Ralimetinib dimesylate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

188 genes differentially expressed following the Ralimetinib dimesylate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.164174
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.146991
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.132477
EFNA5 ephrin-A5 0.128644
FAM13A family with sequence similarity 13, member A 0.121446
ELL2 elongation factor, RNA polymerase II, 2 0.113014
DTNA dystrobrevin, alpha 0.107919
ASPH aspartate beta-hydroxylase 0.107407
TRIO trio Rho guanine nucleotide exchange factor 0.102655
CD109 CD109 molecule 0.0952586
MT2A metallothionein 2A 0.0910862
CREB5 cAMP responsive element binding protein 5 0.0834583
NAV1 neuron navigator 1 0.0793691
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.078777
SAMD4A sterile alpha motif domain containing 4A 0.0777517
SEPTIN2 septin 2 0.0775029
SBF2 SET binding factor 2 0.0774224
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0757338
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0756297
COPA coatomer protein complex, subunit alpha 0.0731826
NALF1 NALCN channel auxiliary factor 1 0.0712703
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0698749
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0682838
KYNU kynureninase 0.0677253
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0667173
PCBP3 poly(rC) binding protein 3 0.0666924
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0618481
USP34 ubiquitin specific peptidase 34 0.0611966
RBM39 RNA binding motif protein 39 0.0602257
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0594903
KCMF1 potassium channel modulatory factor 1 0.0569743
CEMIP cell migration inducing protein, hyaluronan binding 0.0565309
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0550837
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0516587
NKTR natural killer cell triggering receptor 0.0514626
OGA O-GlcNAcase 0.0509662
MYO1B myosin IB 0.0495412
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0481988
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0480242
RPS27A ribosomal protein S27a 0.0473621
CDH13 cadherin 13 0.0444332
RPLP1 ribosomal protein, large, P1 0.043792
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0432889
COG5 component of oligomeric golgi complex 5 0.0424318
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0423096
EGFR epidermal growth factor receptor 0.0397948
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0389686
ESYT2 extended synaptotagmin-like protein 2 0.0374485
PDE10A phosphodiesterase 10A 0.0371425
TMEM165 transmembrane protein 165 0.0366372
IGF1R insulin-like growth factor 1 receptor 0.036422
PRKCA protein kinase C, alpha 0.0345848
FMN1 formin 1 0.0343764
LMO7 LIM domain 7 0.0333256
MED13L mediator complex subunit 13-like 0.0307112
FMNL2 formin-like 2 0.0303251
LPP LIM domain containing preferred translocation partner in lipoma 0.0277284
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0275689
DSCAM Down syndrome cell adhesion molecule 0.0257817
KTN1 kinectin 1 (kinesin receptor) 0.0246598
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0240445
TBC1D22A TBC1 domain family, member 22A 0.0236251
PDIA3 protein disulfide isomerase family A, member 3 0.0183523
PTPRM protein tyrosine phosphatase, receptor type, M 0.0179873
B2M beta-2-microglobulin 0.0173291
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0165698
FN1 fibronectin 1 0.0151505
FNIP1 folliculin interacting protein 1 0.0150381
RPL26 ribosomal protein L26 0.0149315
PKM pyruvate kinase, muscle 0.0145509
RAB1A RAB1A, member RAS oncogene family 0.0120231
S100A6 S100 calcium binding protein A6 0.0119348
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0107385
PDLIM5 PDZ and LIM domain 5 0.0102134
GPHN gephyrin 0.00919319
RPL15 ribosomal protein L15 0.00839998
MACF1 microtubule-actin crosslinking factor 1 0.00812368
SPTBN1 spectrin, beta, non-erythrocytic 1 0.00729663
TPT1 tumor protein, translationally-controlled 1 0.00660975
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.00657606
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00651378
TMSB10 thymosin beta 10 0.00554699
RPS17 ribosomal protein S17 0.00543689
PRRC2C proline-rich coiled-coil 2C 0.00480442
ANKRD11 ankyrin repeat domain 11 0.00393989
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.00360868
SLTM SAFB-like, transcription modulator 0.0027698
PTMA prothymosin, alpha 0.00189572

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.143397
VMP1 vacuole membrane protein 1 -0.0975942
IGF2 insulin-like growth factor 2 -0.0950545
NDRG1 N-myc downstream regulated 1 -0.0950149
