0273505
HOOK2 hook microtubule-tethering protein 2 -0.0273089
ANKRD17 ankyrin repeat domain 17 -0.0271788
MYO1D myosin ID -0.0261637
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0260558
HSPA8 heat shock 70kDa protein 8 -0.0259372