| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRAMD1B | GRAM domain containing 1B | 0.0879534 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0727766 |
| TXNRD1 | thioredoxin reductase 1 | 0.0605226 |
| VIM | vimentin | 0.059012 |
| XPO1 | exportin 1 | 0.0502459 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0498971 |
| RPS3 | ribosomal protein S3 | 0.0444814 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0424681 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0414766 |
| TPM3 | tropomyosin 3 | 0.0413338 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0411689 |
| RPS12 | ribosomal protein S12 | 0.0385963 |
| MKI67 | marker of proliferation Ki-67 | 0.038352 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0378389 |
| RTN4 | reticulon 4 | 0.0362632 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0349066 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0341759 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.033593 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0335691 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0327371 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.032101 |
| RPL37 | ribosomal protein L37 | 0.0314356 |
| MED13L | mediator complex subunit 13-like | 0.0308974 |
| DST | dystonin | 0.0304028 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0298643 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0295782 |
| SET | SET nuclear proto-oncogene | 0.0292978 |
| TMEM41B | transmembrane protein 41B | 0.0288999 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0284016 |
| RPL37A | ribosomal protein L37a | 0.0282498 |
| ZNF292 | zinc finger protein 292 | 0.0275498 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0273834 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0271438 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0267801 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0265959 |
| RPS17 | ribosomal protein S17 | 0.026221 |
| EXOC6B | exocyst complex component 6B | 0.0249774 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.02477 |
| TMEM245 | transmembrane protein 245 | 0.0244438 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0242121 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.0240274 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0239633 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0239099 |
| ENO1 | enolase 1, (alpha) | 0.0238996 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0237385 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0234674 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.022963 |
| MELK | maternal embryonic leucine zipper kinase | 0.0227335 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0226184 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0224767 |
| PNN | pinin, desmosome associated protein | 0.0223783 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0221026 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0219984 |
| PALS1 | protein associated with LIN7 1, MAGUK p55 family member | 0.0219809 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0218331 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0212125 |
| HLTF | helicase-like transcription factor | 0.021193 |
| IPO7 | importin 7 | 0.0209876 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.0208554 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0208493 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0207825 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0206339 |
| RPS7 | ribosomal protein S7 | 0.0205473 |
| GMPS | guanine monphosphate synthase | 0.0204791 |
| SMYD3 | SET and MYND domain containing 3 | 0.0203049 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0202477 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0197902 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0195977 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0195105 |
| MYO6 | myosin VI | 0.0194235 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0194005 |
| CFH | complement factor H | 0.0193188 |
| OGA | O-GlcNAcase | 0.0191737 |
| SRPK2 | SRSF protein kinase 2 | 0.0190618 |
| ZNF148 | zinc finger protein 148 | 0.0189909 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.018966 |
| ITGA6 | integrin, alpha 6 | 0.0189299 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0188605 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.018841 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0187343 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0187201 |
| CIP2A | cellular inhibitor of PP2A | 0.0185879 |
| RNF145 | ring finger protein 145 | 0.018537 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0185088 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0183514 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0183466 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0181303 |
| KRT18 | keratin 18, type I | 0.0180456 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0180082 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0178077 |
| RRM2 | ribonucleotide reductase M2 | 0.0177603 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.017732 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.017581 |
| CDK19 | cyclin-dependent kinase 19 | 0.0175159 |
| MATR3 | matrin 3 | 0.0175036 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0173295 |
| PPM1L | protein phosphatase, Mg2+/Mn2+ dependent, 1L | 0.0172042 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0171453 |
| RNF169 | ring finger protein 169 | 0.0171263 |
| CAVIN1 | caveolae associated protein 1 | 0.0171251 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.457195 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.135589 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.098124 |
| MCL1 | myeloid cell leukemia 1 | -0.0949007 |
| EGR1 | early growth response 1 | -0.0799296 |
| ACTG1 | actin gamma 1 | -0.0716851 |
| YBX3 | Y box binding protein 3 | -0.066589 |
| OSMR | oncostatin M receptor | -0.0588144 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0579123 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0572571 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0549048 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0528892 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0509688 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0487273 |
| TMSB10 | thymosin beta 10 | -0.046483 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0459408 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0458414 |
| NABP1 | nucleic acid binding protein 1 | -0.0453973 |
| POTEF | POTE ankyrin domain family, member F | -0.0444305 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0421561 |
| ATXN1 | ataxin 1 | -0.0418859 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0416875 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0415128 |
| PDE10A | phosphodiesterase 10A | -0.0407497 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0394261 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0391019 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0390621 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0387336 |
| AEBP2 | AE binding protein 2 | -0.0374318 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0374099 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0373504 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0372753 |
| FBXO11 | F-box protein 11 | -0.0371496 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0366821 |
| UBC | ubiquitin C | -0.0364044 |
| RYR3 | ryanodine receptor 3 | -0.0359818 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.035619 |
| INTS6 | integrator complex subunit 6 | -0.0352773 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0347104 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0342621 |
| PDLIM5 | PDZ and LIM domain 5 | -0.033975 |
| CANX | calnexin | -0.0331213 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0327407 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0323383 |
| H1-0 | H1.0 linker histone | -0.0317057 |
| TPM2 | tropomyosin 2 (beta) | -0.031278 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0311043 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0310932 |
| COPA | coatomer protein complex, subunit alpha | -0.0308469 |
| RNF213 | ring finger protein 213 | -0.0305948 |
| FMNL2 | formin-like 2 | -0.0303963 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0301594 |
| RSF1 | remodeling and spacing factor 1 | -0.0300348 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0300286 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0295193 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0294265 |
| RPS21 | ribosomal protein S21 | -0.0293667 |
| ATF6 | activating transcription factor 6 | -0.0288585 |
| NF1 | neurofibromin 1 | -0.0283612 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0281442 |
| USP34 | ubiquitin specific peptidase 34 | -0.0275929 |
| PRELID2 | PRELI domain containing 2 | -0.0274603 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0272214 |
| PFN1 | profilin 1 | -0.0269828 |
| ATG7 | autophagy related 7 | -0.026547 |
| ADAR | adenosine deaminase, RNA-specific | -0.0262995 |
| STYK1 | serine/threonine/tyrosine kinase 1 | -0.0262594 |
| PATJ | PATJ crumbs cell polarity complex component | -0.025853 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0252252 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0250439 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0248852 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0245147 |
| BRD2 | bromodomain containing 2 | -0.0244414 |
| PRKCE | protein kinase C, epsilon | -0.0242484 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0242018 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0240549 |
| SETX | senataxin | -0.0238328 |
| CDK12 | cyclin-dependent kinase 12 | -0.023731 |
| NDRG1 | N-myc downstream regulated 1 | -0.0236145 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0229438 |
| YBX1 | Y box binding protein 1 | -0.0229212 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0227926 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0227539 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0221452 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0219206 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0218733 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0214953 |
| EHBP1 | EH domain binding protein 1 | -0.0214522 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0213419 |
| CUX1 | cut-like homeobox 1 | -0.0211871 |
| RBM39 | RNA binding motif protein 39 | -0.0211633 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0209006 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0208783 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0208305 |
| WASF2 | WAS protein family, member 2 | -0.0205205 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0203236 |
| TLN1 | talin 1 | -0.0200162 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0199603 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0199367 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0197382 |
