| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0726629 |
| ZNF292 | zinc finger protein 292 | 0.0681424 |
| THBS1 | thrombospondin 1 | 0.0659542 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0590397 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0497712 |
| FN1 | fibronectin 1 | 0.0490341 |
| SMYD3 | SET and MYND domain containing 3 | 0.0473116 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0458171 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0453823 |
| DST | dystonin | 0.0439238 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0426927 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0410601 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0403884 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.039762 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0395104 |
| PDGFC | platelet derived growth factor C | 0.0376828 |
| NTM | neurotrimin | 0.0374313 |
| UPP1 | uridine phosphorylase 1 | 0.03695 |
| PROS1 | protein S (alpha) | 0.0363059 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0361336 |
| NPAS3 | neuronal PAS domain protein 3 | 0.036092 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0355606 |
| SET | SET nuclear proto-oncogene | 0.0352773 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0333173 |
| WDR43 | WD repeat domain 43 | 0.0328675 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.032438 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0323834 |
| RAB2A | RAB2A, member RAS oncogene family | 0.0318821 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0317899 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0317032 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0315511 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.031354 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0312369 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0294047 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0293023 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0288648 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0287207 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0280063 |
| HDAC9 | histone deacetylase 9 | 0.0274965 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0274139 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0273202 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0269974 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0267145 |
| NCKAP1 | NCK-associated protein 1 | 0.026501 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0263396 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0260167 |
| DNMBP | dynamin binding protein | 0.0258806 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0256654 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0254072 |
| PHF3 | PHD finger protein 3 | 0.0254068 |
| GPC6 | glypican 6 | 0.0252774 |
| CDC73 | cell division cycle 73 | 0.0248725 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0246649 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0246012 |
| CALCR | calcitonin receptor | 0.0246 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0244647 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0244103 |
| SGCE | sarcoglycan, epsilon | 0.0243395 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0242762 |
| PRPF4B | pre-mRNA processing factor 4B | 0.0242375 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0241823 |
| TAB2 | TGF-beta activated kinase 1/MAP3K7 binding protein 2 | 0.0241231 |
| NUDT3 | nudix (nucleoside diphosphate linked moiety X)-type motif 3 | 0.0238495 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0237749 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0236272 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0236095 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0234231 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0232885 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0230845 |
| DMXL1 | Dmx-like 1 | 0.022939 |
| TOP1 | topoisomerase (DNA) I | 0.0226552 |
| NF1 | neurofibromin 1 | 0.0225238 |
| SBF2 | SET binding factor 2 | 0.022426 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | 0.0222724 |
| GPHN | gephyrin | 0.0217207 |
| ZNF608 | zinc finger protein 608 | 0.0217038 |
| MED21 | mediator complex subunit 21 | 0.0216465 |
| PPP1R12B | protein phosphatase 1, regulatory subunit 12B | 0.021356 |
| CEP170 | centrosomal protein 170kDa | 0.021212 |
| RYK | receptor-like tyrosine kinase | 0.0210938 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.0209922 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0207887 |
| CPNE8 | copine VIII | 0.0206263 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.0205294 |
| AUTS2 | autism susceptibility candidate 2 | 0.0205227 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0205125 |
| DOCK5 | dedicator of cytokinesis 5 | 0.020478 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0203926 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0203666 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.0203483 |
| SYT1 | synaptotagmin I | 0.0202845 |
| NUP153 | nucleoporin 153kDa | 0.0201019 |
| AFDN | afadin, adherens junction formation factor | 0.0200476 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0198523 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0198055 |
| USP53 | ubiquitin specific peptidase 53 | 0.0197724 |
| CORO1C | coronin, actin binding protein, 1C | 0.0196344 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.0195927 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0194614 |
