| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ralimetinib dimesylate perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ralimetinib dimesylate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0418776 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | 0.0330198 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0307336 |
| CENPF | centromere protein F, 350/400kDa | 0.0284885 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0279368 |
| XPO1 | exportin 1 | 0.0277438 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0241337 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0240928 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0233928 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0230455 |
| ZNF292 | zinc finger protein 292 | 0.0227685 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0203904 |
| PCBP2 | poly(rC) binding protein 2 | 0.0203528 |
| MATR3 | matrin 3 | 0.0199656 |
| PCM1 | pericentriolar material 1 | 0.0198491 |
| MTMR7 | myotubularin related protein 7 | 0.0194976 |
| PRKD1 | protein kinase D1 | 0.0193062 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.018447 |
| MKI67 | marker of proliferation Ki-67 | 0.0182779 |
| CEP152 | centrosomal protein 152kDa | 0.0176435 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0173879 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0170664 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0168524 |
| CADM1 | cell adhesion molecule 1 | 0.0168172 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0167557 |
| NUF2 | NUF2, NDC80 kinetochore complex component | 0.0163759 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0161723 |
| SET | SET nuclear proto-oncogene | 0.0161492 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0161333 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0160339 |
| CLASP2 | cytoplasmic linker associated protein 2 | 0.0158963 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0158741 |
| CDC27 | cell division cycle 27 | 0.0158362 |
| RAD21 | RAD21 homolog (S. pombe) | 0.015714 |
| ECT2 | epithelial cell transforming 2 | 0.0154952 |
| TTK | TTK protein kinase | 0.0153029 |
| DIAPH3 | diaphanous-related formin 3 | 0.0152437 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0151144 |
| CCNY | cyclin Y | 0.0150848 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0149931 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.014987 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0146669 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0146562 |
| CABIN1 | calcineurin binding protein 1 | 0.0145991 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0145963 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.0142801 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0140613 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0138527 |
| UVRAG | UV radiation resistance associated | 0.0138323 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0137976 |
| FOXN3 | forkhead box N3 | 0.0137074 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0136195 |
| ANK2 | ankyrin 2, neuronal | 0.0135751 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0134398 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.013392 |
| TTBK2 | tau tubulin kinase 2 | 0.013363 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0133361 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.013164 |
| SMAD9 | SMAD family member 9 | 0.0131334 |
| NDC1 | NDC1 transmembrane nucleoporin | 0.0131244 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0130897 |
| MRTFA | myocardin related transcription factor A | 0.0129992 |
| GPHN | gephyrin | 0.0129661 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0129339 |
| HDAC9 | histone deacetylase 9 | 0.0128998 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.0127776 |
| ZDHHC20 | zinc finger, DHHC-type containing 20 | 0.0126145 |
| CDC25C | cell division cycle 25C | 0.0125702 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0125478 |
| RNF145 | ring finger protein 145 | 0.0125223 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0124259 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | 0.0124153 |
| VIM | vimentin | 0.012356 |
| CDK8 | cyclin-dependent kinase 8 | 0.0122884 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.0121146 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0120945 |
| USP3 | ubiquitin specific peptidase 3 | 0.0120344 |
| SEPTIN9 | septin 9 | 0.0120097 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0119783 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.0119752 |
| HMGN3 | high mobility group nucleosomal binding domain 3 | 0.0119711 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) | 0.0119232 |
| MGAT4C | MGAT4 family, member C | 0.0119231 |
| CENPC | centromere protein C | 0.0118918 |
| TXNIP | thioredoxin interacting protein | 0.0118621 |
| FANCI | Fanconi anemia, complementation group I | 0.0117938 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0117513 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0116942 |
| KIF23 | kinesin family member 23 | 0.0115952 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0115651 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0115434 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0114875 |
| VIRMA | vir like m6A methyltransferase associated | 0.0114744 |
| H2AZ2 | H2A.Z variant histone 2 | 0.0114692 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 0.011356 |
| CNBD1 | cyclic nucleotide binding domain containing 1 | 0.0112065 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0111505 |
| FOXJ3 | forkhead box J3 | 0.0111444 |
