Ralimetinib dimesylate_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ralimetinib dimesylate perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ralimetinib dimesylate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.084732
EXT1 exostosin glycosyltransferase 1 0.0718593
ENO1 enolase 1, (alpha) 0.0699401
CREB5 cAMP responsive element binding protein 5 0.0682659
SMYD3 SET and MYND domain containing 3 0.0668598
MT2A metallothionein 2A 0.0658423
RAD21 RAD21 homolog (S. pombe) 0.0593382
ASPH aspartate beta-hydroxylase 0.0526747
C2CD2 C2 calcium-dependent domain containing 2 0.0518894
AHNAK AHNAK nucleoprotein 0.0480047
ANXA2 annexin A2 0.0477723
MKI67 marker of proliferation Ki-67 0.0475383
TPM4 tropomyosin 4 0.0474891
STC1 stanniocalcin 1 0.0468178
SET SET nuclear proto-oncogene 0.0423158
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0422661
TPD52 tumor protein D52 0.0421135
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0414907
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0414505
S100A2 S100 calcium binding protein A2 0.0411039
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.040332
RASA2 RAS p21 protein activator 2 0.0400538
PTMA prothymosin, alpha 0.0397011
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0395469
FHL2 four and a half LIM domains 2 0.0393963
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0389785
XPO1 exportin 1 0.038749
CAPN2 calpain 2, (m/II) large subunit 0.0383224
ZEB1 zinc finger E-box binding homeobox 1 0.0380238
LAMB3 laminin, beta 3 0.0379215
ARFGEF3 ARFGEF family member 3 0.0373024
UTRN utrophin 0.0366319
BIRC3 baculoviral IAP repeat containing 3 0.0366305
RPL7A ribosomal protein L7a 0.0364089
RAD51B RAD51 paralog B 0.0361865
RPL7 ribosomal protein L7 0.0361748
RPS8 ribosomal protein S8 0.0361584
CENPF centromere protein F, 350/400kDa 0.0356617
UPP1 uridine phosphorylase 1 0.0355411
NAP1L1 nucleosome assembly protein 1-like 1 0.0353682
RPS12 ribosomal protein S12 0.0353127
SAMD4A sterile alpha motif domain containing 4A 0.0346987
ANXA5 annexin A5 0.0346702
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0331521
BRWD1 bromodomain and WD repeat domain containing 1 0.0327471
NIPBL Nipped-B homolog (Drosophila) 0.0323852
RB1CC1 RB1-inducible coiled-coil 1 0.0321876
MATR3 matrin 3 0.0321499
JUN jun proto-oncogene 0.0317741
CEP250 centrosomal protein 250kDa 0.0317014
ADAM9 ADAM metallopeptidase domain 9 0.0316174
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0314433
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.03138
PCM1 pericentriolar material 1 0.0311843
ZNF292 zinc finger protein 292 0.0311128
AKAP9 A kinase (PRKA) anchor protein 9 0.0307881
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0305381
EXOC6B exocyst complex component 6B 0.0304086
KTN1 kinectin 1 (kinesin receptor) 0.0302419
RPL23 ribosomal protein L23 0.0299254
KPNB1 karyopherin (importin) beta 1 0.029628
S100A6 S100 calcium binding protein A6 0.0293779
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.029344
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0292569
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0286466
RPLP1 ribosomal protein, large, P1 0.028481
USP3 ubiquitin specific peptidase 3 0.0283204
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0280665
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.0280496
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0280399
CD44 CD44 molecule (Indian blood group) 0.0279313
OGA O-GlcNAcase 0.0278927
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0277335
TMEM245 transmembrane protein 245 0.0277243
HMGB2 high mobility group box 2 0.0276177
RPS27A ribosomal protein S27a 0.0276136
RPL37A ribosomal protein L37a 0.0266325
PDE4D phosphodiesterase 4D, cAMP-specific 0.0265774
CEP95 centrosomal protein 95kDa 0.0265035
CKAP5 cytoskeleton associated protein 5 0.0263822
ANKRD12 ankyrin repeat domain 12 0.0262358
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0260082
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0258914
PRELID2 PRELI domain containing 2 0.0257335
ZBTB43 zinc finger and BTB domain containing 43 0.0256445
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.025415
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.025405
MYH9 myosin, heavy chain 9, non-muscle 0.0253399
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0250708
KIF20B kinesin family member 20B 0.0250445
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0248922
RPL4 ribosomal protein L4 0.0247491
NCKAP1 NCK-associated protein 1 0.0247251
RPS13 ribosomal protein S13 0.0245801
USP47 ubiquitin specific peptidase 47 0.024525
BUB3 BUB3 mitotic checkpoint protein 0.0245078
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0244264
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) 0.0243418
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0243348
MAPK14 mitogen-activated protein kinase 14 0.0241967

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.168857
DLC1 DLC1 Rho GTPase activating protein -0.16798
FRMD6 FERM domain containing 6 -0.139786
