| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.328241 |
| VIM | vimentin | 0.133663 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.10282 |
| PYGL | phosphorylase, glycogen, liver | 0.0361067 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0354704 |
| RPS17 | ribosomal protein S17 | 0.0343816 |
| ANGPTL4 | angiopoietin-like 4 | 0.0338687 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0290302 |
| RPL31 | ribosomal protein L31 | 0.0289061 |
| RPS27 | ribosomal protein S27 | 0.0279421 |
| RAD51B | RAD51 paralog B | 0.0262037 |
| RPL23 | ribosomal protein L23 | 0.0261226 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0259909 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0259321 |
| RPS3 | ribosomal protein S3 | 0.0252012 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0251855 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0249604 |
| RPS12 | ribosomal protein S12 | 0.0243842 |
| RPL37A | ribosomal protein L37a | 0.023472 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0233901 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0232659 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.022162 |
| FMNL2 | formin-like 2 | 0.021976 |
| HLA-B | major histocompatibility complex, class I, B | 0.0218406 |
| RPL35A | ribosomal protein L35a | 0.0214559 |
| FLNB | filamin B, beta | 0.0209398 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0205124 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.019801 |
| LDHA | lactate dehydrogenase A | 0.0195902 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0193899 |
| NEGR1 | neuronal growth regulator 1 | 0.0193296 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0190368 |
| ITGA6 | integrin, alpha 6 | 0.0190315 |
| FLNA | filamin A, alpha | 0.0188313 |
| TMSB10 | thymosin beta 10 | 0.0188211 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.018801 |
| LMNA | lamin A/C | 0.0185279 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0183254 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0182528 |
| RPL26 | ribosomal protein L26 | 0.0180617 |
| RPL36 | ribosomal protein L36 | 0.017276 |
| RPS8 | ribosomal protein S8 | 0.0165298 |
| PRR16 | proline rich 16 | 0.0165008 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0164397 |
| NEBL | nebulette | 0.0162738 |
| HMGA2 | high mobility group AT-hook 2 | 0.0161629 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.015673 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0155038 |
| FAM107B | family with sequence similarity 107, member B | 0.015055 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.01484 |
| NHSL1 | NHS-like 1 | 0.0148341 |
| RORA | RAR-related orphan receptor A | 0.014778 |
| PRKD1 | protein kinase D1 | 0.0145667 |
| KIAA0319 | KIAA0319 | 0.0145441 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.014518 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0144829 |
| RPS19 | ribosomal protein S19 | 0.0144824 |
| SNX14 | sorting nexin 14 | 0.0144711 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0141284 |
| SBF2 | SET binding factor 2 | 0.0140887 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0140364 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0139531 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0138796 |
| HLA-A | major histocompatibility complex, class I, A | 0.0136767 |
| GRAMD1B | GRAM domain containing 1B | 0.0134795 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0133398 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0131633 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0129751 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0127697 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0127458 |
| RPL12 | ribosomal protein L12 | 0.0124906 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | 0.0124667 |
| CAVIN1 | caveolae associated protein 1 | 0.0124398 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.012333 |
| FEZ2 | fasciculation and elongation protein zeta 2 (zygin II) | 0.0120813 |
| SMYD3 | SET and MYND domain containing 3 | 0.0120754 |
| CMIP | c-Maf inducing protein | 0.0120084 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0120026 |
| MAP4 | microtubule-associated protein 4 | 0.0119793 |
| RPL36AL | ribosomal protein L36a-like | 0.0119581 |
| PDGFC | platelet derived growth factor C | 0.0119394 |
| TMEM245 | transmembrane protein 245 | 0.0118751 |
| RYK | receptor-like tyrosine kinase | 0.011848 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0118432 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | 0.0117011 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.011629 |
| NEMF | nuclear export mediator factor | 0.0113949 |
| B2M | beta-2-microglobulin | 0.0111094 |
| EHBP1 | EH domain binding protein 1 | 0.0110722 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0110399 |
| RPL18 | ribosomal protein L18 | 0.0110371 |
| TMEM14B | transmembrane protein 14B | 0.0109745 |
| FRMD5 | FERM domain containing 5 | 0.010952 |
| EGFR | epidermal growth factor receptor | 0.0107982 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 0.010769 |
| RPL37 | ribosomal protein L37 | 0.0107346 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0106907 |
| TPI1 | triosephosphate isomerase 1 | 0.0106422 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0106328 |
| MT1F | metallothionein 1F | 0.0105165 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.428554 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.139159 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.130154 |