| DCLK1 | doublecortin-like kinase 1 | 0.0111185 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0110996 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.172759 |
| STC1 | stanniocalcin 1 | -0.150668 |
| GPC6 | glypican 6 | -0.144389 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.143726 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.11925 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.114083 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0965255 |
| NDRG1 | N-myc downstream regulated 1 | -0.0958864 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0935766 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0908578 |
| MCL1 | myeloid cell leukemia 1 | -0.084852 |
| SCG2 | secretogranin II | -0.0847112 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0795602 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0791219 |
| SNTG1 | syntrophin, gamma 1 | -0.0754625 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0737559 |
| GPC5 | glypican 5 | -0.0731086 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0730655 |
| ENO1 | enolase 1, (alpha) | -0.0723516 |
| RORA | RAR-related orphan receptor A | -0.0711882 |
| KIF26B | kinesin family member 26B | -0.0704328 |
| CHGB | chromogranin B | -0.0703673 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0696147 |
| MAP1B | microtubule-associated protein 1B | -0.0678167 |
| SMYD3 | SET and MYND domain containing 3 | -0.0648654 |
| PTCHD4 | patched domain containing 4 | -0.0604454 |
| ACTG1 | actin gamma 1 | -0.0599262 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.058276 |
| NCKAP5 | NCK-associated protein 5 | -0.0580199 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0564826 |
| NAV2 | neuron navigator 2 | -0.0562991 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.0546294 |
| CALCA | calcitonin-related polypeptide alpha | -0.0541552 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0538548 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0527754 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0519819 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0515629 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0504272 |
| NBEA | neurobeachin | -0.0504165 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0504029 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0502541 |
| EFNA5 | ephrin-A5 | -0.0492554 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.048975 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0485678 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.0481437 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0466747 |
| EGR1 | early growth response 1 | -0.0444105 |
| KCNMB3 | potassium channel subfamily M regulatory beta subunit 3 | -0.0436358 |
| RNF213 | ring finger protein 213 | -0.04341 |
| TMSB4X | thymosin beta 4, X-linked | -0.0429015 |
| INHBA | inhibin, beta A | -0.0419317 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0416969 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0415929 |
| NELL1 | NEL-like 1 (chicken) | -0.0414951 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0410743 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0409686 |
| NANOS1 | nanos homolog 1 (Drosophila) | -0.0404041 |
| KCNJ6 | potassium channel, inwardly rectifying subfamily J, member 6 | -0.0404022 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0396224 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0396162 |
| ESRRG | estrogen-related receptor gamma | -0.0393525 |
| FAM13A | family with sequence similarity 13, member A | -0.0387732 |
| VGF | VGF nerve growth factor inducible | -0.0385785 |
| SVIL | supervillin | -0.0383662 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0383577 |
| CANX | calnexin | -0.0383483 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0372405 |
| PAEP | progestagen-associated endometrial protein | -0.0370947 |
| KCTD8 | potassium channel tetramerization domain containing 8 | -0.0362795 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0352681 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0346332 |
| RIT2 | Ras-like without CAAX 2 | -0.0345111 |
| ZFHX3 | zinc finger homeobox 3 | -0.0338922 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0337514 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | -0.0337147 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0328021 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0317221 |
| H1-0 | H1.0 linker histone | -0.0316634 |
| FGF14 | fibroblast growth factor 14 | -0.0313304 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0311077 |
| RIGI | RNA sensor RIG-I | -0.0309369 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.030387 |
| ZBTB7C | zinc finger and BTB domain containing 7C | -0.0294462 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.029404 |
| CPE | carboxypeptidase E | -0.0291836 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0289437 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0288059 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0287107 |
| CHGA | chromogranin A | -0.0285785 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0283661 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0280758 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0278581 |
| MYT1L | myelin transcription factor 1-like | -0.0276084 |
| NAV1 | neuron navigator 1 | -0.0275131 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0272968 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0268237 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0262633 |
| MX2 | MX dynamin-like GTPase 2 | -0.0262333 |
| AUTS2 | autism susceptibility candidate 2 | -0.0260868 |
| KLHL29 | kelch-like family member 29 | -0.0259589 |
