Ralimetinib dimesylate_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 0.194145
RPS12 ribosomal protein S12 0.0859471
RPL35A ribosomal protein L35a 0.0834474
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0692025
RPS3 ribosomal protein S3 0.0596067
MT2A metallothionein 2A 0.0594468
RPLP2 ribosomal protein, large, P2 0.0531211
RPL37A ribosomal protein L37a 0.0529474
RPS17 ribosomal protein S17 0.047239
RPL12 ribosomal protein L12 0.0445823
FTL ferritin, light polypeptide 0.0436488
RPLP1 ribosomal protein, large, P1 0.0427232
RPL26 ribosomal protein L26 0.0399619
RPS8 ribosomal protein S8 0.0359852
RPL9 ribosomal protein L9 0.0333569
ZNF292 zinc finger protein 292 0.0309082
PRELID2 PRELI domain containing 2 0.030588
RPL11 ribosomal protein L11 0.0298544
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0296145
ANGPTL4 angiopoietin-like 4 0.0293035
RPS25 ribosomal protein S25 0.0292798
RPS19 ribosomal protein S19 0.0282987
RPL7 ribosomal protein L7 0.0263594
SRRM2 serine/arginine repetitive matrix 2 0.0259472
PNISR PNN-interacting serine/arginine-rich protein 0.0256857
RPLP0 ribosomal protein, large, P0 0.0256406
RPS14 ribosomal protein S14 0.0253162
RPL36 ribosomal protein L36 0.024758
B2M beta-2-microglobulin 0.0240203
DDIT4 DNA-damage-inducible transcript 4 0.0233749
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0232779
RPL23 ribosomal protein L23 0.0228503
KTN1 kinectin 1 (kinesin receptor) 0.0227228
RPL30 ribosomal protein L30 0.0225659
NCOR2 nuclear receptor corepressor 2 0.0222664
PDE3B phosphodiesterase 3B, cGMP-inhibited 0.0221911
RPS6 ribosomal protein S6 0.0220897
RPL37 ribosomal protein L37 0.0218795
RPL31 ribosomal protein L31 0.021784
HSPA1A heat shock 70kDa protein 1A 0.019766
NACA nascent polypeptide-associated complex alpha subunit 0.0195593
NFIA nuclear factor I/A 0.0191986
EIF5B eukaryotic translation initiation factor 5B 0.0190108
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0189293
MBNL1 muscleblind-like splicing regulator 1 0.0187965
NAP1L1 nucleosome assembly protein 1-like 1 0.018568
RPS24 ribosomal protein S24 0.0185332
SET SET nuclear proto-oncogene 0.0184033
SEPTIN7 septin 7 0.01834
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0178998
MATR3 matrin 3 0.0178989
IFITM3 interferon induced transmembrane protein 3 0.0177811
RPL18 ribosomal protein L18 0.0177404
CBX3 chromobox homolog 3 0.017673
KMT2E lysine (K)-specific methyltransferase 2E 0.0176675
RACK1 receptor for activated C kinase 1 0.0175232
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0174009
SRSF11 serine/arginine-rich splicing factor 11 0.0172325
RPL21 ribosomal protein L21 0.01702
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0169911
RPS27 ribosomal protein S27 0.0167908
RPS20 ribosomal protein S20 0.0160849
FAM13A family with sequence similarity 13, member A 0.0160786
FOSL1 FOS-like antigen 1 0.0159323
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0156944
RRM2 ribonucleotide reductase M2 0.0156019
NDUFA4 NDUFA4, mitochondrial complex associated 0.0154225
RPL5 ribosomal protein L5 0.0152449
SOX9 SRY (sex determining region Y)-box 9 0.0149702
MED13L mediator complex subunit 13-like 0.0149155
HPCAL1 hippocalcin-like 1 0.0149122
PRRC2C proline-rich coiled-coil 2C 0.014904
RB1CC1 RB1-inducible coiled-coil 1 0.014846
NXN nucleoredoxin 0.0148071
PA2G4 proliferation-associated 2G4, 38kDa 0.0146382
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.014127
LOC102724023 ES1 protein homolog, mitochondrial 0.0139993
YEATS2 YEATS domain containing 2 0.0139309
TPT1 tumor protein, translationally-controlled 1 0.0139022
RPS2 ribosomal protein S2 0.0138748
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0138024
GPX4 glutathione peroxidase 4 0.0137382
SON SON DNA binding protein 0.0136532
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0135631
UQCRB ubiquinol-cytochrome c reductase binding protein 0.013522
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0134556
NOP58 NOP58 ribonucleoprotein 0.0133723
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0133666
RPL36A ribosomal protein L36a 0.0131322
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0131278
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0131159
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0130578
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0130195
RPL19 ribosomal protein L19 0.0130033
RPL35 ribosomal protein L35 0.0129891
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0129844
TPI1 triosephosphate isomerase 1 0.0128245
ARID4B AT rich interactive domain 4B (RBP1-like) 0.012735
CCDC88A coiled-coil domain containing 88A 0.0125905
TNRC6A trinucleotide repeat containing 6A 0.0124671

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.227727
AKAP12 A kinase (PRKA) anchor protein 12 -0.222629
