Ralimetinib dimesylate_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.14271
EGFR epidermal growth factor receptor 0.102407
NALF1 NALCN channel auxiliary factor 1 0.100092
PTK2 protein tyrosine kinase 2 0.080921
EFNA5 ephrin-A5 0.0802829
NKD1 naked cuticle homolog 1 (Drosophila) 0.0745087
BLTP1 bridge-like lipid transfer protein family member 1 0.0682445
SLTM SAFB-like, transcription modulator 0.067311
PHF3 PHD finger protein 3 0.0656882
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0650332
NAV1 neuron navigator 1 0.0648943
BRD4 bromodomain containing 4 0.0645569
LPP LIM domain containing preferred translocation partner in lipoma 0.064466
CNKSR3 CNKSR family member 3 0.0637612
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0628709
CDK6 cyclin-dependent kinase 6 0.0625701
RBM33 RNA binding motif protein 33 0.062315
TRIO trio Rho guanine nucleotide exchange factor 0.0622518
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0619619
ZSWIM6 zinc finger, SWIM-type containing 6 0.0615414
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0608487
NEK7 NIMA-related kinase 7 0.0604459
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0582076
ATXN1 ataxin 1 0.0581747
FAT1 FAT atypical cadherin 1 0.0578853
MRTFA myocardin related transcription factor A 0.0567017
ARHGAP5 Rho GTPase activating protein 5 0.0563765
ZMYND8 zinc finger, MYND-type containing 8 0.0560175
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0560163
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.055842
MTF2 metal response element binding transcription factor 2 0.055503
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0549694
LCN2 lipocalin 2 0.054876
COL6A3 collagen, type VI, alpha 3 0.0535935
CHD9 chromodomain helicase DNA binding protein 9 0.0528459
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0527203
FN1 fibronectin 1 0.0519963
CADPS2 Ca++-dependent secretion activator 2 0.0517141
LEF1 lymphoid enhancer-binding factor 1 0.051668
PSD3 pleckstrin and Sec7 domain containing 3 0.0513821
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0512314
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0505209
TNRC6B trinucleotide repeat containing 6B 0.0500552
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0499056
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0497853
NAV2 neuron navigator 2 0.0494395
VCL vinculin 0.0489225
VEZT vezatin, adherens junctions transmembrane protein 0.0482277
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0480941
SP100 SP100 nuclear antigen 0.047732
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0466432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0464151
MBTD1 mbt domain containing 1 0.0461026
IGF2 insulin-like growth factor 2 0.0460793
RPS24 ribosomal protein S24 0.0460507
STK24 serine/threonine kinase 24 0.0460492
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0459172
MED12 mediator complex subunit 12 0.0455009
ZMIZ1 zinc finger, MIZ-type containing 1 0.0454472
GLIS3 GLIS family zinc finger 3 0.0454392
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0450978
CCNH cyclin H 0.0450509
ZNF292 zinc finger protein 292 0.0449225
EHBP1 EH domain binding protein 1 0.0448093
GPHN gephyrin 0.0447386
EIF4B eukaryotic translation initiation factor 4B 0.0444922
BBS9 Bardet-Biedl syndrome 9 0.0440628
ACTN4 actinin, alpha 4 0.0439917
APP amyloid beta (A4) precursor protein 0.043717
TBC1D5 TBC1 domain family, member 5 0.0435698
ATP11A ATPase, class VI, type 11A 0.0433636
WWTR1 WW domain containing transcription regulator 1 0.0432193
TAOK1 TAO kinase 1 0.0426398
MSI2 musashi RNA-binding protein 2 0.0421763
RBM6 RNA binding motif protein 6 0.0420734
RPL26 ribosomal protein L26 0.0418909
GMDS GDP-mannose 4,6-dehydratase 0.0417048
TNRC6A trinucleotide repeat containing 6A 0.0414599
CLIP2 CAP-GLY domain containing linker protein 2 0.0412501
SMAD3 SMAD family member 3 0.0411379
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.040688
RAB7A RAB7A, member RAS oncogene family 0.0406178
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0401868
USP34 ubiquitin specific peptidase 34 0.0401682
FLNB filamin B, beta 0.0399967
ZNF207 zinc finger protein 207 0.039916
QKI QKI, KH domain containing, RNA binding 0.0395979
IWS1 IWS1 homolog (S. cerevisiae) 0.0392263
CUL3 cullin 3 0.0388051
STAG2 stromal antigen 2 0.038716
CARD16 caspase recruitment domain family, member 16 0.0384568
IGFBP3 insulin-like growth factor binding protein 3 0.0382772
KMT2A lysine (K)-specific methyltransferase 2A 0.0379616
GLG1 golgi glycoprotein 1 0.0373558
BACE2 beta-site APP-cleaving enzyme 2 0.0372498
PDLIM5 PDZ and LIM domain 5 0.0370737
MEST mesoderm specific transcript 0.0370308
RPL15 ribosomal protein L15 0.0369429
TRIM33 tripartite motif containing 33 0.0360999
MYOF myoferlin 0.0359638

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.198867
NDRG1 N-myc downstream regulated 1 -0.192461
GRB10 growth factor receptor-bound protein 10 -0.157613