CD2AP CD2-associated protein -0.0915918
TENM3 teneurin transmembrane protein 3 -0.0896143
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0839943
NKD1 naked cuticle homolog 1 (Drosophila) -0.082716
SMYD3 SET and MYND domain containing 3 -0.0804963
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0796461
ZFAND3 zinc finger, AN1-type domain 3 -0.0794593
IGFBP3 insulin-like growth factor binding protein 3 -0.0773193
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0760113
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0737907
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0694166
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0651242
MAML2 mastermind-like 2 (Drosophila) -0.0613241
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0607876
EEF2 eukaryotic translation elongation factor 2 -0.0581184
GPC6 glypican 6 -0.057389
NAP1L1 nucleosome assembly protein 1-like 1 -0.0563059
EGR1 early growth response 1 -0.0538875
INTS6 integrator complex subunit 6 -0.0530294
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0524843
RABGAP1L RAB GTPase activating protein 1-like -0.051122
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0500226
RPL35A ribosomal protein L35a -0.0478609
RPS12 ribosomal protein S12 -0.0475854
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0466298
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0457071
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0450076
HDLBP high density lipoprotein binding protein -0.0448804
ZNF638 zinc finger protein 638 -0.0445494
SQSTM1 sequestosome 1 -0.0442856
DENND1A DENN/MADD domain containing 1A -0.0442675
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0433279
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0432384
RPS8 ribosomal protein S8 -0.0394068
KMT2C lysine (K)-specific methyltransferase 2C -0.0389084
RAD51B RAD51 paralog B -0.0389056
NAMPT nicotinamide phosphoribosyltransferase -0.0388498
DLG1 discs, large homolog 1 (Drosophila) -0.0378741
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0373025
ZBTB20 zinc finger and BTB domain containing 20 -0.0371509
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0368606
RTN4 reticulon 4 -0.0367887
CANX calnexin -0.0358047
PGK1 phosphoglycerate kinase 1 -0.0357699
ACTG1 actin gamma 1 -0.0348169
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0344398
SLC38A2 solute carrier family 38, member 2 -0.0343904
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0328297
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0322116
SYT1 synaptotagmin I -0.0316318
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0309314
PTK2 protein tyrosine kinase 2 -0.0308348
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0306626
NAV2 neuron navigator 2 -0.0305971
RB1CC1 RB1-inducible coiled-coil 1 -0.03019
AHNAK AHNAK nucleoprotein -0.0296564
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0287977
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0278224
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0260938
NRG3 neuregulin 3 -0.0259307
CARD16 caspase recruitment domain family, member 16 -0.0258196
GMDS GDP-mannose 4,6-dehydratase -0.0254875
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0246503
ENO1 enolase 1, (alpha) -0.0243384
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0240021
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0236418
CMIP c-Maf inducing protein -0.0228464
GLG1 golgi glycoprotein 1 -0.0224236
AKAP9 A kinase (PRKA) anchor protein 9 -0.0223241
MBD5 methyl-CpG binding domain protein 5 -0.0222051
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0220604
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0216761
ANKRD28 ankyrin repeat domain 28 -0.0213658
ZNF292 zinc finger protein 292 -0.0211831
RPS6 ribosomal protein S6 -0.0204347
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0198044
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0196821
LDHA lactate dehydrogenase A -0.0194921
ACTN4 actinin, alpha 4 -0.0194137
MYO10 myosin X -0.0190102
ANXA2 annexin A2 -0.0181785
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0179295
DST dystonin -0.0171788
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0167176
NIPBL Nipped-B homolog (Drosophila) -0.0154997
MYOF myoferlin -0.0154044
LAMB3 laminin, beta 3 -0.0153601
FLNB filamin B, beta -0.0150955
PDE4D phosphodiesterase 4D, cAMP-specific -0.0139125
CNKSR3 CNKSR family member 3 -0.0123101
HMGA1 high mobility group AT-hook 1 -0.0117515
VIM vimentin -0.0110559
HMGA2 high mobility group AT-hook 2 -0.010798
MYO1E myosin IE -0.0107679
EXT1 exostosin glycosyltransferase 1 -0.00937186
FNDC3B fibronectin type III domain containing 3B -0.00927693