Ralimetinib dimesylate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.141171
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.135054
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.129668
TRIO trio Rho guanine nucleotide exchange factor 0.105305
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0915016
FNDC3B fibronectin type III domain containing 3B 0.084263
TMSB10 thymosin beta 10 0.0790526
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0761596
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.073636
FAM13A family with sequence similarity 13, member A 0.0726837
NPEPPS aminopeptidase puromycin sensitive 0.0683051
ASPH aspartate beta-hydroxylase 0.064599
SOX4 SRY (sex determining region Y)-box 4 0.063231
LPP LIM domain containing preferred translocation partner in lipoma 0.0631051
KMT2E lysine (K)-specific methyltransferase 2E 0.0605257
PTMA prothymosin, alpha 0.0581903
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0561593
HMGB2 high mobility group box 2 0.0525584
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0517928
TOP1 topoisomerase (DNA) I 0.0447526
S100A6 S100 calcium binding protein A6 0.0439078
WSB1 WD repeat and SOCS box containing 1 0.0437874
ALCAM activated leukocyte cell adhesion molecule 0.0436556
LIMCH1 LIM and calponin homology domains 1 0.0436454
ZNF292 zinc finger protein 292 0.0434385
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0430946
PGK1 phosphoglycerate kinase 1 0.0429088
ITCH itchy E3 ubiquitin protein ligase 0.0419901
ELL2 elongation factor, RNA polymerase II, 2 0.0417796
MYO6 myosin VI 0.0411676
KDM3A lysine (K)-specific demethylase 3A 0.0390524
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0390353
PRRC2C proline-rich coiled-coil 2C 0.0385699
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0369966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0363026
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0361489
RAD21 RAD21 homolog (S. pombe) 0.0361411
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0357033
SEC23A Sec23 homolog A (S. cerevisiae) 0.035325
RPS3 ribosomal protein S3 0.0351585
STRN3 striatin, calmodulin binding protein 3 0.0344887
RNF145 ring finger protein 145 0.034211
GPBP1 GC-rich promoter binding protein 1 0.0340175
NAMPT nicotinamide phosphoribosyltransferase 0.0335119
TXNIP thioredoxin interacting protein 0.0334499
TMSB4X thymosin beta 4, X-linked 0.0326439
KLF6 Kruppel-like factor 6 0.0324563
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0318582
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0316922
RLF rearranged L-myc fusion 0.0315979
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0314366
CPNE8 copine VIII 0.0313915
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0313179
UBA6 ubiquitin-like modifier activating enzyme 6 0.0312363
NCKAP1 NCK-associated protein 1 0.0304901
UGCG UDP-glucose ceramide glucosyltransferase 0.0304564
TMEM165 transmembrane protein 165 0.0302605
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0300885
RPL18 ribosomal protein L18 0.0299726
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0298177
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0296355
CDC73 cell division cycle 73 0.0293016
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0290378
MARCHF6 membrane associated ring-CH-type finger 6 0.0289891
BASP1 brain abundant, membrane attached signal protein 1 0.0285455
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.028461
FBXO32 F-box protein 32 0.0284524
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0282839
BBX bobby sox homolog (Drosophila) 0.0280533
FAM162A family with sequence similarity 162, member A 0.028002
TFG TRK-fused gene 0.0273782
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0270127
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0270055
FAM3C family with sequence similarity 3, member C 0.026779
MATR3 matrin 3 0.0266779
PRRC1 proline-rich coiled-coil 1 0.0264424
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0261054
CALR calreticulin 0.0258638
BZW1 basic leucine zipper and W2 domains 1 0.0255769
RBM39 RNA binding motif protein 39 0.0252897
CDK17 cyclin-dependent kinase 17 0.0252703
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0252313
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0251932
YBX3 Y box binding protein 3 0.0251687
UPP1 uridine phosphorylase 1 0.0251367
PNISR PNN-interacting serine/arginine-rich protein 0.0248251
RUNX1 runt-related transcription factor 1 0.0247914
CD47 CD47 molecule 0.0245634
RPL32 ribosomal protein L32 0.0241405
CD46 CD46 molecule, complement regulatory protein 0.0241085
YTHDC1 YTH domain containing 1 0.0239496
CBX3 chromobox homolog 3 0.0237769
PUM1 pumilio RNA-binding family member 1 0.0236722
KMT2C lysine (K)-specific methyltransferase 2C 0.0235464
OGA O-GlcNAcase 0.0234922
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0232511
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0231891