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.155784
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144878
TMSB10 thymosin beta 10 -0.139109
LAMB3 laminin, beta 3 -0.135114
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.116711
PTMA prothymosin, alpha -0.103375
TXNRD1 thioredoxin reductase 1 -0.102761
MYO1E myosin IE -0.0879875
SPAG9 sperm associated antigen 9 -0.0827138
KYNU kynureninase -0.0794734
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0789294
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0785707
POTEF POTE ankyrin domain family, member F -0.0782266
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0748685
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0743498
AKAP9 A kinase (PRKA) anchor protein 9 -0.0720364
B2M beta-2-microglobulin -0.0713746
KRT17 keratin 17, type I -0.0701964
UBC ubiquitin C -0.0666329
FOXO3 forkhead box O3 -0.0662855
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0646402
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0631231
DSCAM Down syndrome cell adhesion molecule -0.0625795
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0625147
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0620789
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0599097
WSB1 WD repeat and SOCS box containing 1 -0.0598912
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0596328
FNDC3B fibronectin type III domain containing 3B -0.0595306
EGR1 early growth response 1 -0.054793
RAB10 RAB10, member RAS oncogene family -0.0547001
BTG1 B-cell translocation gene 1, anti-proliferative -0.0544081
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0542517
WASF2 WAS protein family, member 2 -0.0523575
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.051301
CSDE1 cold shock domain containing E1, RNA-binding -0.0511397
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.050679
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0499424
TJP1 tight junction protein 1 -0.0489328
BRWD1 bromodomain and WD repeat domain containing 1 -0.0487246
SETD5 SET domain containing 5 -0.0487023
ARHGAP21 Rho GTPase activating protein 21 -0.0486033
MORF4L2 mortality factor 4 like 2 -0.0484636
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.048438
TPR translocated promoter region, nuclear basket protein -0.0477348
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0475653
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0475267
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0470548
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0469147
NAMPT nicotinamide phosphoribosyltransferase -0.0465714
BZW1 basic leucine zipper and W2 domains 1 -0.0464923
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0459433
VIM vimentin -0.045916
RNF145 ring finger protein 145 -0.0457089
NPEPPS aminopeptidase puromycin sensitive -0.0451969
LSAMP limbic system-associated membrane protein -0.0450712
ZMYM2 zinc finger, MYM-type 2 -0.0446174
CCNI cyclin I -0.0441185
GSK3B glycogen synthase kinase 3 beta -0.0433341
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0430332
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0427224
HELZ helicase with zinc finger -0.0426578
TSC22D2 TSC22 domain family, member 2 -0.0424427
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0422795
LOC112694756 uncharaterized LOC112694756 -0.0422201
SAR1A secretion associated, Ras related GTPase 1A -0.0417526
LAMC2 laminin, gamma 2 -0.0415769
FTL ferritin, light polypeptide -0.0413052
ITCH itchy E3 ubiquitin protein ligase -0.0388204
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0384492
MAPK6 mitogen-activated protein kinase 6 -0.0380844
ANXA2 annexin A2 -0.0379537
S100A10 S100 calcium binding protein A10 -0.0376308
MXD1 MAX dimerization protein 1 -0.0376168
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0375877
EEF2 eukaryotic translation elongation factor 2 -0.0374974
RCOR1 REST corepressor 1 -0.0372228
PATJ PATJ crumbs cell polarity complex component -0.0372176
YBX3 Y box binding protein 3 -0.0368156
TMOD3 tropomodulin 3 (ubiquitous) -0.0368009
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0363896
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0360704
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0357579
RAB1A RAB1A, member RAS oncogene family -0.0354381
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.035317
RAP1B RAP1B, member of RAS oncogene family -0.0349658
STC1 stanniocalcin 1 -0.0344812
KMT2C lysine (K)-specific methyltransferase 2C -0.0340065
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0338975
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0330125
F3 coagulation factor III (thromboplastin, tissue factor) -0.0320075
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.031635
RIGI RNA sensor RIG-I -0.0315476
VMP1 vacuole membrane protein 1 -0.0309948
AK1 adenylate kinase 1 -0.030693
TUFT1 tuftelin 1 -0.0305706
LDHA lactate dehydrogenase A -0.0305665