| PM20D1 | peptidase M20 domain containing 1 | -0.121672 |
| TXNRD1 | thioredoxin reductase 1 | -0.11339 |
| ACTG1 | actin gamma 1 | -0.10891 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.107836 |
| POTEF | POTE ankyrin domain family, member F | -0.0988745 |
| FTL | ferritin, light polypeptide | -0.0962415 |
| FGB | fibrinogen beta chain | -0.0948146 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0859928 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0723332 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0677151 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0656591 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0653406 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0520983 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0503407 |
| YBX1 | Y box binding protein 1 | -0.0503289 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0500004 |
| IGF2 | insulin-like growth factor 2 | -0.0486259 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0476492 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0473813 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0452773 |
| RBM39 | RNA binding motif protein 39 | -0.04479 |
| ERBIN | erbb2 interacting protein | -0.0444256 |
| RPS2 | ribosomal protein S2 | -0.0443057 |
| UBC | ubiquitin C | -0.0436792 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0412466 |
| IER3 | immediate early response 3 | -0.0393276 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0390361 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0390249 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0360032 |
| PTMA | prothymosin, alpha | -0.0358469 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0353251 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0345495 |
| RPL8 | ribosomal protein L8 | -0.0345192 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0342279 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0342157 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0340099 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0337341 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0332957 |
| GLG1 | golgi glycoprotein 1 | -0.0328819 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0322059 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0320001 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.031746 |
| RHOA | ras homolog family member A | -0.0316129 |
| RPS23 | ribosomal protein S23 | -0.0312416 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.031039 |
| FBXO11 | F-box protein 11 | -0.0306527 |
| RPS21 | ribosomal protein S21 | -0.0304629 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0304025 |
| CANX | calnexin | -0.0303656 |
| RHEB | Ras homolog enriched in brain | -0.0291151 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0290677 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0286924 |
| SPAG9 | sperm associated antigen 9 | -0.0286461 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.028569 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.028201 |
| EGR1 | early growth response 1 | -0.0276447 |
| RPS5 | ribosomal protein S5 | -0.0273901 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0270867 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.026801 |
| RTN4 | reticulon 4 | -0.0266967 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0263897 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0263501 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0262998 |
| NTN4 | netrin 4 | -0.0255928 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0255809 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0253722 |
| PKM | pyruvate kinase, muscle | -0.0251128 |
| LDHB | lactate dehydrogenase B | -0.0247386 |
| RPL4 | ribosomal protein L4 | -0.0247118 |
| RPL19 | ribosomal protein L19 | -0.0245855 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0244381 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0239453 |
| GOLT1B | golgi transport 1B | -0.0237536 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0234851 |
| PTK2 | protein tyrosine kinase 2 | -0.0234798 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.023262 |
| RPS11 | ribosomal protein S11 | -0.0231069 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0228446 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0228419 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0227332 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0227162 |
| ADAR | adenosine deaminase, RNA-specific | -0.0226961 |
| TPM3 | tropomyosin 3 | -0.0225119 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0224978 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0223961 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0223219 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0221506 |
| MCL1 | myeloid cell leukemia 1 | -0.0220365 |
| SRGN | serglycin | -0.0220123 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0218689 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0218631 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0218612 |
| TAGLN2 | transgelin 2 | -0.0218301 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0215744 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0215531 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0213364 |
| CLTC | clathrin, heavy chain (Hc) | -0.0212599 |