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.206448
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.174061
AHNAK AHNAK nucleoprotein -0.170373
VCL vinculin -0.127535
TM4SF1 transmembrane 4 L six family member 1 -0.110968
UBC ubiquitin C -0.109697
ERRFI1 ERBB receptor feedback inhibitor 1 -0.101341
SLC35F3 solute carrier family 35, member F3 -0.0959212
CD44 CD44 molecule (Indian blood group) -0.092421
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0910286
CANX calnexin -0.0896241
VIM vimentin -0.0856894
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0804337
THSD4 thrombospondin, type I, domain containing 4 -0.0776612
ACTN4 actinin, alpha 4 -0.0764326
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0709912
EGFR epidermal growth factor receptor -0.0648873
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0630769
MACF1 microtubule-actin crosslinking factor 1 -0.0599554
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0555106
DST dystonin -0.0554919
ACTG1 actin gamma 1 -0.0542279
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0480549
TRIO trio Rho guanine nucleotide exchange factor -0.0474784
TMEM123 transmembrane protein 123 -0.0472597
MAP1B microtubule-associated protein 1B -0.0457273
RTN4 reticulon 4 -0.0447944
TPM1 tropomyosin 1 (alpha) -0.0432881
H1-0 H1.0 linker histone -0.0427787
LOC112694756 uncharaterized LOC112694756 -0.0423574
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0401271
ZCCHC7 zinc finger, CCHC domain containing 7 -0.039659
FBL fibrillarin -0.0395972
ATG7 autophagy related 7 -0.0392754
CALR calreticulin -0.0388332
PDIA4 protein disulfide isomerase family A, member 4 -0.0385393
CALU calumenin -0.0379276
EXT1 exostosin glycosyltransferase 1 -0.0376199
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0375249
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0370657
AHNAK2 AHNAK nucleoprotein 2 -0.0369189
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0366231
HDLBP high density lipoprotein binding protein -0.0362166
UBASH3B ubiquitin associated and SH3 domain containing B -0.0356415
RASAL2 RAS protein activator like 2 -0.0353781
SPAG9 sperm associated antigen 9 -0.0347569
EHBP1 EH domain binding protein 1 -0.0346949
NT5E 5'-nucleotidase, ecto (CD73) -0.0336867
ELL2 elongation factor, RNA polymerase II, 2 -0.0332508
PDIA6 protein disulfide isomerase family A, member 6 -0.0331829
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0326037
PDIA3 protein disulfide isomerase family A, member 3 -0.0321193
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0299915
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0297209
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0296385
ANXA2 annexin A2 -0.0289933
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0286084
ATM ATM serine/threonine kinase -0.0282829
TRIP12 thyroid hormone receptor interactor 12 -0.0279383
APP amyloid beta (A4) precursor protein -0.0274098
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0272541
RAP1B RAP1B, member of RAS oncogene family -0.0270937
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.026843
MAP4 microtubule-associated protein 4 -0.0264963
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264507
SLC38A2 solute carrier family 38, member 2 -0.0263858
TCF12 transcription factor 12 -0.0262656
SBF2 SET binding factor 2 -0.026182
BMAL2 basic helix-loop-helix ARNT like 2 -0.0259464
JPT2 Jupiter microtubule associated homolog 2 -0.0252569
ASPH aspartate beta-hydroxylase -0.0251643
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0248419
ZFAND3 zinc finger, AN1-type domain 3 -0.0246749
ARHGAP29 Rho GTPase activating protein 29 -0.0240525
HSPG2 heparan sulfate proteoglycan 2 -0.0238599
CTTN cortactin -0.023789
HMGA2 high mobility group AT-hook 2 -0.0236532
PGK1 phosphoglycerate kinase 1 -0.0234235
FRMD5 FERM domain containing 5 -0.0231979
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0231318
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.023105
LPP LIM domain containing preferred translocation partner in lipoma -0.0230862
SETX senataxin -0.0229829
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.022939
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0227382
TAOK1 TAO kinase 1 -0.0226696
JUN jun proto-oncogene -0.0225769
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0225675
NF1 neurofibromin 1 -0.0223732
SAMD4B sterile alpha motif domain containing 4B -0.0220519
WASF2 WAS protein family, member 2 -0.0217766
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0214229
LMAN1 lectin, mannose-binding, 1 -0.0214048
CD59 CD59 molecule, complement regulatory protein -0.0213786
TMEM41B transmembrane protein 41B -0.0210914
MCL1 myeloid cell leukemia 1 -0.0210901
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0210693
ZNF780B zinc finger protein 780B -0.0209982