| MB21D2 | Mab-21 domain containing 2 | 0.0194341 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.171255 |
| VIM | vimentin | -0.109679 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.101535 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0922759 |
| POTEF | POTE ankyrin domain family, member F | -0.084481 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0822606 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0811561 |
| ACTG1 | actin gamma 1 | -0.0793435 |
| COL11A1 | collagen, type XI, alpha 1 | -0.0775889 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0775243 |
| PFN1 | profilin 1 | -0.076993 |
| RPL35A | ribosomal protein L35a | -0.0697852 |
| RPS6 | ribosomal protein S6 | -0.0686461 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0645303 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0628791 |
| COL5A2 | collagen, type V, alpha 2 | -0.0617131 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0577718 |
| YBX1 | Y box binding protein 1 | -0.0566341 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0520067 |
| PHIP | pleckstrin homology domain interacting protein | -0.0516697 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0505361 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.050344 |
| RPS19 | ribosomal protein S19 | -0.0497072 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0483005 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0482026 |
| RPS8 | ribosomal protein S8 | -0.0474043 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0468002 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0452559 |
| RPLP1 | ribosomal protein, large, P1 | -0.044696 |
| MYL12B | myosin, light chain 12B, regulatory | -0.043271 |
| LDHA | lactate dehydrogenase A | -0.0428405 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0425863 |
| H1-0 | H1.0 linker histone | -0.0424061 |
| FBL | fibrillarin | -0.0423963 |
| PEG10 | paternally expressed 10 | -0.0423528 |
| TMSB10 | thymosin beta 10 | -0.0421747 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.041344 |
| TUBA1B | tubulin, alpha 1b | -0.0411227 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0410645 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0407512 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0403477 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0399518 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0395883 |
| GNAS | GNAS complex locus | -0.0388138 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0386582 |
| RPL19 | ribosomal protein L19 | -0.0384152 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | -0.0383037 |
| RPLP0 | ribosomal protein, large, P0 | -0.0380966 |
| DEK | DEK proto-oncogene | -0.0374768 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.037269 |
| SRP54 | signal recognition particle 54kDa | -0.0369193 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0368009 |
| GLG1 | golgi glycoprotein 1 | -0.0366711 |
| TJP1 | tight junction protein 1 | -0.0365847 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0364674 |
| B2M | beta-2-microglobulin | -0.0363537 |
| RPS4X | ribosomal protein S4, X-linked | -0.0357442 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0350307 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0350243 |
| FBXO11 | F-box protein 11 | -0.0343304 |
| EMP1 | epithelial membrane protein 1 | -0.0343221 |
| YY1 | YY1 transcription factor | -0.0341832 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0339848 |
| FTL | ferritin, light polypeptide | -0.0338533 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0335399 |
| RPS14 | ribosomal protein S14 | -0.0333977 |
| WASF2 | WAS protein family, member 2 | -0.0333745 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0328998 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0326641 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0324662 |
| COL3A1 | collagen, type III, alpha 1 | -0.0324116 |
| H3-3B | H3.3 histone B | -0.0321766 |
| CALR | calreticulin | -0.0316533 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0316465 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0314653 |
| AHNAK | AHNAK nucleoprotein | -0.0312838 |
| COL1A2 | collagen, type I, alpha 2 | -0.0312579 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0309069 |
| TAOK1 | TAO kinase 1 | -0.0306989 |
| SKIL | SKI-like proto-oncogene | -0.0306523 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0303884 |
| R3HDM1 | R3H domain containing 1 | -0.0303736 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0302684 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0302189 |
| PTMA | prothymosin, alpha | -0.029885 |
| FGF13 | fibroblast growth factor 13 | -0.0294893 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0293676 |
| TENM3 | teneurin transmembrane protein 3 | -0.0293509 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0292694 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0292011 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0290546 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0290231 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0289431 |
| RPS13 | ribosomal protein S13 | -0.0288643 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0288514 |
| RPL23 | ribosomal protein L23 | -0.0287889 |
| RPL7 | ribosomal protein L7 | -0.0286605 |
| RHOA | ras homolog family member A | -0.0285393 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0284151 |
| GARRE1 | granule associated Rac and RHOG effector 1 | -0.0283823 |