NRIP1 nuclear receptor interacting protein 1 0.0231883
TMF1 TATA element modulatory factor 1 0.023179
NAP1L1 nucleosome assembly protein 1-like 1 0.0229436

decreased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F -0.249644
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.225038
ACTG1 actin gamma 1 -0.159981
FN1 fibronectin 1 -0.100371
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.100364
IGFBP3 insulin-like growth factor binding protein 3 -0.0861278
FTL ferritin, light polypeptide -0.0845185
RPL35A ribosomal protein L35a -0.0736818
UBC ubiquitin C -0.0677718
NDRG1 N-myc downstream regulated 1 -0.0487641
RAB7A RAB7A, member RAS oncogene family -0.0430156
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0393981
FTH1 ferritin, heavy polypeptide 1 -0.0381583
RPS23 ribosomal protein S23 -0.0336494
RHOA ras homolog family member A -0.033371
EIF1 eukaryotic translation initiation factor 1 -0.032661
EGR1 early growth response 1 -0.0315894
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0306508
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0298753
RPS29 ribosomal protein S29 -0.0289869
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0288439
S100A10 S100 calcium binding protein A10 -0.0284021
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0274369
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0272175
RPL8 ribosomal protein L8 -0.0271994
RPS13 ribosomal protein S13 -0.0264969
LOC112694756 uncharaterized LOC112694756 -0.0261213
SDC4 syndecan 4 -0.0256603
SAMD4A sterile alpha motif domain containing 4A -0.0253119
TAPBP TAP binding protein (tapasin) -0.0252397
KRT7 keratin 7, type II -0.0252089
F11R F11 receptor -0.0243865
ATP5F1B ATP synthase F1 subunit beta -0.0238092
MCL1 myeloid cell leukemia 1 -0.0236632
HMGA1 high mobility group AT-hook 1 -0.0230961
CRABP2 cellular retinoic acid binding protein 2 -0.0220983
RPS10 ribosomal protein S10 -0.0220736
FBXO11 F-box protein 11 -0.021963
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0219482
SEPTIN11 septin 11 -0.0218342
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0214951
HLA-B major histocompatibility complex, class I, B -0.0211559
EEF2 eukaryotic translation elongation factor 2 -0.0208889
EXT1 exostosin glycosyltransferase 1 -0.0208396
PGBD5 piggyBac transposable element derived 5 -0.020799
YBX1 Y box binding protein 1 -0.0206905
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0206501
BRD2 bromodomain containing 2 -0.0203796
RAN RAN, member RAS oncogene family -0.0203556
INTS6 integrator complex subunit 6 -0.0199505
ARF1 ADP-ribosylation factor 1 -0.0194898
CCND1 cyclin D1 -0.0193493
MAP1B microtubule-associated protein 1B -0.0190064
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0190017
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0186005
UGDH UDP-glucose 6-dehydrogenase -0.0185681
KRT8 keratin 8, type II -0.018347
GOLGB1 golgin B1 -0.0182199
RPS11 ribosomal protein S11 -0.0181256
CTSB cathepsin B -0.0179491
SRSF3 serine/arginine-rich splicing factor 3 -0.017865
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0174964
ATF4 activating transcription factor 4 -0.0173873
TJP1 tight junction protein 1 -0.0166689
RPL31 ribosomal protein L31 -0.0164462
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0164371
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0161231
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.016044
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0155883
SQSTM1 sequestosome 1 -0.015392
USP53 ubiquitin specific peptidase 53 -0.0151458
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0150374
SEC31A SEC31 homolog A (S. cerevisiae) -0.0150184
TM4SF1 transmembrane 4 L six family member 1 -0.0147899
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0147658
G0S2 G0/G1 switch 2 -0.0147203
MDK midkine (neurite growth-promoting factor 2) -0.0146934
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -0.0146265
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.014615
PLAU plasminogen activator, urokinase -0.0145612
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0144426
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0143449
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0142764
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -0.0141503
CANX calnexin -0.0141358
HLA-A major histocompatibility complex, class I, A -0.0140212
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0140021
NOCT nocturnin -0.0139753
ENO2 enolase 2 (gamma, neuronal) -0.0139577
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0139313
TRAF3 TNF receptor-associated factor 3 -0.0138302
TPM4 tropomyosin 4 -0.0138257
MAGT1 magnesium transporter 1 -0.0137951
PALLD palladin, cytoskeletal associated protein -0.013746
RPS20 ribosomal protein S20 -0.0136636
CHKA choline kinase alpha -0.0136438
AHNAK AHNAK nucleoprotein -0.0135428
AZIN1 antizyme inhibitor 1 -0.0134141
SEPTIN9 septin 9 -0.0134035
LDHB lactate dehydrogenase B -0.0132081