HDAC9 histone deacetylase 9 -0.136323
NABP1 nucleic acid binding protein 1 -0.128729
NAV3 neuron navigator 3 -0.0844449
FLNB filamin B, beta -0.0801271
SLC38A2 solute carrier family 38, member 2 -0.0797922
DGKI diacylglycerol kinase, iota -0.0744711
PBX3 pre-B-cell leukemia homeobox 3 -0.074462
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.072141
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0701497
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0678099
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.049473
NAV2 neuron navigator 2 -0.0485917
SP100 SP100 nuclear antigen -0.0482362
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0473281
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0467006
ZNF438 zinc finger protein 438 -0.0459201
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0457953
EGR1 early growth response 1 -0.0455691
ZFAND3 zinc finger, AN1-type domain 3 -0.0426482
POTEF POTE ankyrin domain family, member F -0.0419751
INTS6 integrator complex subunit 6 -0.0414286
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0408095
RCOR1 REST corepressor 1 -0.0397975
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0396075
BNC2 basonuclin 2 -0.0391501
TMSB10 thymosin beta 10 -0.0373428
ARHGAP22 Rho GTPase activating protein 22 -0.0372116
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0366845
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0360731
EFNB2 ephrin-B2 -0.0355726
LPP LIM domain containing preferred translocation partner in lipoma -0.0349626
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0348899
HMGA2 high mobility group AT-hook 2 -0.0345026
SON SON DNA binding protein -0.0343182
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0338362
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0335234
RIGI RNA sensor RIG-I -0.0333858
PTPRG protein tyrosine phosphatase, receptor type, G -0.0327645
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0320943
LOC112694756 uncharaterized LOC112694756 -0.0317179
MTAP methylthioadenosine phosphorylase -0.0314823
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0312865
DENND1A DENN/MADD domain containing 1A -0.031014
WNT2B wingless-type MMTV integration site family, member 2B -0.0306374
LARP4B La ribonucleoprotein domain family, member 4B -0.0305255
CAST calpastatin -0.0303356
PLSCR1 phospholipid scramblase 1 -0.029995
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0299795
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.029975
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0298795
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0298228
CUX1 cut-like homeobox 1 -0.0292369
CALD1 caldesmon 1 -0.0292267
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0288874
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0286538
IARS1 isoleucyl-tRNA synthetase 1 -0.0286009
IFI16 interferon, gamma-inducible protein 16 -0.0285416
COL27A1 collagen, type XXVII, alpha 1 -0.0280332
GPATCH2L G patch domain containing 2-like -0.028028
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0274306
NLK nemo-like kinase -0.0268123
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0264822
CUTC cutC copper transporter -0.0263622
RAB7A RAB7A, member RAS oncogene family -0.0262346
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0259754
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0258233
MCTP1 multiple C2 domains, transmembrane 1 -0.0256059
FNDC3B fibronectin type III domain containing 3B -0.0255723
FRMD4A FERM domain containing 4A -0.0252439
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0251538
RIC1 RAB6A GEF complex partner 1 -0.0248567
PARD3 par-3 family cell polarity regulator -0.0246574
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0245298
ZNF609 zinc finger protein 609 -0.024051
RUNX1 runt-related transcription factor 1 -0.0237426
BIRC6 baculoviral IAP repeat containing 6 -0.0237418
PCNX4 pecanex 4 -0.0236118
ERBIN erbb2 interacting protein -0.0232732
TRAF3 TNF receptor-associated factor 3 -0.0231048
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0230528
ZBTB38 zinc finger and BTB domain containing 38 -0.0228708
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0227903
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0227387
CTIF CBP80/20-dependent translation initiation factor -0.0225514
BRD4 bromodomain containing 4 -0.0225334
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0223234
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0221714
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0217707
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0216412
PRRC2B proline-rich coiled-coil 2B -0.0215538
SFPQ splicing factor proline/glutamine-rich -0.0214676
FUBP3 far upstream element (FUSE) binding protein 3 -0.0213639
MX2 MX dynamin-like GTPase 2 -0.0211897
ALCAM activated leukocyte cell adhesion molecule -0.0211775
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0211568
TRIP12 thyroid hormone receptor interactor 12 -0.0203954
ZNF407 zinc finger protein 407 -0.0203864